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- Cervin, Anton, et al.
(author)
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Scheduling of Event-Triggered Controllers on a Shared Network
- 2008
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Conference paper (peer-reviewed)abstract
- We consider a system where a number of independent, time-triggered or event-triggered control loops are closed over a shared communication network. Each plant is described by a first-order linear stochastic system. In the event-triggered case, a sensor at each plant frequently samples the output but attempts to communicate only when the magnitude of the output is above a threshold. Once access to the network has been gained, the network is busy for T seconds (corresponding to the communication delay from sensor to actuator), after which the control action is applied to the plant. Using numerical methods, we compute the minimum-variance control performance under various common MAC-protocols, including TDMA, FDMA, and CSMA (with random, dynamic-priority, or static-priority access). The results show that event-triggered control under CSMA gives the best performance throughout.
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| 3. |
- Rodrigues, A G, et al.
(author)
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Is the lack of concurrence of bacterial vaginosis and vaginal candidosis explained by the presence of bacterial amines?
- 1999
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In: American Journal of Obstetrics and Gynecology. - 1097-6868. ; 181:2, s. 367-370
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Journal article (peer-reviewed)abstract
- OBJECTIVE AND STUDY DESIGN: We report for the first time an inhibitory effect on cell division and germ tube formation by Candida albicans and strains of other Candida species by putrescine and cadaverine. RESULTS: Both bacterial amines showed a dose-dependent inhibition of germ tube formation by C albicans, as well as budding (inhibition of cell division) of strains of other Candida species (ie, C glabrata, C krusei, and C tropicalis). CONCLUSIONS: We hypothesize that the presence of these and possibly other bacterial amines produced by anaerobes in the vaginal flora and seen in bacterial vaginosis, as in the healthy gut, may explain why candidosis is rarely seen in these instances.
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| 4. |
- Singh, Sanjay Kumar, et al.
(author)
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Development and evaluation of solid lipid nanoparticles of raloxifene hydrochloride for enhanced bioavailability
- 2013
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In: BioMed Research International. - : Hindawi Limited. - 2314-6133 .- 2314-6141. ; 2013
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Journal article (peer-reviewed)abstract
- Raloxifene hydrochloride (RL-HCL) is an orally selective estrogen receptor modulator (SERM) with poor bioavailability of nearly 2% due to its poor aqueous solubility and extensive first pass metabolism. In order to improve the oral bioavailability of raloxifene, raloxifene loaded solid lipid nanoparticles (SLN) have been developed using Compritol 888 ATO as lipid carrier and Pluronic F68 as surfactant. Raloxifene loaded SLN were prepared by solvent emulsification/evaporation method, and different concentrations of surfactant, and homogenization speed were taken as process variables for optimization. SLN were characterized for particle size, zeta potential, entrapment efficiency, surface morphology, and crystallinity of lipid and drug. In vitro drug release studies were performed in phosphate buffer of pH 6.8 using dialysis bag diffusion technique. Particle sizes of all the formulations were in the range of 250 to 1406 nm, and the entrapment efficiency ranges from 55 to 66%. FTIR and DSC studies indicated no interaction between drug and lipid, and the XRD spectrum showed that RL-HCL is in amorphous form in the formulation. In vitro release profiles were biphasic in nature and followed Higuchi model of release kinetics. Pharmacokinetics of raloxifene loaded solid lipid nanoparticles after oral administration to Wistar rats was studied. Bioavailability of RL-HCL loaded SLN was nearly five times than that of pure RL-HCL
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