| 1. |
- Kattge, Jens, et al.
(author)
-
TRY plant trait database - enhanced coverage and open access
- 2020
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In: Global Change Biology. - : Wiley-Blackwell. - 1354-1013 .- 1365-2486. ; 26:1, s. 119-188
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Journal article (peer-reviewed)abstract
- Plant traits-the morphological, anatomical, physiological, biochemical and phenological characteristics of plants-determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait-based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits-almost complete coverage for 'plant growth form'. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait-environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives.
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| 2. |
- Bellaver, B., et al.
(author)
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Astrocyte reactivity influences amyloid-beta effects on tau pathology in preclinical Alzheimer's disease
- 2023
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In: Nature Medicine. - 1078-8956. ; 29:7
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Journal article (peer-reviewed)abstract
- Cross-sectional and longitudinal analyses of tau pathology in preclinical Alzheimer's disease reveal that tau tangles accumulate as a function of amyloid-beta burden only in individuals positive for an astrocyte reactivity biomarker. An unresolved question for the understanding of Alzheimer's disease (AD) pathophysiology is why a significant percentage of amyloid-beta (A beta)-positive cognitively unimpaired (CU) individuals do not develop detectable downstream tau pathology and, consequently, clinical deterioration. In vitro evidence suggests that reactive astrocytes unleash A beta effects in pathological tau phosphorylation. Here, in a biomarker study across three cohorts (n = 1,016), we tested whether astrocyte reactivity modulates the association of A beta with tau phosphorylation in CU individuals. We found that A beta was associated with increased plasma phosphorylated tau only in individuals positive for astrocyte reactivity (Ast(+)). Cross-sectional and longitudinal tau-positron emission tomography analyses revealed an AD-like pattern of tau tangle accumulation as a function of A beta only in CU Ast(+) individuals. Our findings suggest astrocyte reactivity as an important upstream event linking A beta with initial tau pathology, which may have implications for the biological definition of preclinical AD and for selecting CU individuals for clinical trials.
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| 3. |
- Ferrari-Souza, J. P., et al.
(author)
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APOEε4 potentiates amyloid β effects on longitudinal tau pathology
- 2023
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In: Nature Aging. - 2662-8465. ; 3:10
-
Journal article (peer-reviewed)abstract
- The mechanisms by which the apolipoprotein E epsilon 4 (APOE epsilon 4) allele influences the pathophysiological progression of Alzheimer's disease (AD) are poorly understood. Here we tested the association of APOE epsilon 4 carriership and amyloid-beta (A beta) burden with longitudinal tau pathology. We longitudinally assessed 94 individuals across the aging and AD spectrum who underwent clinical assessments, APOE genotyping, magnetic resonance imaging, positron emission tomography (PET) for A beta ([F-18]AZD4694) and tau ([F-18]MK-6240) at baseline, as well as a 2-year follow-up tau-PET scan. We found that APOE epsilon 4 carriership potentiates A beta effects on longitudinal tau accumulation over 2 years. The APOE epsilon 4-potentiated A beta effects on tau-PET burden were mediated by longitudinal plasma phosphorylated tau at threonine 217 (p-tau217(+)) increase. This longitudinal tau accumulation as measured by PET was accompanied by brain atrophy and clinical decline. Our results suggest that the APOE epsilon 4 allele plays a key role in A beta downstream effects on the aggregation of phosphorylated tau in the living human brain.
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| 4. |
- Daniel, M., et al.
(author)
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Impact of androgen deprivation therapy on apparent diffusion coefficient and T2w MRI for histogram and texture analysis with respect to focal radiotherapy of prostate cancer
- 2019
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In: Strahlentherapie und Onkologie (Print). - : Springer Berlin/Heidelberg. - 0179-7158 .- 1439-099X. ; 195:5, s. 402-411
-
Journal article (peer-reviewed)abstract
- Purpose: Accurate prostate cancer (PCa) detection is essential for planning focal external beam radiotherapy (EBRT). While biparametric MRI (bpMRI) including T2-weighted (T2w) and diffusion-weighted images (DWI) is an accurate tool to localize PCa, its value is less clear in the case of additional androgen deprivation therapy (ADT). The aim of this study was to investigate the value of a textural feature (TF) approach on bpMRI analysis in prostate cancer patients with and without neoadjuvant ADT with respect to future dose-painting applications.Methods: 28 PCa patients (54–80 years) with (n = 14) and without (n = 14) ADT who underwent bpMRI with T2w and DWI were analyzed retrospectively. Lesions, central gland (CG), and peripheral zone (PZ) were delineated by an experienced urogenital radiologist based on localized pre-therapeutic histopathology. Histogram parameters and 20 Haralick TF were calculated. Regional differences (i. e., tumor vs. PZ, tumor vs. CG) were analyzed for all imaging parameters. Receiver-operating characteristic (ROC) analysis was performed to measure diagnostic performance to distinguish PCa from benign prostate tissue and to identify the features with best discriminative power in both patient groups.Results: The obtained sensitivities were equivalent or superior when utilizing the TF in the no-ADT group, while specificity was higher for the histogram parameters. However, in the ADT group, TF outperformed the conventional histogram parameters in both specificity and sensitivity. Rule-in and rule-out criteria for ADT patients could exclusively be defined with the aid of TF.Conclusions: The TF approach has the potential for quantitative image-assisted boost volume delineation in PCa patients even if they are undergoing neoadjuvant ADT.
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| 5. |
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| 6. |
- Ferreira, P. C. L., et al.
(author)
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Plasma p-tau231 and p-tau217 inform on tau tangles aggregation in cognitively impaired individuals
- 2023
-
In: Alzheimers & Dementia. - 1552-5260. ; 19:10, s. 4463-4474
-
Journal article (peer-reviewed)abstract
- INTRODUCTIONPhosphorylated tau (p-tau) biomarkers have been recently proposed to represent brain amyloid-& beta; (A & beta;) pathology. Here, we evaluated the plasma biomarkers' contribution beyond the information provided by demographics (age and sex) to identify A & beta; and tau pathologies in individuals segregated as cognitively unimpaired (CU) and impaired (CI). METHODSWe assessed 138 CU and 87 CI with available plasma p-tau231, 217(+), and 181, A & beta;42/40, GFAP and A & beta;- and tau-PET. RESULTSIn CU, only plasma p-tau231 and p-tau217(+) significantly improved the performance of the demographics in detecting A & beta;-PET positivity, while no plasma biomarker provided additional information to identify tau-PET positivity. In CI, p-tau217(+) and GFAP significantly contributed to demographics to identify both A & beta;-PET and tau-PET positivity, while p-tau231 only provided additional information to identify tau-PET positivity. DISCUSSIONOur results support plasma p-tau231 and p-tau217(+) as state markers of early A & beta; deposition, but in later disease stages they inform on tau tangle accumulation. HighlightsIt is still unclear how much plasma biomarkers contribute to identification of AD pathology across the AD spectrum beyond the information already provided by demographics (age + sex).Plasma p-tau231 and p-tau217(+) contribute to demographic information to identify brain A & beta; pathology in preclinical AD.In CI individuals, plasma p-tau231 contributes to age and sex to inform on the accumulation of tau tangles, while p-tau217(+) and GFAP inform on both A & beta; deposition and tau pathology.
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| 7. |
- Rossi, P., et al.
(author)
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De novo metallonucleases based on helix-loop-helix motifs
- 2004
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In: Chemistry - A European Journal. - : Wiley. - 0947-6539 .- 1521-3765. ; 10:17, s. 4163-4170
-
Journal article (peer-reviewed)abstract
- Three new 42-mer peptides (PRI-III) designed to fold into a hairpin helix-loop-helix motif have been prepared. In the peptide sequence two (PRII-III) or four (PRI) copies of an unnatural amino acid bearing a triazacyclononane metal-ion binding site (ATANP) have been inserted in appropriate positions to allow the ligand subunits to face each other either within the same helix or between the two helices of the hairpin motif. Circular dichroism (C(d) studies in solution have shown that the apopeptides adopt a well-defined helix-loop-helix tertiary structure that dimerizes in solution at concentrations above 2001 µM to form a four-helix bundle. However, the helical content is strongly dependent on pH and metal-ion binding. Both protonation of the amines of the triazacyclononane units present in the ATANP lateral arm and complexation with ZnII ions cause a significant decrease of the helical content of the sequences. The ZnII complexes of the three peptides catalyze the transesterification of the RNA model substrate 2-hydroxypropyl-p-nitrophenyl phosphate (HPNP) with different efficiency. The best catalyst appears to be PRI-4ZnII. that is, the peptide incorporating four ATANP units. Michaelis-Menten saturation kinetics allowed us to estimate that substrate fully bound to the catalyst reacts 380 times faster than in its absence. The kinetic evidence suggests cooperativity between (at least two) metal ions: one activating the nucleophilic species (directly or indirectly) and the other facilitating nucleophilic attack by coordination of the phosphate.
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| 8. |
- Therriault, J., et al.
(author)
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Equivalence of plasma p-tau217 with cerebrospinal fluid in the diagnosis of Alzheimer's disease
- 2023
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In: Alzheimers & Dementia. - 1552-5260. ; 19:11, s. 4967-4977
-
Journal article (peer-reviewed)abstract
- INTRODUCTION: Plasma biomarkers are promising tools for Alzheimer's disease (AD) diagnosis, but comparisons with more established biomarkers are needed.METHODS: We assessed the diagnostic performance of p-tau(181), p-tau(217), and p-tau(231) in plasma and CSF in 174 individuals evaluated by dementia specialists and assessed with amyloid-PET and tau-PET. Receiver operating characteristic (ROC) analyses assessed the performance of plasma and CSF biomarkers to identify amyloid-PET and tau-PET positivity.RESULTS: Plasma p-tau biomarkers had lower dynamic ranges and effect sizes compared to CSF p-tau. Plasma p-tau(181) (AUC = 76%) and p-tau(231) (AUC = 82%) assessments performed inferior to CSF p-tau(181) (AUC = 87%) and p-tau(231) (AUC = 95%) for amyloid-PET positivity. However, plasma p-tau(217) (AUC = 91%) had diagnostic performance indistinguishable from CSF (AUC = 94%) for amyloid-PET positivity.DISCUSSION: Plasma and CSF p-tau(217) had equivalent diagnostic performance for biomarker-defined AD. Our results suggest that plasma p-tau(217) may help reduce the need for invasive lumbar punctures without compromising accuracy in the identification of AD.
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| 9. |
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| 10. |
- Bruhwiler, P, et al.
(author)
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Vibronic coupling in the photoemission bands of condensed C-60
- 1997
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In: CHEMICAL PHYSICS LETTERS. - : ELSEVIER SCIENCE BV. - 0009-2614. ; 279:1-2, s. 85-91
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Journal article (other academic/artistic)abstract
- We present photoelectron spectra for the highest occupied molecular orbital (HOMO) of C-60 in the gas phase and a two-dimensional (2D) condensed layer. For low temperatures the similarity in the spectra is striking and places a strict upper limit of 0.07
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| 11. |
- Davies, Stuart J., et al.
(author)
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ForestGEO: Understanding forest diversity and dynamics through a global observatory network
- 2021
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In: Biological Conservation. - : Elsevier BV. - 0006-3207. ; 253
-
Journal article (peer-reviewed)abstract
- ForestGEO is a network of scientists and long-term forest dynamics plots (FDPs) spanning the Earth's major forest types. ForestGEO's mission is to advance understanding of the diversity and dynamics of forests and to strengthen global capacity for forest science research. ForestGEO is unique among forest plot networks in its large-scale plot dimensions, censusing of all stems ≥1 cm in diameter, inclusion of tropical, temperate and boreal forests, and investigation of additional biotic (e.g., arthropods) and abiotic (e.g., soils) drivers, which together provide a holistic view of forest functioning. The 71 FDPs in 27 countries include approximately 7.33 million living trees and about 12,000 species, representing 20% of the world's known tree diversity. With >1300 published papers, ForestGEO researchers have made significant contributions in two fundamental areas: species coexistence and diversity, and ecosystem functioning. Specifically, defining the major biotic and abiotic controls on the distribution and coexistence of species and functional types and on variation in species' demography has led to improved understanding of how the multiple dimensions of forest diversity are structured across space and time and how this diversity relates to the processes controlling the role of forests in the Earth system. Nevertheless, knowledge gaps remain that impede our ability to predict how forest diversity and function will respond to climate change and other stressors. Meeting these global research challenges requires major advances in standardizing taxonomy of tropical species, resolving the main drivers of forest dynamics, and integrating plot-based ground and remote sensing observations to scale up estimates of forest diversity and function, coupled with improved predictive models. However, they cannot be met without greater financial commitment to sustain the long-term research of ForestGEO and other forest plot networks, greatly expanded scientific capacity across the world's forested nations, and increased collaboration and integration among research networks and disciplines addressing forest science.
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| 12. |
- Granath, Gustaf, et al.
(author)
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Environmental and taxonomic controls of carbon and oxygen stable isotope composition in Sphagnum across broad climatic and geographic ranges
- 2018
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In: Biogeosciences. - : Copernicus Publications. - 1726-4170 .- 1726-4189. ; 15:16, s. 5189-5202
-
Journal article (peer-reviewed)abstract
- Rain-fed peatlands are dominated by peat mosses (Sphagnum sp.), which for their growth depend on nutrients, water and CO2 uptake from the atmosphere. As the isotopic composition of carbon (C-12(,)13) and oxygen (O-16(,)18) of these Sphagnum mosses are affected by environmental conditions, Sphagnum tissue accumulated in peat constitutes a potential long-term archive that can be used for climate reconstruction. However, there is inadequate understanding of how isotope values are influenced by environmental conditions, which restricts their current use as environmental and palaeoenvironmental indicators. Here we tested (i) to what extent C and O isotopic variation in living tissue of Sphagnum is speciesspecific and associated with local hydrological gradients, climatic gradients (evapotranspiration, temperature, precipitation) and elevation; (ii) whether the C isotopic signature can be a proxy for net primary productivity (NPP) of Sphagnum; and (iii) to what extent Sphagnum tissue delta O-18 tracks the delta O-18 isotope signature of precipitation. In total, we analysed 337 samples from 93 sites across North America and Eurasia us ing two important peat-forming Sphagnum species (S. magellanicum, S. fuscum) common to the Holarctic realm. There were differences in delta C-13 values between species. For S. magellanicum delta C-13 decreased with increasing height above the water table (HWT, R-2 = 17 %) and was positively correlated to productivity (R-2 = 7 %). Together these two variables explained 46 % of the between-site variation in delta C-13 values. For S. fuscum, productivity was the only significant predictor of delta C-13 but had low explanatory power (total R-2 = 6 %). For delta O-18 values, approximately 90 % of the variation was found between sites. Globally modelled annual delta O-18 values in precipitation explained 69 % of the between-site variation in tissue delta O-18. S. magellanicum showed lower delta O-18 enrichment than S. fuscum (-0.83 %0 lower). Elevation and climatic variables were weak predictors of tissue delta O-18 values after controlling for delta O-18 values of the precipitation. To summarize, our study provides evidence for (a) good predictability of tissue delta O-18 values from modelled annual delta O-18 values in precipitation, and (b) the possibility of relating tissue delta C-13 values to HWT and NPP, but this appears to be species-dependent. These results suggest that isotope composition can be used on a large scale for climatic reconstructions but that such models should be species-specific.
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| 13. |
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| 14. |
- Aili, Daniel, et al.
(author)
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Polypeptide Folding-Mediated Tuning of the Optical and Structural Properties of Gold Nanoparticle Assemblies
- 2011
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In: Nano letters (Print). - : American Chemical Society (ACS). - 1530-6984 .- 1530-6992. ; 11:12, s. 5564-5573
-
Journal article (peer-reviewed)abstract
- Responsive hybrid nanomaterials with well-defined properties are of significant interest for the development of biosensors with additional applications in tissue engineering and drug delivery. Here, we present a detailed characterization using UV-vis spectroscopy and small angle X-ray scattering of a hybrid material comprised of polypeptide-decorated gold nanoparticles with highly controllable assembly properties. The assembly is triggered by a folding-dependent bridging of the particles mediated by the heteroassociation of immobilized helix-loop-helix polypeptides and a complementary nonlinear polypeptide present in solution. The polypeptides are de novo designed to associate and fold into a heterotrimeric complex comprised of two disulfide-linked four-helix bundles. The particles form structured assemblies with a highly defined interparticle gap (4.8 +/- 0.4 nm) that correlates to the size of the folded polypeptides. Transitions in particle aggregation dynamics, mass-fractal dimensions and ordering, as a function of particle size and the concentration of the bridging polypeptide, are observed; these have significant effects on the optical properties of the assemblies. The assembly and ordering of the particles are highly complex processes that are affected by a large number of variables including the number of polypeptides bridging the particles and the particle mobility within the aggregates. A fundamental understanding of these processes is of paramount interest for the development of novel hybrid nanomaterials with tunable structural and optical properties and for the optimization of nanoparticle-based colorimetric biodetection strategies.
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| 15. |
- Ashton, Nicholas J., et al.
(author)
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Plasma and CSF biomarkers in a memory clinic: Head-to-head comparison of phosphorylated tau immunoassays
- 2023
-
In: Alzheimers & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 19:5, s. 1913-1924
-
Journal article (peer-reviewed)abstract
- Introduction Direct comparisons of the main blood phosphorylated tau immunoassays in memory clinic populations are needed to understand possible differences. Methods In the BIODEGMAR study, 197 participants presenting with cognitive complaints were classified into an Alzheimer's disease (AD) or a non-AD cerebrospinal fluid (CSF) profile group, according to their amyloid beta 42/ phosphorylated tau (A beta 42/p-tau) ratio. We performed a head-to-head comparison of nine plasma and nine CSF tau immunoassays and determined their accuracy to discriminate abnormal CSF A beta 42/p-tau ratio. Results All studied plasma tau biomarkers were significantly higher in the AD CSF profile group compared to the non-AD CSF profile group and significantly discriminated abnormal CSF A beta 42/p-tau ratio. For plasma p-tau biomarkers, the higher discrimination accuracy was shown by Janssen p-tau217 (r = 0.76; area under the curve [AUC] = 0.96), ADx p-tau181 (r = 0.73; AUC = 0.94), and Lilly p-tau217 (r = 0.73; AUC = 0.94). Discussion Several plasma p-tau biomarkers can be used in a specialized memory clinic as a stand-alone biomarker to detect biologically-defined AD. Highlights Patients with an Alzheimer's disease cerebrospinal fluid (AD CSF) profile have higher plasma phosphorylated tau (p-tau) levels than the non-AD CSF profile group. All plasma p-tau biomarkers significantly discriminate patients with an AD CSF profile from the non-AD CSF profile group. Janssen p-tau217, ADx p-tau181, and Lilly p-tau217 in plasma show the highest accuracy to detect biologically defined AD. Janssen p-tau217, ADx p-tau181, Lilly p-tau217, Lilly p-tau181, and UGot p-tau231 in plasma show performances that are comparable to their CSF counterparts.
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| 16. |
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| 17. |
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| 18. |
- BALTZER, P, et al.
(author)
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AN EXPERIMENTAL AND THEORETICAL-STUDY OF THE VALENCE SHELL PHOTOELECTRON-SPECTRUM OF ALLENE
- 1995
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In: CHEMICAL PHYSICS. - : ELSEVIER SCIENCE BV. - 0301-0104. ; 196:3, s. 551-567
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Journal article (other academic/artistic)abstract
- The photoelectron spectrum of allene has been studied using He I, He II and synchrotron radiation as sources for ionisation. In addition to the main bands associated with the single hole states, a complex satellite structure due to many-electron effects h
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| 19. |
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| 20. |
- BALTZER, P, et al.
(author)
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AN EXPERIMENTAL-STUDY OF THE VALENCE SHELL PHOTOELECTRON-SPECTRUM OF HYDROGEN-SULFIDE
- 1995
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In: CHEMICAL PHYSICS. - : ELSEVIER SCIENCE BV. - 0301-0104. ; 195:1-3, s. 403-422
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Journal article (other academic/artistic)abstract
- The complete valence shell photoelectron spectrum of hydrogen sulphide has been studied in the 10 to 25 eV binding energy region using He I, He II and synchrotron radiation. Using monochromated synchrotron radiation, photoelectron angular distributions an
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| 21. |
- Baltzer, P, et al.
(author)
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An experimental study of the valence shell photoelectron spectrum of the NO2 molecule
- 1998
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In: CHEMICAL PHYSICS. - : ELSEVIER SCIENCE BV. - 0301-0104. ; 237:3, s. 451-470
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Journal article (other academic/artistic)abstract
- The complete valence shell photoelectron spectrum of the NO2 molecule has been studied in the binding energy range between 10 and 50 eV. HeI and HeII resonance radiation as well as monochromated synchrotron radiation have been used for the ionisation. Ass
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| 22. |
- Bengtsson, Fia, 1986-, et al.
(author)
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Environmental drivers of Sphagnum growth in peatlands across the Holarctic region
- 2021
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In: Journal of Ecology. - : John Wiley & Sons. - 0022-0477 .- 1365-2745. ; 109:1, s. 417-431
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Journal article (peer-reviewed)abstract
- The relative importance of global versus local environmental factors for growth and thus carbon uptake of the bryophyte genusSphagnum-the main peat-former and ecosystem engineer in northern peatlands-remains unclear. We measured length growth and net primary production (NPP) of two abundantSphagnumspecies across 99 Holarctic peatlands. We tested the importance of previously proposed abiotic and biotic drivers for peatland carbon uptake (climate, N deposition, water table depth and vascular plant cover) on these two responses. Employing structural equation models (SEMs), we explored both indirect and direct effects of drivers onSphagnumgrowth. Variation in growth was large, but similar within and between peatlands. Length growth showed a stronger response to predictors than NPP. Moreover, the smaller and denserSphagnum fuscumgrowing on hummocks had weaker responses to climatic variation than the larger and looserSphagnum magellanicumgrowing in the wetter conditions. Growth decreased with increasing vascular plant cover within a site. Between sites, precipitation and temperature increased growth forS. magellanicum. The SEMs indicate that indirect effects are important. For example, vascular plant cover increased with a deeper water table, increased nitrogen deposition, precipitation and temperature. These factors also influencedSphagnumgrowth indirectly by affecting moss shoot density. Synthesis. Our results imply that in a warmer climate,S. magellanicumwill increase length growth as long as precipitation is not reduced, whileS. fuscumis more resistant to decreased precipitation, but also less able to take advantage of increased precipitation and temperature. Such species-specific sensitivity to climate may affect competitive outcomes in a changing environment, and potentially the future carbon sink function of peatlands.
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| 23. |
- Brum, Wagner S., et al.
(author)
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A two-step workflow based on plasma p-tau217 to screen for amyloid β positivity with further confirmatory testing only in uncertain cases
- 2023
-
In: Nature Aging. - 2662-8465. ; 3:9, s. 1079-1090
-
Journal article (peer-reviewed)abstract
- Cost-effective strategies for identifying amyloid-beta (A beta) positivity in patients with cognitive impairment are urgently needed with recent approvals of anti-A beta immunotherapies for Alzheimer's disease (AD). Blood biomarkers can accurately detect AD pathology, but it is unclear whether their incorporation into a full diagnostic workflow can reduce the number of confirmatory cerebrospinal fluid (CSF) or positron emission tomography (PET) tests needed while accurately classifying patients. We evaluated a two-step workflow for determining A beta-PET status in patients with mild cognitive impairment (MCI) from two independent memory clinic-based cohorts (n = 348). A blood-based model including plasma tau protein 217 (p-tau217), age and APOE epsilon 4 status was developed in BioFINDER-1 (area under the curve (AUC) = 89.3%) and validated in BioFINDER-2 (AUC = 94.3%). In step 1, the blood-based model was used to stratify the patients into low, intermediate or high risk of A beta-PET positivity. In step 2, we assumed referral only of intermediate-risk patients to CSF A beta 42/A beta 40 testing, whereas step 1 alone determined A beta-status for low-and high-risk groups. Depending on whether lenient, moderate or stringent thresholds were used in step 1, the two-step workflow overall accuracy for detecting A beta-PET status was 88.2%, 90.5% and 92.0%, respectively, while reducing the number of necessary CSF tests by 85.9%, 72.7% and 61.2%, respectively. In secondary analyses, an adapted version of the BioFINDER-1 model led to successful validation of the two-step workflow with a different plasma p-tau217 immunoassay in patients with cognitive impairment from the TRIAD cohort (n = 84). In conclusion, using a plasma p-tau217-based model for risk stratification of patients with MCI can substantially reduce the need for confirmatory testing while accurately classifying patients, offering a cost-effective strategy to detect AD in memory clinic settings.
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| 24. |
- Edvardsson, D, et al.
(author)
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A photoabsorption, photodissociation and photoelectron spectroscopy study of NH3 and ND3
- 1999
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In: JOURNAL OF PHYSICS B-ATOMIC MOLECULAR AND OPTICAL PHYSICS. - : IOP PUBLISHING LTD. - 0953-4075. ; 32:11, s. 2583-2609
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Journal article (other academic/artistic)abstract
- The absolute photoabsorption, photoionization and photodissociation cross sections and the photoionization quantum efficiency of ammonia and deuterated ammonia have been measured from the ionization threshold to 25 eV using a double ion chamber and monoch
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| 25. |
- Edvardsson, D, et al.
(author)
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Doppler-free kinetic energy release spectrum of NO2+ and ab initio CI calculations
- 1996
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In: CHEMICAL PHYSICS LETTERS. - 0009-2614. ; 256:3, s. 341-347
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Journal article (other academic/artistic)abstract
- The nitric oxide dication, NO2+, is studied using Doppler-free kinetic energy release spectroscopy and ab initio CI calculations. The C-2 Sigma(+) and 2 (II)-I-4 states have been observed and studied at vibrational resolution. The B (2) Sigma(+) state has
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| 26. |
- EDVARDSSON, D, et al.
(author)
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ROTATIONAL FINE-STRUCTURE IN THE UV PHOTOELECTRON-SPECTRA OF HF AND HCL
- 1995
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In: JOURNAL OF ELECTRON SPECTROSCOPY AND RELATED PHENOMENA. - : ELSEVIER SCIENCE BV. - 0368-2048. ; 73:2, s. 105-124
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Journal article (other academic/artistic)abstract
- He I and Ne I excited photoelectron spectra of the HF and HCl molecules have been recorded at a photoelectron linewidth (FWHM) of 2.5-3.5meV. At this resolution much of the rotational structure has been resolved in the photoelectron bands associated with
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| 27. |
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| 28. |
- Eland, JHD, et al.
(author)
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The photoelectron spectrum of iodine cyanide, ICN
- 1997
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In: CHEMICAL PHYSICS. - : ELSEVIER SCIENCE BV. - 0301-0104. ; 222:2-3, s. 229-240
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Journal article (other academic/artistic)abstract
- The photoelectron spectrum of ICN has been remeasured with much higher resolution than before, The main bands are vibrationally analysed and are reconciled with the ICN+ ion emission spectrum. The spectrum has several very unusual features; one possible i
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| 29. |
- Eland, JHD, et al.
(author)
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Vibrational structure of the BrCN+ ion from high resolution photoelectron spectroscopy
- 1996
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In: CHEMICAL PHYSICS. - : ELSEVIER SCIENCE BV. - 0301-0104. ; 212:2-3, s. 457-469
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Journal article (other academic/artistic)abstract
- Photoelectron spectra of bromine cyanide have been recorded at a resolution better than 5 meV using HeI excitation and at lower resolution using HeII. The existing vibrational analyses of the <(X)over tilde (2) Pi> and <(A)over tilde (2) Sigma> states are
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| 30. |
- Giandomenico, Valeria, et al.
(author)
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Improving the Diagnosis and Management of Neuroendocrine Tumors : Utilizing New Advances in Biomarker and Molecular Imaging Science
- 2013
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In: Neuroendocrinology. - : S. Karger AG. - 0028-3835 .- 1423-0194. ; 98:1, s. 16-30
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Journal article (peer-reviewed)abstract
- Neuroendocrine tumors (NET) are malignant solid tumors that arise in hormone-secreting tissue of the diffuse neuroendocrine system or endocrine glands. Although traditionally understood to be a rare disease, the incidence and prevalence of NET have increased greatly in the past 3 decades. However, during this time, progress in diagnosis and outcome of NET has generally been modest. In order to achieve improved outcome in NET, a better understanding of NET biology combined with more reliable serum markers and better techniques to identify tumor localization and small lesions are needed. Although some NET biomarkers exist, sensitive and specific markers that predict tumor growth and behavior are generally lacking. In addition, the integration of new molecular imaging technologies in patient diagnosis and follow-up has the potential to enhance care. To discuss developments and issues required to improve diagnostics and management of NET patients, with specific focus on the latest advances in molecular imaging and biomarker science, 17 global leaders in the fields of NET, molecular imaging and biomarker technology gathered to participate in a 2-day meeting hosted by Prof. Kjell Oberg at the University of Uppsala in Sweden. During this time, findings were presented regarding methods with potential prognostic and treatment applications in NET or other types of cancers. This paper describes the symposium presentations and resulting discussions.
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| 31. |
- Holland, DMP, et al.
(author)
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A photoabsorption, photodissociation and photoelectron spectroscopy study of C2H4 and C2D4
- 1997
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In: CHEMICAL PHYSICS. - : ELSEVIER SCIENCE BV. - 0301-0104. ; 219:1, s. 91-116
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Journal article (other academic/artistic)abstract
- The absolute photoabsorption, photoionisation and photodissociation cross sections and the photoionisation quantum efficiency of ethylene and deuterated ethylene have been measured from the ionisation threshold to 500 Angstrom using a double ion chamber a
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| 32. |
- Holland, DMP, et al.
(author)
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A study of resonant behaviour in the C(2)E(g) photoelectron band of sulphur hexafluoride
- 1996
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In: JOURNAL OF PHYSICS B-ATOMIC MOLECULAR AND OPTICAL PHYSICS. - : IOP PUBLISHING LTD. ; 29:3, s. 487-498
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Journal article (other academic/artistic)abstract
- Angle-resolved photoelectron spectra encompassing the (A T-2(1u) + B T-2(2u)) and the C(2)E(g) states of sulphur hexafluoride have been recorded in the 20-22 eV photon energy range using synchrotron radiation. The envelope of the C(2)E(g) photoelectron ba
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| 33. |
- Holland, DMP, et al.
(author)
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An experimental and theoretical study of the valence shell photoelectron spectrum of butadiene
- 1996
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In: JOURNAL OF PHYSICS B-ATOMIC MOLECULAR AND OPTICAL PHYSICS. - : IOP PUBLISHING LTD. - 0953-4075. ; 29:14, s. 3091-3107
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Journal article (other academic/artistic)abstract
- The valence shell photoelectron spectrum of butadiene has been studied using He I, Hen and synchrotron radiation. In addition to the main bands associated with the single-hole states, complex satellite structure due to many-electron effects has been obser
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| 34. |
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| 35. |
- Lundqvist, M, et al.
(author)
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Doppler-free kinetic energy release spectrum of N-2(2+)
- 1996
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In: JOURNAL OF PHYSICS B-ATOMIC MOLECULAR AND OPTICAL PHYSICS. - 0953-4075. ; 29:8, s. 1489-1499
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Journal article (other academic/artistic)abstract
- A Doppler-free kinetic energy release spectrum of N-2(2+) has been recorded using a coincident time-of-flight technique, resolving vibrational structure in the optically active A (1) Pi(u), D (3) Pi(g) and D (1) Sigma(u)(+) electronic states. A comparison
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| 36. |
- LUNDQVIST, M, et al.
(author)
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NOVEL TIME-OF-FLIGHT INSTRUMENT FOR DOPPLER-FREE KINETIC-ENERGY RELEASE SPECTROSCOPY
- 1995
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In: PHYSICAL REVIEW LETTERS. - : AMER INST PHYSICS. - 0031-9007. ; 75:6, s. 1058-1061
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Journal article (other academic/artistic)abstract
- A novel Doppler free coincidence time-of-flight technique is presented. The technique allows kinetic energy release spectra to be obtained at vibrational resolution. The only limitation of the technique from a resolution point of view is the thermal rotat
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| 37. |
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| 38. |
- Ohrwall, G, et al.
(author)
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Angle-resolved photoelectron spectrum of rotational states in H-2(+)
- 1998
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In: PHYSICAL REVIEW A. - : AMERICAN PHYSICAL SOC. - 1050-2947. ; 58:3, s. 1960-1965
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Journal article (other academic/artistic)abstract
- We have recorded an angle-resolved photoelectron spectrum of the first four vibrational peaks of the X (2)Sigma(g)(+) state of H-2(+). In the spectrum, the individual peaks of the Delta N=0 rotational branch are completely resolved. From curve fitting of
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| 39. |
- Ohrwall, G, et al.
(author)
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Inner-valence states of CO+: comparison of photoelectron and resonant Auger spectra
- 1999
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In: JOURNAL OF PHYSICS B-ATOMIC MOLECULAR AND OPTICAL PHYSICS. - : IOP PUBLISHING LTD. - 0953-4075. ; 32:2, s. 463-473
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Journal article (other academic/artistic)abstract
- We have recorded very-high-resolution photoelectron spectra of the inner-valence structure of CO+, excited with synchrotron radiation, and have resolved fine structure never previously observed. Recently presented resonant Anger decay spectra (Sundin et a
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| 40. |
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| 41. |
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| 42. |
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| 43. |
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| 44. |
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| 45. |
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| 46. |
- Scrimin, P., et al.
(author)
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Model Systems
- 2005
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In: Editorial Overwiev, Current Opinion of Chemical Biology. ; :9, s. 620-621
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Research review (pop. science, debate, etc.)
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| 47. |
- Woo, M. S., et al.
(author)
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Plasma pTau-217 and N-terminal tau (NTA) enhance sensitivity to identify tau PET positivity in amyloid-β positive individuals
- 2024
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In: Alzheimers & Dementia. - 1552-5260. ; 20:2, s. 1166-1174
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Journal article (peer-reviewed)abstract
- INTRODUCTIONWe set out to identify tau PET-positive (A+T+) individuals among amyloid-beta (A beta) positive participants using plasma biomarkers.METHODSIn this cross-sectional study we assessed 234 participants across the AD continuum who were evaluated by amyloid PET with [18F]AZD4694 and tau-PET with [18F]MK6240 and measured plasma levels of total tau, pTau-181, pTau-217, pTau-231, and N-terminal tau (NTA-tau). We evaluated the performances of plasma biomarkers to predict tau positivity in A beta+ individuals.RESULTSHighest associations with tau positivity in A beta+ individuals were found for plasma pTau-217 (AUC [CI95%] = 0.89 [0.82, 0.96]) and NTA-tau (AUC [CI95%] = 0.88 [0.91, 0.95]). Combining pTau-217 and NTA-tau resulted in the strongest agreement (Cohen's Kappa = 0.74, CI95% = 0.57/0.90, sensitivity = 92%, specificity = 81%) with PET for classifying tau positivity.DISCUSSIONThe potential for identifying tau accumulation in later Braak stages will be useful for patient stratification and prognostication in treatment trials and in clinical practice.HighlightsWe found that in a cohort without pre-selection pTau-181, pTau-217, and NTA-tau showed the highest association with tau PET positivity.We found that in A beta+ individuals pTau-217 and NTA-tau showed the highest association with tau PET positivity.Combining pTau-217 and NTA-tau resulted in the strongest agreement with the tau PET-based classification.
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| 48. |
- Öhrwall, G, et al.
(author)
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Synchrotron radiation excited photoelectron spectrum of H2(+) with rotational resolution
- 1999
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In: J. Phys. B: At. Mol. Opt. Phys. - : IOP Publishing. - 0953-4075. ; 32:3, s. L51-L56
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Journal article (peer-reviewed)abstract
- The rotational branching ratio in the photoelectron spectrum of H-2(+) has been investigated using synchrotron radiation. At the photon energy hv = 27 eV, the S (Delta N = 2) branch has a considerably higher relative intensity than when excited with He I (lambda=584 Å, hv=21.218 eV) or with Ne I (lambda=736 Å, hv=16.848) radiation.
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