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- Lahiri, S, et al.
(author)
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The gut microbiota influences skeletal muscle mass and function in mice
- 2019
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In: Science translational medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6242 .- 1946-6234. ; 11:502
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Journal article (peer-reviewed)abstract
- Transplanting the gut microbiota of pathogen-free mice into germ-free mice improves skeletal muscle mass and strength.
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- Ruiz, VE, et al.
(author)
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A single early-in-life macrolide course has lasting effects on murine microbial network topology and immunity
- 2017
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8:1, s. 518-
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Journal article (peer-reviewed)abstract
- Broad-spectrum antibiotics are frequently prescribed to children. Early childhood represents a dynamic period for the intestinal microbial ecosystem, which is readily shaped by environmental cues; antibiotic-induced disruption of this sensitive community may have long-lasting host consequences. Here we demonstrate that a single pulsed macrolide antibiotic treatment (PAT) course early in life is sufficient to lead to durable alterations to the murine intestinal microbiota, ileal gene expression, specific intestinal T-cell populations, and secretory IgA expression. A PAT-perturbed microbial community is necessary for host effects and sufficient to transfer delayed secretory IgA expression. Additionally, early-life antibiotic exposure has lasting and transferable effects on microbial community network topology. Our results indicate that a single early-life macrolide course can alter the microbiota and modulate host immune phenotypes that persist long after exposure has ceased.
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