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1.	Agardh, HE, et al. (author) Fatty acid binding protein 4 in circulating leucocytes reflects atherosclerotic lesion progression in Apoe(-/-) mice 2013 In: Journal of cellular and molecular medicine. - : Wiley. - 1582-4934 .- 1582-1838. ; 17:2, s. 303-310 Journal article (peer-reviewed)
2.	Czibik, G, et al. (author) Human adaptation to ischemia by preconditioning or unstable angina: involvement of nuclear factor kappa B, but not hypoxia-inducible factor 1 alpha in the heart 2008 In: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. - : Oxford University Press (OUP). - 1873-734X. ; 34:5, s. 976-984 Journal article (peer-reviewed)
3.	Czibik, G, et al. (author) Hypoxia-inducible factor 1 alpha is not activated by human heart preconditioning 2004 In: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. - 0022-2828. ; 36:5, s. 723-723 Conference paper (other academic/artistic)
4.	de Graaf, KL, et al. (author) CDR3 sequence preference of TCRBV8S2+ T cells within the CNS does not reflect single amino acid dependent avidity expansion 2005 In: Journal of neuroimmunology. - : Elsevier BV. - 0165-5728. ; 166:1-2, s. 47-54 Journal article (peer-reviewed)
5.	Hansson, GK, et al. (author) Atherosclerosis and the immune system 2004 In: Acta paediatrica (Oslo, Norway : 1992). Supplement. - : Wiley. - 0803-5326 .- 0803-5253. ; 93:446, s. 63-69 Journal article (peer-reviewed)
6.	Jiang, X, et al. (author) A trait of inflammation pathogenesis in human atherosclerosis: inflammasome driven interleukin-1 signaling in complex atherosclerotic plaques via hyperlipidemia trained innate immunity 2019 In: EUROPEAN HEART JOURNAL. - 0195-668X. ; 40, s. 1232-1232 Conference paper (other academic/artistic)
7.	Lundmark, KT, et al. (author) Reduced atherosclerosis in APO E-/- mice with heparan sulfate-deficient perlecan 2006 In: ATHEROSCLEROSIS SUPPLEMENTS. - 1567-5688. ; 7:3, s. 489-489 Conference paper (other academic/artistic)
8.	Persson, J, et al. (author) LOW ADIPONECTIN CONCENTRATION IS A RISK FACTOR FOR MYOCARDIAL INFARCTION AND LEVELS ARE INFLUENCED BY GENETIC VARIANTS 2009 In: ATHEROSCLEROSIS SUPPLEMENTS. - 1567-5688. ; 10:2 Conference paper (other academic/artistic)
9.	Strodthoff, D, et al. (author) CD3(+)CD4(-)CD8(-)T cells in adipose tissue-implications for type 2 diabetes and atherosclerosis? 2008 In: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. - 0300-9475. ; 68:2, s. 188-189 Conference paper (other academic/artistic)
10.	Tupin, E, et al. (author) CD1d-dependent activation of NKT cells aggravates atherosclerosis 2004 In: ATHEROSCLEROSIS SUPPLEMENTS. - 1567-5688. ; 5:1, s. 42-42 Conference paper (other academic/artistic)
11.	Tupin, E, et al. (author) CD1d-dependent activation of NKT cells aggravates atherosclerosis 2004 In: The Journal of experimental medicine. - : Rockefeller University Press. - 0022-1007 .- 1540-9538. ; 199:3, s. 417-422 Journal article (peer-reviewed)abstract Adaptive and innate immunity have been implicated in the pathogenesis of atherosclerosis. Given their abundance in the lesion, lipids might be targets of the atherosclerosis-associated immune response. Natural killer T (NKT) cells can recognize lipid antigens presented by CD1 molecules. We have explored the role of CD1d-restricted NKT cells in atherosclerosis by using apolipoprotein E–deficient (apoE−/−) mice, a hypercholesterolemic mouse model that develops atherosclerosis. ApoE−/− mice crossed with CD1d−/− (CD1d−/−apoE−/−) mice exhibited a 25% decrease in lesion size compared with apoE−/− mice. Administration of α-galactosylceramide, a synthetic glycolipid that activates NKT cells via CD1d, induced a 50% increase in lesion size in apoE−/− mice, whereas it did not affect lesion size in apoE−/−CD1d−/− mice. Treatment was accompanied by an early burst of cytokines (IFNγ, MCP-1, TNFα, IL-2, IL-4, IL-5, and IL-6) followed by sustained increases in IFNγ and IL-4 transcripts in the spleen and aorta. Early activation of both T and B cells was followed by recruitment of T and NKT cells to the aorta and activation of inflammatory genes. These results show that activation of CD1d-restricted NKT cells exacerbates atherosclerosis.

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Result 1-11 of 11

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Type of publication: conference paper (6); journal article (5)

Type of content: other academic/artistic (6); peer-reviewed (5)

Author/Editor: Berne, GP (10); Hansson, GK (6); Hedin, U (2); Tupin, E (2); Rudling, M (2); Vaage, J (2); show more...; Nicoletti, A (2); Valen, G (2); Czibik, G (2); Wu, ZK (2); Tarkka, M (2); Elhage, R (2); Wang, F. (1); Wang, J. (1); Yan, Z. (1); Olsson, T (1); Gabrielsen, A (1); Ljunggren, HG (1); Roy, J. (1); Persson, J. (1); Arner, P (1); Ljunggren, H. (1); Jiang, X. (1); Agardh, HE (1); Gertow, K (1); Salvado, DM (1); Hermansson, A (1); Puijvelde, GH (1); N-Berne, GP (1); Eriksson, P (1); Hansson, G (1); Gustafsson, T. (1); Gistera, A. (1); Tryggvason, K (1); Lundman, P (1); Soininen, R (1); Sultan, A (1); Tran, PK (1); Robertson, AK (1); Laurikka, J (1); Jarvinen, O (1); Weissert, R (1); de Graaf, KL (1); Herrmann, MM (1); Herrmann, J (1); Strodthoff, D (1); Gerdes, N (1); Lerman, A. (1); Kinsella, MG (1); Wight, TN (1); show less...

University: Karolinska Institutet (11)

Language: English (11)

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