| 1. |
- Bergh, Jonas, et al.
(author)
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Tailored fluorouracil, epirubicin, and cyclophosphamide compared with marrow-supported high-dose chemotherapy as adjuvant treatment for high-risk breast cancer : A randomised trial
- 2000
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In: The Lancet. - 0140-6736 .- 1474-547X. ; 356:9239, s. 1384-1391
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Journal article (peer-reviewed)abstract
- Background: Chemotherapy drug distribution varies greatly among individual patients. Therefore, we developed an individualised fluorouracil, epirubicin, cyclophosphamide (FEC) regimen to improve outcomes in patients with high-risk early breast cancer. We then did a randomised trial to compare this individually tailored FEC regimen with conventional adjuvant chemotherapy followed by consolidation with high-dose chemotherapy with stem-cell support. Methods: 525 women younger than 60 years of age with high-risk primary breast cancer were randomised after surgery to receive nine cycles of tailored FEC to haematological equitoxicity with granulocyte colony-stimulating factor (G-CSF) support (n=251), or three cycles of FEC at standard doses followed by high-dose chemotherapy with cyclophosphamide, thiotepa, and carboplatin (CTCb), and peripheral-blood stem-cell or bone-marrow support (n=274). Both groups received locoregional radiation therapy and tamoxifen for 5 years. The primary outcome measure was relapse-free survival, and analysis was by intention to treat. Findings: At a median follow-up of 34.3 months, there were 81 breast-cancer relapses in the tailored FEC group versus 113 in the CTCb group (double triangular method p=0.04). 60 deaths occurred in the tailored FEC group and 82 in the CTCb group (log-rank p=0.12). Patients in the CTCb group experienced more grade 3 or 4 acute toxicity compared with the tailored FEC group (p<0.0001). Two treatment-related deaths (0.7%) occurred in the CTCb group. Six patients in the tailored FEC group developed acute myeloid leukaemia and three developed myelodysplastic syndrome. Interpretation: Tailored FEC with G-CSF support resulted in a significantly improved relapse-free survival and fewer grade 3 and 4 toxicities compared with marrow-supported high-dose chemotherapy with CTCb as adjuvant therapy of women with high-risk primary breast cancer.
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| 2. |
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| 3. |
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| 4. |
- Blomqvist, Per, et al.
(author)
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Modelling the structural response of fibre-reinforced composites subjected to fire
- 2014
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Conference paper (peer-reviewed)abstract
- The present contribution details the development and implementation of dedicated material models for the finite element computation of the thermal and mechanical response of polymer compositestructures subjected to fire. The material models are developed so that mechanical and thermal properties at the ply level can be calculated from the constituent's properties, therefore allowing for a greater flexibility in architecture and reduced testing programs. The degradation of the resin during fire is predicted during the thermal analysis. Its effect, together with the effect of temperature, on the mechanical response is accounted for in the material model. The models are validated against a mini furnace experiment.
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| 5. |
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| 6. |
- Farnebo, Jacob, et al.
(author)
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Volumetric FDG-PET predicts overall and progression- free survival after 14 days of targeted therapy in metastatic renal cell carcinoma
- 2014
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In: BMC Cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 14, s. 408-
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Journal article (peer-reviewed)abstract
- Background: To determine whether changes in the metabolism of metastatic renal cell carcinoma (mRCC) assessed by F18-FDG-PET after 14 and 28 days of treatment with tyrosine kinase inhibitors can predict overall and progression-free patient survival. Methods: Thirty-nine consecutive patients with mRCC were included prospectively and underwent PET examinations prior to and after 14 and 28 days of standard treatment with sunitinib (n = 18), sorafenib (n = 19) or pazopanib (n = 2). The PET response was analyzed in terms of SUVmax, SULpeak, and total lesion glycolysis and a positive response (defined as a 30% reduction) compared to overall and progression-free survival. Results: Thirty-five patients with at least one metabolically active metastatic lesion prior to treatment underwent additional FDG-PET examinations after 14 (n = 32) and/or 28 days (n = 30) of treatment. Changes in either SULpeak or total lesion glycolysis were correlated to both progression-free and overall survival (for TLG2.5 responders, HR = 0.38 (95% CI: 0.18-0.83) and 0.22 (95% CI: 0.09-0.53), and for TLG50 responders, HR = 0.25 (0.10-0.62) and 0.25 (95% CI: 0.11-0.57) and for SULpeak responders, HR = 0.39 (95% CI: 0.17-0.91) and 0.38 (95% CI: 0.15-0.93), respectively). In contrast SUVmax response did not predict progression-free or overall survival (HR = 0.43 (95% CI: 0.18-1.01) and 0.50 (95% CI: 0.21-1.19), respectively). Conclusions: Assessment of early changes in SULpeak and total lesion glycolysis undergoing treatment with tyrosine kinase inhibitors by FDG-PET can possibly predict progression-free and overall survival in patients with mRCC.
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| 7. |
- Luoma, M. L., et al.
(author)
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Physical performance, toxicity, and quality of life as assessed by the physician and the patient
- 2002
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In: Acta Oncol. - 0284-186X .- 1651-226X. ; 41:1, s. 44-9
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Journal article (peer-reviewed)abstract
- The aim of this study was to study the relationship between physician-assessed quality of life parameters, i.e., toxicity and physical performance, and patients' self-reports of their quality of life (QoL). QoL was assessed at baseline and before each treatment, using the EORTC QLQ-C30. The WHO performance score (PS) and toxicity were assessed in physician interviews. The correlations between the WHO PS and the QLQ-C30 functioning scale scores varied from weak to moderate, depending on the scale. Strongest associations were found in physical-, social-, and role functioning, and in the global QoL. The QLQ-C30 nausea/vomiting and diarrhea scales correlated moderately to corresponding WHO scores. A multiple linear regression analysis was used to analyze the contribution of WHO PS and toxicity variables to the global QoL. The best model explained only 16% of the variance of the global QoL score. The present findings highlight the importance of independent QoL assessments focused on those aspects of QoL not captured in clinical interviews with the physician.
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| 8. |
- Luoma, ML, et al.
(author)
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Prognostic value of quality of life scores for time to progression (TTP) and overall survival time (OS) in advanced breast cancer
- 2003
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In: European Journal of Cancer. - 1879-0852 .- 0959-8049. ; 39:10, s. 1370-1376
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Journal article (peer-reviewed)abstract
- The purpose of the study was to investigate whether baseline quality of life (QoL) and changes in QoL scores from baseline are prognostic for time to progression (TTP) and/or overall survival (OS) in patients with advanced breast cancer receiving docetaxel (T) or sequential methotrexate and 5-fluorouracil (MF). QoL was assessed at baseline and before each treatment using the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ-C30). Survival curves and probabilities were estimated using the Kaplan-Meier technique. The Cox proportional hazards regression model was used for both the univariate and multivariate analyses to explore relationships between baseline QoL variables and TTP, as well as OS. In the univariate analysis, more severe pain and fatigue at baseline were predictive for a shorter OS; global QoL, physical functioning and appetite loss had a borderline significance (P=0.0130 for global QoL; P=0.0256 for physical functioning: P=0.0149 for appetite loss). World Health Organization (WHO) performance status was significantly predictive for OS. In the multivariate analysis, more severe pain at baseline was predictive for a shorter OS. In contrast, baseline QoL had no prognostic value for the duration of TTP. QoL change scores from baseline QoL predicted neither OS nor TTP. Our findings suggest that while QoL measurements are important in evaluating patients' QoL, they have no great importance in predicting primary clinical endpoints such as TTP or OS in advanced breast cancer patients. (C) 2002 Elsevier Science Ltd. All rights reserved.
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| 9. |
- McNamee, Margaret, et al.
(author)
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Challenges and opportunities for reuse of products and materials with fire safety requirements – A Swedish perspective
- 2023
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In: Fire safety journal. - : Elsevier Ltd. - 0379-7112 .- 1873-7226. ; 140
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Journal article (peer-reviewed)abstract
- The construction sector is of great importance to the Swedish economy, but its impact on the climate is significant and the sector accounts for about 40% of Sweden's total energy consumption. The sector also generates a significant share of the total material flows and waste quantities in the society. Thus, due to the large impact of the construction sector, there are great opportunities to contribute positively by reducing the climate impact through change and modernization. There are many activities focused on reducing construction waste in various ways and the issue of material and product reuse has received increasing attention in recent years. However, very little work has focused on products associated with fire safety requirements. This paper provides an overview of research on the reuse of materials and products with a focus on products with fire safety requirements. In addition, it provides a review of the Swedish building legislation and its impact on the possibility of reusing materials and products with fire safety requirements. Finally, possible paths are explored for introducing more large-scale reuse of such materials and products. © 2023 The Authors
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| 10. |
- Shu, Xiang, et al.
(author)
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Associations of obesity and circulating insulin and glucose with breast cancer risk : a Mendelian randomization analysis
- 2019
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In: International Journal of Epidemiology. - : OXFORD UNIV PRESS. - 0300-5771 .- 1464-3685. ; 48:3, s. 795-806
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Journal article (peer-reviewed)abstract
- Background: In addition to the established association between general obesity and breast cancer risk, central obesity and circulating fasting insulin and glucose have been linked to the development of this common malignancy. Findings from previous studies, however, have been inconsistent, and the nature of the associations is unclear. Methods: We conducted Mendelian randomization analyses to evaluate the association of breast cancer risk, using genetic instruments, with fasting insulin, fasting glucose, 2-h glucose, body mass index (BMI) and BMI-adjusted waist-hip-ratio (WHRadj BMI). We first confirmed the association of these instruments with type 2 diabetes risk in a large diabetes genome-wide association study consortium. We then investigated their associations with breast cancer risk using individual-level data obtained from 98 842 cases and 83 464 controls of European descent in the Breast Cancer Association Consortium. Results: All sets of instruments were associated with risk of type 2 diabetes. Associations with breast cancer risk were found for genetically predicted fasting insulin [odds ratio (OR) = 1.71 per standard deviation (SD) increase, 95% confidence interval (CI) = 1.26-2.31, p = 5.09 x 10(-4)], 2-h glucose (OR = 1.80 per SD increase, 95% CI = 1.3 0-2.49, p = 4.02 x 10(-4)), BMI (OR = 0.70 per 5-unit increase, 95% CI = 0.65-0.76, p = 5.05 x 10(-19)) and WHRadj BMI (OR = 0.85, 95% CI = 0.79-0.91, p = 9.22 x 10(-6)). Stratified analyses showed that genetically predicted fasting insulin was more closely related to risk of estrogen-receptor [ER]-positive cancer, whereas the associations with instruments of 2h glucose, BMI and WHRadj BMI were consistent regardless of age, menopausal status, estrogen receptor status and family history of breast cancer. Conclusions: We confirmed the previously reported inverse association of genetically predicted BMI with breast cancer risk, and showed a positive association of genetically predicted fasting insulin and 2-h glucose and an inverse association of WHRadj BMI with breast cancer risk. Our study suggests that genetically determined obesity and glucose/insulin-related traits have an important role in the aetiology of breast cancer.
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| 11. |
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| 12. |
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| 13. |
- Wennstig, Anna-Karin, et al.
(author)
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Inter-observer variation in delineating the coronary arteries as organs at risk
- 2017
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In: Radiotherapy and Oncology. - : ELSEVIER IRELAND LTD. - 0167-8140 .- 1879-0887. ; 122:1, s. 72-78
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Journal article (peer-reviewed)abstract
- Purpose: To determine the inter-observer variation in delineating the coronary arteries as organs at risk (OAR) in breast cancer (BC) radiotherapy (RT) and how this variation affects the estimated coronary artery radiation dose.Method: Delineation of the left main and the left anterior descending coronary artery (LMCA and LAD), and the right coronary artery (RCA), by using the heart atlas by Feng et al., was performed by three radiation oncologists in 32 women who had received adjuvant RT for BC. Centres of the arteries were calculated and distances between artery centres were measured and the artery radiation doses were estimated. The intraclass correlation coefficient (ICC) was used to quantify the variability in doses.Results: Along the extent of RCA, the median distance between centres of arteries varied from 2 to 9 mm with similar patterns over pairs of oncologists. For the LMCA-LAD the median distance varied from 1 to 4 mm. The estimated maximum radiation doses showed an ICC variation from 0.82 to 0.97.Conclusion: The coronary arteries can be reliably identified and delineated as OARs in BC RT. The spatial variance is limited and the total variation in radiation dose is almost completely determined by the between patient variation.
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| 14. |
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| 15. |
- Abe, O, et al.
(author)
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Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials
- 2005
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In: The Lancet. - 1474-547X. ; 365:9472, s. 1687-1717
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Journal article (peer-reviewed)abstract
- Background Quinquennial overviews (1985-2000) of the randomised trials in early breast cancer have assessed the 5-year and 10-year effects of various systemic adjuvant therapies on breast cancer recurrence and survival. Here, we report the 10-year and 15-year effects. Methods Collaborative meta-analyses were undertaken of 194 unconfounded randomised trials of adjuvant chemotherapy or hormonal therapy that began by 1995. Many trials involved CMF (cyclophosphamide, methotrexate, fluorouracil), anthracycline-based combinations such as FAC (fluorouracil, doxombicin, cyclophosphamide) or FEC (fluorouracil, epirubicin, cyclophosphamide), tamoxifen, or ovarian suppression: none involved taxanes, trastuzumab, raloxifene, or modem aromatase inhibitors. Findings Allocation to about 6 months of anthracycline-based polychemotherapy (eg, with FAC or FEC) reduces the annual breast cancer death rate by about 38% (SE 5) for women younger than 50 years of age when diagnosed and by about 20% (SE 4) for those of age 50-69 years when diagnosed, largely irrespective of the use of tamoxifen and of oestrogen receptor (ER) status, nodal status, or other tumour characteristics. Such regimens are significantly (2p=0 . 0001 for recurrence, 2p<0 . 00001 for breast cancer mortality) more effective than CMF chemotherapy. Few women of age 70 years or older entered these chemotherapy trials. For ER-positive disease only, allocation to about 5 years of adjuvant tamoxifen reduces the annual breast cancer death rate by 31% (SE 3), largely irrespective of the use of chemotherapy and of age (<50, 50-69, &GE; 70 years), progesterone receptor status, or other tumour characteristics. 5 years is significantly (2p<0 . 00001 for recurrence, 2p=0 . 01 for breast cancer mortality) more effective than just 1-2 years of tamoxifen. For ER-positive tumours, the annual breast cancer mortality rates are similar during years 0-4 and 5-14, as are the proportional reductions in them by 5 years of tamoxifen, so the cumulative reduction in mortality is more than twice as big at 15 years as at 5 years after diagnosis. These results combine six meta-analyses: anthracycline-based versus no chemotherapy (8000 women); CMF-based versus no chemotherapy (14 000); anthracycline-based versus CMF-based chemotherapy (14 000); about 5 years of tamoxifen versus none (15 000); about 1-2 years of tamoxifen versus none (33 000); and about 5 years versus 1-2 years of tamoxifen (18 000). Finally, allocation to ovarian ablation or suppression (8000 women) also significantly reduces breast cancer mortality, but appears to do so only in the absence of other systemic treatments. For middle-aged women with ER-positive disease (the commonest type of breast cancer), the breast cancer mortality rate throughout the next 15 years would be approximately halved by 6 months of anthracycline-based chemotherapy (with a combination such as FAC or FEC) followed by 5 years of adjuvant tamoxifen. For, if mortality reductions of 38% (age <50 years) and 20% (age 50-69 years) from such chemotherapy were followed by a further reduction of 31% from tamoxifen in the risks that remain, the final mortality reductions would be 57% and 45%, respectively (and, the trial results could well have been somewhat stronger if there had been full compliance with the allocated treatments). Overall survival would be comparably improved, since these treatments have relatively small effects on mortality from the aggregate of all other causes. Interpretation Some of the widely practicable adjuvant drug treatments that were being tested in the 1980s, which substantially reduced 5-year recurrence rates (but had somewhat less effect on 5-year mortality rates), also substantially reduce 15-year mortality rates. Further improvements in long-term survival could well be available from newer drugs, or better use of older drugs.
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| 16. |
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| 17. |
- Ahearn, Thomas U., et al.
(author)
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Common variants in breast cancer risk loci predispose to distinct tumor subtypes
- 2022
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In: Breast Cancer Research. - : Springer Nature. - 1465-5411 .- 1465-542X. ; 24:1
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Journal article (peer-reviewed)abstract
- BackgroundGenome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) status, but how these variants relate with other tumor features and intrinsic molecular subtypes is unclear.MethodsAmong 106,571 invasive breast cancer cases and 95,762 controls of European ancestry with data on 173 breast cancer variants identified in previous GWAS, we used novel two-stage polytomous logistic regression models to evaluate variants in relation to multiple tumor features (ER, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and grade) adjusting for each other, and to intrinsic-like subtypes.ResultsEighty-five of 173 variants were associated with at least one tumor feature (false discovery rate < 5%), most commonly ER and grade, followed by PR and HER2. Models for intrinsic-like subtypes found nearly all of these variants (83 of 85) associated at p < 0.05 with risk for at least one luminal-like subtype, and approximately half (41 of 85) of the variants were associated with risk of at least one non-luminal subtype, including 32 variants associated with triple-negative (TN) disease. Ten variants were associated with risk of all subtypes in different magnitude. Five variants were associated with risk of luminal A-like and TN subtypes in opposite directions.ConclusionThis report demonstrates a high level of complexity in the etiology heterogeneity of breast cancer susceptibility variants and can inform investigations of subtype-specific risk prediction.
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| 18. |
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| 19. |
- Amon, Francine, et al.
(author)
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Challenges to transparency involving intellectual property and privacy concerns in life cycle assessment/costing : A case study of new flame retarded polymers
- 2021
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In: Cleaner Environmental Systems. - : Elsevier BV. - 2666-7894. ; 3
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Journal article (peer-reviewed)abstract
- This work explores the challenges of using life cycle assessment (LCA) and life cycle cost (LCC) analysis to provide easily accessible decision support for early product development in cases where intellectual property (IP) and privacy issues require special consideration. Innovation research projects with partners representing different links along the value chain are potential examples of such cases. A case study in which spreadsheet-based cradle to compounder's gate LCA and LCC screening tools were created for candidate flame retarded polymer formulations exemplifies the need for better solutions to overcome problems associated with lack of transparency due to IP/privacy concerns. These problems affect data quality, scaling up processes, and uncertainty of the results. The consortium in this case study had a common overall goal, although each of the partners had a unique perspective on the polymer development process and different IP/privacy needs. The measures used to overcome the challenges include aggregation, normalisation, and omission of costs and impacts common to all candidate compounds. The resulting LCA and LCC screening tools represent a compromise between providing the requested information at the level of detail required by the partners and reporting results that are as accurate and useful as possible. The findings are: in cases where absolute secrecy must be maintained, no one can learn which materials and processes provide the optimal results; appointing a trusted third party to handle sensitive inventory data can cause increased uncertainty of the results due to lack of peer review; the results of the work cannot be built upon by subsequent research.
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| 20. |
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| 21. |
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| 22. |
- Andersson, Berit, et al.
(author)
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Experimental study of thermal breakdown products from halogenated extinguishing agents
- 2011
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In: Fire Safety Journal. - : Elsevier BV. - 0379-7112. ; 46:3, s. 104-115
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Journal article (peer-reviewed)abstract
- Thermal breakdown products from four different fire extinguishing agents have been analysed. The agents studied were: bromotrifluoromethane (Halon 1301), pentafluoroethane (HFC 125), heptafluoropropane (HFC 227ea) and dodecafluoro-2-methyl-pentane-3-one (C6F-ketone). In the tests, the studied agent was introduced into a propane flame in a diffusion flame burner. The combustion products were analysed using both conventional IR-techniques and FTIR. It could be concluded that for all four extinguishing agents that the extinguishing agent takes part in the combustion process resulting in production of CO and CO2, which was also confirmed by the increase in smoke production with increasing amounts of agent introduced into the flame. Production of HF and COF2 was found in experiments with all four extinguishing agents. In experiments with Halon 1301, the production of HBr was also determined. It was found that the main fraction of fluorine ends up as HF for HFC 227ea and HFC 125 at lower relative application rates. When approaching extinguishing concentrations, the fraction recovered as COF2 increases, but the total recovery of fluorine, including HF and the remaining part of the fluorine, is found in various organic breakdown products. The recovery of fluorine as HF and COF2 for the C6F-ketone is lower compared to HFC 227ea and HFC 125. There is a clear difference in the recovery of fluorine for Halon 1301 where an almost quantitative recovery as HF or COF2 is found. Halon 1301 additionally contains bromine, which, to a large extent, is recovered as HBr.
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| 23. |
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| 24. |
- Andersson, Berit, et al.
(author)
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Thermal breakdown of extinguishing agents
- 2008
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Reports (other academic/artistic)abstract
- Four fire extinguishing agents has been investigated, bromotrifluoromethane, Halon 1301, pentafluoroethane, HFC 125, heptafluoropropane, HFC 227ea and dodecafluoro-2- methylpentane-3-one, C6F-ketone. The inerting concentrations were determined in a cubic pressure vessel with a volume of 8 litres. A cup burner was used to find the flameextinguishing concentrations for the agents. Thermal breakdown was also studied and for this purpose the studied agent was introduced into a flame of propane in a tubular burner. The produced combustion products were analysed both with conventional IR-techniques and with FTIR. It was found that HF and COF2 were produced from all studied agents. Models and theories on the mechanisms of the breakdown processes are presented.
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| 33. |
- Andersson, Petra, et al.
(author)
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Investigation of fire emissions from Li-ion batteries
- 2013
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Reports (other academic/artistic)abstract
- This report presents an investigation on gases emitted during Lithium-ion battery fires. Details of the calibration of an FTIR instrument to measure HF, POF3 and PF5 gases are provided as background to the minimum detection limits for each species. The use of FTIR in tests has been verified by repeating experiments reported in the literature. The study reports on gases emitted both after evaporation and after ignition of the electrolyte fumes. Tests were conducted where electrolyte is injected into a propane flame and the influence of the addition of water is studied. Finally three types of battery cells were burnt and emission of fluorine and/or phosphorous containing species quantified.
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| 34. |
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| 35. |
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| 36. |
- Andersson, Petra, et al.
(author)
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Using Fourier transform infrared spectroscopy to determine toxic gases in fires with lithium-ion batteries
- 2016
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In: Fire and Materials. - : Wiley. - 0308-0501 .- 1099-1018. ; 40:8, s. 999-1015
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Journal article (peer-reviewed)abstract
- Batteries, in particular lithium-ion (Li-ion) batteries, are seen as an alternative to fossil fuels in the automotive sector. Li-ion batteries, however, have some safety issues including possible emissions of toxic fluorine-containing compounds during fire and other abuse situations. This paper demonstrates the possibilities to use the Fourier transform infrared technique to assess some of the most important compounds, including hydrogen fluoride and the far less often measured POF3 and PF5. The study is conducted in the cone calorimeter with different solvents used in Li-ion batteries. The measurements show that, in addition to hydrogen fluoride, with a known high toxicity, POF3 is emitted and can be quantified using Fourier transform infrared.
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| 37. |
- Araujo, Carlos Moyses, et al.
(author)
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Disorder-induced Room Temperature Ferromagnetism in Glassy Chromites
- 2014
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 4, s. 4686-
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Journal article (peer-reviewed)abstract
- We report an unusual robust ferromagnetic order above room temperature upon amorphization of perovskite [YCrO3] in pulsed laser deposited thin films. This is contrary to the usual expected formation of a spin glass magnetic state in the resulting disordered structure. To understand the underlying physics of this phenomenon, we combine advanced spectroscopic techniques and first-principles calculations. We find that the observed order-disorder transformation is accompanied by an insulator-metal transition arising from a wide distribution of Cr-O-Cr bond angles and the consequent metallization through free carriers. Similar results also found in YbCrO3-films suggest that the observed phenomenon is more general and should, in principle, apply to a wider range of oxide systems. The ability to tailor ferromagnetic order above room temperature in oxide materials opens up many possibilities for novel technological applications of this counter intuitive effect.
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| 38. |
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| 39. |
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| 40. |
- Bahadoer, Renu R., et al.
(author)
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Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO) : a randomised, open-label, phase 3 trial
- 2021
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In: The Lancet Oncology. - : Elsevier. - 1470-2045 .- 1474-5488. ; 22:1, s. 29-42
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Journal article (peer-reviewed)abstract
- Background Systemic relapses remain a major problem in locally advanced rectal cancer. Using short-course radiotherapy followed by chemotherapy and delayed surgery, the Rectal cancer And Preoperative Induction therapy followed by Dedicated Operation (RAPIDO) trial aimed to reduce distant metastases without compromising locoregional control. Methods In this multicentre, open-label, randomised, controlled, phase 3 trial, participants were recruited from 54 centres in the Netherlands, Sweden, Spain, Slovenia, Denmark, Norway, and the USA. Patients were eligible if they were aged 18 years or older, with an Eastern Cooperative Oncology Group (ECOG) performance status of 0-1, had a biopsy-proven, newly diagnosed, primary, locally advanced rectal adenocardnoma, which was classified as high risk on pelvic MRI (with at least one of the following criteria: clinical tumour [cT] stage cT4a or cT4b, extramural vascular invasion, clinical nodal [cN] stage cN2, involved mesorectal fascia, or enlarged lateral lymph nodes), were mentally and physically fit for chemotherapy, and could be assessed for staging within S weeks before randomisation. Eligible participants were randomly assigned (1:1), using a management system with a randomly varying block design (each block size randomly chosen to contain two to four allocations), stratified by centre, ECOG performance status, cT stage, and cN stage, to either the experimental or standard of care group. All investigators remained masked for the primary endpoint until a prespecified number of events was reached. Patients allocated to the experimental treatment group received short-course radiotherapy (5 x 5 Gy over a maximum of 8 days) followed by six cycles of CAPDX chemotherapy (capecitabine 1000 mg/m(2) orally twice daily on days 1-14, oxaliplatin 130 mg/m(2) intravenously on day 1, and a chemotherapy-free interval between days 15-21) or nine cycles of FOLFOX4 (oxaliplatin 85 mg/m(2) intravenously on day 1, leucovorin [folinic acid] 200 mg/m 2 intravenously on days 1 and 2, followed by bolus fluorouracil 400 mg/m(2) intravenously and fluorouracil 600 mg/m 2 intravenously for 22 h on days 1 and 2, and a chemotherapy-free interval between days 3-14) followed by total mesorectal excision. Choice of CAPDX or FOLFOX4 was per physician discretion or hospital policy. Patients allocated to the standard of care group received 28 daily fractions of 1.8 Gy up to 50.4 Gy or 25 fractions of 2.0 Gy up to 50.0 Gy (per physician discretion or hospital policy), with concomitant twice-daily oral capecitabine 825 mg/m(2) followed by total mesorectal excision and, if stipulated by hospital policy, adjuvant chemotherapy with eight cycles of CAPDX or 12 cycles of FOLFOX4. The primary endpoint was 3-year disease-related treatment failure, defined as the first occurrence of locoregional failure, distant metastasis, new primary colorectal tumour, or treatment-related death, assessed in the intention-to-treat population. Safety was assessed by intention to treat. This study is registered with the EudraCT, 2010-023957-12, and ClinicalTrials.gov , NCT01558921, and is now complete. Findings Between June 21,2011, and June 2,2016,920 patients were enrolled and randomly assigned to a treatment, of whom 912 were eligible (462 in the experimental group; 450 in the standard of care group). Median follow-up was 4.6 years (IQR 3.5-5.5). At 3 years after randomisation, the cumulative probability of disease-related treatment failure was 23.7% (95% CI 19.8-27.6) in the experimental group versus 30.4% (26.1-34.6) in the standard of care group (hazard ratio 0.75, 95% CI 0.60-0-95; p=0-019). The most common grade 3 or higher adverse event during preoperative therapy in both groups was diarrhoea (81 [18%] of 460 patients in the experimental group and 41 [9%] of 441 in the standard of care group) and neurological toxicity during adjuvant chemotherapy in the standard of care group (16 [9%] of 187 patients). Serious adverse events occurred in 177 (38%) of 460 participants in the experimental group and, in the standard of care group, in 87 (34%) of 254 patients without adjuvant chemotherapy and in 64 (34%) of 187 with adjuvant chemotherapy. Treatment-related deaths occurred in four participants in the experimental group (one cardiac arrest, one pulmonary embolism, two infectious complications) and in four participants in the standard of care group (one pulmonary embolism, one neutropenic sepsis, one aspiration, one suicide due to severe depression). Interpretation The observed decreased probability of disease-related treatment failure in the experimental group is probably indicative of the increased efficacy of preoperative chemotherapy as opposed to adjuvant chemotherapy in this setting. Therefore, the experimental treatment can be considered as a new standard of care in high-risk locally advanced rectal cancer.
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| 41. |
- Blomqvist, Claes, 1945-
(author)
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Distribution of Ventilation Air and Heat by Buoyancy Forces inside Buildings : An Experimental Study
- 2009
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Doctoral thesis (other academic/artistic)abstract
- The main task of the ventilation system in a building is to maintain the air quality and (together with the heating or cooling system) the thermal climate at an acceptable level within the building. This means that a sufficient amount of ventilation air at the appropriate temperature and quality must be supplied to satisfy thermal comfort and air quality demands and that this air is distributed to the parts of the building where people reside. Air movements caused by buoyancy forces can determine the distribution of ventilation air within buildings. The purpose of this thesis is to advance the state of knowledge of buoyancydriven air movements within buildings and to determine their importance both for ventilation air distribution and the maintenance of thermal comfort and air quality in buildings. The work is focused on studying thermally-driven air movements through large openings, both horizontal and vertical (i.e. doorways). The properties of a special type of thermally-driven currents, so called gravity currents, have also been explored. Large vertical openings like doorways are important for air exchange between rooms within a building. Air movements through doorways separating rooms with different air temperatures are often bidirectional and the buoyancy-driven flow rates are often greater than those caused by the mechanical ventilation system alone. Bidirectional flows through doorways can effectively spread contaminants, for example, from a kitchen or a hospital rooms, yet the results of this study indicate that the conversion of a thermally-driven bidirectional flow to a unidirectional flow via an increase of the mechanically forced flow rate requires forced flows that are more than three times greater than the thermally-driven flows. Experiments conducted in this project indicate that the resistance to buoyancy-driven flows in horizontal openings is significantly greater than that in vertical openings. Model tests have shown, however, that this problem may be mitigated if a simple model of a staircase located in the centre of the room (being ventilated) is linked to the horizontal ventilation opening. Gravity currents in rooms occur in connection with so called displacement ventilation as cool gravity currents propagate along the floor that are driven by the density difference of the ventilation air and the ambient, warmer air within the room. As these gravity currents easily pass obstacles and to a certain extent are self-controlling, they can effectively distribute the cool air within rooms in a building. Likewise, warm gravity currents occur when warmer air introduced in a room rises and spreads along the ceiling plane. One application where warm gravity currents may be used to advantage is when converting buildings from electric heating to district hot water heating thus, avoiding the introduction of an expensive hydronic heating system. This report includes a full-scale laboratory study of the basic properties of thermally-driven warm air gravity currents in a residential building and examines the possibilities of using the resulting air movements for the distribution of ventilation air as well as heat. Results from laboratory tests show that this conversion method may prove effective if certain conditions on the layout of the building are fulfilled.
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| 42. |
- Blomqvist, Else-Gun, et al.
(author)
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Intervju med Ingrid Gunter, f.d. bibliotekarie vid Jonsereds bibliotek
- 1976
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Other publication (pop. science, debate, etc.)abstract
- Interview with Ingrid Gunter, born in 1920. She was a public librarian in Jonsered. The interview was conducted by Else-Gun Blomqvist, Per Dessborn, Margareta Ekström, Anna-Lena Holm, Britt Håkansson and Charlotte Åslin, students of the Swedish School of Library and Information Science in Borås, in 1976.
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| 43. |
- Blomqvist, Göran, et al.
(author)
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ROAD SURFACE WETNESS AS AFFECTED BY EVAPORATION, SURFACE RUNOFF AND TRAFFIC SPLASHING
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Other publication (other academic/artistic)abstract
- Road surface wetness governs the fate of pollutants on the road surface. The wetness is also important for estimating the risk of ice formation during winters. The road surface water is affected by evaporation, run-off and traffic induced splash and spray. Increased knowledge of how these processes govern the road surface water and how they could be modelled would help to improve the possibility to abate problems with raised levels of air pollutants, as well as traffic safety issues by facilitating optimization of the use of anti- and de-icing chemicals. The aim of this study was to use a modeling tool in order to differentiate between three processes governing the loss of wetness from the road surface within a cross section of a road during two different climatic scenes (winter and spring). Two new measurement techniques were used for detailed measurements of road surface wetness across a road to validate the model. It could be concluded that the changes in wetness on the road can be simulated from general simple weather and traffic information. Furthermore, the wetness across the road is very heterogeneous and can be described by a distribution of regulating parameter values. The presented model application has a potential for real time application on roads and within a region and also for predictions of future conditions by using weather forecast data.
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| 44. |
- Blomqvist, Göran, et al.
(author)
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Road surface wetness as affected by evaporation, surface runoff and traffic splashing
- 2012
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Other publication (other academic/artistic)abstract
- Road surface wetness governs the fate of pollutants on the road surface. The wetness is also important for estimating the risk of ice formation during winters. The road surface water is affected by evaporation, run-off and traffic induced splash and spray. Increased knowledge of how these processes govern the road surface water and how they could be modelled would help to improve the possibility to abate problems with raised levels of air pollutants, as well as traffic safety issues by facilitating optimization of the use of anti- and de-icing chemicals. The aim of this study was to use a modeling tool in order to differentiate between three processes governing the loss of wetness from the road surface within a cross section of a road during two different climatic scenes (winter and spring). Two new measurement techniques were used for detailed measurements of road surface wetness across a road to validate the model. It could be concluded that the changes in wetness on the road can be simulated from general simple weather and traffic information. Furthermore, the wetness across the road is very heterogeneous and can be described by a distribution of regulating parameter values. The presented model application has a potential for real time application on roads and within a region and also for predictions of future conditions by using weather forecast data.
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| 45. |
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| 46. |
- Blomqvist, J E, et al.
(author)
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Importance of bone graft quality for implant integration after maxillary sinus reconstruction
- 1998
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In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology. - 1079-2104. ; 86:3, s. 268-274
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Journal article (peer-reviewed)abstract
- OBJECTIVE: The aim of this study was to determine whether bone quality, as assessed by osteometry and histologic parameters, can be used to predict implant integration in conjunction with maxillary sinus reconstruction. STUDY DESIGN: Twelve patients with severely atrophied maxillary alveolar processes were treated through use of a two-stage surgical reconstructive strategy with implant placement 4 months after bone grafting. Bone biopsy specimens taken from the iliac crest peroperatively and from the sinus inlay sites 1, 2, 4, 6, or 12 months postoperatively were analyzed by light microscopy and osteomorphometry. Bone mineral content was measured by osteometry. RESULTS: Osteometric and osteomorphometric data (trabecular bone volume [%], assessment of chromatin staining, and an osteocyte index) registered for the biopsy specimens were not statistically correlated with implant failure. CONCLUSIONS: Prognostic evaluation of implant survival is difficult. The tested methods did not contribute to the improvement of guidelines for the clinical handling of these patients.
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| 47. |
- Blomqvist, Karin, et al.
(author)
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Det strålande Athen
- 2008
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In: Förbistringar och förklaringar : festskrift till Anders Piltz. - 9789187976292 ; , s. 123-131
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Book chapter (other academic/artistic)
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| 48. |
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| 49. |
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| 50. |
- Blomqvist, Per, et al.
(author)
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A study of fire performance of textile membranes used as building components
- 2012
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In: Fire and Materials. - : Wiley. - 0308-0501 .- 1099-1018. ; 36:8, s. 648-660
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Journal article (peer-reviewed)abstract
- The advantages of textile materials as building components include low weight, and in the case of textile membranes, the advantages include translucency and architectural possibilities. A common disadvantage, however, is the fire property of textile materials, which highlights the importance of fire safety assessments for building application of such materials. The work presented in this paper was conducted within the European project contex-T, 'Textile Architecture - Textile Structures and Buildings of the Future'. This paper presents the results of reaction-to-fire tests required for European Standard (EN) 13501-1 classification conducted with a number of textile membranes. The classification results are compared for a selection of these membranes with the information gained from a large-scale reference test that was designed within the project. The reference test was based on the International Organization for Standardization (ISO) 9705 room test. It was seen that the reference test could separate the performance of the different types of membranes investigated and the repeatability of duplicate tests performed was acceptable. However, the classification of the materials by test results from the Single Burning Item (SBI) test (EN 13823) and the small flame test (EN ISO 11925-2) did not reflect the performance of the membranes in the large-scale test properly in all aspects important for fire safety. Most significantly, the 'burn-through' and the associated opening of a hole in the polyvinyl chloride/polyester membranes tested ventilated the hot smoke gases out of the reference room that resulted in limited flame spread and heat production. This mechanism is not modelled correctly by the SBI test, which leads to a discrepancy between classification and large-scale behaviour.
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