SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Beckers Patrick) "

Search: WFRF:(Beckers Patrick)

  • Result 1-4 of 4
Sort/group result
   
EnumerationReferenceCoverFind
1.
  • Eisenberg, Tobias, et al. (author)
  • Cardioprotection and lifespan extension by the natural polyamine spermidine
  • 2016
  • In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 22:12, s. 1428-1438
  • Journal article (peer-reviewed)abstract
    • Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Spermidine feeding enhanced cardiac autophagy, mitophagy and mitochondrial respiration, and it also improved the mechano-elastical properties of cardiomyocytes in vivo, coinciding with increased titin phosphorylation and suppressed subclinical inflammation. Spermidine feeding failed to provide cardioprotection in mice that lack the autophagy-related protein Atg5 in cardiomyocytes. In Dahl salt-sensitive rats that were fed a high-salt diet, a model for hypertension-induced congestive heart failure, spermidine feeding reduced systemic blood pressure, increased titin phosphorylation and prevented cardiac hypertrophy and a decline in diastolic function, thus delaying the progression to heart failure. In humans, high levels of dietary spermidine, as assessed from food questionnaires, correlated with reduced blood pressure and a lower incidence of cardiovascular disease. Our results suggest a new and feasible strategy for protection against cardiovascular disease.
  •  
2.
  • Reiche, Myrthe E., et al. (author)
  • Adipocytes control hematopoiesis and inflammation through CD40 signaling
  • 2023
  • In: Haematologica. - : Ferrata Storti Foundation. - 0390-6078 .- 1592-8721. ; 108:7, s. 1873-1885
  • Journal article (peer-reviewed)abstract
    • The co-stimulatory CD40-CD40L dyad plays an important role in chronic inflammatory diseases associated with aging. Although CD40 is mainly expressed by immune cells, CD40 is also present on adipocytes. We aimed to delineate the role of adipocyte CD40 in the aging hematopoietic system and evaluated the effects of adipocyte CD40 deficiency on cardiometabolic diseases. Adult adipocyte CD40-deficient mice (AdiCD40KO) mice had a decrease in bone marrow hematopoietic stem cells (Lin-Sca+cKit+, LSK) and common lymphoid progenitors, which was associated with increased bone marrow adiposity and T-cell activation, along with elevated plasma corticosterone levels, a phenotype that became more pronounced with age. Atherosclerotic AdiCD40koApoE-/- (CD40AKO) mice also displayed changes in the LSK population, showing increased myeloid and lymphoid multipotent progenitors, and augmented corticosterone levels. Increased T-cell activation could be observed in bone marrow, spleen, and adipose tissue, while the numbers of B cells were decreased. Although atherosclerosis was reduced in CD40AKO mice, plaques contained more activated T cells and larger necrotic cores. Analysis of peripheral adipose tissue in a diet-induced model of obesity revealed that obese AdiCD40KO mice had increased T-cell activation in adipose tissue and lymphoid organs, but decreased weight gain and improved insulin sensitivity, along with increased fat oxidation. In conclusion, adipocyte CD40 plays an important role in maintaining immune cell homeostasis in bone marrow during aging and chronic inflammatory diseases, particularly of the lymphoid populations. Although adipocyte CD40 deficiency reduces atherosclerosis burden and ameliorates diet-induced obesity, the accompanying T-cell activation may eventually aggravate cardiometabolic diseases.
  •  
3.
  •  
4.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-4 of 4
Type of publication
journal article (4)
Type of content
peer-reviewed (4)
Author/Editor
Strand, Malin (2)
Sun, Shi-Chun (2)
Kajihara, Hiroshi (2)
Kvist, Sebastian (2)
Giribet, Gonzalo (2)
Meinitzer, Andreas (1)
show more...
Fuchs, Helmut (1)
Gailus-Durner, Valér ... (1)
Horsch, Marion (1)
Beckers, Johannes (1)
Sundberg, Per, 1950 (1)
Andersson, Håkan S., ... (1)
Sundberg, Per (1)
Büttner, Sabrina (1)
Pieske, Burkert (1)
Carmona-Gutierrez, D ... (1)
Eisenberg, Tobias (1)
Neff, Frauke (1)
Janik, Dirk (1)
Rensen, Patrick C. N ... (1)
Zimmermann, Andreas (1)
Kiechl, Stefan (1)
Willeit, Johann (1)
Weber, Christian (1)
Bosmans, Laura A. (1)
Atzler, Dorothee (1)
Lutgens, Esther (1)
van Tiel, Claudia M. (1)
Aarts, Suzanne A.B.M ... (1)
den Toom, Myrthe (1)
Beckers, Linda (1)
Knittelfelder, Oskar (1)
Rockenfeller, Patric ... (1)
Ruckenstuhl, Christo ... (1)
Madeo, Frank (1)
Kroemer, Guido (1)
Norenburg, Jon (1)
Schmidt, Albrecht (1)
Willeit, Peter (1)
Dengjel, Joern (1)
Schroeder, Sabrina (1)
Abdellatif, Mahmoud (1)
Primessnig, Uwe (1)
Stekovic, Slaven (1)
Pendl, Tobias (1)
Harger, Alexandra (1)
Schipke, Julia (1)
Tong, Mingming (1)
Dammbrueck, Christop ... (1)
Gross, Angelina S. (1)
show less...
University
University of Gothenburg (1)
Uppsala University (1)
Stockholm University (1)
University of Gävle (1)
Linnaeus University (1)
Karolinska Institutet (1)
show more...
Swedish Museum of Natural History (1)
Swedish University of Agricultural Sciences (1)
show less...
Language
English (4)
Research subject (UKÄ/SCB)
Natural sciences (3)
Medical and Health Sciences (2)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view