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Träfflista för sökning "WFRF:(Berg Hansen Kristoffer) "

Search: WFRF:(Berg Hansen Kristoffer)

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  • Berg Hansen, Kristoffer, et al. (author)
  • Myocardial efficiency in patients with different aetiologies and stages of heart failure
  • 2022
  • In: European Heart Journal Cardiovascular Imaging. - : Oxford University Press (OUP). - 2047-2404 .- 2047-2412. ; 23:3, s. 328-337
  • Journal article (peer-reviewed)abstract
    • Aims: Myocardial external efficiency (MEE) is the ratio of cardiac work in relation with energy expenditure. We studied MEE in patients with different aetiologies and stages of heart failure (HF) to discover the role and causes of deranged MEE. In addition, we explored the impact of patient characteristics such as sex, body mass index (BMI), and age on myocardial energetics.Methods and results: Cardiac energetic profiles were assessed with C-11-acetate positron emission tomography (PET) and left ventricular ejection fraction (LVEF) was acquired with echocardiography. MEE was studied in 121 participants: healthy controls (n = 20); HF patients with reduced (HFrEF; n = 25) and mildly reduced (HFmrEF; n = 23) LVEF; and patients with asymptomatic (AS-asymp; n = 38) and symptomatic (AS-symp; n = 15) aortic stenosis (AS). Reduced MEE coincided with symptoms of HF irrespective of aetiology and declined in tandem with deteriorating LVEF. Patients with AS-symp and HFmrEF had reduced MEE as compared with controls (22.2 +/- 4.9%, P = 0.041 and 20.0 +/- 4.2%, P < 0.001 vs. 26.1 +/- 5.8% in controls) and a further decline was observed in patients with HFrEF (14.7 +/- 6.3%, P < 0.001). Disproportionate left ventricular hypertrophy was a major cause of reduced MEE. Female sex (P < 0.001), a lower BMI (P = 0.001), and advanced age (P = 0.03) were associated with a lower MEE.Conclusion: MEE was reduced in patients with HFrEF, HFmrEF, and HF due to pressure overload and MEE may therefore constitute a treatment target in HF. Patients with LVH, advanced age, female sex, and low BMI had more pronounced reduction in MEE and personalized treatment within these patient subgroups could be relevant.
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  • Åberg, Anna, et al. (author)
  • Helicobacter pylori adapts to chronic infection and gastric disease via ph-responsive baba-mediated adherence
  • 2017
  • In: Cell Host and Microbe. - : Elsevier BV. - 1931-3128 .- 1934-6069. ; 21:3, s. 376-389
  • Journal article (peer-reviewed)abstract
    • The BabA adhesin mediates high-affinity binding of Helicobacter pylori to the ABO blood group antigen-glycosylated gastric mucosa. Here we show that BabA is acid responsive-binding is reduced at low pH and restored by acid neutralization. Acid responsiveness differs among strains; often correlates with different intragastric regions and evolves during chronic infection and disease progression; and depends on pH sensor sequences in BabA and on pH reversible formation of high-affinity binding BabA multimers. We propose that BabA's extraordinary reversible acid responsiveness enables tight mucosal bacterial adherence while also allowing an effective escape from epithelial cells and mucus that are shed into the acidic bactericidal lumen and that bio-selection and changes in BabA binding properties through mutation and recombination with babA-related genes are selected by differences among individuals and by changes in gastric acidity over time. These processes generate diverse H. pylori subpopulations, in which BabA's adaptive evolution contributes to H. pylori persistence and overt gastric disease.
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journal article (2)
other publication (1)
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peer-reviewed (2)
other academic/artistic (1)
Author/Editor
Borén, Thomas (2)
Engstrand, Lars (2)
Holgersson, Jan (2)
Dubois, Andre (2)
Oscarson, Stefan (2)
Liu, Hui (2)
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Brännström, Kristoff ... (2)
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Gröbner, Gerhard (2)
Strömberg, Nicklas (2)
Hofer, Anders (2)
Henriksson, Sara (2)
Björnham, Oscar (2)
Schmidt, Alexej (2)
Arnqvist, Anna (2)
Vikström, Susanne (2)
Sjöström, Rolf (2)
Mahdavi, Jafar (2)
Gilman, Robert H (2)
Berg, Douglas E (2)
Ilver, Dag (2)
Schedin, Staffan (2)
Danielsson, Dan (2)
Haas, Rainer (2)
Esberg, Anders (2)
Remaut, Han (2)
Chernov, Yevgen A (2)
Mendez, Melissa (2)
Sörensen, Jens (1)
Olofsson, Anders (1)
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Unemo, Magnus, 1970- (1)
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Berg Hansen, Kristof ... (1)
Hansson, Nils Henrik (1)
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University
Umeå University (2)
University of Gothenburg (1)
Uppsala University (1)
Örebro University (1)
Karolinska Institutet (1)
Language
English (3)
Research subject (UKÄ/SCB)
Medical and Health Sciences (3)

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