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- Guerova, G., et al.
(author)
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National Status Reports
- 2020
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In: Advanced GNSS Tropospheric Products for Monitoring Severe Weather Events and Climate. - Cham : Springer International Publishing. - 9783030139001 ; , s. 403-481
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Book chapter (other academic/artistic)abstract
- In this section a summary of the national progress reports is given. GNSS4SWEC Management Committee (MC) members provided outline of the work conducted in their countries combining input from different partners involved. In the COST Action paticipated member from 32 COST countries, 1 Near Neighbour Country and 8 Intrantional Partners from Australia, Canada, Hong Kong and USA. The text reflects the state as of 1 January 2018.
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- Helferich, Anika M., et al.
(author)
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Dysregulation of a novel miR-1825/TBCB/TUBA4A pathway in sporadic and familial ALS
- 2018
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In: Cellular and Molecular Life Sciences (CMLS). - : Springer. - 1420-682X .- 1420-9071. ; 75:23, s. 4301-4319
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Journal article (peer-reviewed)abstract
- Genetic and functional studies suggest diverse pathways being affected in the neurodegenerative disease amyotrophic lateral sclerosis (ALS), while knowledge about converging disease mechanisms is rare. We detected a downregulation of microRNA-1825 in CNS and extra-CNS system organs of both sporadic (sALS) and familial ALS (fALS) patients. Combined transcriptomic and proteomic analysis revealed that reduced levels of microRNA-1825 caused a translational upregulation of tubulin-folding cofactor b (TBCB). Moreover, we found that excess TBCB led to depolymerization and degradation of tubulin alpha-4A (TUBA4A), which is encoded by a known ALS gene. Importantly, the increase in TBCB and reduction of TUBA4A protein was confirmed in brain cortex tissue of fALS and sALS patients, and led to motor axon defects in an in vivo model. Our discovery of a microRNA-1825/TBCB/TUBA4A pathway reveals a putative pathogenic cascade in both fALS and sALS extending the relevance of TUBA4A to a large proportion of ALS cases.
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- Nothhaft, Howard, et al.
(author)
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From Costly Signals and Competitive Niches to Reciprocity, Memes, and Memory Traces : Evolutionary Psychology and Strategic Communication
- 2023
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In: International Journal of Strategic Communication. - 1553-118X. ; 17:3, s. 151-162
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Journal article (other academic/artistic)abstract
- This article gives an overview of the contributions in the special issue of the International Journal of Strategic Communication on evolutionary psychology and strategic communication. Forward-looking, it argues that recent advances in artificial intelligence (AI) have made it imperative for our discipline to come to grips with a biologized view of the human mind as an information-processing system that evolved to solve specific adaptive problems. Backward-looking, it tries to explain why evolutionary psychology, which offers such as perspective, has met with so much resistance in the social sciences.
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- Nothhaft, Howard, et al.
(author)
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Peacocks, penknives and power : On the implications of evolutionary psychology for strategic communication
- 2023
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In: International Journal of Strategic Communication. - 1553-1198. ; 17:3, s. 163-180
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Journal article (peer-reviewed)abstract
- This article conceptualizes evolutionary theory as a bridge between existing theorizing in strategic communication on the one hand, the mind sciences on the other. It discusses six core concepts of evolutionary psychology that have a bearing on strategic communication theory: a) the human as a highly flexible social species; b) the regulation of individually-minded vs. collectively-minded behavior; c) advanced, symbolic communication as a mode of regulation and its second-order problems; d) a consilient conceptualization of communication; e) evolutionary psychology’s role as a heuristic; and f) the limits of cognitive capacity and the role of heuristic shortcuts. The article concludes with a note on the theory of science in strategic communication research and cautions against the common misunderstanding of evolutionary psychology’s agenda.
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- Schnitzbauer, Andreas A., et al.
(author)
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mTOR Inhibition Is Most Beneficial After Liver Transplantation for Hepatocellular Carcinoma in Patients With Active Tumors
- 2020
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In: Annals of Surgery. - : LIPPINCOTT WILLIAMS & WILKINS. - 0003-4932 .- 1528-1140. ; 272:5, s. 855-862
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Journal article (peer-reviewed)abstract
- Objective: The aim of this study was to evaluate the survival benefit of sirolimus in patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC) (exploratory analysis of the SiLVER-trial). Summary and Background Data: Patients receiving LT) for HCC are at a high risk for tumor recurrence. Calcineurin inhibitors have shown evidence to promote cancer growth, whereas mammalian target of rapamycin (mTOR) inhibitors like sirolimus have anticancer effects. In the SiLVER-trial (Clinicaltrials.gov:NCT00355862), the effect of sirolimus on the recurrence of HCC after LTwas investigated in a prospective randomized trial. Although the primary endpoint of improved disease-free survival (DFS) with sirolimus was not met, outcomes were improved for patients in the sirolimus-treatment arm in the first 3 to 5 years. To learn more about the key variables, a multivariate analysis was performed on the SiLVER-trial data. Patients and Methods: Data from 508 patients of the intention-to-treat analysis were included in exploratory univariate and multivariate models for overall survival (OS), DFS and a competing risk analysis for HCC recurrence. Results: Sirolimus use for >= 3 months after LT for HCC independently reduced the hazard for death in the multivariate analysis [hazard ratio (HR): 0.7 (95% confidence interval, CI: 0.52-0.96, P = 0.02). Most strikingly, patients with an alpha-fetoprotein (AFP) >= 10 ng/mL and having used sirolimus for >= 3 months, benefited most with regard to OS, DFS, and HCC-recurrence (HR: 0.49- 0.59, P = 0.0079- 0.0245). Conclusions: mTOR-inhibitor treatment with sirolimus for >= 3 months improves outcomes in LT for HCC, especially in patients with AFP-evidence of higher tumor activity, advocating particularly for mTOR inhibitor use in this subgroup of patients. Clinical Trial Registration: EudraCT: 2005-005362-36 Clinicaltrials.gov: NCT00355862.
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- Seiffert-Brockmann, Jens, et al.
(author)
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The Meme’s-Eye View of Strategic Communication : A Case Study of Social Movements from a Memetic Perspective
- 2023
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In: International Journal of Strategic Communication. - 1553-118X. ; 17:3, s. 245-265
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Journal article (peer-reviewed)abstract
- The article argues that a memetic approach, or meme’s-eye view, could help bring together the strategic management view and the CCO-school. ‘Memes’ are understood as a second-order concept, i.e., as a reference to ‘memory traces’ in people’s minds and anchor-point of joint or collective intentionality. This view, it is argued, permits the conceptualization of communication as a resource. To illustrate, two cases are analyzed: 1) the Montagsdemos in the former German Democratic Republic (GDR) with its core meme Wir sind das Volk (We are the people); 2) the so-called ‘Satanic Panic’ and the QAnon movement with its ‘Save the Children'-meme’. The analysis illustrates how memes endure and resurface in new and different environments. In conclusion, the article proposes that the shift to memetic population dynamics allows strategic communication-researchers to reformulate often unanswerable questions (“What does the strategic actor want?”) into more operationalizable ones (“What memes are launched? How are they constructed?”).
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