| 1. |
- Akkineni, Susrut, et al.
(author)
-
Amyloid-like amelogenin nanoribbons template mineralization via a low-energy interface of ion binding sites
- 2022
-
In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 119:19
-
Journal article (peer-reviewed)abstract
- Protein scaffolds direct the organization of amorphous precursors that transform into mineralized tissues, but the templating mechanism remains elusive. Motivated by models for the biomineralization of tooth enamel, wherein amyloid-like amelogenin nanoribbons guide the mineralization of apatite filaments, we investigated the impact of nanoribbon structure, sequence, and chemistry on amorphous calcium phosphate (ACP) nucleation. Using full-length human amelogenin and peptide analogs with an amyloid-like domain, films of β-sheet nanoribbons were self-assembled on graphite and characterized by in situ atomic force microscopy and molecular dynamics simulations. All sequences substantially reduce nucleation barriers for ACP by creating low-energy interfaces, while phosphoserines along the length of the nanoribbons dramatically enhance kinetic factors associated with ion binding. Furthermore, the distribution of negatively charged residues along the nanoribbons presents a potential match to the Ca–Ca distances of the multi-ion complexes that constitute ACP. These findings show that amyloid-like amelogenin nanoribbons provide potent scaffolds for ACP mineralization by presenting energetically and stereochemically favorable templates of calcium phosphate ion binding and suggest enhanced surface wetting toward calcium phosphates in general.
|
|
| 2. |
- Grice, Christine, et al.
(author)
-
Decentering pedagogical leadership : Educational leading as pedagogical practice
- 2024
-
In: Decentering leadership. - Oxon : Routledge. - 9781032599441 - 9781003456919 ; , s. 89-107
-
Book chapter (peer-reviewed)abstract
- Pedagogical leadership is increasingly emphasised in education policies and leadership standards. Yet conceptualisations of pedagogy and pedagogical leadership vary, from a focus on compliance that operationalises the role of formal school leaders, through to notions of pedagogical leadership as a praxis-oriented practice. This paper focuses on pedagogical leading practices in school settings in Sweden and Australia. Utilising the theory of practice architectures, it explores how historical notions of pedagogical leadership have changed over time in the two countries.Findings show that there are different depths of pedagogical understanding and differences between understandings of individual and collective pedagogy in policy, school leadership and practice in Australia. The traditional way of understanding pedagogical leadership in Sweden is being challenged with ideas that focus on efficiency and student outcomes and where the school’s principal is foremost seen as the school’s pedagogical leader. There is a decentering of pedagogy in both countries in which pedagogy is viewed as a model of individual attainment over the collective moral responsibility of education.Both cases raise questions about the state of educational leadership and pedagogical leadership globally and the decentering of pedagogy from students, the ultimate purpose of pedagogical practice. Educators need to reclaim the original meaning of pedagogy in order to reclaim the core purpose of education for shaping human society. How pedagogy and pedagogical leadership is understood in context will determine the extent to which they are seen as praxis-oriented practices. Properly understanding pedagogy is one way of decentring the popular role title ‘pedagogical leader’.
|
|
| 3. |
-
Gribshunden, Griffen, Gripen
- 2019
-
In: Gränsløs. Tidskrift för studier av Öresundsregionens historia, kultur och samhällsliv.. - 2001-4961. ; :10, s. 1-83
-
Other publication (other academic/artistic)
|
|
| 4. |
|
|
| 5. |
- Rake, B., et al.
(author)
-
Doing science together: Gaining momentum from long-term explorative university-industry research programs
- 2023
-
In: Drug Discovery Today. - 1359-6446 .- 1878-5832. ; 28:9
-
Journal article (peer-reviewed)abstract
- 'Doing science together' collaborations are a more intense form of university-industry interactions and are characterized by a mutual involvement and active participation of academic and company scientists in scientific research. Here, we examine the successful approach that AstraZeneca and its internationally renowned academic partners, Karolinska Institutet and Uppsala University, implemented to fully unlock the potential of all parties in long-term, explorative, truly collaborative research programs. The underlying premises of these successful research programs are three collaborative governance mechanisms (3MCs) that are required that leverage the strengths of each organization: mutual collaboration; mutually beneficial science; and a mutual governance model with senior management involvement.
|
|
| 6. |
- Krantz, Venus, et al.
(author)
-
Localizing the sustainable development goals through an integrated approach in municipalities: early experiences from a Swedish forerunner
- 2021
-
In: Journal of Environmental Planning and Management. - : ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD. - 0964-0568 .- 1360-0559. ; 64:14, s. 2641-2660
-
Journal article (peer-reviewed)abstract
- The 2030 Agenda and its SDGs call for cross-sectoral collaboration and societal transformation. Translating these indivisible goals to the local level is an important undertaking for municipalities given their wide range of responsibilities. This paper explores SDG localization in a Swedish municipal organization, providing analyses on management practice, having an integrated approach to sustainability. Based on document studies and interviews, it reflects experiences from an early phase of SDG localization. Having an integrated approach to SDG localization was shown to be dependent on aspects such as structure, leadership and coordination, yet simultaneously flexibility, organizational learning as well as time and timing. Such an integrated approach also comes with the challenge of operationalizing the SDGs into management systems, budgets and motivating employees across organizational silos and levels. The paper concludes that the SDG framework presents an opportunity for municipalities to understand and review their organizations through a broad systems perspective on sustainability.
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
- Atanasiu, Dragu, et al.
(author)
-
A bridge to linear algebra
- 2019. - 1
-
Book (peer-reviewed)abstract
- The book makes a first course in linear algebra more accessible to the majority of students and it assumes no prior knowledge of the subject. It provides a careful presentation of particular cases of all core topics. Students will find that the explanations are clear and detailed in manner. It is considered as a bridge over the obstacles in linear algebra and can be used with or without the help of an instructor.While many linear algebra texts neglect geometry, this book includes numerous geometrical applications. For example, the book presents classical analytic geometry using concepts and methods from linear algebra, discusses rotations from a geometric viewpoint, gives a rigorous interpretation of the right-hand rule for the cross product using rotations and applies linear algebra to solve some nontrivial plane geometry problems.Many students studying mathematics, physics, engineering and economics find learning introductory linear algebra difficult as it has high elements of abstraction that are not easy to grasp. This book will come in handy to facilitate the understanding of linear algebra whereby it gives a comprehensive, concrete treatment of linear algebra in R² and R³. This method has been shown to improve, sometimes dramatically, a student's view of the subject.
|
|
| 10. |
- Newman, D J, et al.
(author)
-
Serum cystatin C measured by automated immunoassay : a more sensitive marker of changes in GFR than serum creatinine
- 1995
-
In: Kidney International. - : Elsevier BV. - 0085-2538. ; 47, s. 312-318
-
Journal article (peer-reviewed)abstract
- Serum cystatin C has been suggested as a new marker of GFR. For the introduction of this marker into clinical use a rapid and automated method is required. We have developed and validated an assay for serum cystatin C using latex particle-enhanced immunoturbidimetry. Intra- and inter-assay precision were < 3% and < 5% across the assay range. Analytical recovery was 93 +/- 3.8% and no lack of parallelism was demonstrated. Regression analysis of a method comparison with an enzyme-enhanced radial-immunodiffusion method, gave PETIA = 0.074 + 0.93 x SRID, r = 0.98, N = 100. Inter-assay precision profiles showed cystatin C was measured with two-fold better precision than creatinine on the same analyzer. Cystatin C measurement was neither interfered with by icterus nor by hemolysis. 1/cystatin C versus 1/creatinine concentrations gave r = 0.67, N = 469. Comparison of Cr EDTA GFR with 1/cystatin C and 1/creatinine gave r = 0.81 and 0.50, respectively, N = 206. Calculating diagnostic sensitivity for abnormal GFR showed cystatin C to be significantly (P < 0.05) more sensitive than creatinine (71.4 vs. 52.4%). Cystatin C measurement using PETIA technology can be automated on the same instruments used routinely for the measurement of creatinine and offers better analytical performance and probably improved clinical sensitivity as a screening test for early renal damage.
|
|
| 11. |
- Rodríguez de Llera González, Delia, et al.
(author)
-
Automated design of a WCDMA/WLAN multi-standard receiver
- 2006
-
In: ICECS 2006 - 13th IEEE International Conference on Electronics, Circuits and Systems. - 1424403952 ; , s. 1320-1323
-
Conference paper (peer-reviewed)abstract
- In this paper we show how TACT, a recently reported [1] radio system design and optimization tool, can be used to optimize the design of a dual mode WCDMA/WLAN receiver. An overview of the underlying frequency planning and receiver budget analysis routines is discussed first. In a case study, a zero-IF WLAN/WCDMA radio receiver is then designed and optimized using the tool. TACT yields optimized design specs for each block in the chain as well as a summary of the system performance obtained. The obtained performance is shown to meet or exceed the requirements of the WCDMA/WLAN standards. As such, the case study validates the benefits of the proposed tool.
|
|
| 12. |
|
|
| 13. |
- Steen, Stig, et al.
(author)
-
Jan Kugelberg 1928-2001
- 2001
-
In: Årsbok 2001-2002. - 1402-1277.
-
Book chapter (other academic/artistic)
|
|
| 14. |
|
|
| 15. |
- Doohan, Isabelle, et al.
(author)
-
Need for compassion in prehospital and emergency care : a qualitative study on bus crash survivors' experiences
- 2015
-
In: International Emergency Nursing. - : Elsevier BV. - 1755-599X .- 1878-013X. ; 23:2, s. 115-119
-
Journal article (peer-reviewed)abstract
- Aim: To explore the survivors' experiences after a major bus crash. Background: Survivors' experiences of emergency care after transportation related major incidents are relatively unexplored, with research involving survivors mainly focused on pathological aspects or effects of crisis support. Methods: Semi-structured telephone interviews were conducted with 54 out of 56 surviving passengers 5 years after a bus crash in Sweden. Interviews were analyzed using qualitative content analysis. Results: Prehospital discomfort, lack of compassionate care, dissatisfaction with crisis support and satisfactory initial care and support are the categories. Lack of compassion in emergency departments was identified as a main finding. Lack of compassion caused distress among survivors and various needs for support were not met. Survivors' desire to be with their fellow survivors the day of the crash was not facilitated after arriving at emergency departments. Conclusions: Connectedness among survivors ought to be promoted upon arrival at emergency departments. There is a need for emergency department professionals to be sufficiently educated in compassionate care.
|
|
| 16. |
- Hohenthal, Jukka, et al.
(author)
-
Market discovery and the international expansion of the firm
- 2003
-
In: International Business Review. - : Elsevier BV. - 0969-5931 .- 1873-6149. ; 12:6, s. 659-672
-
Journal article (peer-reviewed)abstract
- The objective of this paper is to formulate a theoretical framework for studies of antecedents and consequences of discoveries during international expansion. By introducing market discovery it seems to be possible to offer a richer understanding of the pattern and pace of the international expansion of a firm. Market discovery is the result of both exploration and exploitation activities, but in order to exploit market discovery, a firm must learn to handle the discovered opportunity. A discovery, usually made while a firm is conducting daily activities, occurs in connection with search, planning, routine, and improvisation. The resulting learning can lead to changes in pace, orientation, and extension of the international expansion of the firm. © 2003 Elsevier Ltd. All rights reserved.
|
|
| 17. |
- Rees, S.E, et al.
(author)
-
Reproduction of MIGET retention and excretion data using a simple mathematical model of gas exchange in lung damage caused by oleic acid infusion
- 2006
-
In: Journal of applied physiology. - : American Physiological Society. - 8750-7587 .- 1522-1601. ; 101:3, s. 826-832
-
Journal article (peer-reviewed)abstract
- Reproduction of MIGET retention and excretion data using a simple mathematical model of gas exchange in lung damage caused by oleic acid infusion. J Appl Physiol 101: 826-832, 2006. First published June 8, 2006; doi:10.1152/japplphysiol.01481.2005.-The multiple inert-gas elimination technique ( MIGET) is a complex mathematical model and experimental technique for understanding pulmonary gas exchange. Simpler mathematical models have been proposed that have a limited view compared with MIGET but may be applicable for use in clinical practice. This study examined the use of a simple model of gas exchange to describe MIGET retention and excretion data in seven pigs before and following lung damage caused by oleic acid infusion and subsequently at different levels of positive end-expiratory pressure. The simple model was found to give, on average, a good description of MIGET data, as evaluated by a chi(2) test on the weighted residual sum of squares resulting from the model fit (P > 0.2). Values of the simple model's parameters (dead-space volume, shunt, and the fraction of alveolar ventilation going to compartment 2) compared well with the similar MIGET parameters (dead-space volume, shunt, log of the standard deviation of the perfusion, log of the standard deveation of the ventilation), giving values of bias and standard deviation on the differences between dead-space volume and shunt of 0.002 +/- 0.002 liter and 7.3 +/- 2.1% (% of shunt value), respectively. Values of the fraction of alveolar ventilation going to compartment 2 correlated well with log of the standard deviation of the perfusion (r(2) = 0.86) and log of the standard deviation of the ventilation (r(2) = 0.92). These results indicate that this simple model provides a good description of lung pathology following oleic acid infusion. It remains to be seen whether physiologically valid values of the simple model parameters can be obtained from clinical experiments varying inspired oxygen fraction. If so, this may indicate a role for simple models in the clinical interpretation of gas exchange.
|
|
| 18. |
- Warrant, Eric J.
(author)
-
Visual Tracking : Hot Pursuit with Tiny Eyes
- 2017
-
In: Current Biology. - : Elsevier BV. - 0960-9822. ; 27:6, s. 234-237
-
Journal article (peer-reviewed)abstract
- Flying insect predators intercept their aerial prey with deadly precision. New research reveals that a tiny robber fly, with a brain smaller than a pinhead, achieves this using the same visual mechanism that we ourselves employ to catch a passing ball.
|
|
| 19. |
- Cacciaglia, Raffaele, et al.
(author)
-
APOE-ε4 Shapes the Cerebral Organization in Cognitively Intact Individuals as Reflected by Structural Gray Matter Networks.
- 2020
-
In: Cerebral cortex. - : Oxford University Press (OUP). - 1460-2199 .- 1047-3211. ; 30:7, s. 4110-4120
-
Journal article (peer-reviewed)abstract
- Gray matter networks (GMn) provide essential information on the intrinsic organization of the brain and appear to be disrupted in Alzheimer's disease (AD). Apolipoprotein E (APOE)-ε4 represents the major genetic risk factor for AD, yet the association between APOE-ε4 and GMn has remained unexplored. Here, we determine the impact of APOE-ε4 on GMn in a large sample of cognitively unimpaired individuals, which was enriched for the genetic risk of AD. We used independent component analysis to retrieve sources of structural covariance and analyzed APOE group differences within and between networks. Analyses were repeated in a subsample of amyloid-negative subjects. Compared with noncarriers and heterozygotes, APOE-ε4 homozygotes showed increased covariance in one network including primarily right-lateralized, parietal, inferior frontal, as well as inferior and middle temporal regions, which mirrored the formerly described AD-signature. This result was confirmed in a subsample of amyloid-negative individuals. APOE-ε4 carriers showed reduced covariance between two networks encompassing frontal and temporal regions, which constitute preferential target of amyloid deposition. Our data indicate that, in asymptomatic individuals, APOE-ε4 shapes the cerebral organization in a way that recapitulates focal morphometric alterations observed in AD patients, even in absence of amyloid pathology. This suggests that structural vulnerability in neuronal networks associated with APOE-ε4 may be an early event in AD pathogenesis, possibly upstream of amyloid deposition.
|
|
| 20. |
- Farré-de-Pablo, Júlia, et al.
(author)
-
Orthopyroxenite hosted chromitite veins anomalously enriched in platinum-group minerals from the Havana-Matanzas Ophiolite, Cuba
- 2020
-
In: Boletín de la Sociedad Geológica Mexicana. - : Universidad Nacional Autónoma de México. - 1405-3322 .- 1405-3322. ; 72:3
-
Journal article (peer-reviewed)abstract
- The Havana–Matanzas Ophiolite contains one of the few examples of ophiolitic platinum group minerals (PGM)-rich chromitites associated with orthopyroxenites in the mantle section of ophiolitic complexes. The chromitites occur as veins hosted by orthopyroxenite bands within mantle peridotites. The peridotites are mostly harzburgites and their accessory chromite shows high-Al compositions (Cr# [Cr/(Cr+Al), atomic ratio] = 0.39–0.50), which are typical of spinels in abyssal peridotites. Conversely, chromite from the chromitite veins and their host orthopyroxenite are high-Cr (Cr# = 0.72–0.73 and 0.62–0.69, respectively), with lower Mg# [Mg/(Mg+Fe2+), atomic ratio]. This suggests that both the chromitite and the orthopyroxenite formed from melts with boninitic affinity. The abundant PGM inclusions found in the chromitites are mainly Os-rich laurite grains, which is also characteristic of chromitites formed from magmas with boninitic affinity. Therefore, we propose that the chromitite veins and the orthopyroxenite bands probably formed contemporaneously in the fore-arc setting of an intra-oceanic arc during subduction. The chromitite-orthopyroxenite pair of the Havana-Matanzas Ophiolite could form after the reaction of a Si-rich melt with boninitic affinity and mantle harzburgite, with the orthopyroxenite bands preserving fingerprints of the infiltration of boninitic-affinity melts within the mantle. The small volume of forming chromitite could maximize the efficiency for the mechanical collection of the PGM forming in the parental melt of these rocks, resulting in the anomalous enrichment of primary PGM in the chromitites.
|
|
| 21. |
- Krzyzanowski, Michal, 1977-, et al.
(author)
-
Discourses and practices of the ‘New Normal’ Towards an interdisciplinary research agenda on crisis and the normalization of anti- and post‑democratic action
- 2023
-
In: Journal of Language and Politics. - Amsterdam : John Benjamins Publishing Company. - 1569-2159 .- 1569-9862. ; 22:4, s. 415-437
-
Journal article (peer-reviewed)abstract
- This position paper argues for an interdisciplinary agenda relating crises to on-going processes of normalization of anti- and post-democratic action. We call for exploring theoretically and empirically the ‘new normal’ logic introduced into public imagination on the back of various crises, including the recent ‘Refugee Crisis’ in Europe, COVID-19 pandemic, or the still ongoing Russian invasion of Ukraine. Gathering researchers of populism, extremism, discrimination, and other formats of anti- and post-democratic action, we propose investigating how, why, and under which conditions, discourses and practices underlying normalization processes re-emerge to challenge the liberal democratic order. We argue exploring the multiple variants of ‘the new normal’ related to crises, historically and more recently. We are interested in how and why these open pathways for politics of exclusion, inequality, xenophobia and other patterns of anti- and post-democratic action while deepening polarization and radicalization of society as well as propelling far-right politics and ideologies.
|
|
| 22. |
|
|
| 23. |
- Pocorni, Jetro, 1988-, et al.
(author)
-
Investigation of the Piercing Process in Laser Cutting of Stainless Steel
- 2017
-
In: Journal of laser applications. - : American Institute of Physics (AIP). - 1042-346X .- 1938-1387. ; 29:2
-
Journal article (peer-reviewed)abstract
- This paper investigates the laser piercing process which precedes nearly every laser cutting operation. The two most important aspects of the piercing process are: a) How long does it take to pierce the material? And b) How wide is the pierced hole? If the hole is no wider than the cut line, the material can be pierced on the line to be cut. In this paper 10 mm thick stainless steel was pierced by a multikilowatt fibre laser to compare efficiency and quality when piercing with a continuous wave (cw) output and a selected range of power modulation parameters. The different processes were observed by high speed imaging and subsequently examined by visual observation. High speed imaging is used to time the penetration event and to study the laser-material interactions involved in drilling the pierced holes. The results show that appropriate laser power modulation settings can considerably reduce both the piercing time and the required energy to generate any piercing hole required for the subsequent cutting process. This pulse-pierce technique and the differences between piercing with a continuous and a power modulated laser beam are further explained and discussed. Also the effect on the size of the entrance to the pierced hole depending on power modulation regimes was investigated in this paper.
|
|
| 24. |
- Pocorni, Jetro, 1988-, et al.
(author)
-
The geometry of the cutting front created by Fibre and CO2 lasers when profiling stainless steel under standard commercial conditions
- 2018
-
In: Optics and Laser Technology. - : Elsevier. - 0030-3992 .- 1879-2545. ; 103, s. 318-326
-
Journal article (peer-reviewed)abstract
- Cutting fronts created by CO2 and fibre lasers in stainless steel at thicknesses between 2 mm and 10 mm have been ‘frozen’ and their geometry has been measured. Standard commercial cutting parameters were used to generate the cuts for both types of laser. The resulting three-dimensional cutting front shapes have been curve fitted as polynomials and semicircles. Various features of the cutting front geometry are discussed including the lack of correlation of the cut front inclination with either the relevant Brewster angle or the inclination of the striations on the cut edge.
|
|
| 25. |
|
|
| 26. |
- Rudner, Mary, 1958-
(author)
-
Modalities of Mind : Modality-specific and nonmodality-specific aspects of working memory for sign and speech
- 2005
-
Doctoral thesis (other academic/artistic)abstract
- Language processing is underpinned by working memory and while working memory for signed languages has been shown to display some of the characteristics of working memory for speech-based languages, there are a range of anomalous effects related to the inherently visuospatial modality of signed languages. On the basis of these effects, four research questions were addressed in a series of studies:1. Are differences in working memory storage for sign and speech reflected in neural representation?2. Do the neural networks supporting speech-sign switching during a working memory task reflect executive or semantic processes?3. Is working memory for sign language enhanced by a spatial style of information presentation?4. Do the neural networks supporting word reversal indicate tongue-twisting or mind-twisting?The results of the studies showed that:1. Working memory for sign and speech is supported by a combination of modality-specific and nonmodality-specific neural networks.2. Switching between sign and speech during a working memory task is supported by semantic rather than executive processes.3. Working memory performance in educationally promoted native deaf signers is enhanced by a spatial style of presentation.4. Word reversal is a matter of mind-twisting, rather than tongue-twisting.These findings indicate that working memory for sign and speech has modality-specific components as well as nonmodality-specific components. Modality-specific aspects can be explained in terms of Wilson’s (2001) sensorimotor account, which is based on the component model (Baddeley, 2000), given that the functionality of the visuospatial sketchpad is extended to include language processing. Nonmodality-specific working memory processing is predicted by Rönnberg’s (2003) model of cognitive involvement in language processing. However, the modality-free, cross-modal and extra-modal aspects of working memory processing revealed in the present work can be explained in terms of the central executive and the episodic buffer, providing the functionality and neural representation of the episodic buffer are extended.A functional ontology is presented which ties cognitive processes to their neural representation, along with a model explaining modality-specific findings relating to sign language cognition. Predictions of the ontology and the model are discussed in relation to future work.
|
|
| 27. |
- Rudner, Mary, et al.
(author)
-
Preexisting semantic representation improves working memory performance in the visuospatial domain
- 2016
-
In: Memory & Cognition. - : Springer. - 0090-502X .- 1532-5946. ; 44:4, s. 608-620
-
Journal article (peer-reviewed)abstract
- Working memory (WM) for spoken language improves when the to-be-remembered items correspond to preexisting representations in long-term memory. We investigated whether this effect generalizes to the visuospatial domain by administering a visual n-back WM task to deaf signers and hearing signers, as well as to hearing nonsigners. Four different kinds of stimuli were presented: British Sign Language (BSL; familiar to the signers), Swedish Sign Language (SSL; unfamiliar), nonsigns, and nonlinguistic manual actions. The hearing signers performed better with BSL than with SSL, demonstrating a facilitatory effect of preexisting semantic representation. The deaf signers also performed better with BSL than with SSL, but only when WM load was high. No effect of preexisting phonological representation was detected. The deaf signers performed better than the hearing nonsigners with all sign-based materials, but this effect did not generalize to nonlinguistic manual actions. We argue that deaf signers, who are highly reliant on visual information for communication, develop expertise in processing sign-based items, even when those items do not have preexisting semantic or phonological representations. Preexisting semantic representation, however, enhances the quality of the gesture-based representations temporarily maintained in WM by this group, thereby releasing WM resources to deal with increased load. Hearing signers, on the other hand, may make strategic use of their speech-based representations for mnemonic purposes. The overall pattern of results is in line with flexible-resource models of WM.
|
|
| 28. |
- Pocorni, Jetro, et al.
(author)
-
The Effect of Laser Type and Power on the Efficiency of Industrial Cutting of Mild and Stainless Steels
- 2016
-
In: Journal of manufacturing science and engineering. - : ASME International. - 1087-1357 .- 1528-8935. ; 138:3
-
Journal article (peer-reviewed)abstract
- This paper investigates the effect of material type, material thickness, laser wavelength and laser power on the efficiency of the cutting process for industrial state-of-the-art cutting machines. The cutting efficiency is defined in its most basic terms: as the area of cut edge created per Joule of laser energy. This fundamental measure is useful in producing a direct comparison between the efficiency of fiber and CO2 lasers when cutting any material. It is well known that the efficiency of the laser cutting process generally reduces as the material thickness increases, because conductive losses from the cut zone are higher at the lower speeds associated with thicker section material. However, there is an efficiency dip at the thinnest sections. This paper explains this dip in terms of a change in laser-material interaction at high cutting speeds. Fiber lasers have a higher cutting efficiency at thin sections than their CO2 counterparts, but the efficiency of fiber laser cutting falls faster than that of CO2 lasers as material thickness is increased. This is the result of a number of factors including changes in cut zone absorptivity and kerf width. This paper presents phenomenological explanations for the relative cutting efficiencies of fiber lasers and CO2 lasers, and the mechanisms affecting these efficiencies for stainless steels (cut with nitrogen) and mild steel (cut with oxygen or nitrogen) over a range of thicknesses. The paper involves a discussion of both theoretical and practical engineering issues. Key Words; Laser Cutting, Fiber Laser, CO2 Laser, Efficiency.
|
|
| 29. |
|
|
| 30. |
- Steen, Johanna, et al.
(author)
-
The correlation between antigen solubility and immunogenicity
-
Other publication (other academic/artistic)abstract
- In antigen design, several characteristics contribute to the final success of the antigen to elicit the desired immunogenicity. However, it is difficult to screen theses attributes due to the variability within the host immune receptor repertoire. Herein, with the massive numeral of immunizations performed within a proteome-wide endeavor to produce affinity reagents to human proteins, the correlation between the solubility of the antigens and the immunogenicity was investigated. We showed that increased solubility of the antigen resulted in higher success rate in provoking the immune defense as well as higher antibody titers. We have also shown, that the increased antibody titers after affinity purifications indeed reflectthe concentration of target specific antibodies within the serum. Finally, the amino acid composition of soluble antigens was determined to be over-represented in polar residues.
|
|
| 31. |
- Steen, Jesper, 1945-, et al.
(author)
-
Useful Buildings for Office activities
- 2005
-
In: Facilities. - : Emerald. - 0263-2772 .- 1758-7131. ; 23:3/4, s. 176-186
-
Journal article (peer-reviewed)abstract
- Purpose – There is lack of knowledge about how movements and interaction within offices are related to the work activities and the premises. This paper aims to develop such knowledge and to develop analytic methods for differentiating office buildings regarding their usefulness to different kind of office activities and sectors. Design/methodology/approach – The empirical data were collected from several comparative case studies. The spatial configuration of each office is analysed with Space syntax-methods. The organisation and work activities of each office and the use of the spatial system are surveyed by means of interviews, observations and private logbooks and questionnaires. Findings – The spatial configuration influences the relation between movements and actual interaction, and, as most interaction occurs at one's workstation, which people will be interacting with whom. The building's spatial influence is largest on intra-group movement. The spatial behaviour – the pattern of occupation and movement of the office workers – is on an average level quite the same for different organisations. Research limitations/implications – The project is so far concentrated on the main work category in many large organisations, the handling officer, a clerk handling tasks individually more or less routinely. The sample of office concepts, or spatial forms, is also restricted so far. Practical implications – The findings are of great interest for architects in designing offices in order to be both well functioning for a specific organisation and robust in permitting changes of different kind. For the real estate owners the knowledge will facilitate defining the market and for the users this will strengthen the potential to express the demands. Originality/value – This research project is focused on spatial configuration and interaction, unlike the most of the studies about the individual workstations.
|
|
| 32. |
- Steen Jensen, Camilla, et al.
(author)
-
Cerebrospinal Fluid Amyloid Beta and Tau Concentrations Are Not Modulated by 16 Weeks of Moderate- to High-Intensity Physical Exercise in Patients with Alzheimer Disease.
- 2016
-
In: Dementia and geriatric cognitive disorders. - : S. Karger AG. - 1421-9824 .- 1420-8008. ; 42:3-4, s. 146-158
-
Journal article (peer-reviewed)abstract
- Physical exercise may have some effect on cognition in patients with Alzheimer disease (AD). However, the underlying biochemical effects are unclear. Animal studies have shown that amyloid beta (Aβ), one of the pathological hallmarks of AD, can be altered with high levels of physical activity.The objective of this study was to elucidate the effect of 16 weeks of moderate- to high-intensity physical exercise on the biomarkers of AD, with special emphasis on the amyloidogenic pathway.From a total of 53 patients with AD participating in the Preserving Cognition, Quality of Life, Physical Health and Functional Ability in Alzheimer's Disease: The Effect of Physical Exercise (ADEX) study we analyzed cerebrospinal fluid samples for Aβ species, total tau (t-tau), phosphorylated tau (p-tau) and soluble amyloid precursor protein (sAPP) species. We also assessed the patients for apolipoprotein E ε4 (ApoE ε4) genotype.We found no effect of 16 weeks of physical exercise on the selected biomarkers, and no effect of ApoE ε4 genotype.Our findings suggest that the possible effect of physical exercise on cognition in patients with AD is not due to modulation of Aβ, t-tau, p-tau and sAPP species.
|
|
| 33. |
- Törnquist, Agneta, 1953-
(author)
-
Kommunal äldreomsorg kräver också utbildning
- 2001. - 1:1
-
In: Villkor och vägar för grundläggande yrkesutbildning. - Stockholm : Skolverket. - 9189314638 ; , s. 169-186
-
Book chapter (pop. science, debate, etc.)
|
|
