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1.	Thomas, HS, et al. (author) 2019 swepub:Mat__t
2.	Bhangu, A, et al. (author) Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study 2018 In: The Lancet. Infectious diseases. - : Elsevier. - 1474-4457 .- 1473-3099. ; 18:5, s. 516-525 Journal article (peer-reviewed)
3.	Yusuf, D, et al. (author) The transcription factor encyclopedia 2012 In: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906. ; 13:3, s. R24- Journal article (peer-reviewed)
4.	Sigvardsson, Mikael, et al. (author) Early B-Cell Factor, E2A, and Pax-5 Cooperate To Activate the Early B Cell-Specific mb-1 Promoter. 2002 In: Molecular and Cellular Biology. - 0270-7306. ; 22:24, s. 8539-8551 Journal article (peer-reviewed)abstract Previous studies have suggested that the early-B-cell-specific mb-1(Ig{alpha}) promoter is regulated by EBF and Pax-5. Here, we used in vivo footprinting assays to detect occupation of binding sites in endogenous mb-1 promoters at various stages of B-cell differentiation. In addition to EBF and Pax-5 binding sites, we detected occupancy of a consensus binding site for E2A proteins (E box) in pre-B cells. EBF and E box sites are crucial for promoter function in transfected pre-B cells, and EBF and E2A proteins synergistically activated the promoter in transfected HeLa cells. Other data suggest that EBF and E box sites are less important for promoter function at later stages of differentiation, whereas binding sites for Pax-5 (and its Ets ternary complex partners) are required for promoter function in all mb-1-expressing cells. Using DNA microarrays, we found that expression of endogenous mb-1 transcripts correlates most closely with EBF expression and negatively with Id1, an inhibitor of E2A protein function, further linking regulation of the mb-1 gene with EBF and E2A. Together, our studies demonstrate the complexity of factors regulating tissue-specific transcription and support the concept that EBF, E2A, and Pax-5 cooperate to activate target genes in early B-cell development.

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Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Park, J (3); O'Neill, S (3); Cole, S. (2); Haddad, N. (2); Mahmoud, S. (2); Palma, A. (2); show more...; White, R. (2); Ye, J. (2); Ahmed, H. (2); Gupta, A. (2); Lim, H. (2); Aziz, NA (2); Kumar, S (2); Wilson, M (2); Moore, R. (2); Zielinski, M. (2); Evans, D. (2); Roy, C. (2); Davies, R (2); Mohamed, A. (2); Mostafa, M. (2); Lopez, M. (2); Mohan, M. (2); Patel, P. (2); Hall, E (2); Ali, S (2); Mohammed, H (2); Mohammed, S (2); Negoi, I (2); Rickard, J (2); Abbas, A. (2); Kumar, B (2); Carpio, J. (2); Sharma, A (2); Mohamed, M. (2); Muller, J. (2); Sanchez, D. (2); Mustafa, M (2); Abdelhady, S (2); Abdelkader, M. (2); Yang, J. (2); Cox, M (2); Sander, A. (2); Roy, S (2); King, S. (2); Ali, A. (2); Sacco, M (2); Walker, M (2); Khan, R. (2); Sallinen, V (2); show less...

University: Karolinska Institutet (2); Umeå University (1); Lund University (1)

Language: English (4)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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