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1.	Adam, A, et al. (author) Abstracts from Hydrocephalus 2016. 2017 In: Fluids and Barriers of the CNS. - : Springer Science and Business Media LLC. - 2045-8118. ; 14:Suppl 1 Journal article (peer-reviewed)
2.	Craven, C. L., et al. (author) The predictive value of T-tau and AB1-42 levels in idiopathic normal pressure hydrocephalus 2017 In: Acta Neurochirurgica. - : Springer Science and Business Media LLC. - 0001-6268 .- 0942-0940. ; 159:12, s. 2293-2300 Journal article (peer-reviewed)abstract Idiopathic normal pressure hydrocephalus (INPH) has no reliable biomarker to assist in the selection of patients who could benefit from ventriculo-peritoneal (VP) shunt insertion. The neurodegenerative markers T-tau and A beta 1-42 have been found to successfully differentiate between Alzheimer's disease (AD) and INPH and therefore are candidate biomarkers for prognosis and shunt response in INPH. The aim of this study was to test the predictive value of cerebrospinal fluid (CSF) T-tau and A beta 1-42 for shunt responsiveness. In particular, we pay attention to the subset of INPH patients with raised T-tau, who are often expected to be poor surgical candidates. Single-centre retrospective analysis of probable INPH patients with CSF samples collected from 2006 to 2016. Index test: CSF levels of T-tau and A beta 1-42. Reference standard: postoperative outcome. ROC analysis assessed the predictive value. A total of 144 CSF samples from INPH patients were analysed. Lumbar T-tau was a good predictor of post-operative mobility (AUROC 0.80). The majority of patients with a co-existing neurodegenerative disease responded well, including those with high T-tau levels. INPH patients tended to exhibit low levels of CSF T-tau, and this can be a good predictor outcome. However levels are highly variable between individuals. Raised T-tau and being shunt-responsive are not mutually exclusive, and such patients ought not necessarily be excluded from having a VP shunt. A combined panel of markers may be a more specific method for aiding selection of patients for VP shunt insertion. This is the most comprehensive presentation of CSF samples from INPH patients to date, thus providing further reference values to the current literature.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Garcia, C. (1); Martin, B. (1); Schmidt, E. (1); Yamamoto, K. (1); Shin, T. (1); Cheng, S. (1); show more...; Lu, J. (1); Yamada, S. (1); Thompson, D. (1); Foley, S. (1); Modesto, P. (1); Williams, M (1); Asgari, M. (1); Zetterberg, Henrik, ... (1); Xu, J (1); Alafuzoff, Irina (1); Rodriguez, S. (1); Adam, A. (1); Robison, J (1); Jose, R (1); Badran, N (1); Vivas-Buitrago, T (1); Rigamonti, D (1); Sattar, A (1); Omoush, O (1); Hammad, M (1); Dawood, M (1); Maghaslah, M (1); Belcher, T (1); Carson, K (1); Hoffberger, J (1); Jusué Torres, I (1); Yasar, S (1); Thai, Q A (1); Wemmer, J (1); Klinge, P (1); Al-Mutawa, L (1); Al-Ghamdi, H (1); Carson, K A (1); de Zélicourt, D (1); Kurtcuoglu, V (1); Garnotel, S (1); Salmon, S (1); Balédent, O (1); Lokossou, A (1); Page, G (1); Balardy, L (1); Czosnyka, Z (1); Payoux, P (1); Schmidt, E A (1); show less...

University: University of Gothenburg (1); Uppsala University (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

Year: 2017 (2)

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