SwePub - search: WFRF:(Berglund Anna)

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1.	Nadeau, Elisabet, et al. (author) Idisslare har viktig roll i vårt livsmedelssystem 2019 In: Svenska dagbladet. - 1101-2412. Journal article (pop. science, debate, etc.)
2.	Alhamdow, Ayman, et al. (author) Low-level exposure to polycyclic aromatic hydrocarbons is associated with reduced lung function among Swedish young adults 2021 In: Environmental Research. - : Elsevier BV. - 0013-9351 .- 1096-0953. ; 197 Journal article (peer-reviewed)abstract Background: Exposure to polycyclic aromatic hydrocarbons (PAHs) has been linked to adverse pulmonary effects. However, the impact of low-level environmental PAH exposure on lung function in early adulthood remains uncertain. Objectives: To evaluate the associations between urinary PAH metabolites and lung function parameters in young adults. Methods: Urinary metabolites of pyrene, phenanthrene, and fluorene were analysed in 1000 young adults from Sweden (age 22–25 years) using LC-MS/MS. Lung function and eosinophilic airway inflammation were measured by spirometry and exhaled nitric oxide fraction (FeNO), respectively. Linear regression analysis was used to evaluate associations between PAH metabolites and the outcomes. Results: Median urinary concentrations of 1-OH-pyrene, ∑OH-phenanthrene, and ∑OH-fluorene were 0.066, 0.36, 0.22 μg/L, respectively. We found inverse associations of ∑OH-phenanthrene and ∑OH-fluorene with FEV1 and FVC, as well as between 1-OH-pyrene and FEV1/FVC ratio (adjusted P < 0.05; all participants). An increase of 1% in ∑OH-fluorene was associated with a decrease of 73 mL in FEV1 and 59 mL in FVC. In addition, ∑OH-phenanthrene concentrations were, in a dose-response manner, inversely associated with FEV1 (B from −109 to −48 compared with the lowest quartile of ∑OH-phenanthrene; p trend 0.004) and FVC (B from −159 to −102 compared with lowest quartile; p-trend <0.001). Similar dose-response associations were also observed between ∑OH-fluorene and FEV1 and FVC, as well as between 1-OH-pyrene and FEV1/FVC (p-trend <0.05). There was no association between PAH exposure and FeNO, nor was there an interaction with smoking, sex, or asthma. Conclusion: Low-level PAH exposure was, in a dose-response manner, associated with reduced lung function in young adults. Our findings have public health implications due to i) the widespread occurrence of PAHs in the environment and ii) the clinical relevance of lung function in predicting all-cause and cardiovascular disease mortality.
3.	Berglund, Anna, et al. (author) Successful implementation of evidence-based routines in Ukrainian maternities 2010 In: Acta Obstetricia et Gynecologica Scandinavica. - : Wiley. - 0001-6349 .- 1600-0412. ; 89:2, s. 230-237 Journal article (peer-reviewed)abstract Objective. To describe the process of change and assess compliance and effect on maternal and infant outcome when the WHO package Effective Perinatal Care (EPC) was implemented at maternities in Ukraine. Design. Intervention study comparing outcomes before and during 2.5 years after training. Setting. Three maternities in Donetsk, Lutsk and Lviv 2003-2006. Population. Baseline data were collected for 652, 742 and 302 deliveries and 420, 381 and 135 infants, respectively, in Donetsk, Lutsk and Lviv. Follow-up data included 4,561, 9,865 and 7,227 deliveries and 3,829, 8,658 and 6,401 infants. Methods. Staff training on evidence-based guideline. Main outcome measures. Interventions during labor, maternal outcomes and hypothermia in the infants. Results: EPC procedures were successfully implemented and adherence to the protocols was excellent. For most variables, the change occurred during the first three months but was well sustained. The use of partogram increased fourfold in Donetsk and from 0% to 60% in Lviv. Induction and augmentation of labor decreased to less than 1% and less than 5%, respectively. Cesarean section rate dropped significantly in two of the maternities. The proportion of hypothermic infants decreased from 60% (Donetsk), 85% (Lutsk) and 77% (Lviv) to 1% in all three maternities during the first three months and was stable throughout the study period. Admission to Neonatal Intensive Care Unit decreased significantly in two of the maternities and there was no effect on early neonatal mortality. Conclusions: The process of education and change was well anchored in the organization, and implementation of new procedures was quick and successful.
4.	Berglund, Aseel, 1973-, et al. (author) Understanding and assessing gamification in digital healthcare interventions for patients with cardiovascular disease 2022 In: European Journal of Cardiovascular Nursing. - : Oxford University Press. - 1474-5151 .- 1873-1953. ; 21:6, s. 630-638 Journal article (peer-reviewed)abstract Gamification is defined as the use of game design elements in contexts other than gaming to increase user engagement and experience. Gamification in cardiovascular care can contribute to positively change health behaviour with possible effects and benefits on physical health and mental well-being. Based on previous literature, in this article we describe: the conceptualization of gamification, the five gamification principles for gamified digital health programmes or applications, the six most common game elements used to impact health behaviour applied in gamified digital health interventions and finally scientifically validated instruments to use for assessment of gamification in terms of self-reported psychological outcomes.
5.	Berglund Kristiansson, Elisabeth, et al. (author) A qualitative study of older persons’ experiences of getting individual support with digital needs in the context of home ID 281 2024 In: The first Global Conference on Person-Centred Care. - : University of Gothenburg Centre for Person-Centred Care. - 9789153106708 ; , s. 216-216 Conference paper (peer-reviewed)abstract Background: Digitalization is seen as a necessity to manage the increasing burden on the health care system and is accordingly considered an important tool in the transformation to integrated care (Swedish Nära vård). However, when health care is digitalized older persons are at increased risk of being marginalized and dependent on others due to their generally lower digital competence. To address this, several Swedish municipalities offer individual support to older persons in their own home, a service called Digital Coach (DC). As this service is new, the aim is to describe older persons’ experiences of getting individual support with digital needs in the context of home. Method: Semi-structured interviews (n=14) were conducted with older persons who have had DC support in their home. The focus was on older persons’ experiences of the support. Data was analyzed with qualitative content analysis. Results, preliminary: The overall theme, to be a valued person in the digital society, represents a feeling of being taken seriously and worth investing resources in to gain access to society. Three categories emerged: (1) The need to keep up with the times which means to understand and navigate the new digital landscape with the opportunity for independence and participation, (2) Support and respect in the learning situation, is crucial for feeling comfortable to expose insufficient knowledge, and (3) Increased digital competence empowers autonomy and is manifested as the ability to handle the digital tools and services by your own creates a feeling of joy and satisfaction and increases the opportunity to participate in both social and community activities. Conclusion: The result shows that individual support with digital needs in the context of home increase digital competence in older persons and create feelings of being valued and included in the digital society, which can extend to integrated person-centered care.
6.	Berglund, Lisa, et al. (author) Glucose-Dependent Insulinotropic Polypeptide (GIP) Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB. 2016 In: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 65:1, s. 239-254 Journal article (peer-reviewed)abstract Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone with extrapancreatic effects beyond glycemic control. Here we demonstrate unexpected effects of GIP signaling in the vasculature. GIP induces the expression of the pro-atherogenic cytokine osteopontin (OPN) in mouse arteries, via local release of endothelin-1 (ET-1) and activation of cAMP response element binding protein (CREB). Infusion of GIP increases plasma OPN levels in healthy individuals. Plasma ET-1 and OPN levels are positively correlated in patients with critical limb ischemia. Fasting GIP levels are higher in individuals with a history of cardiovascular disease (myocardial infarction, stroke) when compared to controls. GIP receptor (GIPR) and OPN mRNA levels are higher in carotid endarterectomies from patients with symptoms (stroke, transient ischemic attacks, amaurosis fugax) than in asymptomatic patients; and expression associates to parameters characteristic of unstable and inflammatory plaques (increased lipid accumulation, macrophage infiltration and reduced smooth muscle cell content). While GIPR expression is predominantly endothelial in healthy arteries from human, mouse, rat and pig; remarkable up-regulation is observed in endothelial and smooth muscle cells upon culture conditions yielding a "vascular disease-like" phenotype. Moreover, a common variant rs10423928 in the GIPR gene associated with increased risk of stroke in type 2 diabetes patients.
7.	Berglund, Lisa, et al. (author) Nuclear Factor of Activated T Cells Regulates Osteopontin Expression in Arterial Smooth Muscle in Response to Diabetes-Induced Hyperglycemia 2010 In: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. - Baltimore : Lippincott Williams & Wilkins. - 1079-5642. ; 30, s. 154-218 Journal article (peer-reviewed)abstract Objective-Hyperglycemia is a recognized risk factor for cardiovascular disease in diabetes. Recently, we reported that high glucose activates the Ca2+/calcineurin-dependent transcription factor nuclear factor of activated T cells (NFAT) in arteries ex vivo. Here, we sought to determine whether hyperglycemia activates NFAT in vivo and whether this leads to vascular complications. Methods and Results-An intraperitoneal glucose-tolerance test in mice increased NFATc3 nuclear accumulation in vascular smooth muscle. Streptozotocin-induced diabetes resulted in increased NFATc3 transcriptional activity in arteries of NFAT-luciferase transgenic mice. Two NFAT-responsive sequences in the osteopontin (OPN) promoter were identified. This proinflammatory cytokine has been shown to exacerbate atherosclerosis and restenosis. Activation of NFAT resulted in increased OPN mRNA and protein in native arteries. Glucose-induced OPN expression was prevented by the ectonucleotidase apyrase, suggesting a mechanism involving the release of extracellular nucleotides. The calcineurin inhibitor cyclosporin A or the novel NFAT blocker A-285222 prevented glucose-induced OPN expression. Furthermore, diabetes resulted in higher OPN expression, which was significantly decreased by in vivo treatment with A-285222 for 4 weeks or prevented in arteries from NFATc3(-/-) mice. Conclusions-These results identify a glucose-sensitive transcription pathway in vivo, revealing a novel molecular mechanism that may underlie vascular complications of diabetes.
8.	Berglund, Maria M., 1977- (author) Värv och verk : Förnyelse och tradition i Nordisk kvinnolitteraturhistoria från tillkomst till tryckt bok 2013 Doctoral thesis (other academic/artistic)abstract Nordisk kvinnolitteraturhistoria [The History of Nordic Women’s Literature; henceforth NKLH] is a history of literature published in five volumes 1993–1998. It was written with the overtly stated intention to change literary history on feminist grounds. The primary aim of this doctoral thesis is to map out and analyze the ways in which NKLH shows renewal and tradition compared to the histories of literature that it was a critique of. What conventions and criteria in the genre of literary history has the group of researchers strived to challenge, and what have they overlooked or neglected? How was the ambition of renewal in NKLH received on publication? What underlying factors in the project’s design and execution can account for the final product? The thesis explores these questions in three main chapters: one that analyses the processes of writing NKLH by means of an archival study, one that analyses the reception of the volumes in newspapers and journals, and one that analyses aspects of renewal and tradition in the four chronological volumes.The most significant ways in which NKLH shows renewal compared to previous histories of literature are in its reinterpretations of canonized authors and in its broad inclusion of different types of texts in the first two volumes. The Nordic approach is another area of renewal. The inter-Nordic perspectives in the volumes tend, however, toward a Danish-Swedish dominance. In some aspects NKLH also shows tradition, most notably in its strong developmental narrative and in its selection of literary genres in the latter two volumes. That NKLH shows both renewal and tradition is a result partly of what the researchers involved wanted to convey, partly of long-lived traditions and expectations within the genre of literary history, and partly of material factors such as organization, funding, geographical outspread and the parallel production of national histories of women’s literature in two of the Nordic countries.
9.	Berglund, Torkel, et al. (author) Slutrapport, fält- och laboratorietest av substanser för aktivering av det egna försvaret hos gran- och tallplantor 2012 Reports (other academic/artistic)
10.	Cedervall, Ylva, et al. (author) Timed Up-and-Go Dual-Task Testing in the Assessment of Cognitive Function : A Mixed Methods Observational Study for Development of the UDDGait Protocol 2020 In: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 17:5 Journal article (peer-reviewed)abstract New methods to screen for and identify early-stage dementia disorders are highly sought after. The purpose of this pilot study is to develop a study protocol for a dual-task test aimed at aiding the early detection of dementia disorders. We used the Timed Up-and-Go (TUG) test, which is a mobility task involving starting in a sitting position, standing up, walking three meters to cross a line on the floor, turning around, walking back and sitting down again. We combined TUG with the verbal task of naming different animals. Pilot study participants were 43 individuals with and without established dementia diagnoses who attended a clinic for memory assessment. Video-recorded test performances were systematically analysed. Deviant test performances concerning the interplay between test administration and participants' responses to the assessment instructions were revealed and led to refinements being made to the final study protocol. Exploration of the dual-task test outcome measures in a sub-sample of 22 persons, ten with and twelve without dementia, indicated that step-length and number of named animals after the turning point of the dual-task test might constitute appropriate measures for examining this kind of sample. We concluded that the refined study protocol is feasible for testing individuals undergoing initial memory assessments and healthy controls. Follow-up studies with larger samples are being carried out and will bring new knowledge to this area of research. It may also provide an opportunity for further studies exploring possibilities for broad clinical implementation.
11.	Fasth Berglund, Åsa, 1978, et al. (author) CREATING STRATEGIES FOR GLOBAL ASSEMBLY INSTRUCTIONS – CURRENT STATE ANALYSIS 2014 In: The sixth Swedish Production Symposium. - 9789198097412 Conference paper (peer-reviewed)abstract This paper present result from three global companies regarding strategies for creating global instructions, the studies are from a current state perspective. The result is based from a survey with 65 respondents. The designers are responsible for instructions and are from two different areas; assembly and service market. Furthermore a workshop has been arranged were two of three companies participated. Three main issues towards formulating a strategy will be discussed; (1) Information carrier; the results reveal that the most common information carrier for instructions are, Paper, Personal meetings and Desktops. (2) Who is responsible for quality assurance, most answers were production engineers. (3) Are there any standards concerning instruction at your company today? The respondents answered yes or under development in over 80 % of the cases on the question; if it exist any standards today.
12.	Gad, Helge, et al. (author) MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool 2014 In: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 508:7495, s. 215-221 Journal article (peer-reviewed)abstract Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication. Although MTH1 is non-essential in normal cells, we show that cancer cells require MTH1 activity to avoid incorporation of oxidized dNTPs, resulting in DNA damage and cell death. We validate MTH1 as an anticancer target in vivo and describe small molecules TH287 and TH588 as first-in-class nudix hydrolase family inhibitors that potently and selectively engage and inhibit the MTH1 protein in cells. Protein co-crystal structures demonstrate that the inhibitors bindin the active site of MTH1. The inhibitors cause incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts. This study exemplifies the non-oncogene addiction concept for anticancer treatment and validates MTH1 as being cancer phenotypic lethal.
13.	Garcia-Vaz, Eliana, et al. (author) Inhibition of NFAT signaling restores microvascular endothelial function in diabetic mice 2020 In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 69:3, s. 424-435 Journal article (peer-reviewed)abstract Central to the development of diabetic macro- and microvascular disease is endothelial dysfunction, which appears well before any clinical sign but, importantly, is potentially reversible. We previously demonstrated that hyperglycemia activates nuclear factor of activated T cells (NFAT) in conduit and medium-sized resistance arteries and that NFAT blockade abolishes diabetes-driven aggravation of atherosclerosis. In this study, we test whether NFAT plays a role in the development of endothelial dysfunction in diabetes. NFAT-dependent transcriptional activity was elevated in skin microvessels of diabetic Akita (Ins21/2) mice when compared with nondiabetic littermates. Treatment of diabetic mice with the NFAT blocker A-285222 reduced NFATc3 nuclear accumulation and NFAT-luciferase transcriptional activity in skin microvessels, resulting in improved microvascular function, as assessed by laser Doppler imaging and iontophoresis of acetylcholine and localized heating. This improvement was abolished by pretreatment with the nitric oxide (NO) synthase inhibitor L-NGnitro-L-arginine methyl ester, while iontophoresis of the NO donor sodium nitroprusside eliminated the observed differences. A-285222 treatment enhanced dermis endothelial NO synthase expression and plasma NO levels of diabetic mice. It also prevented induction of inflammatory cytokines interleukin-6 and osteopontin, lowered plasma endothelin-1 and blood pressure, and improved mouse survival without affecting blood glucose. In vivo inhibition of NFAT may represent a novel therapeutic modality to preserve endothelial function in diabetes.
14.	Granfors, Michaela, 1972-, et al. (author) Thyroid Testing and Management of Hypothyroidism During Pregnancy : A Population-based Study 2013 In: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 98:7, s. 2687-2692 Journal article (peer-reviewed)abstract Context: There are international guidelines on thyroid function testing and management of hypothyroidism during pregnancy. Few studies have evaluated how they are implemented into clinical practice. Objective: In this descriptive study, we assessed the implementation of international guidelines in this field into local guidelines and also into clinical practice. Design and Participants: In a nationwide survey, all guidelines in Sweden were collected (n = 29), and the adherence of the local guidelines to The Endocrine Society Guidelines 2007 was evaluated. In a follow-up in 1 district, 5254 pregnant women with an estimated date of delivery between January 1, 2009, and December 31, 2011, were included for subsequent review of their medical reports. Results: All but 1 district had guidelines on the subject. All local guidelines included fewer than the 10 listed reasons for thyroid testing recommended by The Endocrine Society Guidelines. Furthermore, most guidelines recommended additional types of thyroid function tests to TSH sampling and lower trimester-specific TSH upper reference limits for women on levothyroxine treatment (P < .001). In the follow-up, the thyroid testing rate was 20%, with an overall frequency of women with trimester-specific elevated TSH of 18.5%. More than half of the women (50.9%) who were on levothyroxine treatment at conception had an elevated TSH level at thyroid testing according to The Endocrine Society Guidelines. Conclusions: The local guidelines are variable and poorly compliant with international guidelines. Performance of thyroid testing is not optimal, and rates of elevated TSH at testing are extremely high in subgroups.
15.	Gudmundsson, Anders, et al. (author) Health Effects in Healthy Volunteers Exposed to Diesel Exhaust and Traffic Noise 2012 In: Proceedings of the "Workplace and Indoor Aerosols Conference" (electronic version only). ; , s. 26-26 Conference paper (peer-reviewed)
16.	Gudmundsson, Anders, et al. (author) Health Effects in Healthy Volunteers in Controlled Experimental Exposure to Diesel Exhaust and Traffic Noise 2011 In: Arbete och hälsa. - 0346-7821. ; 45:5, s. 30-30 Conference paper (peer-reviewed)
17.	Heimer, Gun, et al. (author) ”Vården måste fråga kvinnor om de har utsatts för våld” 2011 In: DN.se / DN-debatt. ; :13 maj Journal article (pop. science, debate, etc.)
18.	Heimer, Gun, et al. (author) ”Vården måste fråga kvinnor om de har utsatts för våld” 2011 In: DN.se / DN-debatt. ; :13 maj Journal article (other academic/artistic)
19.	Högfeldt, Anna-Karin, et al. (author) Leading the teacher team - balancing between formal and informal power in program leadership 2018 In: Tertiary Education and Management. - : Springer Nature. - 1358-3883 .- 1573-1936. ; 24:1, s. 49-65 Journal article (peer-reviewed)abstract This continuous research within Nordic engineering institutions targets the contexts and possibilities for leadership among engineering education program directors. The IFP-model, developed based on analysis of interviews with program leaders in these institutions, visualizes the program director's informal and formal power. The model is presented as a tool for starting a shared discussion on the complexities of the leadership of engineering program development. The authors liken program development to hunting in teams. Each individual expert in the program is needed, and all experts will need to work and collaborate for the same target. This calls for strategic and long-term thinking of engineering education development. Institutions should support the development of both formal structures as well as informal leadership skills among their program directors, but never fall for the temptation to see the program director as the only actor on the stage.
20.	Högfeldt, Anna-Karin, et al. (author) Pedagogisk meritering på KTH - Samarbete, excellens och utbildningsinnovation 2019 In: Bidrag från 7:e Utvecklingskonferensen för Sveriges ingenjörsutbildningar. - Luleå : Luleå University of Technology. ; , s. 76-81 Conference paper (peer-reviewed)abstract Detta bidrag beskriver och analyserar förberedelsefasen inför implementeringen av ett högskolepedagogiskt excellensprogram vid Kungliga Tekniska Högskolan, KTH. Programmet syftar till att ytterligare stärka värdet av pedagogiska meriter och samtidigt bidra till lärosätets fortsatta och fördjupade utveckling av utbildningarna och organisationen. De tydligaste riskerna som har identifierats med befintliga pedagogiska meriteringsmodeller är att de kan skapa ett A- och B-lag (mellan en karriär som forskare och en karriär som lärare). Dessutom är det ofta oklart hur personer som har utnämnts till excellenta lärare ska kunna bidra till organisationens och utbildningens utveckling ur ett kortsiktigt såväl som ett långsiktigt perspektiv. En tydlig svaghet med befintliga pedagogiska meriteringsmodeller är att de inte explicit nog ger emfas till aktivt och relevant utvecklingsarbete, utan fokuserar på egenhändigt skrivna pedagogiska portföljer som sällan är framtidsinriktade. KTH:s högskolepedagogiska excellensprogram siktar på att försöka möta dessa risker och svagheter. KTH har, alltjämt sedan det nationella obligatoriet om 15 hp Högskolepedagogik infördes, kvarhållit detta obligatorium. Stora satsningar har gjorts på den högskolepedagogiska verksamheten. Ett gediget utbud av fortbildningsmöjligheter samt arenor för nätverkande har utvecklats. Samtidigt råder svagheter i systemet gällande prövande och tillvaratagande av pedagogisk skicklighet, och det är tydligt att KTH behöver ytterligare utveckling i området. Författarna menar också att i och med att de utmaningar vi står inför gällande pedagogisk meritering ser relativt lika ut vid landets lärosäten, bör ett stärkt nationellt samarbete och nätverkande inom landets ingenjörsutbildningar främjas inom området. Artikelförfattarna representerar KTH:s övergripande ledning, utbildningsledning samt ledningen för den högskolepedagogiska verksamheten.
21.	Högfeldt, Anna-Karin, et al. (author) Program leadership from a nordic perspective : Program leaders' power to influence their program 2013 In: Proceedings of the 9th International CDIO Conference. Conference paper (peer-reviewed)abstract In this paper a continuation research at five technical universities in Nordic countries (N5T network) in 2012 is presented, wheretheaim was to find out how the program leadersconceived their function, role and mandate, and the work situations between the universitieswere compared. The previous research demonstrated that programleadershave quite different positions, strategies and methods when it comes to monitoring and developing their programs.In this paper, a deeper investigationis carried out ofthe (im-) possibilitiesto make realinfluence on the study courses that constitutesthe respective Engineering study programs. Eightprogram leaders from thefiveN5Tuniversities have been interviewed, and theanalysis of these studies, has culminatedina model for the analysis of program leadership for Engineering educationdevelopment.
22.	Ingadottir, Brynja, et al. (author) Let the games begin : serious games in prevention and rehabilitation to improve outcomes in patients with cardiovascular disease 2020 In: European Journal of Cardiovascular Nursing. - : Sage Publications. - 1474-5151 .- 1873-1953. ; 19:7, s. 558-560 Journal article (other academic/artistic)
23.	Janson, Staffan, 1945-, et al. (author) Äldre i Värmland : Om hälsa, levnadsvanor och livssituation 2006 2007 Book (other academic/artistic)abstract Landstinget har i samarbete med Karlstads universitet gjort flera befolkningsundersökningar i Värmland och publicerat rapporter om både den vuxna befolkningens och barns hälsa, senast med rapporten Värmlänningarnas Liv och Hälsa 2004. Någon befolkningsstudie av de äldres hälsa och livsvillkor har dock inte gjorts tidigare.Efter tre års förarbeten och samråd mellan landstinget, Värmlands kommuner och flera institutioner vid Karlstads universitet genomfördes den föreliggande studien av de äldres hälsa under senhösten 2006, i form av en omfattande postenkät. Urvalet utgjordes av 2500 slumpmässigt uttagna kvinnor och män som var 80 år eller äldre. Svarsfrekvensen var 60 procent, vilket får betraktas som mycket bra med tanke på att cirka 15 procent i denna åldersgrupp lever i särskilda boenden.Studien avspeglar således hälsan och livsvillkoren för de äldre. Överlag visar det sig att de äldre mår bra och har stor kapacitet att fungera som aktiva samhällsmedborgare. Samtidigt är det många som har kroniska besvär, med värk, syn- och hörselnedsättning, inkontinensbesvär etc. Det föreligger också en klar social gradient, där särskilt äldre kvinnor med arbetarbakgrund har både mer sjukdom och större ekonomiska problem än de övriga.
24.	Kurdve, Martin, 1971, et al. (author) Implementation of daily visual management at five small and medium sized enterprises in Produktionslyftet compared to six larger Swedish companies 2016 In: Swedish Production Symposium 2016. Conference paper (peer-reviewed)abstract This paper compares the implementation of daily visual management (DVM) in five SMEs (small and medium sized enterprises), with practice in six large Swedish companies, considering the challenge to include sustainability aspects. With method definition from Produktionslyftet (PL), a Swedish development programme, DVM includes daily meetings around key performance indices (KPIs) and visualised information on boards. The SMEs were studied within PL while the large companies were studied in the research project SuReBPMS (Sustainable and resource efficient Business Performance Measurement Systems). The empirical result from SMEs shows that KPIs often cover few areas (most common: delivery, safety and quality) while the larger companies have wider range of areas. In some SMEs the meeting agendas, KPIs and pulse-boards are standardised while in others there are differences between teams or operations. The larger companies were mainly standardised. Both SMEs and larger companies mostly include all employees in DVM, in line with PL-DVM methodology. The general tendency is to focus on short term rather than follow-up of strategic challenges in the DVM. Furthermore, environmental issues, such as climate impact, are rarely found on boards, while often reflected in company policy. However, many KPIs have a strong, indirect, connection to sustainability and environment.
25.	Kwiecinska, Anna, et al. (author) Amplification of 2p as a Genomic Marker for Transformation in Lymphoma 2014 In: Genes, Chromosomes and Cancer. - : Wiley. - 1045-2257 .- 1098-2264. ; 53:9, s. 750-768 Journal article (peer-reviewed)abstract To outline further genetic mechanisms of transformation from follicular lymphoma (FL) to diffuse large B-cell lymphoma (DLBCL), we have performed whole genome array-CGH in 81 tumors from 60 patients [29 de novo DLBCL (dnDLBCL), 31 transformed DLBCL (tDLBCL), and 21 antecedent FL]. In 15 patients, paired tumor samples (primary FL and a subsequent tDLBCL) were available, among which three possessed more than two subsequent tumors, allowing us to follow specific genetic alterations acquired before, during, and after the transformation. Gain of 2p15-16.1 encompassing, among others, the REL, BCL11A, USP34, COMMD1, and OTX1 genes was found to be more common in the tDLBCL compared with dnDLBCL (P < 0.001). Furthermore, a high-level amplification of 2p15-16.1 was also detected in the FL stage prior to transformation, indicating its importance during the transformation event. Quantitative real-time PCR showed a higher level of amplification of REL, USP34, and COMMD1 (all involved in the NF kappa B-pathway) compared with BCL11A, which indicates that the altered genes disrupting the NF kappa B pathway may be the driver genes of transformation rather than the previously suggested BCL11A. Moreover, a 17q21.33 amplification was exclusively found in tDLBCL, never in FL (P < 0.04) or dnDLBCL, indicating an upregulation of genes of importance during the later phase of transformation. Taken together, our study demonstrates potential genomic markers for disease progression to clinically more aggressive forms. We also confirm the importance of the TP53-, CDKN2A-, and NF kappa B-pathways for the transformation from FL to DLBCL.
26.	Lyssenko, Valeriya, et al. (author) Pleiotropic Effects of GIP on Islet Function Involve Osteopontin 2011 In: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 60:9, s. 2424-2433 Journal article (peer-reviewed)abstract OBJECTIVE-The incretin hormone GIP (glucose-dependent insulinotropic polypeptide) promotes pancreatic beta-cell function by potentiating insulin secretion and beta-cell proliferation. Recently, a combined analysis of several genome-wide association studies (Meta-analysis of Glucose and Insulin-Related Traits Consortium [MAGIC]) showed association to postprandial insulin at the GIP receptor (GIPR) locus. Here we explored mechanisms that could explain the protective effects of GIP on islet function. RESEARCH DESIGN AND METHODS-Associations of GIPR rs10423928 with metabolic and anthropometric phenotypes in both nondiabetic (N = 53,730) and type 2 diabetic individuals (N = 2,731) were explored by combining data from 11 studies.Insulin secretion was measured both in vivo in nondiabetic subjects and in vitro in islets from cadaver donors. Insulin secretion was also measured in response to exogenous GIP. The in vitro measurements included protein and gene expression as well as measurements of beta-cell viability and proliferation. RESULTS-The A allele of GIPR rs10423928 was associated with impaired glucose- and GIP-stimulated insulin secretion and a decrease in BMI, lean body mass, and waist circumference. The decrease in BMI almost completely neutralized the effect of impaired insulin secretion on risk of type 2 diabetes. Expression of GIPR mRNA was decreased in human islets from carriers of the A allele or patients with type 2 diabetes. GIP stimulated osteopontin (OPN) mRNA and protein expression. OPN expression was lower in carriers of the A allele. Both GIP and OPN prevented cytokine-induced reduction in cell viability (apoptosis). In addition, OPN stimulated cell proliferation in insulin-secreting cells. CONCLUSIONS-These findings support beta-cell proliferative and antiapoptotic roles for GIP in addition to its action as an incretin hormone. Identification of a link between GIP and OPN may shed new light on the role of GIP in preservation of functional beta-cell mass in humans. Diabetes 60:2424-2433, 2011
27.	Newton-Cheh, Christopher, et al. (author) Genome-wide association study identifies eight loci associated with blood pressure 2009 In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:6, s. 666-676 Journal article (peer-reviewed)abstract Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N <= 71,225 European ancestry, N <= 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 x 10(-24)), CYP1A2 (P = 1 x 10(-23)), FGF5 (P = 1 x 10(-21)), SH2B3 (P = 3 x 10(-18)), MTHFR (P = 2 x 10(-13)), c10orf107 (P = 1 x 10(-9)), ZNF652 (P = 5 x 10(-9)) and PLCD3 (P = 1 x 10(-8)) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.
28.	Nilsson, Christina, et al. (author) Varför vårdvetenskap? 2008 In: Vårdvetenskapliga vägskäl. - Växjö : Växjö universitet. ; , s. 49-60 Reports (other academic/artistic)
29.	[Nyberg] Berglund, Anna-Britt, et al. (author) Electrophoretic evidence for disomic inheritance and allopolyploid origin of the octoploid Cerastium alpinum (Caryophyllaceae). 2006 In: J Hered. - : Oxford University Press (OUP). - 0022-1503 .- 1465-7333. ; 97:3, s. 296-302 Journal article (peer-reviewed)abstract The mode of inheritance of six enzyme markers in the octoploid alpine plant Cerastium alpinum was analyzed. Offspring from crosses between heterozygotes showed fixed heterozygosity at malate dehydrogenase-2, phosphoglucoisomerase-2, triosephosphate isomerase-2, and triosephosphate isomerase-3. Phosphoglucomutase-1 also showed fixed heterozygosity except in offspring from one cross. Fixed heterozygosity in five enzyme systems suggests that C. alpinum has originated through at least some allopolyploidization. Offspring from plants heterozygous for two alleles at the menadione reductase-1 (Mr-1) locus did not deviate significantly from a 1:2:1 ratio. The large proportion of homozygotes suggests disomic inheritance because any kind of polysomic inheritance would result in a substantially increased proportion of heterozygotes relative to disomic inheritance. Assuming a diploid model for Mr-1, this locus was used to analyze the population genetic structure within C. alpinum populations. Inbreeding was found in many alpine populations. This may help explain the large genetic distances found among alpine populations in a previous study. The analysis is only based on one segregating locus, and the results should therefore be treated with caution. However, by establishing the mode of inheritance through crosses, we have been able to use a codominant marker in population genetic analysis of an octoploid plant.
30.	Nyberg Berglund, Anna Britt, et al. (author) Evidence for parallel evolution and site-specific selection of serpentine tolerance in Cerastium alpinum during the colonization of Scandinavia 2004 In: New Phytologist. - : Wiley. - 0028-646X .- 1469-8137. ; 161:1, s. 199-209 Journal article (peer-reviewed)abstract The effects of Ni and Mg, two factors involved in the infertility of serpentine soils, were studied in the alpine plant Cerastium alpinum. Root growth of plants from adjacent serpentine and non-serpentine populations in Scandinavia, representing an eastern and western postglacial immigration lineage and the hybrid zone between them, were compared to study the adaptation of C. alpinum populations. • Seedlings were placed in solutions with low or high concentrations of Ni and Mg in a full factorial experiment according to a randomized block design. The growth of roots was analyzed and discussed in relation to the soil content. • The serpentine populations showed higher tolerance to Ni and Mg stress than non-serpentine populations. The degree of metal tolerance differed among the serpentine populations and was related to the effective concentrations of Ni and Mg in the soil at each site. • The results suggest that serpentine tolerance is locally evolved in C. alpinum and that tolerance has arisen in parallel during the postglacial colonization of Scandinavia on serpentine soils with similar composition.
31.	Nyberg Berglund, Anna Britt, et al. (author) Two postglacial immigration lineages of the polyploid Cerastium alpinum (Caryophyllaceae) 2001 In: Hereditas. - : Springer Science and Business Media LLC. - 0018-0661 .- 1601-5223. ; 134:2, s. 171-183 Journal article (peer-reviewed)abstract The plant cover of Fennoscandia is young because of the recent glaciation. This study covers the early stages of diversification and the genetic consequences of postglacial migration of a hermaphroditic polyploid plant, Cerastium alpinum. It has a continuous distribution in the alpine region, where it grows on alpine heaths and serpentine soils that are rich in heavy metals. Within the boreal forest C. alpinum has a scattered distribution on serpentine, dolomite and steep slopes. Plants from 31 populations in Norway, Sweden and Finland were subjected to enzyme electrophoresis. Analyses of the enzyme phenotypes suggest that C. alpinum has colonized Fennoscandia through two postglacial immigration events resulting in a southeastern and a southwestern lineage. These two lineages seem to meet in a hybrid zone in northern Sweden. Large genetic differences were found among most populations in both the southeastern and the southwestern lineages. This suggests that the populations are effectively isolated from each other.
32.	Ohlsson, Anna B., et al. (author) UV-B Exposure of Indoor-Grown Picea abies Seedlings Causes an Epigenetic Effect and Selective Emission of Terpenes 2013 In: Zeitschrift für Naturforschung C - A Journal of Biosciences. - Tübingen : Verlag der Zeitschrift für Naturforschung. - 0939-5075 .- 1865-7125. ; 68:3-4, s. 139-147 Journal article (peer-reviewed)abstract Terpenoids are involved in various defensive functions in plants, especially conifers. Epigenetic mechanisms, for example DNA methylation, can influence plant defence systems. The purpose of the present study was to investigate the influence of UV-B exposure on the release of terpenoids from spruce seedlings and on needle DNA methylation. Ten-week-old seedlings grown indoors were exposed to UV-B radiation during 4 h, and the volatile compounds emitted from the seedlings were analysed. Analysis of the volatiles 1, 3, and 22 d after this UV-B exposure showed that bornyl acetate, borneol, myrcene, and limonene contents increased during the first 3 days, while at day 22 the level of emission had returned to the control level. UV-B exposure decreased the level of DNA methylation in needles of young seedlings, reflected in methylation changes in CCGG sequences. Exposure of young seedlings to UV-B radiation might be a way to potentiate the general defensive capacity, improving their ability to survive in outdoor conditions. UV-B-induced defence is discussed in the light of epigenetic mechanisms.
33.	Peterson, Anna, 1988, et al. (author) Dynamic Nanocellulose Networks for Thermoset-like yet Recyclable Plastics with a High Melt Stiffness and Creep Resistance 2019 In: Biomacromolecules. - : American Chemical Society (ACS). - 1525-7797 .- 1526-4602. ; 20:10, s. 3924-3932 Journal article (peer-reviewed)abstract Many polymers, including polyethylene, feature a relatively low melting point and hence must be cross-linked to make them viable for applications that demand a high stiffness and creep resistance at elevated temperatures. The resulting thermoset plastics cannot be recycled, and therefore alternative materials with a reconfigurable internal network structure are in high demand. Here, we establish that such a thermoset-like yet recyclable material can be realized through the addition of a nanocellulose reinforcing agent. A network consisting of cellulose nanocrystals, nano- or microfibrils imparts many of the characteristics that are usually achieved through chemical cross-linking. For instance, the addition of only 7.5 wt % of either nanocellulose material significantly enhances the melt stiffness of an otherwise molten ethylene-acrylate copolymer by at least 1 order of magnitude. At the same time, the nanocellulose network reduces the meltcreep elongation to less than 10%, whereas the neat molten matrix would rupture. At high shear rates, however, the molten composites do not display a significantly higher viscosity than the copolymer matrix, and therefore retain the processability of a thermoplastic material. Repeated re-extrusion at 140 °C does not compromise the thermomechanical properties, which indicates a high degree of recyclability. The versatility of dynamic nanocellulose networks is illustrated by 3D printing of a cellulose composite, where the high melt stiffness improves the printability of the resin.
34.	Poborilova, Zuzana, et al. (author) DNA hypomethylation concomitant with the overproduction of ROS induced by naphthoquinone juglone on tobacco BY-2 suspension cells 2015 In: Environmental and Experimental Botany. - : Elsevier BV. - 0098-8472 .- 1873-7307. ; 113, s. 28-39 Journal article (peer-reviewed)abstract Juglone, 5-hydroxy-1,4-naphthoquinone, is a naturally occurring plant secondary metabolite with allelopathic and cytotoxic properties. The cytotoxic effect of juglone and changes at the level of DNA methylation were investigated on a plant cell model, tobacco BY-2 cell suspension culture. We found that juglone in a concentration-dependent manner inhibits cell growth and causes creation of reactive oxygen species (ROS) that were visible mainly in nucleus, nucleolus, cytoplasm, and plasma membrane. Analysis of the changes in DNA methylation level using Luminometric Methylation Assay showed that juglone at the concentrations of 60 and 80 mu m causes hypomethylation of DNA. Decrease in DNA methylation was confirmed by the more sensitive technique, confocal immunofluorescence microscopy, already at 30 mu m, and was accompanied by significant overproduction of hydrogen peroxide, hydroxyl radicals, and superoxide anion radicals. The highest percentage of the signs of programed cell death, especially apoptic-like bodies that indicate DNA fragmentation was observed at 30 mu m of juglone. On the basis of results we suggest that overproduction of ROS is the main mechanism that causes hypomethylation of DNA, which may contribute to the initiation of the programmed cell death.
35.	Poborilova, Zuzana, et al. (author) DNA methylation changes caused by lawsone 2014 In: International Journal of Agricultural and Biosystems Engineering. - 2319-3913. ; 8:7, s. 654-657 Journal article (peer-reviewed)
36.	Roig-Sanchez, Soledad, et al. (author) Nanocellulose films with multiple functional nanoparticles in confined spatial distribution 2019 In: Nanoscale Horizons. - : ROYAL SOC CHEMISTRY. - 2055-6764 .- 2055-6756. ; 4:3, s. 634-641 Journal article (peer-reviewed)abstract Industries, governments and consumers increasingly request sustainable resources and greener routes for the integration of advanced functional nanocomposites in products and devices. Among renewable biopolymers, cellulose deserves special consideration since it is the most abundant one. While inorganic nanoparticles add functional properties to a nanocomposite, a flexible and porous cellulosic support will facilitate the interaction of the nanoparticles with the surroundings, their handling and recycling. A significant challenge is to develop high strength, flexible nanobiocomposites controlling the nanoparticle properties, their volume fraction and their topographic distribution within the scaffold. A new concept is presented here for multifunctional laminates where layers consist of bacterial cellulose fibrils decorated by inorganic nanoparticles. Each layer can provide a specific function using a different nanoparticle. As model systems, we have selected two metals (Au, Ag) and two semiconductors (TiO2 and Fe2O3). Energy-efficient microwave-assisted synthetic routes have been used to in situ nucleate and grow the inorganic nanocrystals on the cellulose fibrils. Then, functionalized bacterial cellulose films can be arranged as laminates in a millefeuille construct simply by layering and drying the wet films at 60 degrees C. After drying, they perform as a single integrated and thicker film. Structural, functional and mechanical integrity of the laminates have been investigated. Molecular dynamics simulations were used to compute the surface adhesion energy between two cellulose fibrils and the results are discussed in light of the experimental peel-off data for the separation of the layers in the laminate.
37.	Rolandsson, Bertil, et al. (author) Digital Transformations of Traditional Work in the Nordic Countries - Edited by Bertil Rolandsson 2020 Book (other academic/artistic)abstract Research and debates on the impact of digitalization of work often depict the effects as disruptive, and recurrently portray inherited institutions and existing policy co-ordination as out of sync with today’s changes at work. This TemaNord report presents empirically grounded studies of digitalization in traditional parts of Nordic working life, enabling readers to assess critically the claim that dramatic technologydriven changes are currently unfolding at Nordic workplaces. Recognized by their well-developed digital infrastructures, stable welfare arrangements and strong social partners, the Nordic countries provide an interesting context for studying how digitalization shapes work and what kind of policy co-ordination is needed to tackle the impact of digital change and other megatrends on jobs, employment and employment relations.
38.	Svagan, Anna J., et al. (author) Cellulose Nanofiber/Nanocrystal Reinforced Capsules : A Fast and Facile Approach Toward Assembly of Liquid-Core Capsules with High Mechanical Stability 2014 In: Biomacromolecules. - : American Chemical Society (ACS). - 1525-7797 .- 1526-4602. ; 15:5, s. 1852-1859 Journal article (peer-reviewed)abstract Liquid-core capsules of high mechanical stability open up for many solid state-like applications where functionality depending on liquid mobility is vital. Herein, a novel concept for fast and facile improvement of the mechanical properties of walls of liquid-core capsules is reported. By imitating nature's own way of enhancing the mechanical properties in liquid-core capsules, the parenchyma plant cells found in fruits and vegetables, a blend of short cellulose nanofibers (<1 mu m, NFC) and nanocrystals (CNC) was exploited in the creation of the capsule walls. The NFC/CNC blend was prepared from a new version of the classical wood pulp hydrolysis. The capsule shell consisted of a covalently (by aromatic diisocyanate) cross-linked NFC/CNC structure at the outer capsule wall and an inner layer dominated by aromatic polyurea. The mechanical properties revealed an effective capsule elastic modulus of 4.8 GPa at 17 wt % NFC/CNC loading, about six times higher compared to a neat aromatic polyurea capsule (0.79 GPa) and 3 orders of magnitude higher than previously reported capsules from regenerated cellulose (0.0074 GPa). The outstanding mechanical properties are ascribed to the dense nanofiber structure, present in the outer part of the capsule wall, that is formed by oriented NFC/CNC of high average aspect ratio (L/d similar to 70) and held together by both covalent (urethane bonds) and physical bonds (hydrogen bonds).
39.	Uhlén, Mathias, et al. (author) A human protein atlas for normal and cancer tissues based on antibody proteomics 2005 In: Molecular & Cellular Proteomics. - 1535-9476 .- 1535-9484. ; 4:12, s. 1920-1932 Journal article (peer-reviewed)abstract Antibody-based proteomics provides a powerful approach for the functional study of the human proteome involving the systematic generation of protein-specific affinity reagents. We used this strategy to construct a comprehensive, antibody-based protein atlas for expression and localization profiles in 48 normal human tissues and 20 different cancers. Here we report a new publicly available database containing, in the first version, similar to 400,000 high resolution images corresponding to more than 700 antibodies toward human proteins. Each image has been annotated by a certified pathologist to provide a knowledge base for functional studies and to allow queries about protein profiles in normal and disease tissues. Our results suggest it should be possible to extend this analysis to the majority of all human proteins thus providing a valuable tool for medical and biological research.
40.	Virta, J, et al. (author) Impact of metabolic substrate modification on myocardial efficiency in a rat model of obesity and diabetes 2022 In: European Heart Journal, Supplement. - : Oxford University Press (OUP). - 1520-765X .- 0195-668X .- 1522-9645. ; 43:2, s. 3076-3076 Conference paper (peer-reviewed)abstract BackgroundCongenic leptin receptor deficient rat generated by introgression of the Koletsky leptin receptor mutation into BioBreeding Diabetes Resistant rat (BBDR.lepr−/−) is a novel animal model combining obesity, systemic insulin resistance and diabetes. Systemic insulin resistance is associated with reduced myocardial glucose utilization, but its effect on myocardial external efficiency, i.e. the ability of the myocardium to convert energy into external stroke work, remains uncertain.PurposeTo characterize cardiac energy metabolism and function in BBDR.lepr−/− rats and to study the effect of dipeptidyl peptidase 4 (DPP-4) inhibitor linagliptin in this model.MethodsCardiac phenotype was evaluated in six-month-old male BBDR.lepr−/− rats (n=11) and age-matched male non-diabetic lean control littermates (BBDR.lepr+/− or BBDR.lepr+/+ rats, n=14). Of these, 7 BBDR.lepr−/− rats and 6 controls underwent cardiac ultrasound, 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT), and [11C]acetate PET in order to evaluate cardiac structure and function as well as glucose and oxidative metabolism. In the remaining rats, fatty acid metabolism was evaluated by [18F]fluorothia-6-heptadecanoic acid ([18F]FTHA) PET/CT. In the linagliptin intervention study, 25 BBDR.lepr−/− male rats were randomly divided into control group (n=11) that received regular chow diet and linagliptin group (n=14) that received linagliptin (10mg/kg/d) mixed in the chow diet for three months. After the intervention, the rats underwent cardiac ultrasound, [18F]FDG PET/CT, and [11C]acetate PET.ResultsCompared with controls, BBDR.lepr−/− rats showed increased left ventricle (LV) mass (∼40%, p>0.001) and higher systolic blood pressure (∼10%, p=0.02). However, fractional shortening and cardiac output were similar in both groups. Myocardial fractional uptake rate of glucose measured with [18F]FDG PET was significantly reduced (∼86%, p=0.004) (Fig. 1A, E), whereas myocardial fatty acid uptake measured by [18F]FTHA PET was not significantly increased (free fatty acid (FFA) corrected standardized uptake value (SUV) ∼21%, p=0.54) (Fig. 1B) in BBDR.lepr−/− compared to controls. Myocardial oxygen consumption assessed by [11C]acetate PET was similar in both groups (Fig. 1C, E), but LV work per gram of myocardium was reduced (∼28%, p=0.001) resulting in reduced myocardial external efficiency (∼21%, p=0.03) (Fig. 1D) in BBDR.lepr−/− compared to controls. Treatment with linagliptin significantly enhanced myocardial fractional uptake rate of glucose (∼166%, p=0.006) (Fig. 2A, C), but had no effect on efficiency of cardiac work (Fig. 2B).ConclusionsObese and diabetic BBDR.lepr−/− rats demonstrate LV hypertrophy and markedly reduced myocardial glucose utilization associated with impaired myocardial external efficiency despite normal LV systolic function. Enhancement of myocardial glucose uptake by linagliptin did not improve efficiency of cardiac work.Funding AcknowledgementType of funding sources: Public grant(s) – EU funding. Main funding source(s): IMI-SUMMIT
41.	Walsh, Sarah H, et al. (author) Telomere length and correlation with histopathogenesis in B-cell leukemias/lymphomas 2007 In: European Journal of Haematology. - : Wiley. - 0902-4441 .- 1600-0609. ; 78:4, s. 283-289 Journal article (peer-reviewed)abstract Telomere length was recently reported to correlate with cellular origin of B-cell malignancies in relation to the germinal center (GC). In this report, we measured telomere length by quantitative-PCR in 223 B-cell lymphomas/leukemias and correlated results with immunoglobulin (Ig) mutation status and immunostainings for GC/non-GC subtypes of diffuse large B-cell lymphoma (DLBCL). Shortest telomeres were found in Ig-unmutated chronic lymphocytic leukemia (CLL) [median telomere to single copy gene value (T/S) 0.33], differing significantly to Ig-mutated CLL (0.63). Contrary to this, mantle cell lymphomas (MCLs) exhibited similar telomere lengths regardless of Ig mutation status (0.47). Telomere length differed significantly between GC-like (0.73) and non-GC-like DLBCLs (0.43), and follicular lymphomas (FLs) had shorter telomeres (0.53) than GC-DLBCL. Hairy cell leukemias, which display Ig gene intraclonal heterogeneity, had longer telomeres (0.62) than FLs and non-GC-DLBCL, but shorter than GC-DLBCL. We conclude that although DLBCL and CLL subsets can be clearly distinguished, telomere length reflects many parameters and may not simply correlate with GC-related origin.
42.	Walsh, Sarah, et al. (author) Telomere length in mature B cell malignancies - correlation with cellular origin with respect to the germinal center Other publication (other academic/artistic)
43.	Wierzbicka, Aneta, et al. (author) A Methodology for Assessment of Combined Effects of Particles and Noise on Humans During Controlled Chamber Exposure 2010 In: IARA. ; , s. 1-3 Conference paper (other academic/artistic)
44.	Wierzbicka, Aneta, et al. (author) Health Effects of Combined Exposure to Diesel Particles and Traffic Noise - a Methodology for Controlled Chamber Study 2011 Conference paper (peer-reviewed)
45.	Zettergren, Anna, et al. (author) Exposure to environmental phthalates during preschool age and obesity from childhood to young adulthood 2021 In: Environmental Research. - : Elsevier BV. - 0013-9351 .- 1096-0953. ; 192 Journal article (peer-reviewed)abstract Obesity rates are increasing globally, and recent theories suggest that phthalates may contribute to obesity development. This longitudinal study aimed to investigate associations between environmental phthalate exposure during childhood and obesity, utilizing data from 100 participants from a Swedish birth cohort. The participants were followed repeatedly from birth and provided spot urine samples at 4 years. Weight and height were measured at ages 4, 8, 16 and 24 years, as well as additional anthropometric indices at 24 years. Urine samples were analysed for 10 phthalate metabolites using liquid chromatography tandem mass spectrometry. Generalized estimating equation models were performed to assess overall and age-specific associations between urinary phthalate concentrations and BMI groups; thin/normal weight vs overweight/obese. After adjustment for potential confounders, overall associations were observed for diisononyl phthalate (DiNP) metabolites mono(oxo-isononyl) phthalate (MOiNP) (OR per increase ng/ml: 1.18; 95% CI: 1.05, 1.33), mono(carboxy-isooctyl) phthalate (MCiOP) (OR: 1.06; 95% CI: 1.01, 1.11) and ∑DiNP (OR: 1.02; 95% CI:1.00, 1.04) and development of overweight/obesity up to age 24 years. Age-specific associations were observed for the same metabolites at 8, 16 and 24 years. Furthermore, linear regression analysis revealed associations between increased body fat % at age 24 years and MHiNP (β: 2.42; 95% CI: 0.44, 4.39), MOiNP (β: 2.32; 95% CI: 0.46, 4.18), MCiOP (β: 2.65; 95% CI: 0.41, 4.89) and ∑DiNP (β: 2.65; 95% CI: 0.52, 4.77). These findings suggest that DiNP exposure during preschool age may be associated with subsequent obesity, however these findings need to be corroborated by further research.
46.	Zettergren, Anna, et al. (author) Urinhalter av organiska miljöföroreningar hos unga vuxna : Resultat från födelsekohorten BAMSE 2020 Reports (other academic/artistic)abstract Allmänbefolkningen exponeras dagligen för en mängd miljöföroreningar via livsmedel, vardagsartiklar och i inomhusmiljöer. Dessa kan ha skadliga hälsoeffekter och det är därför viktigt att kontinuerligt utvärdera exponeringsnivåer av miljöföroreningar. Biomonitorering av befolkningen möjliggör en uppskattning av exponering via alla upptagsvägar och ger därför en samlad utvärdering av vilka mängder av miljöföroreningar vi utsätts för.I denna studie undersöktes biomarkörer i urin för ämnesgrupperna polyaromatiska kolväten (PAH), nikotin, organofosfatiska flamskyddsmedel, bekämpningsmedel, alkylfenoler, ftalater, DINCH och UVfilter hos 1000 unga vuxna (21 – 24 år) från födelsekohorten BAMSE.Vi fann att studiepopulationen hade en utbredd, men låg, exponering för samtliga ämnesgrupper.Detektionsfrekvenser över LOD låg mellan 12–100%. Högst nivåer, och mest utbredd exponering,uppmättes av kemikaliegruppen ftalater. Kvinnor hade generellt en högre exponering för miljöföroreningar än män, med undantag för ett fåtal ämnen.Urinnivåer av miljöföroreningar hos denna studiepopulation är jämförbara med resultat från liknande svenska populationer från de senaste åren. Jämfört med tidigare studier följer dessa resultat observerade trender, där urinnivåer av kemikalier som fasats ut de senaste åren sjunker, medan nivåer av nyintroducerade kemikalier ökar, vilket speglar de regleringar och introduktioner av ämnen som skett i Sverige och Europa.
47.	Zetterqvist, Anna, et al. (author) Inhibition of nuclear factor of activated T-cells (NFAT) suppresses accelerated atherosclerosis in diabetic mice. 2013 In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 8:6 Journal article (peer-reviewed)abstract Diabetic patients have a much more widespread and aggressive form of atherosclerosis and therefore, higher risk for myocardial infarction, peripheral vascular disease and stroke, but the molecular mechanisms leading to accelerated damage are still unclear. Recently, we showed that hyperglycemia activates the transcription factor NFAT in the arterial wall, inducing the expression of the pro-atherosclerotic protein osteopontin. Here we investigate whether NFAT activation may be a link between diabetes and atherogenesis.
48.	Abu Sabaa, Amal, et al. (author) T-cell Leukaemia/Lymphoma Protein 1A (TCL1A) In Diffuse Large B-cell lymphoma (DLBCL) Other publication (other academic/artistic)
49.	Ahnesjö, Ingrid, et al. (author) En beteende-ekologisk forskningsperiod på Klubbans biologiska station : Rapport från återträff med Doktorer som disputerade (1983-2001) på avhandlingar med fältarbete på Klubbans Biologiska station. I en värld av kantnålar, stubbar, spiggar och nudingar. 2018 Reports (pop. science, debate, etc.)abstract We had the fortune as PhD-students and scientists in Animal Ecology at Uppsala University, to spend joyful and creative field work summers at Klubban Biological Station, during the 1980-90’s. A reunion in June 2018 resulted in this report highlighting research on pipefishes, gobies, sticklebacks and nudibranchs. Our research on these animals have provided novel insights and knowledge of the process of sexual selection and paternal care. These animals have, in many aspects, now become model organisms in evolutionary behavioral ecology in marine environments. Our list of publications provides many examples of how environmental factors influence how sexual selection and mate choice operate, how predictors like potential reproductive rates, operational sex ratios work and how male parental care is prominent in influencing selection. This research, that started at Klubban, has broadened our understanding of the ecological importance of shallow marine areas. The evolutionary understanding of how males and females can behave and how adaptive traits are selected in interaction with social and an increasingly changing ambient environment is in focus in our continued scientific endeavors. We have happily compiled this report illustrating how science and scientist can stimulate each other at a wonderful place like Klubban Biological Station, with the access to amazing organisms like pipefishes, gobies, sticklebacks and nudibranchs.
50.	Al-Behadili, Ali, et al. (author) A two-nuclease pathway involving RNase H1 is required for primer removal at human mitochondrial OriL 2018 In: Nucleic acids research. - : Oxford University Press (OUP). - 0305-1048 .- 1362-4962. ; 46:18, s. 9471-9483 Journal article (peer-reviewed)abstract The role of Ribonuclease H1 (RNase H1) during primer removal and ligation at the mitochondrial origin of light-strand DNA synthesis (OriL) is a key, yet poorly understood, step in mitochondrial DNA maintenance. Here, we reconstitute the replication cycle of L-strand synthesis in vitro using recombinant mitochondrial proteins and model OriL substrates. The process begins with initiation of DNA replication at OriL and ends with primer removal and ligation. We find that RNase H1 partially removes the primer, leaving behind the last one to three ribonucleotides. These 5'-end ribonucleotides disturb ligation, a conclusion which is supported by analysis of RNase H1-deficient patient cells. A second nuclease is therefore required to remove the last ribonucleotides and we demonstrate that Flap endonuclease 1 (FEN1) can execute this function in vitro. Removal of RNA primers at OriL thus depends on a two-nuclease model, which in addition to RNase H1 requires FEN1 or a FEN1-like activity. These findings define the role of RNase H1 at OriL and help to explain the pathogenic consequences of disease causing mutations in RNase H1.

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