| 1. |
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| 2. |
- Savolainen, Vincent, et al.
(author)
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Phylogeny of the eudicots : a nearly complete familial analysis based on rbcL gene sequences
- 2000
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In: Kew bulletin. - 0075-5974 .- 1874-933X. ; 55:2, s. 257-309
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Journal article (peer-reviewed)abstract
- A phylogenetic analysis of 589 plastid rbcL gene sequences representing nearly all eudicot families (a total of 308 families; seven photosynthetic and four parasitic families are missing) was performed, and bootstrap re-sampling was used to assess support for clades. Based on these data, the ordinal classification of eudicots is revised following the previous classification of angiosperms by the Angiosperm Phylogeny Group (APG). Putative additional orders are discussed (e.g. Dilleniales, Escalloniales, Vitales), and several additional families are assigned to orders for future updates of the APG classification. The use of rbcL alone in such a large matrix was found to be practical in discovering and providing bootstrap support for most orders. Combination of these data with other matrices for the rest of the angiosperms should provide the framework for a complete phylogeny to be used in macro-evolutionary studies.
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| 3. |
- Butlin, Roger, 1955, et al.
(author)
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Homage to Felsenstein 1981, or why are there so few/many species?
- 2021
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In: Evolution. - : Wiley. - 0014-3820 .- 1558-5646. ; 75:5, s. 978-988
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Journal article (peer-reviewed)abstract
- If there are no constraints on the process of speciation, then the number of species might be expected to match the number of available niches and this number might be indefinitely large. One possible constraint is the opportunity for allopatric divergence. In 1981, Felsenstein used a simple and elegant model to ask if there might also be genetic constraints. He showed that progress towards speciation could be described by the build-up of linkage disequilibrium among divergently selected loci and between these loci and those contributing to other forms of reproductive isolation. Therefore, speciation is opposed by recombination, because it tends to break down linkage disequilibria. Felsenstein then introduced a crucial distinction between "two-allele" models, which are subject to this effect, and "one-allele" models, which are free from the recombination constraint. These fundamentally important insights have been the foundation for both empirical and theoretical studies of speciation ever since.
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| 4. |
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| 5. |
- McEvoy, Peter M., et al.
(author)
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Imagery-enhanced v. verbally-based group cognitive behavior therapy for social anxiety disorder : a randomized clinical trial
- 2022
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In: Psychological Medicine. - : Cambridge University Press. - 0033-2917 .- 1469-8978. ; 52:7, s. 1277-1286
-
Journal article (peer-reviewed)abstract
- BackgroundCognitive behavior therapy (CBT) is effective for most patients with a social anxiety disorder (SAD) but a substantial proportion fails to remit. Experimental and clinical research suggests that enhancing CBT using imagery-based techniques could improve outcomes. It was hypothesized that imagery-enhanced CBT (IE-CBT) would be superior to verbally-based CBT (VB-CBT) on pre-registered outcomes.MethodsA randomized controlled trial of IE-CBT v. VB-CBT for social anxiety was completed in a community mental health clinic setting. Participants were randomized to IE (n = 53) or VB (n = 54) CBT, with 1-month (primary end point) and 6-month follow-up assessments. Participants completed 12, 2-hour, weekly sessions of IE-CBT or VB-CBT plus 1-month follow-up.ResultsIntention to treat analyses showed very large within-treatment effect sizes on the social interaction anxiety at all time points (ds = 2.09-2.62), with no between-treatment differences on this outcome or clinician-rated severity [1-month OR = 1.45 (0.45, 4.62), p = 0.53; 6-month OR = 1.31 (0.42, 4.08), p = 0.65], SAD remission (1-month: IE = 61.04%, VB = 55.09%, p = 0.59); 6-month: IE = 58.73%, VB = 61.89%, p = 0.77), or secondary outcomes. Three adverse events were noted (substance abuse, n = 1 in IE-CBT; temporary increase in suicide risk, n = 1 in each condition, with one being withdrawn at 1-month follow-up).ConclusionsGroup IE-CBT and VB-CBT were safe and there were no significant differences in outcomes. Both treatments were associated with very large within-group effect sizes and the majority of patients remitted following treatment.
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| 6. |
- McEvoy, Peter M., et al.
(author)
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Impacts of imagery-enhanced versus verbally-based cognitive behavioral group therapy on psychophysiological parameters in social anxiety disorder : Results from a randomized-controlled trial
- 2022
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In: Behaviour Research and Therapy. - : Elsevier. - 0005-7967 .- 1873-622X. ; 155
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Journal article (peer-reviewed)abstract
- Social anxiety disorder (SAD) is associated with marked physiological reactivity in social-evaluative situations. However, objective measurement of biomarkers is rarely evaluated in treatment trials, despite potential utility in clarifying disorder-specific physiological correlates. This randomized controlled trial sought to examine the differential impact of imagery-enhanced vs. verbal-based cognitive behavioral group therapy (IE-CBGT, n = 53; VB-CBGT, n = 54) on biomarkers of emotion regulation and arousal during social stress in people with SAD (pre and post-treatment differences in heart rate variability (HRV) and skin conductance). We acquired psycho physiological data from randomized participants across four social stress test phases (baseline, speech preparation, speech, interaction) at pre-treatment, and 1-and 6-months post-treatment. Analyses revealed that IECBGT selectively attenuated heart rate as indexed by increases in median heart rate interval (median-RR) compared to VB-CBGT at post-treatment, whereas one HRV index showed a larger increase in the VB-CBGT condition before but not after controlling for median-RR. Other psychophysiological indices did not differ between conditions. Lower sympathetic arousal in the IE-CBGT condition may have obviated the need for parasympathetic downregulation, whereas the opposite was true for VB-CBGT. These findings provide preliminary insights into the impact of imagery-enhanced and verbally-based psychotherapy for SAD on emotion regulation biomarkers.
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| 7. |
- Takahashi, H., et al.
(author)
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Beam test results of the polarized gamma-ray observer, PoGOLite
- 2008
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In: 2008 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE (2008 NSS/MIC), VOLS 1-9. - 9781424427147 ; , s. 732-736
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Conference paper (peer-reviewed)abstract
- The Polarized Gamma-ray Observer, PoGOLite, is a balloon experiment with the capability of detecting 10% polarization from a 200 mCrab celestial object in the energy range 25 #x2013;80 keV. During a beam test at KEK-PF in February 2008, 20 detector units were assembled, and a 50 keV X-ray beam with a polarization degree of #x223C;90% was irradiated at the center unit. Signals from all 20 units were fed into flightversion electronics consisting of six circuit boards (four waveform digitizer boards, one digital I/O board and one router board) and one microprocessor (SpaceCube), which communicate using a SpaceWire interface. One digitizer board, which can associate up to 8 PDCs, outputs a trigger signal. The digital I/O board handles the trigger and returns a data acquisition request if there is no veto signal (upper or pulse-shape discriminators) from any detector unit. This data acquisition system worked well, and the modulation factor was successfully measured to be #x223C;34%. These results confirmed the capabilities of both detector and data-acquisition system for a pathfinder flight planned in 2010.
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| 8. |
- Wortel, Meike T., et al.
(author)
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Towards evolutionary predictions : current promises and challenges
- 2023
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In: Evolutionary Applications. - : John Wiley & Sons. - 1752-4571. ; 16:1, s. 3-21
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Research review (peer-reviewed)abstract
- Evolution has traditionally been a historical and descriptive science, and predicting future evolutionary processes has long been considered impossible. However, evolutionary predictions are increasingly being developed and used in medicine, agriculture, biotechnology and conservation biology. Evolutionary predictions may be used for different purposes, such as to prepare for the future, to try and change the course of evolution or to determine how well we understand evolutionary processes. Similarly, the exact aspect of the evolved population that we want to predict may also differ. For example, we could try to predict which genotype will dominate, the fitness of the population or the extinction probability of a population. In addition, there are many uses of evolutionary predictions that may not always be recognized as such. The main goal of this review is to increase awareness of methods and data in different research fields by showing the breadth of situations in which evolutionary predictions are made. We describe how diverse evolutionary predictions share a common structure described by the predictive scope, time scale and precision. Then, by using examples ranging from SARS-CoV2 and influenza to CRISPR-based gene drives and sustainable product formation in biotechnology, we discuss the methods for predicting evolution, the factors that affect predictability and how predictions can be used to prevent evolution in undesirable directions or to promote beneficial evolution (i.e. evolutionary control). We hope that this review will stimulate collaboration between fields by establishing a common language for evolutionary predictions.
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| 9. |
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| 10. |
- Mizuno, T., et al.
(author)
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High sensitivity balloon-borne hard X-ray/soft Gamma-Ray Polarimeter PoGOLite
- 2007
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In: Nuclear Science Symposium Conference Record, 2007. NSS ’07. IEEE. - : IEEE. - 9781424409228 ; , s. 2538-2544
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Conference paper (peer-reviewed)abstract
- The Polarized Gamma-ray Observer - Lightweight version (PoGOLite) is a new balloon experiment capable of detecting 10% polarization from a 200 mCrab source in the 25-80 keV energy range in a single 6-hour flight for the first time. Polarization measurements of hard X-rays and soft gamma-rays are expected to provide a powerful probe into high-energy emission mechanisms as well as source geometries. PoGOLite uses Compton scattering and photo-absorption to measure polarization in an array of 217 well-type phoswich detector cells made of plastic and BGO scintillators. The adoption of a well-type phoswich counter concept and a thick polyethylene neutron shield provides a narrow field-of-view (1.25 msr), a large effective area ( gt; 250 cm2 at 40-50 keV), a high modulation factor (more than 25%) and the low background ( 100 mCrab) required to conduct high-sensitivity polarization measurements. Through tests in laboratories and accelerator facilities of a scaled-down prototype with the front-end electronics of flight design and an extensive study by Monte Carlo simulation, we have demonstrated high instrument performance. PoGOLite will be ready for a first engineering flight in 2009 and a science flight in 2010, during which polarization signals from the Crab Nebula/pulsar, Cygnus X-1 and other objects will be observed.
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| 11. |
- Ovaskainen, Otso, et al.
(author)
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Global Spore Sampling Project: A global, standardized dataset of airborne fungal DNA
- 2024
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In: Scientific Data. - 2052-4463. ; 11
-
Journal article (peer-reviewed)abstract
- Novel methods for sampling and characterizing biodiversity hold great promise for re-evaluating patterns of life across the planet. The sampling of airborne spores with a cyclone sampler, and the sequencing of their DNA, have been suggested as an efficient and well-calibrated tool for surveying fungal diversity across various environments. Here we present data originating from the Global Spore Sampling Project, comprising 2,768 samples collected during two years at 47 outdoor locations across the world. Each sample represents fungal DNA extracted from 24 m3 of air. We applied a conservative bioinformatics pipeline that filtered out sequences that did not show strong evidence of representing a fungal species. The pipeline yielded 27,954 species-level operational taxonomic units (OTUs). Each OTU is accompanied by a probabilistic taxonomic classification, validated through comparison with expert evaluations. To examine the potential of the data for ecological analyses, we partitioned the variation in species distributions into spatial and seasonal components, showing a strong effect of the annual mean temperature on community composition.
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| 12. |
- Saevarsdottir, S., et al.
(author)
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Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset
- 2022
-
In: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 81:8
-
Journal article (peer-reviewed)abstract
- Objectives To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA positive) and seronegative subsets. Methods We performed a genome-wide association study (GWAS) of 31 313 RA cases (68% seropositive) and similar to 1 million controls from Northwestern Europe. We searched for causal genes outside the HLA-locus through effect on coding, mRNA expression in several tissues and/or levels of plasma proteins (SomaScan) and did network analysis (Qiagen). Results We found 25 sequence variants for RA overall, 33 for seropositive and 2 for seronegative RA, altogether 37 sequence variants at 34 non-HLA loci, of which 15 are novel. Genomic, transcriptomic and proteomic analysis of these yielded 25 causal genes in seropositive RA and additional two overall. Most encode proteins in the network of interferon-alpha/beta and IL-12/23 that signal through the JAK/STAT-pathway. Highlighting those with largest effect on seropositive RA, a rare missense variant in STAT4 (rs140675301-A) that is independent of reported non-coding STAT4-variants, increases the risk of seropositive RA 2.27-fold (p=2.1x10(-9)), more than the rs2476601-A missense variant in PTPN22 (OR=1.59, p=1.3x10(-160)). STAT4 rs140675301-A replaces hydrophilic glutamic acid with hydrophobic valine (Glu128Val) in a conserved, surface-exposed loop. A stop-mutation (rs76428106-C) in FLT3 increases seropositive RA risk (OR=1.35, p=6.6x10(-11)). Independent missense variants in TYK2 (rs34536443-C, rs12720356-C, rs35018800-A, latter two novel) associate with decreased risk of seropositive RA (ORs=0.63-0.87, p=10(-9)-10(-27)) and decreased plasma levels of interferon-alpha/beta receptor 1 that signals through TYK2/JAK1/STAT4. Conclusion Sequence variants pointing to causal genes in the JAK/STAT pathway have largest effect on seropositive RA, while associations with seronegative RA remain scarce.
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| 13. |
- Takahashi, H., et al.
(author)
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The Polarized Gamma-Ray Observer, PoGOLite
- 2010
-
In: Transactions of the Japanese Society for Artificial Intelligence, Aerospace Technology Japan. - 1346-0714 .- 1346-0714. ; 8
-
Journal article (peer-reviewed)abstract
- The Polarized Gamma-ray Observer, PoGOLite, is a balloon experiment with the capability of detecting 10% polarization from a 200 mCrab celestial object in the energy-range 25–80 keV. During a beam test at KEK-PF in 2008, 19 detector units and one anti-coincidence detector were assembled, and a 50 keV X-ray beam with a polarization degree of ∼90% was irradiated at the center unit. Signals from all 20 units were fed into flight-version electronics consisting of six circuit boards (four waveform digitizer boards, one digital I/O board and one router board) and one microprocessor (SpaceCube), which communicate using a SpaceWire interface. One digitizer board, which can associate up to 8 detectors, outputs a trigger signal. The digital I/O board handles the trigger and returns a data acquisition request if there is no veto signal (upper or pulse-shape discriminators) from any detector unit. This data acquisition system worked well, and the modulation factor was successfully measured to be ∼34%. These results confirmed the capabilities of the data-acquisition system for a “pathfinder” flight planned in 2010.
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| 14. |
- Bank, Ingrid E. M., et al.
(author)
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Prevalence and Clinical Significance of Diabetes in Asian Versus White Patients With Heart Failure
- 2017
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In: JACC. Heart failure. - : ELSEVIER SCI LTD. - 2213-1779 .- 2213-1787. ; 5:1, s. 14-24
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Journal article (peer-reviewed)abstract
- OBJECTIVES The study sought to compare the prevalence, clinical correlates and prognostic impact of diabetes in Southeast Asian versus white patients with heart failure (HF) with preserved or reduced ejection fraction. BACKGROUND Diabetes mellitus is common in HF and is associated with impaired prognosis. Asia is home to the majority of the worlds diabetic population, yet data on the prevalence and clinical significance of diabetes in Asian patients with HF are sparse, and no studies have directly compared Asian and white patients. METHODS Two contemporary population-based HF cohorts were combined: from Singapore (n 1,002, median [25th to 75th percentile] age 62 [54 to 70] years, 76% men, 19.5% obesity) and Sweden (n =19,537, 77 [68 to 84] years, 60% men, 24.8% obesity). The modifying effect of ethnicity on the relationship between diabetes and clinical correlates or prognosis (HF hospitalization and all-cause mortality) was examined using interaction terms. RESULTS Diabetes was present in 569 (57%) Asian patients versus 4,680 (24%) white patients (p amp;lt; 0.001). Adjusting for clinical covariates, obesity was more strongly associated with diabetes in white patients (odds ratio [OR]: 3.45;. 95% confidence interval [CI]: 2.86 to 4.17) than in Asian patients (OR: 1.82; 95% CI: 1.13 to 2.96; P-interaction = 0.026). Diabetes was more strongly associated with increased HF hospitalization and all-cause mortality in Asian patients (hazard ratio: 1.50; 95% CI: 1.21 to 1.87) than in white patients (hazard ratio: 1.29; 95% CI: 1.22 to 1.36; P-interaction = 0.045). CONCLUSIONS Diabetes was 3-fold more common in Southeast Asian compared to white patients with HF, despite younger age and less obesity, and more strongly associated with poor outcomes in Asian patients than white patients. These results underscore the importance of ethnicity-tailored aggressive strategies to prevent diabetes and its complications. (C) 2017 by the American College of Cardiology Foundation.
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| 15. |
- Crauwels, P., et al.
(author)
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Cathelicidin Contributes to the Restriction of Leishmania in Human Host Macrophages
- 2019
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In: Frontiers in Immunology. - : Frontiers Media SA. - 1664-3224. ; 10
-
Journal article (peer-reviewed)abstract
- In cutaneous Leishmaniasis the parasitic control in human host macrophages is still poorly understood. We found an increased expression of the human cathelicidin CAMP in skin lesions of Ethiopian patients with cutaneous leishmaniasis. Vitamin D driven, Cathelicidin-type antimicrobial peptides (CAMP) play an important role in the elimination of invading microorganisms. Recombinant cathelicidin was able to induce cell-death characteristics in Leishmania in a dose dependent manner. Using human primary macrophages, we demonstrated pro-inflammatory macrophages (hMDM1) to express a higher level of human cathelicidin, both on gene and protein level, compared to anti-inflammatory macrophages (hMDM2). Activating the CAMP pathway using Vitamin D in hMDM1 resulted in a cathelicidin-mediated-Leishmania restriction. Finally, a reduction of cathelicidin in hMDM1, using a RNA interference (RNAi) approach, increased Leishmania parasite survival. In all, these data show the human cathelicidin to contribute to the innate immune response against Leishmaniasis in a human primary cell model.
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| 16. |
- Takahashi, H., et al.
(author)
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A thermal-neutron detector with a phoswich system of LiCaAlF6 and BGO crystal scintillators onboard PoGOLite
- 2010
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In: 2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010. ; , s. 32-37
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Conference paper (peer-reviewed)abstract
- To measure the flux of atmospheric neutrons and study the neutron contribution to the background of the main detector of the PoGOLite (Polarized Gamma-ray Observer) balloon-borne experiment, a thermal-neutron detector with a phoswich system of LiCaAlF6 (Eu) and BGO crystal scintillators is developed. The performance to separate thermal-neutron events from those of gamma-rays and charged particles is validated with 252Cf on ground. The detector is attached to the PoGOLite instrument and is launched in 2011 from the Esrange facility in the North of Sweden. Although the emission wavelength of the LiCaAlF6 (Ce) is 300 nm and overlaps with the absorption wavelength of the BGO, the phoswich capability of the LiCaAlF6 (Ce) with the BGO is also confirmed with installing a waveform shifter.
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| 17. |
- van der Bank, M. G., et al.
(author)
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Dietary success of a 'new' key fish in an overfished ecosystem : evidence from fatty acid and stable isotope signatures
- 2011
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In: Marine Ecology Progress Series. - : Inter-Research Science Center. - 0171-8630 .- 1616-1599. ; 428, s. 219-233
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Journal article (peer-reviewed)abstract
- The bearded goby Sufflogobius bibarbatus has become a key component of the pelagic food web off Namibia following the crash in pelagic fish populations during the 1970s, and its biomass is increasing despite significant predation pressure and apparent life-history constraints. The integrated feeding of the bearded goby was studied from samples collected during April 2008, using stable isotope ratios (delta(13)C, delta(15)N, delta(34)S) and fatty acids, to resolve conflict amongst previous dietary studies based on gut-content analysis and to understand how diet could influence its success within the region. Isotopes of carbon and nitrogen suggest that the now abundant jellyfish could contribute up to 74% of the diet, and delta(34)S signatures indicate that the diatom- and bacteria-rich sulphidic sediments on the central shelf may contribute around 15% to the diet. Fatty acid analyses provided support for sulphur bacterial and jellyfish-feeding amongst gobies, and further suggest that small gobies fed more on zooplankton while large gobies fed more on sedimented diatoms. Both data sets suggest that ontogenetic changes in diet were linked to changes in habitat: pelagic when small, more demersal when large. The study highlights the value of using multiple tracers in trophic studies and indicates that the dietary flexibility of the bearded goby, in conjunction with its behaviour and physiology, likely contributes to its success within the northern Benguela ecosystem.
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| 18. |
- van Engelen, Marie Paule E., et al.
(author)
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The bvFTD phenocopy syndrome : a case study supported by repeated MRI, [18F]FDG-PET and pathological assessment
- 2021
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In: Neurocase. - : Informa UK Limited. - 1355-4794 .- 1465-3656. ; 27:2, s. 181-189
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Journal article (peer-reviewed)abstract
- A clinical syndrome with neuropsychiatric features of bvFTD without neuroimaging abnormalities and a lack of decline is a phenocopy of bvFTD (phFTD). Growing evidence suggests that psychological, psychiatric and environmental factors underlie phFTD. We describe a patient diagnosed with bvFTD prior to the revision of the diagnostic guidelines of FTD. Repeated neuroimaging was normal and there was no FTD pathology at autopsy, rejecting the diagnosis. We hypothesize on etiological factors that on hindsight might have played a role. This case report contributes to the understanding of phFTD and adds to the sparse literature of the postmortem assessment of phFTD.
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| 19. |
- Doro, Kennedy O., et al.
(author)
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Geophysical imaging of buried human remains in simulated mass and single graves : Experiment design and results from pre-burial to six months after burial
- 2022
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In: Forensic Science International. - : Elsevier. - 0379-0738 .- 1872-6283. ; 335
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Journal article (peer-reviewed)abstract
- In this study, we present an experiment design and assess the capability of multiple geophysical techniques to image buried human remains in mass and individual graves using human cadavers willingly donated for scientific research. The study is part of a novel, interdisciplinary mass grave experiment established in May 2021 which consists of a mass grave with 6 human remains, 3 individual graves and two empty control graves dug to the same size as the mass grave and individual graves. Prior to establishing the graves, we conducted background measurements of electrical resistivity tomography (ERT), electromagnetics (EM), and ground penetrating radar (GPR) while soil profiles were analyzed in situ after excavating the graves. All graves were also instrumented with soil sensors for monitoring temporal changes in soil moisture, temperature, and electrical conductivity in situ. Measurements of ERT, EM and GPR were repeated 3, 37, 71 and 185 days after burial with further repeated measurements planned for another twelve months. ERT results show an initial increase in resistivity in all graves including the control graves at 3 days after burial and a continuous decrease thereafter in the mass and individual graves with the strongest decrease in the mass grave. Conductivity distribution from the EM shows a similar trend to the ERT with an initial decrease in the first 3 days after burial. Distortion in linear reflectors, presence of small hyperbolas and isolated strong amplitude reflectors in the GPR profiles across the graves is associated with known locations of the graves. These initial results validate the capability of geoelectrical methods in detecting anomalies associated with disturbed ground and human decay while GPR though show some success is limited by the geology of the site.
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| 20. |
- Romantsik, Olga, et al.
(author)
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Value of preclinical systematic reviews and meta-analyses in pediatric research
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In: Pediatric Research. - 1530-0447. ; , s. 1-11
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Research review (peer-reviewed)abstract
- Similar to systematic reviews (SRs) in clinical fields, preclinical SRs address a specific research area, furnishing information on current knowledge, possible gaps, and potential methodological flaws of study design, conduct, and report. One of the main goals of preclinical SRs is to identify aspiring treatment strategies and evaluate if currently available data is solid enough to translate to clinical trials or highlight the gaps, thus justifying the need for new studies. It is imperative to rigorously follow the methodological standards that are widely available. These include registration of the protocol and adherence to guidelines for assessing the risk of bias, study quality, and certainty of evidence. A special consideration should be made for pediatric SRs, clinical and preclinical, due to the unique characteristics of this age group. These include rationale for intervention and comparison of primary and secondary outcomes. Outcomes measured should acknowledge age-related physiological changes and maturational processes of different organ systems. It is crucial to choose the age of the animals appropriately and its possible correspondence for specific pediatric age groups. The findings of well-conducted SRs of preclinical studies have the potential to provide a reliable evidence synthesis to guide the design of future preclinical and clinical studies. IMPACT: This narrative review highlights the importance of rigorous design, conduct and reporting of preclinical primary studies and systematic reviews. A special consideration should be made for pediatric systematic reviews of preclinical studies, due to the unique characteristics of this age group.
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| 21. |
- Seehausen, Ole, et al.
(author)
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Genomics and the origin of species
- 2014
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In: Nature reviews genetics. - : Springer Science and Business Media LLC. - 1471-0056 .- 1471-0064. ; 15:3, s. 176-192
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Research review (peer-reviewed)abstract
- Speciation is a fundamental evolutionary process, the knowledge of which is crucial for understanding the origins of biodiversity. Genomic approaches are an increasingly important aspect of this research field. We review current understanding of genome-wide effects of accumulating reproductive isolation and of genomic properties that influence the process of speciation. Building on this work, we identify emergent trends and gaps in our understanding, propose new approaches to more fully integrate genomics into speciation research, translate speciation theory into hypotheses that are testable using genomic tools and provide an integrative definition of the field of speciation genomics.
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| 22. |
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