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| 5. |
- Dominguez-Valentin, M, et al.
(author)
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No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in MLH1 and MSH2: A Prospective Lynch Syndrome Database Study
- 2021
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In: Journal of clinical medicine. - : MDPI AG. - 2077-0383. ; 10:13
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Journal article (peer-reviewed)abstract
- Background. Lynch syndrome is the most common genetic predisposition for hereditary cancer. Carriers of pathogenic changes in mismatch repair (MMR) genes have an increased risk of developing colorectal (CRC), endometrial, ovarian, urinary tract, prostate, and other cancers, depending on which gene is malfunctioning. In Lynch syndrome, differences in cancer incidence (penetrance) according to the gene involved have led to the stratification of cancer surveillance. By contrast, any differences in penetrance determined by the type of pathogenic variant remain unknown. Objective. To determine cumulative incidences of cancer in carriers of truncating and missense or aberrant splicing pathogenic variants of the MLH1 and MSH2 genes. Methods. Carriers of pathogenic variants of MLH1 (path_MLH1) and MSH2 (path_MSH2) genes filed in the Prospective Lynch Syndrome Database (PLSD) were categorized as truncating or missense/aberrant splicing according to the InSiGHT criteria for pathogenicity. Results. Among 5199 carriers, 1045 had missense or aberrant splicing variants, and 3930 had truncating variants. Prospective observation years for the two groups were 8205 and 34,141 years, respectively, after which there were no significant differences in incidences for cancer overall or for colorectal cancer or endometrial cancers separately. Conclusion. Truncating and missense or aberrant splicing pathogenic variants were associated with similar average cumulative incidences of cancer in carriers of path MLH1 and path_MSH2.
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| 8. |
- Yoo, S. J. B., et al.
(author)
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Spectral phase encoded time spread optical code division multiple access technology for next generation communication networks Invited
- 2007
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In: Journal of Optical Networking. - 1536-5379. ; 6:10, s. 1210-1227
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Journal article (peer-reviewed)abstract
- We overview and summarize the progress of the spectral phase encoded time spreading (SPECTS) optical code division multiple access (O-CDMA) technology. Recent progress included a demonstration of a 320 Gbit/s (32-user x 10 Gbit/s) all-optical passive optical network testbed based on the SPECTS O-CDMA technology and a theoretical prediction of the spectral efficiency at 100% and above. In particular, InP-based integrated photonics allows implementation of SPECTS O-CDMA transmitters and receivers monolithically integrated on a chip. The integrated InP chip technology not only allows robust and compact configurations for practical and low-cost O-CDMA network deployments but also offers code reconfigurations at rapid rates for secure communication applications.
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| 9. |
- Hanna, E., et al.
(author)
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Short- and long-term variability of the Antarctic and Greenland ice sheets
- 2024
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In: Nature Reviews Earth & Environment. - : Springer Nature. - 2662-138X. ; 5, s. 193-210
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Research review (peer-reviewed)abstract
- The variability of the Antarctic and Greenland ice sheets occurs on various timescales and is important for projections of sea level rise; however, there are substantial uncertainties concerning future ice-sheet mass changes. In this Review, we explore the degree to which short-term fluctuations and extreme glaciological events reflect the ice sheets’ long-term evolution and response to ongoing climate change. Short-term (decadal or shorter) variations in atmospheric or oceanic conditions can trigger amplifying feedbacks that increase the sensitivity of ice sheets to climate change. For example, variability in ocean-induced and atmosphere-induced melting can trigger ice thinning, retreat and/or collapse of ice shelves, grounding-line retreat, and ice flow acceleration. The Antarctic Ice Sheet is especially prone to increased melting and ice sheet collapse from warm ocean currents, which could be accentuated with increased climate variability. In Greenland both high and low melt anomalies have been observed since 2012, highlighting the influence of increased interannual climate variability on extreme glaciological events and ice sheet evolution. Failing to adequately account for such variability can result in biased projections of multi-decadal ice mass loss. Therefore, future research should aim to improve climate and ocean observations and models, and develop sophisticated ice sheet models that are directly constrained by observational records and can capture ice dynamical changes across various timescales.
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| 11. |
- ten Broeke, SW, et al.
(author)
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Cancer Risks for PMS2-Associated Lynch Syndrome
- 2018
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In: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. - 1527-7755. ; 36:29, s. 2961-
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Journal article (peer-reviewed)
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| 12. |
- Ji, C., et al.
(author)
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Monolithically integrated InP-based photonic chip development for O-CDMA systems
- 2005
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In: IEEE Journal of Selected Topics in Quantum Electronics. - : Institute of Electrical and Electronics Engineers (IEEE). - 1077-260X .- 1558-4542. ; 11:1, s. 66-77
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Journal article (peer-reviewed)abstract
- This paper discusses photonic integration efforts toward developing an InP-based inonolithically integrated photonic chip for optical code-division multiple-access (O-CDMA) system applications. The chip design includes the colliding pulsed mode (CPM) locked laser, the. Mach-Zehnder interferometer-based threshold detector (MZI), and the monolithic O-CDMA encoder/decoder chip based on array-waveguide-gratings and phase modulator arrays. The compact 4 x I cm monolithic chip can replace a complex and large O-CDMA setup based on bulk optics. The integration technique involves active-passive integration using dry etching, metal organic chemical vapor deposition growth, and lateral hydride vapor phase epitaxy regrowth technologies. The fabricated CPM showed stable 1.54 ps modelocked laser output, the MZI showed excellent O-CDMA threshold detection, and the O-CDMA encoder showed Walsh-code O-CDMA, encoding. Further, the fabricated devices showed excellent planarity, which accelerate our progress toward monolithic integration of O-CDMA systems.
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| 14. |
- Morlighem, M., et al.
(author)
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BedMachine v3 : Complete Bed Topography and Ocean Bathymetry Mapping of Greenland From Multibeam Echo Sounding Combined With Mass Conservation
- 2017
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In: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 44:21, s. 11051-11061
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Journal article (peer-reviewed)abstract
- Greenland's bed topography is a primary control on ice flow, grounding line migration, calving dynamics, and subglacial drainage. Moreover, fjord bathymetry regulates the penetration of warm Atlantic water (AW) that rapidly melts and undercuts Greenland's marine-terminating glaciers. Here we present a new compilation of Greenland bed topography that assimilates seafloor bathymetry and ice thickness data through a mass conservation approach. A new 150m horizontal resolution bed topography/bathymetric map of Greenland is constructed with seamless transitions at the ice/ocean interface, yielding major improvements over previous data sets, particularly in the marine-terminating sectors of northwest and southeast Greenland. Our map reveals that the total sea level potential of the Greenland ice sheet is 7.420.05m, which is 7cm greater than previous estimates. Furthermore, it explains recent calving front response of numerous outlet glaciers and reveals new pathways by which AW can access glaciers with marine-based basins, thereby highlighting sectors of Greenland that are most vulnerable to future oceanic forcing.
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| 16. |
- Baek, J. H., et al.
(author)
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10-GHz and 20-GHz channel spacing high-resolution AWGs on InP
- 2009
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In: IEEE Photonics Technology Letters. - 1041-1135 .- 1941-0174. ; 21:5, s. 298-300
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Journal article (peer-reviewed)abstract
- This letter reports on 10-GHz and 20-GHz channel-spacing arrayed waveguide gratings (AWGs) based on InP technology. The dimensions of the AWGs are 6.8 × 8.2 mm2 and 5.0 × 6.0 mm2, respectively, and the devices show crosstalk levels of 12 dB for the 10-GHz and 17 dB for the 20-GHz AWG without any compensation for the phase errors in the arrayed waveguides. The root-mean-square phase errors for the center arrayed waveguides were characterized by using an optical vector network analyzer, and are 18° for the 10-GHz AWG and 28° for the 10-GHz AWG.
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| 17. |
- Cao, J., et al.
(author)
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A monolithic ultra-compact inp o-cdma encoder with : Planarization by hvpe regrowth
- 2006
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In: OFC/NFOEC. - : Optical Society of America. - 1557528020 - 9781557528025
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Conference paper (peer-reviewed)abstract
- We report a monolithic, ultra-compact optical-CDMA encoder/decoder photonic chip in InP with surface planarization by low-pressure Hydride-Vapor-Phase-Epitaxy regrowth. The chip consists of an AWG pair and eight electro-optic phase shifters and demonstrated excellent encoding operation.
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| 18. |
- Cao, J., et al.
(author)
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A monolithic ultra-compact inp o-cdma encoder with : Planarization by hvpe regrowth
- 2005
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In: Optics InfoBase Conference Papers. - : Optics Info Base, Optical Society of America. - 1557527849 - 9781557527844
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Conference paper (peer-reviewed)abstract
- We report a monolithic, ultra-compact optical-CDMA encoder/decoder photonic chip in InP with surface planarization by low-pressure Hydride-Vapor-Phase-Epitaxy regrowth. The chip consists of an AWG pair and eight electro-optic phase shifters and demonstrated excellent encoding operation.
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| 19. |
- Cao, Jing, et al.
(author)
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Demonstration of Spectral Phase O-CDMA Encoding and Decoding in Monolithically Integrated Arrayed-Waveguide-Grating-Based Encoder
- 2006
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In: IEEE Photonics Technology Letters. - 1041-1135 .- 1941-0174. ; 18:21-24, s. 2602-2604
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Journal article (peer-reviewed)abstract
- We report on successful spectral phase encoding and decoding operation in a pair of monolithically integrated InP encoder chips, each consisting of an arrayed waveguide grating (AWG) pair and an eight-channel electrooptic phase shifter array. The monolithic fabrication process includes anisotropic reactive ion etching and planarizing hydride-vapor-phase-epitaxy lateral regrowth to realize buried hetero-waveguide structures in AWGs and phase shifters. Electrooptical modulation in the phase shifter arrays in the encoder chip achieved Walsh-code-based optical code-division multiple access (O-CDMA) encoding and decoding. The matched-code encoding-decoding operation resulted in error-free performance in the presence of an interferer, indicating good potential for O-CDMA network applications.
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| 20. |
- Cao, J., et al.
(author)
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Error-free spectral encoding and decoding operation of InP O-CDMA encoder
- 2006
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In: 2006 Optical Fiber Communication Conference, and the 2006 National Fiber Optic Engineers Conference. - : IEEE. - 1557528039 - 9781557528032
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Conference paper (peer-reviewed)abstract
- We report error-free spectral encoding and decoding operation of an InP monolithic, ultra-compact optical-CDMA encoder/decoder photonic chip pair. The experimental results demonstrate the strong potential for realizing high performance O-CDMA networks with InP micro-systems.
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| 21. |
- Cao, J., et al.
(author)
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Spectral encoding and decoding of monolithic InP OCDMA encoder
- 2005
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In: 31st European Conference on Optical Communications (ECOC 2005), 2005. - : Institution of Engineering and Technology. ; , s. 501-502
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Conference paper (peer-reviewed)abstract
- We report the optical-coding operation of monolithic, ultra-compact optical-CDMA encoder and decoder pair, consisting of InP based integrated AWGs and phase modulators. The encoder and decoder successfully demonstrate eight-bit Walsh code based encoding and decoding.
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| 22. |
- Fontaine, N. K., et al.
(author)
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Determination of 20 GHz InP AWG phase errors by measurement of AWG pulse train
- 2007
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In: 2007 IEEE LEOS Annual Meeting Conference Proceedings. - : IEEE. - 142440925X - 9781424409259 ; , s. 725-726
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Conference paper (peer-reviewed)abstract
- The phase errors of a 20 GHz AWG fabricated on InP are determined by measuring the intensity and phase of the pulse train produced by the transmission of a short pulse through an AWG.
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| 24. |
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| 25. |
- Lourdudoss, Sebastian, et al.
(author)
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Heteroepitaxy and selective epitaxy for discrete and integrated devices
- 2006
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In: 2006 CONFERENCE ON OPTOELECTRONIC AND MICROELECTRONIC MATERIALS & DEVICES. - NEW YORK : IEEE. - 9781424405770 ; , s. 309-311
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Conference paper (peer-reviewed)abstract
- We present first results on heteroepitaxy of InP on silicon on insulator (SOI). We also demonstrate InP nanopillar fabrication by means of selective epitaxy. Selective epitaxy is also exploited to fabricate advanced photonic integrated devices for Optical Code Division Multiplex Access (OCDMA) networking applications.
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| 26. |
- Rotschky, G, et al.
(author)
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A new surface accumulation map for western Dronning Maud Land, Antarctica, from interpolation of point measurements
- 2007
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In: Journal of Glaciology. ; 53:182, s. 385-398
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Journal article (peer-reviewed)abstract
- s a result of intensive field activities carried out by several nations over the past 15 years, a set of accumulation measurements for western Dronning Maud Land, Antarctica, was collected, based on firn-core drilling and snow-pit sampling. This new information was supplemented by earlier data taken from the literature, resulting in I I I accumulation values. Using Geographical information Systems software, a first region-wide mean annual snow-accumulation field was derived. in order to define suitable interpolation criteria, the accumulation records were analyzed with respect to their spatial autocorrelation and statistical properties. The resulting accumulation pattern resembles well-known characteristics such as a relatively wet coastal area with a sharp transition to the dry interior, but also reveals complex topographic effects. Furthermore, this work identifies new high-return shallow-drilling sites by uncovering areas of insufficient sampling density.
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| 27. |
- Scares, F. M., et al.
(author)
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20GHz channel spacing InP-based arrayed waveguide grating
- 2007
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In: 2007 33rd European Conference and Exhibition of Optical Communication, ECOC 2007. - : IEEE conference proceedings. - 9783800730421
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Conference paper (peer-reviewed)abstract
- We demonstrate a 10-channel InP-based Arrayed-Waveguide Grating (dimensions = 5.0×6.0 mm2) with a 20-GHz channel spacing. The excess loss of the AWG is 5.5-6.3 dB, and the crosstalk level is below -15 dB.
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| 28. |
- Soares, F. M., et al.
(author)
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Compact InP-Based 16-channel O-CDMA encoder/decoder
- 2007
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In: 2007 IEEE LEOS annual meeting conference proceedings. - : IEEE. - 142440925X - 9781424409259 ; , s. 723-724
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Conference paper (peer-reviewed)abstract
- A very compact InP-Based 16-channel O-CDMA encoder-/decoder chip (3.8mm × 6.8mm) has been designed, fabricated and characterized. The device successfully performs O-CDMA spectral encoding.
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| 29. |
- Soares, F. M., et al.
(author)
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InP-based arrayed-waveguide grating with a channel spacing of 10 GHz
- 2008
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In: OFC/NFOEC - Conf. Opt. Fiber Commun./Natl. Fiber Opt. Eng. Conf.. - 9781557528551 ; , s. -69
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Conference paper (peer-reviewed)abstract
- We realize a high-precision 10-channel InP-based Arrayed-Waveguide Grating (AWG) with a 10-GHz channel spacing. The AWG showed approximately 10dB excess-loss, 10 dB crosstalk, and 8.2 × 6.8 mm2 dimensions.
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