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1.	Ruilope, LM, et al. (author) Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial 2019 In: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356 Journal article (peer-reviewed)abstract <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
2.	Ridker, PM, et al. (author) Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients 2017 In: The New England journal of medicine. - 1533-4406 .- 0028-4793. ; 376:16, s. 1527-1539 Journal article (peer-reviewed)
3.	Kim, S. S., et al. (author) Bullying, Mental Health, and the Moderating Role of Supportive Adults : A Cross-National Analysis of Adolescents in 45 Countries 2022 In: International Journal of Public Health. - : Frontiers Media S.A.. - 1661-8556 .- 1661-8564. ; 67 Journal article (peer-reviewed)abstract Objectives: Relationships with supportive adults during adolescence may be a protective factor that lowers the risks associated with bullying. The current study aimed to examine the moderating role of supportive adults in the associations between bullying involvement (in-person and cyber) and mental health problems (psychological symptoms and low life satisfaction). Methods: Data from 45 countries and regions taking part in the 2017/18 Health Behaviour in School-Aged Children study (N = 230,757) were used. Multivariable Poisson regression models were used to estimate relative risks of bullying on mental health. Effect estimates were compared across the number of supportive adults to examine a possible cumulative protective effect of relationships with supportive adults. Results: Bullying involvement was consistently associated with poor mental health across the 45 countries. Risk of mental health problems associated with bullying involvement was greatest among students reporting relationships with multiple supportive adults. This was true for all indicators of bullying involvement. Conclusion: Bullying remains a prevalent and harmful experience for youth worldwide. Merely having supportive adults is not sufficient in protecting youth from experiencing the mental health risks associated with bullying.

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Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: El Shahawy, M (3); Li, Y. (2); Zhang, Y. (2); Sharma, S. (2); Saxena, S (2); Szilagyi, I (2); show more...; Liu, F. (2); Lerman, S. (2); Adams, A (2); Strand, J. (2); Baker, J (2); Bonora, E (2); Montero, M (2); Nadkarni, S (2); Sritara, P (2); Nagy, L (2); Atar, S (2); Dzupina, A (2); Ranjith, N (2); Arif, I (2); Soroka, E (2); Urina, M (2); Horacek, T (2); Kosmacheva, E (2); Lindholm, CJ (2); Tellier, G (2); Axthelm, C (2); Scheen, A (2); Popescu, A (2); Mosenzon, O. (2); Kantola, I (2); Wuerzner, G (2); Curiac, D. (2); Tengmark, BO (2); Landa, K (2); Rice, S. (2); Gelersztein, E (2); Chahin, M (2); Hissa, M (2); Teitelbaum, I (2); Humaloja, K (2); Contzen, C (2); Sigal, H (2); Kirschner, R (2); Zilahi, Z (2); Bajcsi, D (2); Wainstein, J (2); Reyna, LS (2); Ortiz, RV (2); Rusicka, T (2); show less...

University: Karolinska Institutet (2); Uppsala University (1); Jönköping University (1); Lund University (1)

Language: English (3)

Research subject (UKÄ/SCB): Medical and Health Sciences (3)

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