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1.	Berglund, Anders, et al. (author) Discipline-based staff development courses to promote a sustainable SOTL environment : An example from science and engineering at Uppsala University 2014 In: Proc. ICED 2014. - London, UK : International Consortium for Educational Development. ; , s. 392-392 Conference paper (peer-reviewed)abstract Discipline-based courses are a part of the strategic educational development at the Faculty of Science and Technology, Uppsala University, Sweden. A factor contributing to the success of these courses is that the instructors are colleagues, sharing competence and interest in the disciplinse. This, as well as a strong research foundation, establishes the relevance and legitimacy of the courses.
2.	Berglund, Helene, et al. (author) Care planning at home : a way to increase the influence of older people? 2014 Conference paper (peer-reviewed)
3.	Berglund, Helene, 1957, et al. (author) Care planning at home: a way to increase the influence of older people? 2012 In: International Journal of Integrated Care. - : Igitur, Utrecht Publishing & Archiving Services. - 1568-4156. ; 12:September Journal article (peer-reviewed)abstract Introduction: Care-planning meetings represent a common method of needs assessment and decision-making practices in elderly care. Older people's influence is an important and required aspect of these practices. This study's objective was to describe and analyse older people's influence on care-planning meetings at home and in hospital. Methods: Ten care-planning meetings were audio-recorded in the older people's homes and nine were recorded in hospital. The study is part of a project including a comprehensive continuum-of-care model. A qualitative content analysis was performed. Results: Care-planning meetings at home appeared to enable older people's involvement in the discussions. Fewer people participated in the meetings at home and there was less parallel talking. Unrelated to the place of the care-planning meeting, the older people were able to influence concerns relating to the amount of care/service and the choice of provider. However, they were not able to influence the way the help should be provided or organised. Conclusion: Planning care at home indicated an increase in involvement on the part of the older people, but this does not appear to be enough to obtain any real influence. Our findings call for attention to be paid to older people's opportunities to receive care and services according to their individual needs and their potential for influencing their day-to-day provision of care and service.
4.	Berglund, Helene, 1957, et al. (author) Older people's views of quality of care: a randomised controlled study of continuum of care 2013 In: Journal of Clinical Nursing. - : Wiley-Blackwell. - 0962-1067 .- 1365-2702. ; 22:19-20, s. 2934-2944 Journal article (peer-reviewed)abstract Aims and objectives To analyse frail older peoples views of quality of care when receiving a comprehensive continuum of care intervention, compared with those of people receiving the usual care (control group). The intervention included early geriatric assessment, case management, interprofessional collaboration, support for relatives and organising of care-planning meetings in older peoples own homes. less thanbrgreater than less thanbrgreater thanBackground Prior studies indicate that tailored/individualised care planning conducted by a case manager/coordinator often led to greater satisfaction with care planning among older people. However, there is no obvious evidence of any effects of continuum of care interventions on older peoples views of quality of care. less thanbrgreater than less thanbrgreater thanDesign Randomised controlled study. less thanbrgreater than less thanbrgreater thanMethods Items based on a validated questionnaire were used in face-to-face interviews to assess older peoples views of quality of care at three, six and 12months after baseline. less thanbrgreater than less thanbrgreater thanResults Older people receiving a comprehensive continuum of care intervention perceived higher quality of care on items about care planning (p0005), compared with those receiving the usual care. In addition, they had increased knowledge of whom to contact about care/service, after three and 12months (pandlt;003). less thanbrgreater than less thanbrgreater thanConclusions The study gives evidence of the advantages of a combination of components such as organising care-planning meetings in older peoples own homes, case management and interprofessional teamwork. less thanbrgreater than less thanbrgreater thanRelevance to clinical practice The results have implications for policymakers, managers and professionals in the area of health and social care for older people to meet individual needs of frail older people.
5.	Berglund, Helene, 1957, et al. (author) Organizing integrated care for older persons: Strategies in Sweden during the past decade 2015 In: Journal of Health Organisation & Management. - : Emerald Group Publishing Limited. - 1477-7266 .- 1758-7247. ; 29:1, s. 128-151 Journal article (peer-reviewed)abstract Purpose – The purpose of this paper is to describe and analyse ways of organizing integrated care for older persons in Sweden during the past decade. Design/methodology/approach – The data consist of 62 cases of development work, described in official reports. A meta-analysis of cases was performed, including content analysis of each case. A theoretical framework comprising different forms of integration (co-ordination, contracting, co-operation and collaboration) was applied. Findings – Co-operation was common and collaboration, including multiprofessional teamwork, was rare in the cases. Contracting can be questioned as being a form of integration, and the introduction of consumer choice models appeared problematic in inter-organization integration. Goals stated in the cases concerned steering and designing care, rather than outcome specifications for older persons. Explicit goals to improve integration in itself could imply that the organizations adapt to strong normative expectations in society. Trends over the decade comprised development of local health care systems, introduction of consumer choice models and contracting out. Research limitations/implications – Most cases were projects, but others comprised evaluations of regular organization of integrated care. These evaluations were often written normatively, but constituted the conditions for practice and were important study contributions. Practical implications – Guiding clinical practice to be aware of importance of setting follow-up goals.
6.	Berglund, Magnus, et al. (author) SAR studies of capsazepinoid bronchodilators 3: The thiourea part (coupling region) and the 2-(4-chlorophenyl)ethyl moiety (C-region). 2008 In: Bioorganic & Medicinal Chemistry. - : Elsevier BV. - 0968-0896. ; 16:5, s. 2529-2540 Journal article (peer-reviewed)abstract Certain derivatives and analogues of capsazepine are potent in vitro inhibitors of bronchoconstriction in human small airways. During an investigation of the dependency of the potency on the structural features of the capsazepinoids in the thiourea moiety (coupling region) and the 2-(4-chlorophenyl)ethyl moiety (C-region), it was revealed that capsazepinoids with a thiourea or an amide link between the B-ring and the C-region in general have a good bronchorelaxing activity, while urea is a less attractive choice. Further, it was shown that 1,2,3,4-tetrahydroisoquinolines with a 2-(phenyl)ethyl derivative as the C-region are considerably more potent than those with an octyl group, while 2,3,4,5-tetrahydro-1H-2-benzazepines were found to be more insensitive to the nature of the C-region.
7.	Berglund, Magnus, et al. (author) SAR studies of capsazepinoid bronchodilators. Part 2: Chlorination and catechol replacement in the A-ring. 2008 In: Bioorganic & Medicinal Chemistry. - : Elsevier BV. - 0968-0896. ; 16:5, s. 2513-2528 Journal article (peer-reviewed)abstract Capsazepine as well as its derivatives and analogues are general inhibitors of constriction of human small airways. From a systematic variation of the capsazepine structure, divided into four regions, SARs were established. This paper concerns the chlorination of the A-ring as well as the replacement of the catechol with bioisosteric groups. It is revealed that chlorination of the A-ring has a profound effect on activity. Moreover, di-chlorination of the 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline structure results in a 10-fold increase in potency compared to capsazepine.
8.	Berglund, Staffan (author) Att födas för liten 2011 In: BarnBladet. - 0349-1994. ; 36:4, s. 6-9 Journal article (other academic/artistic)
9.	Berglund, Staffan, et al. (author) Barns järnbehov och hur vi bäst kan skydda barnhjärnan 2014 In: Läkartidningen. - 0023-7205 .- 1652-7518. ; 111:11, s. 460-463 Journal article (peer-reviewed)
10.	Berglund, Staffan (author) Competing Everyday Discourses : The Construction of Heterosexual Risk-Taking Behaviour among Adolescents in Nicaragua 2008 Reports (other academic/artistic)
11.	Berglund, Staffan, et al. (author) Delaktighet och hälsa : med ungdomar och beslutsfattare i Simrishamn mot hållbara strategier för ökad egenmakt, livskvalitet och jämlikhet i hälsa 2011 Reports (peer-reviewed)abstract Trots att vi lever i ett välfärdssamhälle, där kunskap och resurser inte borde vara något problem, ser vi en bestående ojämlikhet i hälsa och en ökande psykosocial ohälsa bland ungdomar. Hur är detta möjligt och vad kan man göra åt det? Genom vilka sociala interventioner och andra insatser kan unga människors reella delaktighet, egenmakt, välfärd, livskvalitet och hälsa främjas på ett hållbart sätt? Denna rapport från en pilotstudie genomförd i Simrishamn presenterar de teoretiska och empiriska bevekelsegrunderna för hur och varför en deltagarbaserad aktionsforskningsansats skulle kunna vara ett bra sätt att arbeta för att förbättra villkoren för ungdomars hälsa. Rapporten förespråkar dels ett ökat tvärvetenskapligt och professionsöverskridande samarbete mellan forskare och beslutsfattare, dels ett nära samarbete med ungdomarna själva. Det handlar om att få till stånd ett mer jämlikt utbyte av kunskap målgrupper och makthavare emellan – och därmed förhoppningsvis ett i längden mer jämlikt inflytande över användningen av samhällets resurser.
12.	Berglund, Staffan, et al. (author) Delaktighet och hälsa : med ungdomar och beslutsfattare i Simrishamn mot hållbara strategier för ökad egenmakt, livskvalitet och jämlikhet i hälsa 2011 Book (pop. science, debate, etc.)abstract Trots att vi lever i ett välfärdssamhälle, där kunskap och resurser inte borde vara något problem, ser vi en bestående ojämlikhet i hälsa och en ökande psykosocial ohälsa bland ungdomar. Hur är detta möjligt och vad kan man göra åt det? Genom vilka sociala interventioner och andra insatser kan unga människors reella delaktighet, egenmakt, välfärd, livskvalitet och hälsa främjas på ett hållbart sätt? Denna rapport från en pilotstudie genomförd i Simrishamn presenterar de teoretiska och empiriska bevekelsegrunderna för hur och varför en deltagarbaserad aktionsforskningsansats skulle kunna vara ett bra sätt att arbeta för att förbättra villkoren för ungdomars hälsa. Rapporten förespråkar dels ett ökat tvärvetenskapligt och professionsöverskridande samarbete mellan forskare och beslutsfattare, dels ett nära samarbete med ungdomarna själva. Det handlar om att få till stånd ett mer jämlikt utbyte av kunskap målgrupper och makthavare emellan – och därmed förhoppningsvis ett i längden mer jämlikt inflytande över användningen av samhällets resurser.
13.	Berglund, Staffan, et al. (author) Delaktighet och hälsa: med ungdomar och beslutsfattare mot hållbara strategier för ökad egenmakt, livskvalitet och jämlikhet i hälsa : Delrapport 1: Utgångspunkter för en deltagarbaserad aktionsforskningsansats 2011 Reports (other academic/artistic)abstract Trots att vi lever i ett välfärdssamhälle, där kunskap och resurser inte borde vara något problem, ser vi en bestående ojämlikhet i hälsa och en ökande psykosocial ohälsa bland ungdomar. Hur är detta möjligt och vad kan man göra åt det? Genom vilka sociala interventioner och andra insatser kan unga människors reella delaktighet, egenmakt, välfärd, livskvalitet och hälsa främjas på ett hållbart sätt? Denna rapport från en pilotstudie genomförd i Simrishamn presenterar de teoretiska och empiriska bevekelsegrunderna för hur och varför en deltagarbaserad aktionsforskningsansats skulle kunna vara ett bra sätt att arbeta för att förbättra villkoren för ungdomars hälsa. Rapporten förespråkar dels ett ökat tvärvetenskapligt och professionsöverskridande samarbete mellan forskare och beslutsfattare, dels ett nära samarbete med ungdomarna själva. Det handlar om att få till stånd ett mer jämlikt utbyte av kunskap målgrupper och makthavare emellan – och därmed förhoppningsvis ett i längden mer jämlikt inflytande över användningen av samhällets resurser.
14.	Berglund, Staffan, 1975-, et al. (author) Effects of iron supplementation of LBW infants on cognition and behavior at 3 years 2013 In: Pediatrics. - : American Academy of Pediatrics (AAP). - 0031-4005 .- 1098-4275. ; 131, s. 47-55 Journal article (peer-reviewed)abstract OBJECTIVE: Low birth weight (LBW) infants are at increased risk of cognitive and behavioral problems and at risk for iron deficiency, which is associated with impaired neurodevelopment. We hypothesized that iron supplementation of LBW infants would improve cognitive scores and reduce behavioral problems. METHODS: In a randomized controlled trial, 285 marginally LBW (2000-2500 g) infants received 0, 1, or 2 mg/kg/day of iron supplements from 6 weeks to 6 months of age. At 3.5 years of age, these infants and 95 normal birth weight controls were assessed with a psychometric test (Wechsler Preschool and Primary Scale of Intelligence) and a questionnaire of behavioral problems (Child Behavior Checklist; CBCL). RESULTS: There were no significant differences in IQ between the LBW groups or LBW infants versus controls. Mean (SD) full-scale IQ was 105.2 (14.5), 104.2 (14.7), and 104.5 (12.7) in the placebo, 1 mg, and 2 mg groups, respectively (P = .924). However, for behavioral problems, there was a significant effect of intervention. The prevalence of children with CBCL scores above the US subclinical cutoff was 12.7%, 2.9%, and 2.7% in the placebo, 1-mg, and 2-mg groups, respectively (P = .027), compared with 3.2% in controls. Relative risk (95% confidence interval) for CBCL score above cutoff in placebo-treated children versus supplemented was 4.5 (1.4-14.2). CONCLUSIONS: Early iron supplementation of marginally LBW infants does not affect cognitive functions at 3.5 years of age but significantly reduces the prevalence of behavioral problems. The study suggests a causal relation between infant iron deficiency and later behavioral problems.
15.	Berglund, Staffan, 1975-, et al. (author) Effects of iron supplementation on auditory brainstem response in marginally LBW infants 2011 In: Pediatric Research. - Baltimore : International Pediatrics Research Foundation, Inc. - 0031-3998 .- 1530-0447. ; 70:6, s. 601-606 Journal article (peer-reviewed)abstract LBW infants are at risk of iron deficiency (ID), which is associated with impaired nervous system development and may lead to prolonged auditory brainstem response (ABR) latencies. We hypothesized that iron supplementation shortens ABR latencies in marginally LBW (MLBW, 2000-2500 g) infants. In a randomized, controlled trial, 285 healthy MLBW infants received 0, 1, or 2 mg iron/kg/d of iron supplements from 6 wk to 6 mo of age. ABR absolute wave V latencies and central conduction time (CCT) were measured at the endpoint. There were no significant differences between groups in ABR wave V latencies (n = 218). Furthermore, there were no significantly prolonged ABR latencies in infants with ID (n = 32). CCT was significantly higher in the 2 mg group than in the placebo group (n = 126). However, there were no significant correlations between CCT and iron intake or any iron status variable, suggesting that differences in CCT were not caused by iron. We conclude that iron supplements did not improve ABR latencies, and iron-deficient MLBW infants did not have impaired ABR latencies at 6 mo, suggesting that ABR is not a sensitive measure of impaired neurological development or that mild/moderate ID causes no such impairment in MLBW infants.
16.	Berglund, Staffan, 1975- (author) Effects of iron supplementation on iron status, health and neurological development in marginally low birth weight infants. 2012 Doctoral thesis (other academic/artistic)abstract Background Due to small iron stores and rapid growth during the first months of life, infants with low birth weight (LBW) are at risk of iron deficiency (ID). ID in infancy is associated with irreversible impaired neurodevelopment. Preventive iron supplementation may reduce the risk of ID and benefit neurodevelopment, but there is also a possible risk of adverse effects. More than 50% of all LBW infants are born with marginally LBW (MLBW, 2000-2500g), and it is not known if they benefit from iron supplementation. Methods We randomized 285 healthy, Swedish, MLBW infants to receive 3 different doses of oral iron supplements; 0 (Placebo), 1, and 2 mg/kg/day from six weeks to six months of age. Iron status, during and after the intervention was assessed and so was the prevalence of ID and ID anemia (IDA), growth, morbidity and the interplay with iron and the erythropoetic hormones hepcidin and erythropoietin (EPO). As a proxy for conduction speed in the developing brain, auditory brainstem response (ABR) was analyzed at six months. In a follow up at 3.5 years of age, the children were assessed with a cognitive test (WPPSI-III) and a validated parental checklist of behavioral problems (CBCL), and compared to a matched reference group of 95 children born with normal birth weight. Results At six months of age, the prevalence of ID and IDA was significantly higher in the placebo group compared to the iron supplemented infants. 36% had ID in the placebo group, compared to 8% and 4 % in the 1 and 2mg/kg/day-groups, respectively. The prevalence of IDA was 10%, 3% and 0%, respectively. ABR-latencies did not correlate with the iron intake and was not increased in infants with ID or IDA. ABR wave V latencies were similar in all three groups. Hepcidin correlated to ferritin and increased in supplemented infants while EPO, which was negatively correlated to iron status indicators, decreased. At follow up there were no differences in cognitive scores between the groups but the prevalence of behavioral problems was significantly higher in the placebo group compared to those supplemented and to controls. The relative risk increase of CBCL-scores above a validated cutoff was 4.5 (1.4 – 14.2) in the placebo-group compared to supplemented children. There was no detected difference in growth or morbidity at any age. Conclusion MLBW infants are at risk of ID in infancy and behavioral problems at 3 years of age. Iron supplementation at a dose of 1-2 mg/kg/day from six weeks to six months of age reduces the risks with no adverse effects, suggesting both short and long term benefit. MLBW infants should be included in general iron supplementation programs during their first six months of life.
17.	Berglund, Staffan, 1975-, et al. (author) Effects of iron supplementation on serum hepcidin and serum erythropoietin in low-birth-weight infants 2011 In: American Journal of Clinical Nutrition. - : American Society for Nutrition. - 0002-9165 .- 1938-3207. ; 94:6, s. 1553-1561 Journal article (peer-reviewed)abstract BACKGROUND: The iron-regulatory hormone hepcidin has not been studied in infants, who experience large physiologic changes in iron status. OBJECTIVE: The objective was to study hepcidin and erythropoietin and their correlation with iron status in iron-replete and iron-deficient low-birth-weight (LBW) infants-a group at particular risk of iron deficiency (ID). DESIGN: We randomly assigned 285 otherwise healthy LBW infants to receive, from 6 wk to 6 mo of age, 3 doses of iron supplements: 0 (placebo), 1, or 2 mg/kg daily. Hepcidin, erythropoietin, hemoglobin, and variables of iron status were analyzed. RESULTS: Serum hepcidin did not change over time in the placebo group, despite a rapid decrease in serum ferritin. In iron-supplemented infants, hepcidin increased significantly, reaching a mean (±SD) concentration of 19.2 ± 2.5 ng/mL in the 2-mg/kg group compared with 13.0 ± 2.6 ng/mL in the placebo group at age 6 mo (P < 0.001). The difference was even larger between iron-deficient and iron-replete infants. Hepcidin was independently positively correlated with ferritin at all ages and was negatively correlated with the transferrin receptor concentration at age 6 wk and with transferrin at age 6 mo. Erythropoietin was initially similar between groups but decreased significantly in iron-supplemented infants. In addition to being negatively correlated with hemoglobin, it was also independently negatively correlated with indicators of iron status. CONCLUSIONS: Hepcidin is closely associated with iron status and may be a useful indicator of iron stores and ID in infants. Erythropoietin is negatively correlated with iron status, which suggests a feedback mechanism that needs further study. This trial is registered at clinicaltrials.gov as NCT00558454.
18.	Berglund, Staffan, 1975-, et al. (author) Iron supplements reduce the risk of iron deficiency anemia in marginally low birth weight infants 2010 In: Pediatrics. - : American Academy of Pediatrics. - 0031-4005 .- 1098-4275. ; 126:4, s. e874-e883 Journal article (peer-reviewed)abstract OBJECTIVE: Low birth weight infants are at risk for iron deficiency (ID). Most LBW infants have marginally low birth weight (MLBW, 2000–2500 g) and it is not known whether they benefit from iron supplements. The objective of this trial was to study the effects of iron supplementation in MLBW infants. METHOD: In a randomized controlled trial, we assigned 285 healthy, MLBW infants to receive iron supplements at a dose of 0 (placebo), 1, or 2 mg/kg per day between 6 weeks and 6 months of age. Hemoglobin levels, ferritin levels, transferrin saturation, mean cell volume, and transferrin receptor levels were analyzed at 6 months. Growth and morbidity were monitored. RESULTS: Iron supplementation resulted in significant dose-dependent effects on hemoglobin and all iron status indicators at 6 months. The prevalence of ID at 6 months was 36% in the placebo group, 8.2% in the 1 mg/kg per day group, and 3.8% in the 2 mg/kg per day group (P < .001). The prevalence rates of ID anemia (IDA) were 9.9%, 2.7%, and 0%, respectively (P = .004). Among infants who were exclusively breastfed at 6 weeks, the prevalence of IDA was 18% in the placebo group. There were no significant differences between groups in growth or morbidity. CONCLUSIONS: MLBW infants have relatively high risks of ID and IDA, especially if they are breastfed. Iron supplementation at 2 mg/kg per day from 6 weeks to 6 months reduces this risk effectively, with no short-term adverse effects on morbidity or growth.
19.	Berglund, Staffan (author) Järnbrist - ett problem bland svenska barn? 2012 In: Barnläkaren. - Stockholm : Svenska barnläkarföreningen. - 1651-0534. ; :5, s. 13-14 Journal article (other academic/artistic)
20.	Berglund, Staffan K., et al. (author) Effects of iron supplementation of low-birth-weight infants on cognition and behavior at 7 years : a randomized controlled trial 2018 In: Pediatric Research. - New York : Nature Publishing Group. - 0031-3998 .- 1530-0447. ; 83, s. 111-118 Journal article (peer-reviewed)abstract Background Low-birth-weight infants (LBW) are at an increased risk of iron deficiency that has been associated with impaired neurodevelopment. We hypothesized that iron supplementation of LBW infants improves cognitive scores and reduces behavioral problems until school age.Methods We randomized 285 marginally LBW (2,000-2,500 g) infants to receive 0, 1, or 2 mg/kg/day of iron supplements from 6 weeks to 6 months of age. At 7 years of age, 205 participants were assessed regarding cognition using Wechsler Intelligence Scale for Children (WISC-IV) and behavior using the parental questionnaires Child Behavior Checklist (CBCL) and Five to Fifteen (FTF).Results There were no significant differences between the intervention groups in WISC-IV or FTF. However, the CBCL scores for externalizing problems were significantly different, in favor of supplemented children (P=0.045). When combining the supplemented groups, they had significantly lower scores for externalizing behavior compared with placebo (median (interquartile range): 44 [34;51] vs. 48.5 [41;56] P=0.013), and their risk ratio (95% confidence interval) for a total behavioral score above the cutoff for clinical problems was 0.31 (0.09-1.0), P=0.054.Conclusion Lower scores of externalizing behavior in supplemented children support our previous findings at 3 years, and suggest that iron supplementation may have long-lasting effects on behavioral functions.
21.	Berglund, Staffan K, et al. (author) Effects of iron supplements and perinatal factors on fetal hemoglobin disappearance in LBW infants 2014 In: Pediatric Research. - : Nature Publishing Group. - 0031-3998 .- 1530-0447. ; 76:5, s. 477-482 Journal article (peer-reviewed)abstract BACKGROUND:The homeostatic mechanisms of iron metabolism and erythropoiesis in infants are unclear. Infants synthesize both fetal hemoglobin (HbF) and adult hemoglobin (HbA), and it is not known how the hemoglobin switch is regulated. We hypothesized that iron supplements to infants affect the disappearance of HbF. METHODS: We randomized 285 low-birth-weight infants (2,000-2,500g) into three intervention groups receiving 0, 1, or 2 mg/kg/d of iron supplements from 6 wk to 6 mo of age. In the present secondary analysis, we analyzed iron status, total hemoglobin (Hb), and HbF fraction at 6 wk, 12 wk, and at 6 mo and calculated absolute levels of HbF. RESULTS: We observed dose-dependent increased levels of Hb in iron-supplemented groups at 6 mo of age. However, for absolute HbF concentration, there was no similar effect of intervention. Mean (SD) HbF was 81.2 (16.8), 37.0 (13.8), and 8.1 (5.6) g/l at 6 wk, 12 wk, and 6 mo, respectively, similar in all groups. In linear regression analyses, postconceptional age turned out as the major predictor of HbF, independent of gestational age at birth. CONCLUSION: Our hypothesis was rejected. Instead, we confirmed a close correlation to postconceptional age, supporting a genetically programmed switch, insensitive to most environmental factors including birth.
22.	Berglund, Staffan K., et al. (author) Hepcidin is a relevant iron status indicator in infancy : results from a randomized trial of early vs. delayed cord clamping 2021 In: Pediatric Research. - : Nature Publishing Group. - 0031-3998 .- 1530-0447. ; 89:5, s. 1216-1221 Journal article (peer-reviewed)abstract Background: We aimed to evaluate whether serum hepcidin is a useful indicator of iron status in infants.Methods: Term infants (n = 400) were randomized to delayed (≥180 s) or early (≤10 s) cord clamping (CC). Iron status was assessed at 4 and 12 months. In all cases with iron depletion or iron deficiency (ID) (as defined in “Methods”) (n = 30) and 97 randomly selected iron-replete infants, we analyzed hepcidin and explored its correlation to the intervention, iron status, and perinatal factors.Results: Serum hepcidin concentrations were significantly lower in the early CC group at both time points and in ID infants at 4 months. Median (2.5th–97.5th percentile) hepcidin in non-ID infants in the delayed CC group (suggested reference) was 64.5 (10.9–142.1), 39.5 (3.5–157.7), and 32.9 (11.2–124.2) ng/mL in the cord blood and at 4 and 12 months, respectively. The value of 16 ng/mL was a threshold detecting all cases of iron depletion/ID at 4 months. No similar threshold for ID was observed at 12 months. The strongest predictor of hepcidin at both ages was ferritin.Conclusions: Hepcidin is relevant as iron status indicator in early infancy and may be useful to detect ID. Levels <16 ng/mL at 4 months of age indicates ID.ImpactSerum hepcidin is a relevant indicator of iron status in early infancy.Normal reference in healthy infants is suggested in this study.Serum hepcidin may be useful in clinical practice to detect iron deficiency.
23.	Berglund, Staffan K., et al. (author) Iron deficiency in infancy : current insights 2021 In: Current opinion in clinical nutrition and metabolic care. - : Wolters Kluwer. - 1363-1950 .- 1473-6519. ; 24:3, s. 240-245 Research review (peer-reviewed)abstract PURPOSE OF REVIEW: Iron deficiency is the most common micronutrient deficiency and infants are at particular risk. The purpose of this review is to summarize recent studies that explored the metabolism of iron in infants as well as the risks and benefits of iron supplementation in different populations.RECENT FINDINGS: The ability of infants to regulate iron homeostasis is not fully known but most likely different from adults. Reducing iron deficiency has beneficial effects on neurodevelopment but iron overload may have adverse functional effects including diarrhea and even poor neurodevelopment. Recent studies have confirmed benefits of delayed cord clamping and supplementation of infants in risk groups while iron supplementation to pregnant women has shown limited effect in the offspring with regard to iron status and neurodevelopment. Further support is given to the recommendation that exclusive breast feeding, without supplementation, is safe for normal birth weight infants until 6 months whereafter an iron-rich diet should be given.SUMMARY: Iron deficiency negatively impacts global health but efforts to identify optimal interventions are progressing. Yet, questions remain, particularly regarding long-term risks, benefits and optimal interventions for low birth weight infants as well as the level of iron fortification in infant formula.
24.	Berglund, Staffan K, et al. (author) Iron Supplementation Until 6 Months Protects Marginally Low-Birth-Weight Infants From Iron Deficiency During Their First Year of Life 2015 In: Journal of Pediatric Gastroenterology and Nutrition - JPGN. - : Lippincott Williams & Wilkins. - 0277-2116 .- 1536-4801. ; 60:3, s. 390-395 Journal article (peer-reviewed)abstract Objectives: Low-birth-weight (LBW) infants (<2500 g) have an increased risk of iron deficiency (ID) during their first 6 months of life. The optimal dose and duration of iron supplementation to LBW infants are, however, unknown. The objective of the present study was to investigate the long-term effect on iron status and growth in marginally LBW (2000-2500 g) infants, of iron supplements given until 6 months of life. Methods: In a randomized controlled trial, 285 healthy marginally LBW infants received 0, 1, or 2 mg . kg(-1).day(-1) of iron supplements from 6 weeks to 6 months of age: At 12 months and 3.5 years of life we measured length, weight, head circumference, and indicators of iron status (hemoglobin, ferritin, mean corpuscular volume, and transferrin saturation) and assessed the prevalence of iron depletion, functional ID, and ID anemia. Results: At 12 months of age, there was a significant difference in ferritin between the groups (P = 0.00 6). Furthermore, there was a significant difference in the prevalence of iron depletion (23.7%, 10.6%, and 6.8%, respectively, in the placebo, 1-mg, and 2-mg groups, P = 0.009) and similar nonsignificant trends for functional ID and ID anemia. At 3.5 years of life there were no significant differences in iron status and the mean prevalence of iron depletion was 3.2%. Anthropometric data were not affected by the intervention. Conclusions: Iron supplements with 2 mg . kg(-1) . day(-1) until 6 months of life effectively reduces the risk of ID during the first 12 months of life and is an effective intervention for preventing early ID in marginally LBW infants.
25.	Berglund, Staffan K. (author) Järntillskott bör ges till alla nyfödda med marginellt låg födelsevikt 2012 In: Läkartidningen. - : Sveriges läkarförbund. - 0023-7205 .- 1652-7518. ; 109:17-18, s. 872-872 Journal article (other academic/artistic)
26.	Berglund, Staffan K., et al. (author) Marginally low birth weight increases the risk of underweight and short stature at three and a half years of age 2016 In: Acta Paediatrica. - : John Wiley & Sons. - 0803-5253 .- 1651-2227. ; 105:6, s. 610-617 Journal article (peer-reviewed)abstract AIM: Little is known about the long-term health of marginally low birth weight (LBW) children. This study characterised growth among infants weighing 2,000g-2,500g and explored the prevalence and predictors of sustained growth restriction.METHOD: This prospective observational trial followed the weight and height of 281 Swedish marginally LBW children from birth to 3.5 years of age. Children with a standard deviation score (SDS) for body mass index or height below -2 were considered underweight and short respectively.RESULTS: The mean SDS for weight and height showed a rapid increase before 12-19 weeks of age. The most rapid weight gain was in infants born small for gestational age. However, at 3.5 years of age, 9.5% of the children remained underweight and 6.5% had short stature. Regression models showed that slow weight gain before 19 weeks of age was the strongest predictor for lasting underweight, while slow height gain before 19 weeks of age and male sex were associated with short stature.CONCLUSION: Marginally LBW infants were more likely to be underweight and have a short stature at 3.5 years of age and the absence of catch-up growth during the first five months after birth identified those at highest risk.
27.	Berglund, Staffan K., et al. (author) Maternal, fetal and perinatal alterations associated with obesity, overweight and gestational diabetes : an observational cohort study (PREOBE) 2016 In: BMC Public Health. - : Springer Science and Business Media LLC. - 1471-2458. ; 16 Journal article (peer-reviewed)abstract Background: Maternal overweight, obesity, and gestational diabetes (GD) have been negatively associated with offspring development. Further knowledge regarding metabolic and nutritional alterations in these mother and their offspring are warranted.Methods: In an observational cohort study we included 331 pregnant women from Granada, Spain. The mothers were categorized into four groups according to BMI and their GD status; overweight (n:56), obese (n:64), GD (n:79), and healthy normal weight controls (n:132). We assessed maternal growth and nutritional biomarkers at 24 weeks (n = 269), 34 weeks (n = 310) and at delivery (n = 310) and the perinatal characteristics including cord blood biomarkers.Results: Obese and GD mothers had significantly lower weight gain during pregnancy and infant birth weight, waist circumference, and placental weight were higher in the obese group, including a significantly increased prevalence of macrosomia. Except for differences in markers of glucose metabolism (glucose, HbA1c, insulin and uric acid) we found at some measures that overweight and/or obese mothers had lower levels of transferrin saturation, hemoglobin, Vitamin B12 and folate and higher levels of C-reactive protein, erythrocyte sedimentation rate, ferritin, and cortisol. GD mothers had similar differences in hemoglobin and C-reactive protein but higher levels of folate. The latter was seen also in cord blood.Conclusions: We identified several metabolic alterations in overweight, obese and GD mothers compared to controls. Together with the observed differences in infant anthropometrics, these may be important biomarkers in future research regarding the programming of health and disease in children.
28.	Berglund, Staffan K., et al. (author) The impacts of maternal iron deficiency and being overweight during pregnancy on neurodevelopment of the offspring 2017 In: British Journal of Nutrition. - : Cambridge University Press. - 0007-1145 .- 1475-2662. ; 118:7, s. 533-540 Journal article (peer-reviewed)abstract Both maternal Fe deficiency (ID) and being overweight or obese (Ow/Ob, BMI >= 25 kg/m(2)) may negatively affect offspring brain development. However, the two risk factors correlate and their independent effects on infant neurodevelopment are unclear. PREOBE is a prospective observational study that included 331 pregnant Spanish women, of whom 166 had pre-gestational Ow/Ob. Fe status was analysed at 34 weeks and at delivery, and babies were assessed using Bayley III scales of neurodevelopment at 18 months. In confounder-adjusted analyses, maternal ID at 34 weeks was associated with lower composite motor scores at 18 months (mean 113.3 (SD 9.9) v. 117.1 (SD 9.2), P=0.039). Further, the offspring of mothers with ID at delivery had lower cognitive scores (114.0 (SD 9.7) v. 121.5 (SD 10.9), P = 0.039) and lower receptive, expressive and composite (99.5 (SD 8.6) v. 107.6 (SD 8.3), P= 0.004) language scores. The negative associations between maternal ID at delivery and Bayley scores remained even when adjusting for maternal Ow/Ob and gestational diabetes. Similarly, maternal Ow/Ob correlated with lower gross motor scores in the offspring (12.3 (SD 2.0) v. 13.0 (SD 2.1), P = 0.037), a correlation that remained when adjusting for maternal ID. In conclusion, maternal ID and pre-gestational Ow/Ob are both negatively associated with Bayley scores at 18 months, but independently and on different subscales. These results should be taken into account when considering Fe supplementation for pregnant women.
29.	Berglund, Staffan, et al. (author) Meeting iron needs for infants and children 2014 In: Current opinion in clinical nutrition and metabolic care. - 1363-1950 .- 1473-6519. ; 17:3, s. 267-272 Research review (peer-reviewed)abstract Purpose of reviewIron deficiency early in life is associated with impaired neurological development. This study reviews the latest research on how to best meet iron requirements in infants and children.Recent findingsThere is concurrent evidence that delayed cord clamping is well tolerated and improves infant iron stores. Iron supplements or enriched complementary foods starting before 6 months of life do not reduce iron deficiency prevalence in low-risk populations. However, for low birth weight infants, iron supplements before 6 months of life have long-term benefits. Iron deficiency anaemia (IDA) during the second half year of life is rare in countries with high compliance to iron-rich complementary foods, but remains a major problem globally. In high-risk populations, iron supplementation reduces IDA and possibly improves growth. However, increased risk of infections is a concern and optimal preventive strategies have not yet been determined. Finally, there is concurrent evidence that iron supplementation of anaemic school-aged children reduces IDA and possibly improves neuropsychological outcomes.SummaryInterventions for prevention of iron deficiency should be prioritized in risk groups. However, the unclear long-term benefits and possible risk of adverse effects, particularly increased infections in developing countries, prompt further large-scale, double-blinded trials.
30.	Berglund, Staffan, 1949- (author) Resisting poverty : perspectives on participation and social development. The case of CRIC and the eastern rural region of Cauca in Colombia 1982 Doctoral thesis (other academic/artistic)abstract With the reproduction of severe deprivation among the campesinado in Latin America as a starting-point,the report explores the mechanisms of impoverishment in the eastern rural region of the department of Cauca in Colombia and the forms of resistance initiated by the Regional Indigenous Council of Cauca (CRIC). It is postulated that the continued existence of poverty derives its root-causes not from lacking integration of the traditional sector of the national economy into the modern sector, but from the processes through which the poor indigenous staple-food producer and agricultural worker by way of his actual participation within the capitalistic system is continously deprived of his energy and capacity by the power elite as he himself lacks the means to realize his own developmental power* Sham-participation, refering to the dysfunctionality of systemic participation performed by the poor who lack access to the bases for accumulating social power, is a concept applied to understand these mechanisms. Participation per se does not necessarily correspond to influence and power. Rather, systemic political participation can give legitimacy to the very system and to those structural conditions oppressing the indigenous small-holders and workers and consequently contributes to the consolidation of the transfer-process of power and thereby the reproduction of deprivation. Thus the poor indigenous population in Cauca cannot expect to be given access to the fundaments of social power. Thus the elements of real participation and the conditions for resisting deprivation are less likely to be obtained only through the creation of new institutions and channels for popular participation# In the case of the indigenous movement in Colombia, the problem is rather to revoke the repression of the indigenous organizations which have emerged from below and instead promote their spontaneous mobilization.
31.	Björkman, Mats, et al. (author) Slutrapport I forskningsprojektet: Utveckling av produktiva monteringssystem 2001 Reports (other academic/artistic)
32.	Björmsjö, Maria, 1978- (author) Clinical effects of reduced iron content and fortification with bovine lactoferrin in infant formula 2023 Doctoral thesis (other academic/artistic)abstract Background: Breast milk, with its complex, individual and over time adapting composition, is considered the optimal source of nutrition for infants during the first months of life. Two possible contributing factors to the benefits of breastfeeding compared to infant formula-feeding are the differences in iron and lactoferrin (Lf) concentrations between breast milk and infant formula. The overall purpose of the LIME (a Swedish acronym) study was to add knowledge on how to reduce the gap in health and development between breastfed and formula-fed infants. The aim of this double-blinded controlled trial, and doctoral thesis, was to investigate how added bovine lactoferrin and reduced iron concentration in infant formula affect health and development.Methods: Recruitment took place from June 2014 to June 2018. With equal gender distribution, healthy term Swedish formula-fed infants (n=180) were randomly assigned, from 6 weeks to 6 months of age, to receive a low iron formula (2 mg/L) with bovine Lf (1.0 g/L) (Lf+, n=72), a low iron formula without Lf (Lf-, n=72) or a control standard formula with 8 mg/L iron and no Lf (CF, n=36). Additionally, 72 breastfed infants were recruited as a reference (BF) group. Blood samples were drawn at 4, 6, and 12 months. Primary outcomes were cytokine levels and iron status. Secondary outcomes were growth, gastrointestinal symptoms, infection-related morbidity and treatments, antibody response to vaccines and cognitive development.Findings: All explored outcomes were unaffected by Lf fortification and the two low iron groups (Lf+ and Lf-) were combined and compared to the CF group. At 6 months of age the TGF-β2 levels were lower among the low iron groups and more similar to the BF infants. No other significant differences in cytokine levels were observed. There was a trend of lower geometric mean of ferritin at 4, 6, and 12 months for the combined low iron groups compared to the CF group (67.7 vs 88.7, 39.5 vs 50.9, and 20.5 vs 25.1 μg/L, respectively, p=0.054, p=0.056, and p=0.082). No similar trends or significant differences were found for any of the other iron status indicators, except for hepcidin at 12 months with lower levels in the low iron group compared to CF (37.8 vs 49.4 ng/mL, p=0.027). Overall, infants fed low iron formula had iron status indicators closer to the breastfed reference group and the prevalence of iron deficiency (ID) and iron deficiency anemia (IDA) was generally low with no significant differences among the intervention groups.There were no clinically relevant effects of the interventions on growth, gastrointestinal symptoms, infection-related morbidity, vaccine antibody response or neurocognitive development.In secondary analyses, the present study confirmed previous results of higher cognitive scores among breastfed infants compared to formula-fed and observed an unexpected lower IgG response to vaccines against Hib and Diphtheria.Conclusion: Adding bovine lactoferrin did not affect any of the clinical outcomes explored. Lowering infant formula iron concentration from 8 to 2 mg/L minimally reduced iron stores to levels closer to breastfed infants but did not increase the risk of ID/IDA during the first year of life. Consequently, 2 mg/L is a sufficient level of iron fortification during the first six months of life in a population with low risk of ID. Both adjustments are considered safe with no observed adverse effects.
33.	Björmsjö, Maria, et al. (author) Immunological Effects of Adding Bovine Lactoferrin and Reducing Iron in Infant Formula : A Randomized Controlled Trial 2022 In: Journal of Pediatric Gastroenterology and Nutrition - JPGN. - : Wolters Kluwer. - 0277-2116 .- 1536-4801. ; 74:3, s. e65-e72 Journal article (peer-reviewed)abstract OBJECTIVES: Compared to formula-fed infants, breastfed infants have a lower risk of infections. Two possible reasons for this are the presence of the anti-infective and anti-inflammatory protein lactoferrin and the lower level of iron in breast milk. We explored how adding bovine lactoferrin and reducing the iron concentration in infant formula affect immunology and risk of infections in healthy infants.METHODS: In a double-blind controlled trial, term formula-fed (FF) Swedish infants (n = 180) were randomized to receive, from 6 weeks to 6 months of age, a low-iron formula (2 mg/L) with added bovine lactoferrin (1.0 g/L) (Lf+; n = 72); low-iron formula with no added lactoferrin (Lf-; n = 72); and standard formula at 8 mg/L iron and no added lactoferrin (control formula [CF]; n = 36). Cytokines, infections, and infection related treatments were assessed until 12 months of age.RESULTS: No adverse effects were observed. There were no apparent effects on transforming growth factor beta (TGF-β)1, TGF-β2, tumor necrosis factor alfa (TNF-α) or interleukin2 (IL-2) at 4, 6, or 12 months, except of higher TGF-β2 at 6 months in the CF group in comparison to the low iron groups combined (P = 0.033). No significant differences in otitis, respiratory infections, gastroenteritis, or other monitored infections and treatments were detected for any of the study feeding groups during the first 6 months and only a few and diverging effects were observed between 6 and 12 months.CONCLUSIONS: Adding bovine lactoferrin and reducing iron from 8 to 2 mg/L in infant formula was safe. No clinically relevant effects on cytokines or infection related morbidity were observed in this well-nourished and healthy population.
34.	Björmsjö, Maria, et al. (author) Reducing infant formula iron fortification to 2 mg/L does not increase the risk of iron deficiency or impact neurocognitive development at 12 months : a randomized controlled trial Other publication (other academic/artistic)
35.	Björmsjö, Maria, et al. (author) Reducing Iron Content in Infant Formula from 8 to 2 mg/L Does Not Increase the Risk of Iron Deficiency at 4 or 6 Months of Age : A Randomized Controlled Trial 2021 In: Nutrients. - : MDPI. - 2072-6643. ; 13:1 Journal article (peer-reviewed)abstract Many infant formulas are fortified with iron at 8-14 mg/L whereas breast milk contains about 0.3 mg/L. Another major difference between breast milk and infant formula is its high concentration of lactoferrin, a bioactive iron-binding protein. The aim of the present study was to investigate how reducing the iron content and adding bovine lactoferrin to infant formula affects iron status, health and development. Swedish healthy full-term formula-fed infants (n = 180) were randomized in a double-blind controlled trial. From 6 weeks to 6 months of age, 72 infants received low-iron formula (2 mg/L) fortified with bovine lactoferrin (1.0 g/L) (Lf+), 72 received low-iron formula un-fortified with lactoferrin (Lf-) and 36 received standard formula with 8 mg of iron/L and no lactoferrin fortification as controls (CF). Iron status and prevalence of iron deficiency (ID) were assessed at 4 and 6 months. All iron status indicators were unaffected by lactoferrin. At 4 and 6 months, the geometric means of ferritin for the combined low-iron groups compared to the CF-group were 67.7 vs. 88.7 and 39.5 vs. 50.9 mu g/L, respectively (p = 0.054 and p = 0.056). No significant differences were found for other iron status indicators. In the low-iron group only one infant (0.7%) at 4 months and none at 6 months developed ID. Conclusion: Iron fortification of 2 mg/L is an adequate level during the first half of infancy for healthy term infants in a well-nourished population. Adding lactoferrin does not affect iron status.
36.	Björmsjö, Maria, et al. (author) Vaccine IgG antibody response is higher in formula-fedcompared to breastfed infants but not affected by added bovine lactoferrin or lowered iron content : results from a randomized controlled trial Other publication (other academic/artistic)
37.	Björmsjö, Maria, et al. (author) Vaccine response was higher in formula-fed infants compared to breastfed but not affected by lactoferrin or iron in a randomised controlled trial 2024 In: Acta Paediatrica. - : John Wiley & Sons. - 0803-5253 .- 1651-2227. Journal article (peer-reviewed)abstract Aim: To examine how reduced iron content and added bovine lactoferrin in infant formula affect the antibody response following routine immunisation.Methods: In this randomised controlled trial, 180 Swedish formula-fed infants received, from 6 weeks to 6 months of age, a 2 mg/L iron formula with (n = 72) or without (n = 72) bovine lactoferrin, or a control formula with 8 mg/L iron and no lactoferrin (n = 36). Another 72 infants were recruited as a breastfed reference. Serum immunoglobulin G (IgG) levels against Haemophilus influenzae type b (Hib), diphtheria and tetanus were assessed at four, six and 12 months of age.Results: With an equal gender distribution, 180 + 72 term infants were included with a mean age of 7.0 ± 0.7 weeks. At 12 months, infants fed low iron formula showed a significantly higher geometric mean Hib IgG (1.40 μg/mL [1.07–1.83]) compared to the control formula infants (0.67 μg/mL [0.42–1.07]). For all three vaccines, breastfed infants had significantly lower IgG levels at six and 12 months of age.Conclusion: Except for higher Hib IgG levels at 12 months in infants fed low iron formula, the interventions did not affect vaccine IgG response. Unexpectedly, breastfed infants had significantly lower vaccine IgG levels compared to formula-fed infants.
38.	Borgström, Magnus, et al. (author) Electron Donor-Acceptor Dyads and Triads Based on Tris(bipyridine) Ruthenium(II) and Benzoquinone: Synthesis, Characterization, and Photoinduced Electron Transfer Reactions 2003 In: Inorganic Chemistry. - 0020-1669 .- 1520-510X. ; 42, s. 5173-5184 Journal article (peer-reviewed)
39.	Brege, Staffan, 1951-, et al. (author) Trämanufaktur och möbler : en strukturbild 2009. - 1 In: Affärsutveckling inom trämanufaktur och möbler. - Stockholm : Vinnova. - 9789185959396 ; , s. 34-46 Book chapter (other academic/artistic)abstract Trämanufaktur- och möbelbranscherna har under perioden 2001-2007 gått från en omsättning på ca 45 till 60 miljarder SEK. Trämanufaktur har haft en imponerande tillväxt, från 28 till 40 miljarder, med Möbler uppvisar en, något mera blygsam utveckling (från 17 till 20, exklusive Kök/bas som räknas till Trämanufaktur).Av speciellt intresse är att delbranschen Prefabricering av flervåningshus mm (exkl småhus) haft den snabbaste tillväxten på 71 % under perioden 2005-2007 och vuxit till en storlek på ca 2,4 miljarder SEK. Man placerar sig även i en grupp av högpresterande delbranscher (eller strategiska grupper) som har en genomsnittlig lönsamhet under perioden 2001-2007 på 10 % avkastning på totalt kapital eller högre. Även delbranscherna Småhus, Kök/Bad och Fönster inom Trämanufaktur och Sängar inom Möbler placerar sig i det högpresterande segmentet. Bland lågpresterarna ifråga om lönsamhet återfinns Golv, Limfog/limträ inom Trämanufaktur samt Designmöbler för offentligt bruk, Traditionella hemmöbler och Underleverantörer på Möbelsidan.Vi kan också konstatera att båda branscherna omsättningsmässigt domineras av i detta sammanhang stora företag (över 100 MSEK) och att de större företagen också är lönsammare. En djupare analys av de båda delbranscherna visar ett antal faktorer som utöver storlek är viktiga för framgång: 1) Värdeskapande i erbjudandet (system lönsammare än produkt och komponent), 2) kontroll över säljkanalen samt 3) att man vänder sig till konsumenter (B2C) istället för företag och organisationer som kunder(B2B).
40.	Bäckström, Fredrik, et al. (author) Normal range and predictors of serum erythroferrone in infants 2023 In: Pediatric Research. - : Springer Nature. - 0031-3998 .- 1530-0447. ; 94:3, s. 965-970 Journal article (peer-reviewed)abstract Background: Erythroferrone (ERFE) has been identified as a hepcidin-regulating hormone synthetized by erythroblasts correlating to the erythropoietic activity and the needs for iron substrate in bone marrow of adults. The present study aimed to assess the ERFE serum concentrations and its predictors in infants.Methods: ERFE was explored at 4 time points during the first year of life in 45 healthy, breastfed, normal birth weight (NBW) infants, and 136 marginally low birth weight infants (LBW, 2000–2500 g) receiving iron (N = 58) or placebo (N = 78) between 6 weeks and 6 months of age.Results: ERFE concentrations were low at birth, increasing gradually during the first year of life. In NBW infants, reference ranges (5th to 95th percentile) were at 6 weeks <0.005–0.99 ng/mL and at 12 months <0.005–33.7 ng/mL. ERFE was higher in LBW infants at 6 weeks but lower at 12 months compared to NBW and minimally affected by iron supplementation among LBW infants. Correlations of ERFE with erythropoietic and iron status markers were weak and inconsistent.Conclusions: The role of ERFE in the crosstalk of erythropoiesis and iron homeostasis remains unclear in infants and further studies on ERFE in infants and older children are warranted within the framework of the erythropoietin–ERFE–hepcidin axis.Impact: Normal range of erythroferrone in healthy infants is described for the first time. Erythroferrone in infants lacks correlation to iron status and markers of erythropoiesis. The findings indicate differences in infant regulation of iron homeostasis as compared to adults. The findings point to a need to study infant erythropoiesis separately from its adult counterpart. The findings may have clinical impact on management strategies of iron-loading anemia in infancy.
41.	Chmielewska, Anna, et al. (author) HEAD GROWTH AND NEURODEVELOPMENT UNTIL 7 YEARS OF AGE : A STUDY IN LOW BIRTH WEIGHT INFANTS 2016 In: EUROPEAN JOURNAL OF PEDIATRICS. - New York : Springer. - 0340-6199 .- 1432-1076. ; 175:11, s. 1485-1485 Journal article (peer-reviewed)
42.	Christiansen, Line, 1986- (author) Using Mobile Health Technology to Support Health-related Quality of Life : From the Perspective of Older Adults with Cognitive Impairment 2022 Doctoral thesis (other academic/artistic)abstract The prevalence of cognitive impairment and illness increases with age. For older adults, maintaining or improving health-related quality of life (HRQoL) in the early stages of cognitive impairment is important to prevent consequences related to the progression of the condition. This thesis aims to identify factors affecting HRQoL and describe how mHealth technology can support HRQoL in older adults with cognitive impairment.Four studies were conducted using quantitative and qualitative approaches. A cross-sectional design was used to identify factors affecting older adults’ HRQoL (Study I) and investigate the relationship between mHealth technology use and self-rated quality of life (QoL) (Study III). A phenomenographical design was used to describe variations in older adults’ perceptions of mHealth technology and its impact on HRQoL (Study II). A prospective longitudinal design was used to examine older adults’ HRQoL changes over time (Study IV).Participants were selected from two longitudinal population studies using a purposive sampling strategy to include those aged 55 years and above with mild cognitive impairment or mild dementia. Data were obtained from questionnaires and semi-structured interviews. Data from the quantitative studies were analysed using statistical analysis, including descriptive and comparative analysis and regression analysis, while data from the qualitative study were examined using phenomenographical analysis in consecutive steps.The results showed that most older adults experienced good HRQoL with regard to both physical and mental health. The likelihood of having good-to-excellent QoL increased with age and was higher among males and those with higher education levels. Those diagnosed with dementia reported poorer HRQoL. Factors associated with low HRQoL included dependency in activities of daily living, receiving informal care and feelings of loneliness and pain. The use of mHealth technology was perceived as supportive in maintaining social interactions and facilitating independent living. The technology literacy levels among the study sample varied significantly. Those who reported having moderate-to-high technical skills and using the internet regularly via mHealth technology had higher odds of experiencing good-to-excellent QoL. No significant changes were observed in the older adults’ HRQoL over time in relation to the non-use and use of a customized mHealth application.The indicators of HRQoL are clinically relevant for the secondary prevention of dementia to help maintain good HRQoL in older adults with incipient cognitive impairment. The technology-related differences reflect the risk of digital exclusion. To improve preconditions for being digitally involved in society, societal initiatives that aim to empower the technology literacy level of older adults are needed.
43.	Dalence, Maria, et al. (author) SAR studies of capsazepinoid bronchodilators. Part 1: The importance of the catechol moiety and aspects of the B-ring structure. 2008 In: Bioorganic & Medicinal Chemistry. - : Elsevier BV. - 0968-0896. ; 16:5, s. 2499-2512 Journal article (peer-reviewed)abstract Capsazepine as well as its derivatives and analogues are general inhibitors of constriction of human small airways. From a systematic variation of the capsazepine structure, divided into four regions, SARs were established. This part concerns the catechol moiety of the A-ring as well as the 2,3,4,5-tetrahydro-1H-2-azepine moiety (the B-ring) of capsazepine. It is revealed that a conformational constrain (as a fused ring) is important and that compounds with a six-membered B-ring (as a 1,2,3,4-tetrahydroisoquinoline) in general are more potent than the corresponding isoindoline, 2,3,4,5-tetrahydro-1H-2-benzazepine and 2,3,4,5-tetrahydro-1H-3-benzazepine derivatives.
44.	Delin, Malin, et al. (author) Validation of red flags in the workup of children with long-term abdominal pain : a retrospective study 2024 In: Acta Paediatrica. - : John Wiley & Sons. - 0803-5253 .- 1651-2227. ; 113:5, s. 1095-1102 Journal article (peer-reviewed)abstract Aim: To evaluate red flags as an instrument to distinguish other medical conditions from Functional Gastrointestinal Disorders (FGID) in children with long-term abdominal pain.Methods: In a retrospective follow-up, data were collected from 317 children who were referred for medical assessment due to long-term abdominal pain between the years 2011 and 2012 at three Swedish paediatric open clinic units in Sweden. Throughout the review of medical records, any documented red flags at the primary consultation and finally set diagnosis after 1 year were noted for all cases.Results: A non-FGID disease was diagnosed in 32 cases (10.1%). The sensitivity of red flags to predict inflammatory bowel disease (IBD) was 100% and the specificity 64.1%. The sensitivity of red flags to predict celiac disease was 45.5% and the specificity 63.7%. The sensitivity of red flags to predict any non-FGID disease was 59.4%, and the specificity was 65.6%.Conclusion: The use of red flags is a sensitive instrument to identify patients with IBD but less applicable when identifying celiac disease and other organic diseases. Specificity is generally low and future biomarkers for assessing children with long-term abdominal pain is needed.
45.	Enbom, Jesper, 1972- (author) Facket i det medialiserade samhället : En studie av LO:s och medlemsförbundens tillämpning av news management 2009 Doctoral thesis (other academic/artistic)abstract According to most ways of measuring it the Swedish trade union movement is the strongest in the world. The Swedish Trade Union Confederation is the largest and most influential union confederation by far. Since the 1980s though, Sweden experienced a shift in the power relations between employers and unions in favour of the former. This has coincided with a growing importance for political communication, public relations and the mass media. This development has presented the Swedish trade union movement with a multitude of challenges. One of the major ones is how to influence the representations of trade unions and their viewpoints in the news media. The purpose of this study is to describe and try to explain how the Swedish Trade Union Confederation and its affiliated unions act to confront the “medialisation” of the public debate. A combination of research methods are used in this study in order to investigate both the historical development of trade union news management and the use of news management by trade union personnel in their everyday work. The study of how news management historically became a part in the overall union activity was performed through qualitative analysis of archive material. The study of the everyday uses of news management and the factors constraining this work builds upon interviews with the press officers of the TUC affiliated unions and the TUC itself. The study shows how both the historical development and the everyday use of news management by the Swedish trade union movement need to be understood in a context. This context contains political, economical, ideological and organisational structures that at the same time enables and constrains the adaption of news management. The study points towards five central paradoxes which faces the trade unions when they seek desired media attention and try to avoid unwanted publicity. The first paradox concerns how to fight hard in the interest of the members, while at the same time avoid being described as a sectional interest. The second paradox stems from the desire of the trade unions to be perceived as big and strong and how this might result in the labelling of them as ‘Goliath’ during a conflict. The next paradox concerns how trade unions want to show the importance of the work done by their members during a conflict and the way this might lead to media attention about how the strike affects ‘innocent bystanders’. The fourth paradoxes come from the wish of the trade unions to make their local representatives visible in mass media. This could result in unwanted publicity, due to the difference between blue-collar trade unionists and middleclass journalists. The fifth paradox stems from the importance of acting quickly to achieve wanted media attention and to avoid unwanted. The paradox is that it might be hard to be fast and at the same time have a thorough democratic process on a controversial issue.
46.	Hanberg, Annika, et al. (author) Phthalates and their metabolites in human breast milk, blood and urine as measures for monitoring exposure in human risk groups 2005 Reports (other academic/artistic)abstract För att undersöka halter av ftalater i svenskar och vilken matris som bäst lämpar sig för hälsorelaterad miljöövervakning har ftalater och ftalatmetaboliter analyserats i en grupp kvinnor som nyligen fött barn. I samband med förlossning på Universitetssjukhuset i Lund tillfrågades förstföderskor om medverkan och 42 kvinnor kom att ingå i studien. När barnet var 2-3 veckor gammalt pumpade mamman ut 50 mL bröstmjölk. Blod- och urinprov togs en vecka senare. Omfattande förändringar av standardmetoder för provtagning av mjölk och blod gjordes för att minimera risken för kontaminering av proverna. För mjölkprovtagningen användes en specialkonstruerad manuell pump av polykarbonat med ftalatfri packning. Blodprov togs med hjälp av endast kanyl och provrör (eftersom propparna i vaccutainrör innehåller ftalater). Proverna förvarades i värmebehandlade glasbehållare och fosforsyra tillsattes för att motverka metabolism av ftalater i mjölk- och blodprover. Analyserna av bröstmjölk visade värden nära eller under detektionsgränsen (LOD) för flertalet ftalater eller deras metaboliter. Även i blod och serum var nivåerna vanligtvis nära eller under LOD. I urin analyserades endast metaboliter och dessa kunde kvantifieras i 53-100 % av proverna. Nivåerna av ftalatmetaboliter i urin hos de svenska kvinnorna var i paritet med nivåerna hos en allmänbefolkning i USA och Tyskland. Några klara korrelationer mellan nivåer i t ex urin och bröstmjölk respektive blod påvisades inte. Resultaten av studien anger att för närvarande är analys av ftalatmetaboliter i urin den mest framkomliga vägen för skattning av ftalatexponering hos människa. Provtagning och analys av mjölk och blod innebar betydligt större svårigheter. Framför allt framstår risken för kontaminering vid provtagning som betydande och en stor del av ftalaterna och dess metaboliter uppvisade låga halter, vid eller under LOD. Dessutom kan ftalater brytas ned i blod och mjölk. I flertalet internationella publicerade studier av ftalatexponering används urinmetabolit-analyser som ett mått på exponering för ftalater. I en nyligen publicerad amerikansk studie av ett 80-tal nyfödda pojkar sågs ett samband mellan kort ano-genitalt avstånd och nivåer av ftalatmetaboliter i urin hos deras mammor under graviditeten. Den amerikanska studien behöver bekräftas, men metaboliterna var desamma som i vår studie och en jämförelse visar att mediannivåerna var lägre för vissa men högre för andra metaboliter. Vår studie indikerar att svenska kvinnor i fertil ålder inte sällan exponeras för ftalater i nivåer som satts i samband med fosterpåverkan.
47.	Heimer, Gun, et al. (author) ”Vården måste fråga kvinnor om de har utsatts för våld” 2011 In: DN.se / DN-debatt. ; :13 maj Journal article (pop. science, debate, etc.)
48.	Heimer, Gun, et al. (author) ”Vården måste fråga kvinnor om de har utsatts för våld” 2011 In: DN.se / DN-debatt. ; :13 maj Journal article (other academic/artistic)
49.	Hermelin, Brita, et al. (author) Regionalpolitik och regional utveckling i Kanda - erfarenheter från enstudieresa. 1995 Reports (other academic/artistic)
50.	Hogberg, Johan, et al. (author) Phthalate diesters and their metabolites in human breast milk, blood or serum, and urine as biomarkers of exposure in vulnerable populations 2008 In: Journal of Environmental Health Perspectives. - : Environmental Health Perspectives. - 0091-6765 .- 1552-9924. ; 116:3, s. 334-339 Journal article (peer-reviewed)abstract BACKGROUND: Phthalates may pose a risk for perinatal developmental effects. An important question relates to the choice of suitable biological matrices for assessing exposure during this period. OBJECTIVES: This study was designed to measure the concentrations of phthalate diesters or their metabolites in breast milk, blood or serum, and urine and to evaluate their suitability for assessing perinatal exposure to phthalates. METHODS: In 2001, 2-3 weeks after delivery, 42 Swedish primipara provided breast milk, blood, and urine samples at home. Special care was taken to minimize contamination with phthalates (e.g., use of a special breast milk pump, heat treatment of glassware and needles, addition of phosphoric acid). RESULTS: Phthalate diesters and metabolites in milk and blood or serum, if detected, were present at concentrations close to the limit of detection. By contrast, most phthalate metabolites were detectable in urine at concentrations comparable to those from the general population in the United States and in Germany. No correlations existed between urine concentrations and those found in milk or blood/serum for single phthalate metabolites. Our data are at odds with a previous study documenting frequent detection and comparatively high concentrations of phthalate metabolites in Finnish and Danish mothers' milk. CONCLUSIONS: Concentrations of phthalate metabolites in urine are more informative than those in milk or serum. Furthermore, collection of milk or blood may be associated with discomfort and potential technical problems such as contamination (unless oxidative metabolites are measured). Although urine is a suitable matrix for health-related phthalate monitoring, urinary concentrations in nursing mothers cannot be used to estimate exposure to phthalates through milk ingestion by breast-fed infants.

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