| 1. |
- Allard, Christina, et al.
(author)
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Rasbiologiskt språkbruk i statens rättsprocess mot sameby
- 2015
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In: Dagens Nyheter. - 1101-2447.
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Journal article (pop. science, debate, etc.)abstract
- Statens hantering av forskningsresultat i rättsprocessen med Girjas sameby utgör ett hot mot Sverige som rättsstat och kunskapsnation. Åratal av svensk och internationell forskning underkänns och man använder ett språkbruk som skulle kunna vara hämtat från rasbiologins tid. Nu måste staten ta sitt ansvar och börja agera som en demokratisk rättsstat, skriver 59 forskare.
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| 2. |
- Allard, Christina, et al.
(author)
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Rasbiologiskt språkbruk i statens rättsprocess mot sameby : DN Debatt 2015-06-11
- 2015
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Other publication (pop. science, debate, etc.)abstract
- Statens hantering av forskningsresultat i rättsprocessen med Girjas sameby utgör ett hot mot Sverige som rättsstat och kunskapsnation. Åratal av svensk och internationell forskning underkänns och man använder ett språkbruk som skulle kunna vara hämtat från rasbiologins tid. Nu måste staten ta sitt ansvar och börja agera som en demokratisk rättsstat, skriver 59 forskare.
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| 3. |
- Almeida, Pedro, et al.
(author)
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Genome assembly of the basket willow, Salix viminalis, reveals earliest stages of sex chromosome expansion
- 2020
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In: BMC Biology. - : Springer Science and Business Media LLC. - 1741-7007. ; 18:1
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Journal article (peer-reviewed)abstract
- BackgroundSex chromosomes have evolved independently multiple times in eukaryotes and are therefore considered a prime example of convergent genome evolution. Sex chromosomes are known to emerge after recombination is halted between a homologous pair of chromosomes, and this leads to a range of non-adaptive modifications causing gradual degeneration and gene loss on the sex-limited chromosome. However, the proximal causes of recombination suppression and the pace at which degeneration subsequently occurs remain unclear.ResultsHere, we use long- and short-read single-molecule sequencing approaches to assemble and annotate a draft genome of the basket willow, Salix viminalis, a species with a female heterogametic system at the earliest stages of sex chromosome emergence. Our single-molecule approach allowed us to phase the emerging Z and W haplotypes in a female, and we detected very low levels of Z/W single-nucleotide divergence in the non-recombining region. Linked-read sequencing of the same female and an additional male (ZZ) revealed the presence of two evolutionary strata supported by both divergence between the Z and W haplotypes and by haplotype phylogenetic trees. Gene order is still largely conserved between the Z and W homologs, although the W-linked region contains genes involved in cytokinin signaling regulation that are not syntenic with the Z homolog. Furthermore, we find no support across multiple lines of evidence for inversions, which have long been assumed to halt recombination between the sex chromosomes.ConclusionsOur data suggest that selection against recombination is a more gradual process at the earliest stages of sex chromosome formation than would be expected from an inversion and may result instead from the accumulation of transposable elements. Our results present a cohesive understanding of the earliest genomic consequences of recombination suppression as well as valuable insights into the initial stages of sex chromosome formation and regulation of sex differentiation.
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| 4. |
- Bjerg, Anders, et al.
(author)
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Shorter time to clinical decision in work-related asthma using a digital tool
- 2020
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In: ERJ open research. - Lausanne, Switzerland : European Respiratory Society (ERS). - 2312-0541. ; 6:3
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Journal article (other academic/artistic)abstract
- PEF curves are a useful but cumbersome tool in diagnosing work-related asthma. Using a digital spirometer and smartphone app, time to clinical decision could be shortened by 6-7 weeks. Physician's time spent analysing PEF data is also shortened.
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| 5. |
- Borres, Nora, et al.
(author)
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Parents' perceptions are that their child's health-related quality of life is more impaired when they have a wheat rather than a grass allergy
- 2017
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In: Acta Paediatrica, International Journal of Paediatrics. - : Wiley. - 0803-5253 .- 1651-2227. ; 106:3, s. 478-484
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Journal article (peer-reviewed)abstract
- Aim: It is unknown whether food allergies have greater impact on quality of life than respiratory allergies. This study compared health-related quality of life (HRQoL) in children allergic to wheat or grass. Methods: We surveyed 63 children with wheat allergies (median age of five) and 72 with grass allergies (median age 12), with their parents. The Child Health Questionnaires for parents (CHQ-PF28) and children (CHQ-CF87) were applied. Results: The parents of children in the wheat group recorded significantly lower CHQ-PF28 scores for the impact of their child's allergy on general behaviour, general health perceptions, parental impact of emotions and time and family activities, than the parents of children with grass allergies (p values ≤0.001). However, parents in the grass group recorded lower scores for the change in health item than the parents of children with wheat allergies (p = 0.020). In the grass group, children and parents reported similar scores for the different questions, but there was poorer correlation between parents and children in the wheat allergy group. Conclusion: HRQoL was lower in children with wheat than grass allergies according to parental reports, with more consistent perceptions of HRQoL among parents and children in the grass allergy than wheat allergy group.
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| 6. |
- Brink-Elfegoun, T., et al.
(author)
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Neuromuscular and circulatory adaptation during combined arm and leg exercise with different maximal work loads
- 2007
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In: European Journal of Applied Physiology. - : Springer Science and Business Media LLC. - 1439-6319 .- 1439-6327. ; 101:5, s. 603-611
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Journal article (peer-reviewed)abstract
- Cardiopulmonary kinetics and electromyographic activity (EMG) during exhausting exercise were measured in 8 males performing three maximal combined arm + leg exercises (cA+L). These exercises were performed at different rates of work (mean ± SD; 373 ± 48, 429 ± 55 and 521 ± 102 W) leading to different average exercise work times in all tests and subjects. reached a plateau versus work rate in every maximal cA+L exercise (range 6 min 33 s to 3 min 13 s). The three different exercise protocols gave a maximal oxygen consumption of 4.67 ± 0.57, 4.58 ± 0.52 and 4.66 ± 0.53 l min−1 (P = 0.081), and a maximal heart rate (HRmax) of 190 ± 6, 189 ± 4 and 189 ± 6 beats min−1 (P = 0.673), respectively. Root mean square EMG (EMGRMS) of the vastus lateralis and the triceps brachii muscles increased with increasing rate of work and time in all three cA+L protocols. The study demonstrates that despite different maximal rates of work, leading to different times to exhaustion, the circulatory adaptation to maximal exercise was almost identical in all three protocols that led to a plateau. The EMGRMS data showed increased muscle recruitment with increasing work rate, even though the HRmax and was the same in all three cA+L protocols. In conclusion, these findings do not support the theory of the existence of a central governor (CG) that regulates circulation and neuronal output of skeletal muscles during maximal exercise. Thibault Brink-Elfegoun and Hans-Christer Holmberg contributed equally to this article.
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| 7. |
- Färdig, Martin, et al.
(author)
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Eosinophil-derived neurotoxin levels in early childhood and association with preschool asthma - A prospective observational study
- 2023
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In: Clinical and Experimental Allergy. - : John Wiley & Sons. - 0954-7894 .- 1365-2222. ; 53:11, s. 1198-1211
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Journal article (peer-reviewed)abstract
- Introduction: Eosinophil-derived neurotoxin (EDN) is related to childhood asthma, while normal values are lacking. We aimed to document serum EDN levels at 1 and 3 years in general and in non-atopic children, and explore if EDN levels differed by sex or were associated with preschool asthma at 3 years.Methods: From the PreventADALL birth cohort, we included 1233 children with EDN analysed using ImmunoCAP at 1 and/or 3 years. Non-atopic children had no history of wheeze, asthma, allergic sensitization or atopic dermatitis. Preschool asthma was defined as having ≥3 episodes of bronchial obstruction between 2 and 3 years, plus doctor diagnosed asthma and/or asthma medication use by 3 years. The upper limit of normal (ULN) of EDN was defined as the 95th percentile. With Youden Index we calculated EDN cut-off levels for risk of preschool asthma.Results: The overall median (ULN) EDN levels were 27.4 (121) μg/L at 1 year (n = 787), and 20.1 (87.8) μg/L at 3 years (n = 857). Non-atopic children had EDN levels of 24.0 (107) μg/L at 1 year (n = 147), and 17.3 (84.6) μg/L at 3 years (n = 173). EDN levels were higher in boys compared to girls; 32.0 (133) versus 24.5 (97.0) μg/L at 1 year, and 20.9 (96.3) versus 19.0 (72.4) μg/L at 3 years. Preschool asthma was observed in 109/892 (12.2%) children. Higher EDN levels at 1 (>26.7 μg/L) and 3 (≥20.5 μg/L) years were associated with preschool asthma; adjusted OR (95% CI) 2.20 (1.09, 4.41) and 4.68 (2.29, 9.55), respectively.Conclusion and Clinical Relevance: We report EDN values in early childhood, demonstrating higher levels at 1 compared to 3 years and in boys compared to girls at both ages. Higher EDN levels at both ages were associated with preschool asthma. However, EDN cut-off levels for preschool asthma were overall lower than the ULN of non-atopic children, limiting translation into clinical practice.
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| 8. |
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| 9. |
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| 11. |
- Henckel, Ewa, et al.
(author)
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A novel association between ykl-40, a marker of structural lung disease, and short telomere length in 10-year-old children with bronchopulmonary dysplasia
- 2021
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In: Children. - : MDPI. - 2227-9067. ; 8:2
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Journal article (peer-reviewed)abstract
- Extremely preterm infants are born with immature lungs and are exposed to an inflammatory environment as a result of oxidative stress. This may lead to airway remodeling, cellular aging and the development of bronchopulmonary dysplasia (BPD). Reliable markers that predict the long-term consequences of BPD in infancy are still lacking. We analyzed two biomarkers of cellular aging and lung function, telomere length and YKL-40, respectively, at 10 years of age in children born preterm with a history of BPD (n = 29). For comparison, these markers were also evaluated in sex-and-age-matched children born at term with childhood asthma (n = 28). Relative telomere length (RTL) was measured in whole blood with qPCR and serum YKL-40 with ELISA, and both were studied in relation to gas exchange and the regional ventilation/perfusion ratio using three-dimensional V/Q-scintigraphy (single photon emission computer tomography, SPECT) in children with BPD. Higher levels of YKL-40 were associated with shorter leukocyte RTL (Pearson’s correlation: −0.55, p = 0.002), but were not associated with a lower degree of matching between ventilation and perfusion within the lung. Serum YKL-40 levels were significantly higher in children with BPD compared to children with asthma (17.7 vs. 13.2 ng/mL, p < 0.01). High levels of YKL-40 and short RTLs were associated to the need for ventilatory support more than 1 month in the neonatal period (p < 0.01). The link between enhanced telomere shortening in childhood and structural remodeling of the lung, as observed in children with former BPD but not in children with asthma at the age of 10 years, suggests altered lung development related to prematurity and early life inflammatory exposure. In conclusion, relative telomere length and YKL-40 may serve as biomarkers of altered lung development as a result of early-life inflammation in children with a history of prematurity.
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| 12. |
- Hermansson, Cecilia, et al.
(author)
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DN Debatt: Klimatlagen kräver att regeringen ändrar politik
- 2022
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In: Dagens nyheter (DN debatt). - 1101-2447.
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Journal article (pop. science, debate, etc.)abstract
- Nästa år ska regeringen enligt klimatlagen presentera en handlingsplan för hur Sverige ska nå klimatmålen. Minst ett dussin myndigheter har bidragit med underlag. Men inte ens om samtliga förslag i dessa rapporter genomförs kommer det att räcka för att fylla det gap som har uppstått med den nya regeringens politik, skriver Klimatpolitiska rådet.
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| 13. |
- Hermansson, Cecilia, et al.
(author)
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Klimatpolitiska rådets rapport 2023
- 2023
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Reports (pop. science, debate, etc.)abstract
- Stigande halter av växthusgaser i atmosfären har rubbat balansen i jordens klimatsystem vilket har medfört en snabbt stigande global medeltemperatur. Den globala uppvärmningen ligger nu på drygt 1,1 grader jämfört med förindustriell tid. Utöver högre temperaturer har detta lett till fler extrema väderhändelser, smältande isar och stigande havsnivåer. De ekologiska, ekonomiska och sociala effekterna av klimatförändringarna blir allt påtagligare.
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| 14. |
- Hoel, Sveinung T., et al.
(author)
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Birth mode is associated with development of atopic dermatitis in infancy and early childhood
- 2023
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In: Journal of Allergy and Clinical Immunology: Global. - : Elsevier BV. - 2772-8293. ; 2:3
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Journal article (peer-reviewed)abstract
- Background: Birth by caesarean section (CS) is associated with development of allergic diseases, but its role in the development of atopic dermatitis (AD) is less convincing. Objective: Our primary aim was to determine if birth mode was associated with AD in 3-year-olds and secondarily to determine if birth mode was associated with early onset and/or persistent AD in the first 3 years of life. Methods: We included 2129 mother–child pairs from the Scandinavian population-based prospective PreventADALL cohort with information on birth mode including vaginal birth, either traditional (81.3%) or in water (4.0%), and CS before (6.3%) and after (8.5%) onset of labor. We defined early onset AD as eczema at 3 months and AD diagnosis by 3 years of age. Persistent AD was defined as eczema both in the first year and at 3 years of age, together with an AD diagnosis by 3 years of age. Results: AD was diagnosed at 3, 6, 12, 24, and/or 36 months in 531 children (25%). Compared to vaginal delivery, CS was overall associated with increased odds of AD by 3 years of age, with adjusted odds ratio (95% confidence interval) of 1.33 (1.02-1.74), and higher odds of early onset AD (1.63, 1.06-2.48). The highest odds for early onset AD were observed in infants born by CS after onset of labor (1.83, 1.09-3.07). Birth mode was not associated with persistent AD. Conclusion: CS was associated with increased odds of AD by 3 years of age, particularly in infants presenting with eczema at 3 months of age.
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| 15. |
- Konradsen, Jon R, et al.
(author)
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Predicting asthma morbidity in children using proposed markers of Th2-type inflammation.
- 2015
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In: Pediatric Allergy and Immunology. - : Wiley. - 0905-6157 .- 1399-3038. ; 26:8, s. 772-779
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Journal article (peer-reviewed)abstract
- BACKGROUND: Assessment of inflammation is becoming a common practice in the clinical work-up of children with persistent asthma. Biomarkers of Th2-mediated inflammation include blood eosinophils (B-Eos), exhaled nitric oxide (FeNO), total serum IgE (S-IgE), and serum periostin. The aim of this study was to investigate the associations between asthma morbidity and increased levels of these biomarkers in pediatric asthma.METHODS: School-age children (n = 96) with various manifestations of persistent asthma were included in this nationwide Swedish study. The protocol included the asthma control test, Juniper's quality of life questionnaire (QoL), assessment of pulmonary function, bronchial hyperresponsiveness, height-adjusted FeNO, blood sampling for S-IgE, B-Eos, and periostin, and high-resolution computed tomography (HRCT) of the lungs.RESULTS: Children with both high levels of height-adjusted FeNO and B-Eos were younger (p = 0.001), had more often severe asthma (p = 0.015), were more allergic (p < 0.001), had a reduced asthma control (p = 0.035), reduced QoL (p = 0.035), more exacerbations (p = 0.004), reduced FEV1/FVC (p = 0.001), and increased bronchial hyperresponsiveness (p < 0.001) as well as greater bronchial wall thickening on HRCT (p = 0.022) compared to those with low levels of both biomarkers. Grouping children according to high and low serum periostin levels did not relate to differences in clinical characteristics and biomarkers.CONCLUSIONS: Assessment of both local and systemic Th2-mediated inflammation by the analysis of easily attainable biomarkers such as exhaled NO and blood eosinophils has a high predictive value for the identification of children with the highest asthma morbidity. Adjusting FeNO values according to the individual child's height increases the clinical usefulness of this biomarker.
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| 16. |
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| 17. |
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| 18. |
- Loza, M. J., et al.
(author)
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Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study
- 2016
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In: Respiratory Research. - : Springer Nature. - 1465-9921 .- 1465-993X. ; 17:1
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Journal article (peer-reviewed)abstract
- Background: Asthma is a disease of varying severity and differing disease mechanisms. To date, studies aimed at stratifying asthma into clinically useful phenotypes have produced a number of phenotypes that have yet to be assessed for stability and to be validated in independent cohorts. The aim of this study was to define and validate, for the first time ever, clinically driven asthma phenotypes using two independent, severe asthma cohorts: ADEPT and U-BIOPRED. Methods: Fuzzy partition-around-medoid clustering was performed on pre-specified data from the ADEPT participants (n = 156) and independently on data from a subset of U-BIOPRED asthma participants (n = 82) for whom the same variables were available. Models for cluster classification probabilities were derived and applied to the 12-month longitudinal ADEPT data and to a larger subset of the U-BIOPRED asthma dataset (n = 397). High and low type-2 inflammation phenotypes were defined as high or low Th2 activity, indicated by endobronchial biopsies gene expression changes downstream of IL-4 or IL-13. Results: Four phenotypes were identified in the ADEPT (training) cohort, with distinct clinical and biomarker profiles. Phenotype 1 was "mild, good lung function, early onset", with a low-inflammatory, predominantly Type-2, phenotype. Phenotype 2 had a "moderate, hyper-responsive, eosinophilic" phenotype, with moderate asthma control, mild airflow obstruction and predominant Type-2 inflammation. Phenotype 3 had a "mixed severity, predominantly fixed obstructive, non-eosinophilic and neutrophilic" phenotype, with moderate asthma control and low Type-2 inflammation. Phenotype 4 had a "severe uncontrolled, severe reversible obstruction, mixed granulocytic" phenotype, with moderate Type-2 inflammation. These phenotypes had good longitudinal stability in the ADEPT cohort. They were reproduced and demonstrated high classification probability in two subsets of the U-BIOPRED asthma cohort. Conclusions: Focusing on the biology of the four clinical independently-validated easy-to-assess ADEPT asthma phenotypes will help understanding the unmet need and will aid in developing tailored therapies. Trial registration:NCT01274507(ADEPT), registered October 28, 2010 and NCT01982162(U-BIOPRED), registered October 30, 2013.
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| 19. |
- Myrebøe, Synne, 1972-
(author)
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Kultiveringens politik : Martha Nussbaum, antiken och filosofins praktik
- 2019
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Doctoral thesis (other academic/artistic)abstract
- The Politics of Cultivation is a study on how the American philosopher Martha Nussbaum actualizes Ancient political philosophy to re-negotiate core assumptions in her own contemporary ethical-political discussions. The aim is to explore the potentiality Nussbaum discerns in Ancient philosophy and how this potentiality is actualized in her thoughts on cultivation as a critique of what she sees as reductive cultures of knowledge. Also, I highlight what Nussbaum’s philosophical practice can contribute to a Swedish discourse on bildning as resistance. Following Nussbaum’s philosophy of cultivation from her first articles on Heraclitus in 1972 to her recent work, I focus on how she emphasizes the role of sensibility, sexuality and emotions for reason. The thesis is divided in six chapters. The first chapter gives an overview of cultivation as a recurrent theme throughout Nussbaum’s authorship. In the second chapter I explore her reading of Heraclitus and how this reading highlight her philosophy of cultivation. The third and fourth chapters study how Nussbaum mobilizes Plato and Aristotle to point at some of the problems she finds at the core of her contemporary political philosophy. The fifth chapter investigates how Nussbaum renegotiates Stoic and Epicurean philosophy in her defence of a therapeutic philosophical approach. The last chapter exposes how aesthetical, ethical and political dimensions are weaved into Nussbaum’s thoughts on cultivation. Here, I study her reading of two tragedies and one comedy, showing how Nussbaum’s philosophical practice can be understood as an art of memory.Set in a contemporary, Swedish discussion on bildning [Bildung], and the role of education for liberal democracy, I argue that Nussbaum lay bare the constructed division between education and self-formation where she calls for the urgency to scrutinize educational politics and educational practice. Hence, what Nussbaum emphasizes, is that everywhere people meet, we are already embedded in a process of cultivation of thoughts, emotions and perceptions. The central question on how we can live together in a pluralistic world will thus have different answers depending on what can be seen and heard within the epistemological and political regulation of the sensible. Nussbaum’s politics of cultivation insists not only on being a gadfly on the back of power, but also to change the political structures from a reductive masculinity to the dialectics of love.
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| 20. |
- Nordlund, Björn
(author)
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Severe asthma and asthma control in schoolchildren
- 2013
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Doctoral thesis (other academic/artistic)abstract
- Background: Asthma is a major health problem in children and most troublesome during severe or persistent symptoms. Children with problematic severe asthma have a disproportionate consumption of health care, despite high-dose treatment with inhaled corticosteroids (ICS). Little is known about children with impaired asthma control or problematic severe asthma in regards to prevalence in a normal population, characterisation and classification, and health effects measured as health-related quality of life (HR-QoL). Aim: The overall aim of this doctoral thesis was to evaluate the burden of symptoms and factors associated with impaired asthma control in schoolchildren. Materials and Methods: The study population consisted of 3 015 children up to 12 years of age from the prospective birth cohort BAMSE, and children from the Severe asthma study with problematic severe asthma (n = 56) and, for comparison, controlled asthma (n = 39). Parental questionnaires collected data on environmental exposures, asthma symptoms and treatments. In the BAMSE study, asthma control was classified based on parental reports and according to a modified GINA classification. The prevalence of severe asthma with dispensed high-dose ICS was estimated through the Swedish drug register. Evaluations with component-resolved allergy diagnostics, exhaled nitric oxide (FeNO), bronchial hyperresponsiveness to methacholine (BHR), blood count of eosinophils and HR-QoL were applied in the Severe asthma study. Results: In the BAMSE cohort, a high proportion of children with asthma were classified as impaired in their asthma control (partly or uncontrolled) at 8 years, 84% of 323, and at 12 years, 53% of 329, (p < 0.001). Parental report of symptoms varied in these children, with more activity limitation (66% vs. 48%, p < 0.001) and wheeze > 4 times in last year (52% vs. 38%, p = 0.002) at 12 years compared with at 8 years, but fewer with nocturnal symptoms (36% vs. 82%, p < 0.001) and less acute healthcare utilization (15% vs. 34%, p < 0.001) at 12 years. Severe asthma was prevalent in 0.4% of children in a normal urban population at age 12, or 4% among children with asthma. Children with impaired asthma control at both 8 and 12 years in the BAMSE cohort (n = 91) and children with problematic severe asthma had more often a family history of allergic disease and comorbidity of rhinitis than children with controlled asthma. Multi-sensitization to animal-derived components was more pronounced in problematic severe asthma than in controlled asthma, 25% vs. 8% (p = 0.03), and was associated with increased eosinophil inflammation as compared with children sensitized to fewer animal-derived components, FeNO 38 ppb vs. 25 ppb (p = 0.002), blood eosinophils 0.65 vs. 0.39 (p = 0.021), and BHR 112 vs. 28 (p = 0.002). Children with problematic severe asthma were more impaired in HR-QoL than children with controlled asthma 5.4 vs. 6.7 (p < 0.001). Conclusion: A high proportion of schoolchildren reported impaired asthma control. Children with problematic severe asthma have impaired HR-QoL, with effects of limitations in daily activities and reduced emotional well-being. Common factors associated with children having impaired asthma control at both 8 and 12 years and problematic severe asthma were family history of allergic disease and comorbidity of rhinitis.
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| 24. |
- Norlin, Björn, 1976-
(author)
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Bildning i skuggan av läroverket : Bildningsaktivitet och kollektivt identitetsskapande i svenska gymnasistföreningar 1850-1914
- 2010
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Doctoral thesis (other academic/artistic)abstract
- The present dissertation investigates pupil fraternities in the Swedish state grammar school system from 1850 to 1914, in an effort to contribute to the understanding of peer group socialisation as part of the overall pedagogical process. Focus is trained on the practice of liberal education (Sw. bildning ) and the construction of collective identity. Modern pupil associations emerged in the mid-nineteenth century from the ruins of outdated educational traditions. Due to sharpened discipline, institutional changes and external societal pressure, previously existing corporative modes of organisation successively disappeared. To fill the void, pupils began founding fraternities, thereby introducing a new organisational form and a new set of activities based on an ideological foundation more in sync with the ideals of the emerging industrial society. Infused with the liberal, neo-Romantic ideals of the day, the introduction of fraternal life laid out new tools for selfadministered socialisation. After analysing the growth of pupil associations in the mid- nineteenth century, the thesis concentrates on fraternal practice at one particular institution, Umeå State Grammar School. This case study shows that fraternal activity revolved around creating lending libraries and reading circles, assemblies, school magazines and aesthetic pursuits including musicmaking, singing, acting and dancing. The thesis suggests that the fraternity had a structuring impact on the student body as a whole, serving to homogenise the school experience and provide a viable alternative to the allurements of town life. Subjects favoured by the fraternity included philosophy and ethics, literature and history and, to a lesser extent, current events. A slight shift in interest toward the natural sciences can be detected at the end of the period under investigation. Furthermore, it is revealed that peer socialisation encouraged identification with the school. It transmitted a set of values stressing idealism and anti-materialism, patriotism and regionalism, intellectualism (as opposed to athleticism), religious and/or secular piety, historism, cultural and political traditionalism, an acknowledgement of the powers – and limitations – of youth and an idealisation of friendship and camraderie. Insofar as social mores and relationships between the sexes was concerned, peer socialisation also provided pupils with practical instruction on proper conduct, and laid the foundation for an ambiguous understanding of the opposite sex. It promoted an ideal of masculinity closely associated with what may be characterised as the civil servant ideal. The thesis finally reveals that strong links were forged between fraternities on a regional, nationwide and Nordic level, bearing strong resemblance to contemporary social youth movements regarding attitudes toward society, culture and knowledge. Upper secondary school fraternities considered themselves guardians of the nation and its culture and became a conformist force in late nineteenth-century Sweden. On the other hand, pupils also constituted an active force in the modernisation of Swedish institutional practice, in the vitalisation of the state grammar schools, and as forerunners in the conceptualisation of a new cult of youth.
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| 26. |
- Smidfelt-Rosqvist, Lena, et al.
(author)
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Trafikplanering i en hållbar, energisnål stadsutveckling : Med exempel från Lund
- 2010
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Reports (other academic/artistic)abstract
- Rapporten visar att det finns kunskapen om vilka åtgärder och processer som leder till en hållbar fysisk planering där inte bilens framkomlighet och rörligheten står i fokus utan tillgängligheten och möjligheten att kunna välja alternativa, hållbara färdsätt. De åtgärder som beskrivs är varken nya eller ickeimplementerade, men skulle kunna användas i betydligt större omfattning. För i princip alla åtgärder finns goda exempel (fast inte alla på en och samma plats). Svårigheten verkar alltså vara att ta tillvara på kunskapen och införa de goda exemplen även i ett mer rikstäckande svenskt sammanhang.Det finns enklaver där ett nytt synsätt och planering börjar få fäste, med Lund som ett exempel och de transportpolitiska målens formulering bort från rörligheten till tillgängligheten som ett annat. Frågan är naturligtvis hur man kan utöka dessa enklavers utbredning.En viktig förutsättning i omställningen som tydligt framträdde i samtalen med Lunds kommun handlar om normförändringar vilket även tidigare forskning visat.Planerarens och beslutfattarens arbete är i mångt och mycket kompetens- och erfarenhetsbaserat. Detta innebär att många arbeten görs till viss del genom att lita på den egna känslan, kompetensen och erfarenheten. Att bryta de rådande normerna där bilen står i fokus kan därför inte åstadkommas genom enbart handböcker eller liknande. Istället måste handböckernas innehåll bli basen för en förankringsprocess och kompetensutveckling (t.ex. studieresor och seminarier). Kunskapskapitalet som den enskilde beslutsfattaren eller planeraren har måste utvecklas och förändras. Planeraren måste genom sin erfarenhet och kompetens kunna se fördelarna med de skrivna regler i exempelvis bilsnålhandboken från Lunds kommun. Ligger den utanför det upplevda och det ”normala” blir det en hyllvärmare.En viktig rekommendation är därför att systematiskt arbeta med denna normförändring som krävs för en långtgående hållbarhetsutveckling i den fysiska planeringen.Att hitta dörröppnare genom exempelvis introduktionsprojekt är en annan viktig rekommendation. Att planera för ett hållbart samhälle är mycket komplext och innebär förändringar på många områden i planeringen. Att göra förändringar inom en så kallad komfortzon (eller den rådande normen för att anknyta till avsnittet ovan) är möjliga men räcker inte till för att kunna ta långtgående steg till ett energieffektivt och hållbart samhälle. Hur man rör sig ur denna zon på ett komfortabelt sätt handlar naturligtvis om kulturella förändringar som det har beskrivits ovan men även om att hitta vägar där inte allt försöks ändra på en och samma gång. Motståndet till sådana abrupta lösningar är sannolikt för stort för att verkligen kunna bära frukt. Att arbeta med instegsportar där man använder sig av introduktionsprojekt kan vara en gångbar väg. Fördelen ligger i projektens begränsning, möjligheten till att backa och allmänhetens chans att göra sig en praktisk bild av hur man tänker sig utforma transportapparaten i framtiden. Lyckas man att få en positiv opinion kan ett introduktionsprojekt bli till det goda exemplet.Introduktionsprojekten kan gärna också vara begränsade på att förbättra för enbart ett av de hållbara transportslagen. Eftersom gång, cykeltrafik och kollektivtrafik är en nära kopplade i ett hållbart transportsystem kan sådana instegsportar ge en spinn off-effekt på alla hållbara transportslag. Att det blir så kräver naturligtvis att planerarnas kompetens och erfarenhet är medveten om systemeffekten av de hållbara transportslagen.Avslutningsvis tycker vi det är relevant att ställa frågan hur man med styrmedel på regional och nationell nivå bättre skulle kunna stödja kommunernas arbete inom hållbar och energieffektiv planering? Vi tror att det behövs stöd på många områden, t ex:Ekonomiskt stöd – stödformer som LIP och KLIMP har haft stor betydelse för både mer hållbar planering och för det faktiska införandet av olika åtgärder. För närvarande finns inget motsvarande stöd vilket riskerar att bromsa upp kommunernas arbete.Kompetensstöd – vi diskuterar ovan den stora betydelsen som planerarnas kompetens har för vilken slags planering det i slutändan blir. Det finns behov av mer utbildning och kompetensutveckling inom detta område.Modell- och metodstöd – metoderna att använda som beslutsstöd för hållbar planering behöver utvecklas och spridas. Bl a exemplet från Lunds översiktsplan visar att indikatorer kan användas för att beskriva t ex ”bilsnålhet” men de behöver utvecklas och spridas ytterligare.Datatillgång och uppföljning – det finns relativt begränsat nationellt insamlad data för att beskriva olika kommuners och städers tillstånd avseende transportsystemet och hållbar markanvändning. Detta försvårar jämförelser och erfarenhetsutbyte.Lagstiftning – den nuvarande planeringslagstiftningen ger kommunerna små möjligheter att ställa krav på byggherrar och verksamhetsutövare avseende deras ansvar för transporterna till/från befintlig och tillkommande bebyggelse. Andra europeiska länders lagstiftning ger kommunerna många gånger större handlingsfrihet.
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| 27. |
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| 28. |
- Wiik, Johanna, et al.
(author)
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Maternal human papillomavirus infection during pregnancy and preterm delivery, a mother–child cohort study in Norway and Sweden
- 2023
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In: Acta Obstetricia et Gynecologica Scandinavica. - : Wiley. - 1600-0412 .- 0001-6349. ; 102:3, s. 344-354
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Journal article (peer-reviewed)abstract
- Introduction: Human papillomavirus (HPV) infection is common in women of reproductive age. Infection and inflammation are leading causes for preterm delivery (PTD), but the role of HPV infection in PTD and prelabor rupture of membranes (PROM) is unclear. We aimed to explore whether HPV infection during pregnancy in general, and high-risk-HPV (HR-HPV) infection specifically, increased the risk of PTD, preterm prelabor rupture of membranes (PPROM), PROM at term, and/or chorioamnionitis. Material and Methods: In pregnant women, who were participating in a prospective multicenter cohort study from a general population in Norway and Sweden (PreventADALL, ClinicalTrials.gov NCT02449850), HPV DNA was analyzed in available urine samples at mid-gestation (16–22 weeks) and at delivery, and in the placenta after delivery with Seegene Anyplex II HPV28 PCR assay. The risk of PTD, PPROM, PROM, and chorioamnionitis was analyzed using unadjusted and adjusted logistic regression analyses for any 28 HPV genotypes, including 12 HR-HPV genotypes, compared with HPV-negative women. Further, subgroups of HPV (low-risk/possibly HR-HPV, HR-HPV-non-16 and HR-HPV-16), persistence of HR-HPV from mid-gestation to delivery, HR-HPV-viral load, and presence of multiple HPV infections were analyzed for the obstetric outcomes. Samples for HPV analyses were available from 950 women with singleton pregnancies (mean age 32 years) at mid-gestation and in 753 also at delivery. Results: At mid-gestation, 40% of women were positive for any HPV and 24% for HR-HPV. Of the 950 included women, 23 had PTD (2.4%), nine had PPROM (0.9%), and six had chorioamnionitis (0.6%). Of the term pregnancies, 25% involved PROM. The frequency of PTD was higher in HR-HPV-positive women (8/231, 3.5%) than in HPV-negative women (13/573, 2.3%) at mid-gestation, but the association was not statistically significant (odds ratio 1.55; 95% confidence interval 0.63–3.78). Neither any HPV nor subgroups of HPV at mid-gestation or delivery, nor persistence of HR-HPV was significantly associated with increased risk for PTD, PPROM, PROM, or chorioamnionitis. No HPV DNA was detected in placentas of women with PTD, PPROM or chorioamnionitis. Conclusions: HPV infection during pregnancy was not significantly associated with increased risk for PTD, PPROM, PROM, or chorioamnionitis among women from a general population with a low incidence of adverse obstetric outcomes.
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| 29. |
- Woksepp, Hanna, et al.
(author)
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High target attainment for beta-lactam antibiotics in intensive care unit patients when actual minimum inhibitory concentrations are applied
- 2017
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In: European Journal of Clinical Microbiology and Infectious Diseases. - Heidelberg : Springer. - 0934-9723 .- 1435-4373. ; 36:3, s. 553-563
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Journal article (peer-reviewed)abstract
- Patients in the intensive care unit (ICU) are at risk for suboptimal levels of beta-lactam antibiotics, possibly leading to poor efficacy. Our aim was to investigate whether the actual minimum inhibitory concentration (MIC) compared to the more commonly used arbitrary epidemiological cut-off values (ECOFFs) would affect target attainment in ICU patients on empirical treatment with broad-spectrum beta-lactam antibiotics and to identify risk factors for not reaching target. In a prospective, multicenter study, ICU patients ae18 years old and treated with piperacillin/tazobactam, meropenem, or cefotaxime were included. Clinical and laboratory data were recorded. Serum trough antibiotic levels from three consecutive days were analyzed by liquid chromatography-mass spectrometry (LC-MS). The target was defined as the free trough concentration above the MIC (100% fT(> MIC)). MICECOFF was used as the target and, when available, the actual MIC (MICACTUAL) was applied. The median age of the patients was 70 years old, 52% (58/111) were males, and the median estimated glomerular filtration rate (eGFR) was 48.0 mL/min/1.73 m(2). The rate of patients reaching 100% fT > MICACTUAL was higher (89%, 31/35) compared to the same patients using MICECOFF (60%, p = 0.002). In total, 55% (61/111) reached 100% fT > MICECOFF. Increased renal clearance was independently associated to not reaching 100% fT > MICECOFF. On repeated sampling, > 77% of patients had stable serum drug levels around the MICECOFF. Serum concentrations of beta-lactam antibiotics vary extensively between ICU patients. The rate of patients not reaching target was markedly lower for the actual MIC than when the arbitrary MIC based on the ECOFF was used, which is important to consider in future studies.
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| 30. |
- Wärnberg Gerdin, Sabina, et al.
(author)
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Impaired skin barrier and allergic sensitization in early infancy
- 2022
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In: Allergy. European Journal of Allergy and Clinical Immunology. - : John Wiley & Sons. - 0105-4538 .- 1398-9995. ; 77:5, s. 1464-1476
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Journal article (peer-reviewed)abstract
- Background: Factors predicting allergic sensitization in the first 6 months of life are poorly understood. We aimed to determine whether eczema, dry skin, and high transepidermal water loss (TEWL) at 3 months were associated with allergic sensitization at 6 months of age and, secondarily, to establish whether these characteristics predicted sensitization from 3 to 6 months of age.Methods: At 3 months of age, 1,994 infants from the population-based PreventADALL birth cohort in Norway and Sweden were assessed for eczema and dry skin on the cheeks and/or extensors; impaired skin barrier function, defined as TEWL in the upper quartile (>9.4 g/m(2)/h), and allergen-specific IgE levels <0.1 kU(A)/L, available in 830. At 6 months, we assessed allergic sensitization to any food (egg, cow's milk, peanut, wheat, soy) or inhalant (birch, timothy grass, dog, and cat) allergen by a skin prick test wheal diameter >= 2 mm larger than negative control.Results: Any sensitization was found in 198 of the 1,994 infants (9.9%), the majority to food allergens (n = 177, 8.9%). Eczema, dry skin, and high TEWL at 3 months increased the risk of sensitization at 6 months; adjusted odds ratios 4.20 (95% CI 2.93-6.04), 2.09 (95% CI 1.51-2.90) and 3.67 (95% CI 2.58-5.22), respectively. Eczema predicted sensitization with 55.6% sensitivity and 68.1% specificity; dry skin with 65.3% sensitivity and 57.3% specificity; and high TEWL with 61.7% sensitivity and 78.1% specificity.Conclusion: Eczema, dry skin, and high TEWL at 3 months predicted allergic sensitization at 6 months of age.
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