SwePub - search: WFRF:(Bruch J.)

Enumeration	Reference	Cover	Find
1.	Brennan, Seán J., 1995-, et al. (author) Spectroscopic observations of progenitor activity 100 days before a Type Ibn supernova 2024 In: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 684 Journal article (peer-reviewed)abstract Obtaining spectroscopic observations of the progenitors of core-collapse supernovae is often unfeasible, due to an inherent lack of knowledge as to what stars experience supernovae and when they will explode. In this Letter we present photometric and spectroscopic observations of the progenitor activity of SN 2023fyq before the He-rich progenitor explodes as a Type Ibn supernova. The progenitor of SN 2023fyq shows an exponential rise in flux prior to core collapse. Complex He I emission line features are observed in the progenitor spectra, with a P Cygni-like profile, as well as an evolving broad base with velocities of the order of 10 000 km s−1. The luminosity and evolution of SN 2023fyq is consistent with a Type Ibn, reaching a peak r-band magnitude of −18.8 mag, although there is some uncertainty regarding the distance to the host, NGC 4388, which is located in the Virgo cluster. We present additional evidence of asymmetric He-rich material being present both prior to and after the explosion of SN 2023fyq, which suggests that this material survived the ejecta interaction. Broad [O I], C I, and the Ca II triplet lines are observed at late phases, confirming that SN 2023fyq was a genuine supernova, rather than a non-terminal interacting transient. SN 2023fyq provides insight into the final moments of a massive star’s life, demonstrating that the progenitor is likely highly unstable before core collapse.
2.	Gal-Yam, A., et al. (author) A WC/WO star exploding within an expanding carbon-oxygen-neon nebula 2022 In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 601:7892, s. 201-204 Journal article (peer-reviewed)abstract The final fate of massive stars, and the nature of the compact remnants they leave behind (black holes and neutron stars), are open questions in astrophysics. Many massive stars are stripped of their outer hydrogen envelopes as they evolve. Such Wolf-Rayet stars(1) emit strong and rapidly expanding winds with speeds greater than 1,000 kilometres per second. A fraction of this population is also helium-depleted, with spectra dominated by highly ionized emission lines of carbon and oxygen (types WC/WO). Evidence indicates that the most commonly observed supernova explosions that lack hydrogen and helium (types Ib/Ic) cannot result from massive WC/WO stars(2,3), leading some to suggest that most such stars collapse directly into black holes without a visible supernova explosion(4). Here we report observations of SN 2019hgp, beginning about a day after the explosion. Its short rise time and rapid decline place it among an emerging population of rapidly evolving transients(5-8). Spectroscopy reveals a rich set of emission lines indicating that the explosion occurred within a nebula composed of carbon, oxygen and neon. Narrow absorption features show that this material is expanding at high velocities (greater than 1,500 kilometres per second), requiring a compact progenitor. Our observations are consistent with an explosion of a massive WC/WO star, and suggest that massive Wolf-Rayet stars may be the progenitors of some rapidly evolving transients.
3.	Ho, Anna Y. Q., et al. (author) A Search for Extragalactic Fast Blue Optical Transients in ZTF and the Rate of AT2018cow-like Transients 2023 In: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 949:2 Journal article (peer-reviewed)abstract We present a search for extragalactic fast blue optical transients (FBOTs) during Phase I of the Zwicky Transient Facility (ZTF). We identify 38 candidates with durations above half-maximum light 1 day < t (1/2) < 12 days, of which 28 have blue (g - r less than or similar to -0.2 mag) colors at peak light. Of the 38 transients (28 FBOTs), 19 (13) can be spectroscopically classified as core-collapse supernovae (SNe): 11 (8) H- or He-rich (Type II/IIb/Ib) SNe, 6 (4) interacting (Type IIn/Ibn) SNe, and 2 (1) H&He-poor (Type Ic/Ic-BL) SNe. Two FBOTs (published previously) had predominantly featureless spectra and luminous radio emission: AT2018lug (The Koala) and AT2020xnd (The Camel). Seven (five) did not have a definitive classification: AT 2020bdh showed tentative broad H alpha in emission, and AT 2020bot showed unidentified broad features and was 10 kpc offset from the center of an early-type galaxy. Ten (eight) have no spectroscopic observations or redshift measurements. We present multiwavelength (radio, millimeter, and/or X-ray) observations for five FBOTs (three Type Ibn, one Type IIn/Ibn, one Type IIb). Additionally, we search radio-survey (VLA and ASKAP) data to set limits on the presence of radio emission for 24 of the transients. All X-ray and radio observations resulted in nondetections; we rule out AT2018cow-like X-ray and radio behavior for five FBOTs and more luminous emission (such as that seen in the Camel) for four additional FBOTs. We conclude that exotic transients similar to AT2018cow, the Koala, and the Camel represent a rare subset of FBOTs and use ZTF's SN classification experiments to measure the rate to be at most 0.1% of the local core-collapse SN rate.
4.	Perley, Daniel A., et al. (author) The Zwicky Transient Facility Bright Transient Survey. II. A Public Statistical Sample for Exploring Supernova Demographics 2020 In: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 904:1 Journal article (peer-reviewed)abstract We present a public catalog of transients from the Zwicky Transient Facility (ZTF) Bright Transient Survey, a magnitude-limited (m g or r filter) survey for extragalactic transients in the ZTF public stream. We introduce cuts on survey coverage, sky visibility around peak light, and other properties unconnected to the nature of the transient, and show that the resulting statistical sample is spectroscopically 97% complete at <18 mag, 93% complete at <18.5 mag, and 75% complete at <19 mag. We summarize the fundamental properties of this population, identifying distinct duration-luminosity correlations in a variety of supernova (SN) classes and associating the majority of fast optical transients with well-established spectroscopic SN types (primarily SN Ibn and II/IIb). We measure the Type Ia SN and core-collapse (CC) SN rates and luminosity functions, which show good consistency with recent work. About 7% of CC SNe explode in very low-luminosity galaxies (M-i > -16 mag), 10% in red-sequence galaxies, and 1% in massive ellipticals. We find no significant difference in the luminosity or color distributions between the host galaxies of SNe Type II and SNe Type Ib/c, suggesting that line-driven wind stripping does not play a major role in the loss of the hydrogen envelope from their progenitors. Future large-scale classification efforts with ZTF and other wide-area surveys will provide high-quality measurements of the rates, properties, and environments of all known types of optical transients and limits on the existence of theoretically predicted but as yet unobserved explosions.
5.	Soumagnac, Maayane T., et al. (author) Early Ultraviolet Observations of Type IIn Supernovae Constrain the Asphericity of Their Circumstellar Material 2020 In: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 899:1 Journal article (peer-reviewed)abstract We present a survey of the early evolution of 12 Type IIn supernovae (SNe IIn) at ultraviolet and visible light wavelengths. We use this survey to constrain the geometry of the circumstellar material (CSM) surrounding SN IIn explosions, which may shed light on their progenitor diversity. In order to distinguish between aspherical and spherical CSM, we estimate the blackbody radius temporal evolution of the SNe IIn of our sample, following the method introduced by Soumagnac et al. We find that higher-luminosity objects tend to show evidence for aspherical CSM. Depending on whether this correlation is due to physical reasons or to some selection bias, we derive a lower limit between 35% and 66% for the fraction of SNe IIn showing evidence for aspherical CSM. This result suggests that asphericity of the CSM surrounding SNe IIn is common-consistent with data from resolved images of stars undergoing considerable mass loss. It should be taken into account for more realistic modeling of these events.
6.	van de Sande-Bruinsma, Nienke, et al. (author) Antimicrobial drug use and resistance in Europe 2008 In: Emerging Infectious Diseases. - : Centers for Disease Control and Prevention (CDC). - 1080-6040 .- 1080-6059. ; 14:11, s. 1722-30 Journal article (peer-reviewed)abstract Our study confronts the use of antimicrobial agents in ambulatory care with the resistance trends of 2 major pathogens, Streptococcus pneumoniae and Escherichia coli, in 21 European countries in 2000-2005 and explores whether the notion that antimicrobial drug use determines resistance can be supported by surveillance data at national aggregation levels. The data obtained from the European Surveillance of Antimicrobial Consumption and the European Antimicrobial Resistance Surveillance System suggest that variation of consumption coincides with the occurrence of resistance at the country level. Linear regression analysis showed that the association between antimicrobial drug use and resistance was specific and robust for 2 of 3 compound pathogen combinations, stable over time, but not sensitive enough to explain all of the observed variations. Ecologic studies based on routine surveillance data indicate a relation between use and resistance and support interventions designed to reduce antimicrobial drug consumption at a national level in Europe.
7.	Bruch, Rachel J., et al. (author) A Large Fraction of Hydrogen-rich Supernova Progenitors Experience Elevated Mass Loss Shortly Prior to Explosion 2021 In: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 912:1 Journal article (peer-reviewed)abstract Spectroscopic detection of narrow emission lines traces the presence of circumstellar mass distributions around massive stars exploding as core-collapse supernovae. Transient emission lines disappearing shortly after the supernova explosion suggest that the material spatial extent is compact and implies an increased mass loss shortly prior to explosion. Here, we present a systematic survey for such transient emission lines (Flash Spectroscopy) among Type II supernovae detected in the first year of the Zwicky Transient Facility survey. We find that at least six out of ten events for which a spectrum was obtained within two days of the estimated explosion time show evidence for such transient flash lines. Our measured flash event fraction (>30% at 95% confidence level) indicates that elevated mass loss is a common process occurring in massive stars that are about to explode as supernovae.
8.	Bruch, Rachel J., et al. (author) The Prevalence and Influence of Circumstellar Material around Hydrogen-rich Supernova Progenitors 2023 In: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 952:2 Journal article (peer-reviewed)abstract Narrow transient emission lines (flash-ionization features) in early supernova (SN) spectra trace the presence of circumstellar material (CSM) around the massive progenitor stars of core-collapse SNe. The lines disappear within days after the SN explosion, suggesting that this material is spatially confined, and originates from enhanced mass loss shortly (months to a few years) prior to the explosion. We performed a systematic survey of H-rich (Type II) SNe discovered within less than 2 days from the explosion during the first phase of the Zwicky Transient Facility survey (2018–2020), finding 30 events for which a first spectrum was obtained within <2 days from the explosion. The measured fraction of events showing flash-ionization features (>36% at the 95% confidence level) confirms that elevated mass loss in massive stars prior to SN explosion is common. We find that SNe II showing flash-ionization features are not significantly brighter, nor bluer, nor more slowly rising than those without. This implies that CSM interaction does not contribute significantly to their early continuum emission, and that the CSM is likely optically thin. We measured the persistence duration of flash-ionization emission and find that most SNe show flash features for ≈5 days. Rarer events, with persistence timescales >10 days, are brighter and rise longer, suggesting these may be intermediate between regular SNe II and strongly interacting SNe IIn.
9.	Herbst, SA, et al. (author) Proteogenomics refines the molecular classification of chronic lymphocytic leukemia 2022 In: Nature communications. - 2041-1723. ; 13:1, s. 6226- Journal article (peer-reviewed)
10.	Ho, Anna Y. Q., et al. (author) SN 2020bvc : A Broad-line Type Ic Supernova with a Double-peaked Optical Light Curve and a Luminous X-Ray and Radio Counterpart 2020 In: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 902:1 Journal article (peer-reviewed)abstract We present optical, radio, and X-ray observations of SN 2020bvc (=ASASSN-20bs, ZTF 20aalxlis), a nearby (z = 0.0252; d.=.114Mpc) broad-line (BL) Type Ic supernova (SN) and the first double-peaked Ic-BL discovered without a gamma-ray burst (GRB) trigger. Our observations show that SN 2020bvc shares several properties in common with the Ic-BL SN 2006aj, which was associated with the low-luminosity gamma-ray burst (LLGRB) 060218. First, the 10 GHz radio luminosity (L-radio approximate to 10(37) erg s(-1)) is brighter than ordinary core-collapse SNe but fainter than LLGRB SNe such as SN 1998bw (associated with LLGRB 980425). We model our VLA observations (spanning 13-43 days) as synchrotron emission from a mildly relativistic (v greater than or similar to 0.3c) forward shock. Second, with Swift and Chandra, we detect X-ray emission (L-X approximate to 10(41) erg s(-1)) that is not naturally explained as inverse Compton emission or part of the same synchrotron spectrum as the radio emission. Third, high-cadence (6x night(-1)) data from the Zwicky Transient Facility (ZTF) show a double-peaked optical light curve, the first peak from shock cooling of extended low-mass material (mass M-e < 10(-2) M-circle dot at radius R-e > 10(12) cm) and the second peak from the radioactive decay of 56Ni. SN 2020bvc is the first double-peaked Ic-BL SN discovered without a GRB trigger, so it is noteworthy that it shows X-ray and radio emission similar to LLGRB SNe. For four of the five other nearby (z less than or similar to 0.05) Ic-BL SNe with ZTF high-cadence data, we rule out a first peak like that seen in SN 2006aj and SN 2020bvc, i.e., that lasts approximate to 1 day.and reaches a peak luminosity M approximate to -18. Follow-up X-ray and radio observations of Ic-BL SNe with well-sampled early optical light curves will establish whether double-peaked optical light curves are indeed predictive of LLGRB-like X-ray and radio emission.
11.	Soumagnac, Maayane T., et al. (author) SN 2018fif : The Explosion of a Large Red Supergiant Discovered in Its Infancy by the Zwicky Transient Facility 2020 In: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 902:1 Journal article (peer-reviewed)abstract High-cadence transient surveys are able to capture supernovae closer to their first light than ever before. Applying analytical models to such early emission, we can constrain the progenitor stars' properties. In this paper, we present observations of SN 2018fif (ZTF 18abokyfk). The supernova was discovered close to first light and monitored by the Zwicky Transient Facility (ZTF) and the Neil Gehrels Swift Observatory. Early spectroscopic observations suggest that the progenitor of SN 2018fif was surrounded by relatively small amounts of circumstellar material compared to all previous cases. This particularity, coupled with the high-cadence multiple-band coverage, makes it a good candidate to investigate using shock-cooling models. We employ the SOPRANOS code, an implementation of the model by Sapir & Waxman and its extension to early times by Morag et al. Compared with previous implementations, SOPRANOS has the advantage of including a careful account of the limited temporal validity domain of the shock-cooling model as well as allowing usage of the entirety of the early UV data. We find that the progenitor of SN 2018fif was a large red supergiant with a radius of R = 744.0(-128.0)(+183.0) R-circle dot and an ejected mass of M-ej = 9.3(-5.8)(+0.4) M-circle dot. Our model also gives information on the explosion epoch, the progenitor's inner structure, the shock velocity, and the extinction. The distribution of radii is double-peaked, with smaller radii corresponding to lower values of the extinction, earlier recombination times, and a better match to the early UV data. If these correlations persist in future objects, denser spectroscopic monitoring constraining the time of recombination, as well as accurate UV observations (e.g., with ULTRASAT), will help break the extinction/radius degeneracy and independently determine both.
12.	Bliman, S, et al. (author) Soft x-ray and Auger electron spectroscopy of single and double electron capture processes in slow Ne8++He collisions 1997 In: REVIEW OF SCIENTIFIC INSTRUMENTS. - : AMER INST PHYSICS. - 0034-6748. ; 68:1, s. 1080-1082 Journal article (other academic/artistic)abstract We have performed high resolution extreme ultraviolet (EUV) photon and Auger electron measurements to elucidate single and double capture processes in Ne8++He single collisions at 80 keV impact energy. Numerous new transitions both in the Auger and the EU
13.	Dencker, Kerstin, et al. (author) Proactive assembly systems-realizing the potential of human collaboration with automation 2007 In: Cost Effective Automation. - : International Federation of Automatic Control. - 9783902661326 ; , s. 79-84 Conference paper (peer-reviewed)abstract Manufacturing competitiveness relies on the companies' ability to rapidly reconfigure their assembly systems. This paper introduces assembly system proactivity, a concept based on interrelated levels of human involvement, automation, and information handling. Increased and structured human involvement contributes to increased system ability to proactively address predicted and unpredicted events. Correct involvement of human operators will utilize the fully combined potential of human and technical capabilities, providing cost-efficient assembly system solutions. The ProAct project is developing proactive assembly system models and evaluating proactive, feature-based solutions. Focus is on realizing the potential of cost-efficient and semi-automated systems with relevant human involvement, i.e. highly skilled operators that add flexibility and functionality.
14.	Fubini, B., et al. (author) Non-animal tests for evaluating the toxicity of solid xenobiotics - The report and recommendations of ECVAM Workshop 30 1998 In: ATLA Alternatives to Laboratory Animals. - 0261-1929. ; 26:5, s. 579-617 Journal article (other academic/artistic)
15.	Gemoll, Timo, et al. (author) HDAC2 and TXNL1 distinguish aneuploid from diploid colorectal cancers 2011 In: Cellular and Molecular Life Sciences (CMLS). - : Springer. - 1420-682X .- 1420-9071. ; 68:19, s. 3261-3274 Journal article (peer-reviewed)abstract DNA aneuploidy has been identified as a prognostic factor for epithelial malignancies. Further understanding of the translation of DNA aneuploidy into protein expression will help to define novel biomarkers to improve therapies and prognosis. DNA ploidy was assessed by image cytometry. Comparison of gel-electrophoresis-based protein expression patterns of three diploid and four aneuploid colorectal cancer cell lines detected 64 ploidy-associated proteins. Proteins were identified by mass spectrometry and subjected to Ingenuity Pathway Analysis resulting in two overlapping high-ranked networks maintaining Cellular Assembly and Organization, Cell Cycle, and Cellular Growth and Proliferation. CAPZA1, TXNL1, and HDAC2 were significantly validated by Western blotting in cell lines and the latter two showed expression differences also in clinical samples using a tissue microarray of normal mucosa (n=19), diploid (n=31), and aneuploid (n=47) carcinomas. The results suggest that distinct protein expression patterns, affecting TXNL1 and HDAC2, distinguish aneuploid with poor prognosis from diploid colorectal cancers.
16.	Herbst, SA, et al. (author) Proteogenomics refines the molecular classification of chronic lymphocytic leukemia 2022 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1, s. 6226- Journal article (peer-reviewed)abstract Cancer heterogeneity at the proteome level may explain differences in therapy response and prognosis beyond the currently established genomic and transcriptomic-based diagnostics. The relevance of proteomics for disease classifications remains to be established in clinically heterogeneous cancer entities such as chronic lymphocytic leukemia (CLL). Here, we characterize the proteome and transcriptome alongside genetic and ex-vivo drug response profiling in a clinically annotated CLL discovery cohort (n = 68). Unsupervised clustering of the proteome data reveals six subgroups. Five of these proteomic groups are associated with genetic features, while one group is only detectable at the proteome level. This new group is characterized by accelerated disease progression, high spliceosomal protein abundances associated with aberrant splicing, and low B cell receptor signaling protein abundances (ASB-CLL). Classifiers developed to identify ASB-CLL based on its characteristic proteome or splicing signature in two independent cohorts (n = 165, n = 169) confirm that ASB-CLL comprises about 20% of CLL patients. The inferior overall survival in ASB-CLL is also independent of both TP53- and IGHV mutation status. Our multi-omics analysis refines the classification of CLL and highlights the potential of proteomics to improve cancer patient stratification beyond genetic and transcriptomic profiling.
17.	Karambelkar, Viraj R., et al. (author) Volumetric Rates of Luminous Red Novae and Intermediate-luminosity Red Transients with the Zwicky Transient Facility 2023 In: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 948:2 Journal article (peer-reviewed)abstract Luminous red novae (LRNe) are transients characterized by low luminosities and expansion velocities, and they are associated with mergers or common-envelope ejections in stellar binaries. Intermediate-luminosity red transients (ILRTs) are an observationally similar class with unknown origins, but they are generally believed to be either electron-capture supernovae in super-asymptotic giant branch stars or outbursts in dusty luminous blue variables (LBVs). In this paper, we present a systematic sample of eight LRNe and eight ILRTs detected as part of the Census of the Local Universe (CLU) experiment on the Zwicky Transient Facility (ZTF). The CLU experiment spectroscopically classifies ZTF transients associated with nearby (<150 Mpc) galaxies, achieving 80% completeness for m ( r ) < 20 mag. Using the ZTF-CLU sample, we derive the first systematic LRNe volumetric rate of 7.8-3.7+6.5x10-5 M ( r ) <= -11 mag. We find that, in this luminosity range, the LRN rate scales as dN/dL proportional to L-2.5 +/- 0.3 L (-1.4 +/- 0.3) for lower-luminosity LRNe (M ( V ) >= -10 mag). The steeper power law for LRNe at high luminosities is consistent with the massive merger rates predicted by binary population synthesis models. We find that the rates of the brightest LRNe (M ( r ) <= -13 mag) are consistent with a significant fraction of them being progenitors of double compact objects that merge within a Hubble time. For ILRTs, we derive a volumetric rate of 2.6-1.4+1.8x10-6 M ( r ) <= -13.5 mag, which scales as dN/dL proportional to L-2.5 +/- 0.5
18.	Roblick, U J, et al. (author) Sequential proteome alterations during genesis and progression of colon cancer. 2004 In: Cellular and Molecular Life Sciences (CMLS). - : Springer Science and Business Media LLC. - 1420-682X .- 1420-9071. ; 61:10 Journal article (peer-reviewed)abstract Changes in the proteome of colon mucosal cells accompany the transition from normal mucosa via adenoma and invasive cancer to metastatic disease. Samples from 15 patients with sporadic sigmoid cancers were analyzed. Proteins were separated by two-dimensional gel electrophoresis. Relative differences in expression levels between normal tissue, adenoma, carcinoma and metastasis were evaluated in both intra- and inter-patient comparisons. Up- and down-regulated proteins (> twofold) during development to cancer or metastasis were excised and submitted to peptide mass fingerprinting and MS/MS sequence analysis, facilitated by the use of a compact disc workstation. In total, 112 protein spots were found to be differentially regulated, of which 72 were determined as to protein identity, 46 being up-regulated toward the progression of cancer, and 26 down-regulated. Several of the identifications correlate with proteins of the cell cycle, cytoskeleton or metabolic pathways. The pattern changes now identified have the potential for design of marker panels for assistance in diagnostics and therapeutic strategies in colorectal cancer.
19.	Roblick, U.J., et al. (author) Undifferentiated pelvic adenocarcinomas : diagnostic potential of protein profiling and multivariate analysis 2008 In: International Journal of Colorectal Disease. - : Springer Science and Business Media LLC. - 0179-1958 .- 1432-1262. ; 23:5, s. 483-491 Journal article (peer-reviewed)abstract BACKGROUND AND AIMS: Despite improved techniques, the determination of tumor origin in poorly differentiated adenocarcinomas still remains a challenge for the pathologist. Here we report the use of protein profiling combined with principal component analysis to improve diagnostic decision-making in tumor samples, in which standard pathologic investigations cannot present reliable results. MATERIALS AND METHODS: A poorly differentiated adenocarcinoma of unknown origin located in the pelvis, infiltrating the sigmoid colon as well as the ovary, served as a model to evaluate our proteomic approach. Firstly, we characterized the protein expression profiles from eight advanced colon and seven ovarian adenocarcinomas using two-dimensional gel electrophoresis (2-DE). Qualitative and quantitative patterns were recorded and compared to the tumor of unknown origin. Based on these protein profiles, match sets from the different tumors were created. Finally, a multivariate principal component analysis was applied to the entire 2-DE data to disclose differences in protein patterns between the different tumors. RESULTS: Over 89% of the unknown tumor sample spots could be matched with the colon standard gel, whereas only 63% of the spots could be matched with the ovarian standard. In addition, principal component analysis impressively displayed the clustering of the unknown case within the colon cancer samples, whereas this case did not cluster at all within the group of ovarian adenocarcinomas. CONCLUSION: These results show that 2-DE protein expression profiling combined with principal component analysis is a sensitive method for diagnosing undifferentiated adenocarcinomas of unknown origin. The described approach can contribute greatly to diagnostic decision-making and, with further technical improvements and a higher throughput, become a powerful tool in the armentarium of the pathologist.
20.	Sharma, Yashvi, et al. (author) A Systematic Study of Ia-CSM Supernovae from the ZTF Bright Transient Survey 2023 In: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 948:1 Journal article (peer-reviewed)abstract Among the supernovae (SNe) that show strong interaction with a circumstellar medium (CSM), there is a rare subclass of Type Ia supernovae, SNe Ia-CSM, which show strong narrow hydrogen emission lines much like SNe IIn but on top of a diluted Type Ia spectrum. The only previous systematic study of this class identified 16 SNe Ia-CSM, eight historic and eight from the Palomar Transient Factory (PTF). Now using the successor survey to PTF, the Zwicky Transient Facility (ZTF), we have classified 12 additional SNe Ia-CSM through the systematic Bright Transient Survey (BTS). Consistent with previous studies, we find these SNe to have slowly evolving optical light curves with peak absolute magnitudes between -19.1 and -21, spectra having weak H ss and large Balmer ldecrements of similar to 7. Out of the 10 SNe from our sample observed by NEOWISE, nine have 3 sigma detections, with some SNe showing a reduction in the red wing of Ha, indicative of newly formed dust. We do not find our SN Ia-CSM sample to have a significantly different distribution of equivalent widths of He I.5876 than SNe IIn as observed in Silverman et al. The hosts tend to be late-type galaxies with recent star formation. We derive a rate estimate of 29+(27)(21) Gpc(-3) yr(-1) for SNe Ia-CSM, which is similar to 0.02%-0.2% of the SN Ia rate. We also identify six ambiguous SNe IIn/Ia-CSM in the BTS sample and including them gives an upper limit rate of 0.07%-0.8%. This work nearly doubles the sample of well-studied Ia-CSM objects in Silverman et al., increasing the total number to 28.
21.	Bliman, S, et al. (author) Case study of the Ar9+-He collision system at low velocity 2002 In: Physical Review A. ; 66:5 Journal article (peer-reviewed)
22.	Bliman, S, et al. (author) Collision spectroscopy of Ar8++H-2 at low velocities (upsilon < 1 a.u.) 1999 In: PHYSICAL REVIEW A. - : AMERICAN PHYSICAL SOC. - 1050-2947. ; 60:4, s. 2799-2807 Journal article (other academic/artistic)abstract Single and double electron transfer have been studied for the collision system Ar8++H-2 at low velocities (V<1 a.u.). X-ray ultraviolet and Auger spectroscopies complemented by translational energy gain and time-of-flight spectroscopies reveal details on
23.	Bruch, Jessica, et al. (author) Information management for production system desingn with a new portfolio approach 2011 In: 21st International Conference on Production Research. - Stuttgart : Fraunhofer-Verlag. - 9783839602935 Conference paper (peer-reviewed)abstract An effective management of information is vital for successful development of new products. However, knowledge is lacking about the management of information during production system design and its effects on innovation. This exploratory case study in the automotive industry furthers understanding of how management of information contributes to the design of robust and dynamic production systems that can handle changing production situations. The results from the case study indicate that the management of information should consider requirements of current and future production system generations facilitating a conscious planning of a production systems portfolio that corresponds to the product portfolio. This approach allows for new ways of designing production system concepts and production technology solutions, which also can accelerate the innovation capabilities of the manufacturing company.
24.	Cornille, M, et al. (author) Radiative and Auger decay probabilities, branching ratios and fluorescence yields of the Be-like (1s(2)3/4/') doubly excited states in Ne6 1997 In: PHYSICA SCRIPTA. - : ROYAL SWEDISH ACAD SCIENCES. - 0281-1847. ; T73, s. 41-42 Journal article (other academic/artistic)abstract Radiative and Auger transitions energies, decay rates, Auger branching ratios and fluorescence yields have been calculated for the Be-like (1s(2)3l4l') doubly excited states in Ne6+. The calculations have been performed in the intermediate coupling scheme
25.	Gemoll, Timo, et al. (author) Chromosomal aneuploidy affects the global proteome equilibrium of colorectal cancer cells 2013 In: Analytical Cellular Pathology. - 2210-7177 .- 2210-7185. ; 36:5-6, s. 149-161 Journal article (peer-reviewed)abstract BACKGROUND: Chromosomal aneuploidy has been identified as a prognostic factor in the majority of sporadic carcinomas. However, it is not known how chromosomal aneuploidy affects chromosome-specific protein expression in particular, and the cellular proteome equilibrium in general. OBJECTIVE: The aim was to detect chromosomal aneuploidy-associated expression changes in cell clones carrying trisomies found in colorectal cancer. METHODS: We used microcell-mediated chromosomal transfer to generate three artificial trisomic cell clones of the karyotypically stable, diploid, yet mismatch-deficient, colorectal cancer cell line DLD1 - each of them harboring one extra copy of either chromosome 3, 7 or 13. Protein expression differences were assessed by two-dimensional gel electrophoresis and mass spectrometry, compared to whole-genome gene expression data, and evaluated by PANTHER classification system and Ingenuity Pathway Analysis (IPA). RESULTS: In total, 79 differentially expressed proteins were identified between the trisomic clones and the parental cell line. Up-regulation of PCNA and HMGB I as well as down-regulation of IDH3A and PSMB3 were revealed as trisomy-associated alterations involved in regulating genome stability. CONCLUSIONS: These results show that trisomies affect the expression of genes and proteins that are not necessarily located on the trisomic chromosome, but reflect a pathway-related alteration of the cellular equilibrium.
26.	Gemoll, T, et al. (author) Protein expression of CSTF2T and ACTB discern sporadic from FAP-associated colon carcinomas at various stages of carcinogenesis 2018 In: ONCOLOGY RESEARCH AND TREATMENT. - : KARGER. - 2296-5270 .- 2296-5262. ; 41, s. 173-173 Conference paper (other academic/artistic)
27.	Gemoll, Timo, et al. (author) Protein profiling of genomic instability in endometrial cancer 2012 In: Cellular and Molecular Life Sciences (CMLS). - : Springer. - 1420-682X .- 1420-9071. ; 69:2, s. 325-333 Journal article (peer-reviewed)abstract DNA aneuploidy has been identified as a prognostic factor in the majority of epithelial malignancies. We aimed at identifying ploidy-associated protein expression in endometrial cancer of different prognostic subgroups. Comparison of gel electrophoresis-based protein expression patterns between normal endometrium (n = 5), diploid (n = 7), and aneuploid (n = 7) endometrial carcinoma detected 121 ploidy-associated protein forms, 42 differentially expressed between normal endometrium and diploid endometrioid carcinomas, 37 between diploid and aneuploid endometrioid carcinomas, and 41 between diploid endometrioid and aneuploid uterine papillary serous cancer. Proteins were identified by mass spectrometry and evaluated by Ingenuity Pathway Analysis. Targets were confirmed by liquid chromatography/mass spectrometry. Mass spectrometry identified 41 distinct polypeptides and pathway analysis resulted in high-ranked networks with vimentin and Nf-kappa B as central nodes. These results identify ploidy-associated protein expression differences that overrule histopathology-associated expression differences and emphasize particular protein networks in genomic stability of endometrial cancer.
28.	Gemoll, T, et al. (author) The role of genomic stability/instability in endometrial carcinogenesis 2008 In: ONKOLOGIE. - 0378-584X. ; 31, s. 106-106 Conference paper (other academic/artistic)
29.	Habermann, JK, et al. (author) Genomic instability influences the transcriptome and proteome in endometrial cancer subtypes 2011 In: Molecular cancer. - : Springer Science and Business Media LLC. - 1476-4598. ; 10, s. 132- Journal article (peer-reviewed)
30.	Habermann, J, et al. (author) Long-term assessment of dysplasia, DNA ploidy, proliferation and p53 alteration in ulcerative colitis 1997 In: EUROPEAN JOURNAL OF CANCER. - 0959-8049. ; 33, s. 43-43 Conference paper (other academic/artistic)
31.	Habermann, JK, et al. (author) The gene expression signature of genomic instability in breast cancer is an independent predictor of clinical outcome 2009 In: International journal of cancer. - : Wiley. - 1097-0215 .- 0020-7136. ; 124:7, s. 1552-1564 Journal article (peer-reviewed)
32.	Habermann, J, et al. (author) Ulcerative colitis and colorectal carcinoma: DNA-profile, laminin-5 gamma2 chain and cyclin A expression as early markers for risk assessment 2001 In: Scandinavian journal of gastroenterology. - : Informa UK Limited. - 0036-5521 .- 0000-0000. ; 36:7, s. 751-758 Journal article (peer-reviewed)
33.	Hong, Xu, et al. (author) Memory deficits correlate with tau and spine pathology in P301S MAPT transgenic mice. 2014 In: Neuropathology and Applied Neurobiology. - : Wiley. - 0305-1846 .- 1365-2990. ; 40:7, s. 833-843 Journal article (peer-reviewed)abstract AIM: P301SMAPT transgenic mice (P301S mice) are a widely used model of frontotemporal dementia and parkinsonism linked to chromosome 17 with tau pathology (FTDP-17-tau). However, a systematic correlation between cognitive deficits and cellular tau pathology at different ages is still missing. Therefore, our study investigated memory deficits of P301S mice in relation to pathological tau species and dendritic spine pathology throughout adulthood. METHODS: We analysed P301S mice behaviourally with the novel open field, rotarod, and Morris water maze tests to measure deficits in locomotion, balance and cognition, respectively; immunohistochemically with different tau antibodies for specific tau species; and with Golgi staining for dendritic spine pathology. RESULTS: We confirmed the occurrence of locomotor deficits at an age of 5months and newly report memory deficits from 2.5months of age onwards. At this early age, MC1 and CP13, but not AT180 immunoreactivity, was prominent in the hippocampus of P301S mice. Neuronal cell loss in the hippocampus of P301S mice was not observed to occur till 6months of age. However, there was a significant reduction in the density of dendritic spines from young adulthood onwards in hippocampal pyramidal neurones. CONCLUSION: In P301S mice, memory deficits precede the onset of locomotor dysfunction and coincide with the appearance of conformationally changed, S202-phosphorylated tau and reduced spine density in the absence of neuronal cell loss in the hippocampus. Our finding provides insights into the toxic effects of different tau species in vivo and may facilitate the development of new therapies against neurodegenerative tauopathies. © 2014 British Neuropathological Society.
34.	Irani, Ido, et al. (author) SN 2022oqm-A Ca-rich Explosion of a Compact Progenitor Embedded in C/O Circumstellar Material 2024 In: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 962:2 Journal article (peer-reviewed)abstract We present the discovery and analysis of SN 2022oqm, a Type Ic supernova (SN) detected <1 day after the explosion. The SN rises to a blue and short-lived (2 days) initial peak. Early-time spectral observations of SN 2022oqm show a hot (40,000 K) continuum with high ionization C and O absorption features at velocities of 4000 km s−1, while its photospheric radius expands at 20,000 km s−1, indicating a pre-existing distribution of expanding C/O material. After ∼2.5 days, both the spectrum and light curves evolve into those of a typical SN Ic, with line velocities of ∼10,000 km s−1, in agreement with the evolution of the photospheric radius. The optical light curves reach a second peak at t ≈ 15 days. By t = 60 days, the spectrum of SN 2022oqm becomes nearly nebular, displaying strong Ca ii and [Ca ii] emission with no detectable [O i], marking this event as Ca-rich. The early behavior can be explained by 10−3M⊙ of optically thin circumstellar material (CSM) surrounding either (1) a massive compact progenitor such as a Wolf–Rayet star, (2) a massive stripped progenitor with an extended envelope, or (3) a binary system with a white dwarf. We propose that the early-time light curve is powered by both the interaction of the ejecta with the optically thin CSM and shock cooling (in the massive star scenario). The observations can be explained by CSM that is optically thick to X-ray photons, is optically thick in the lines as seen in the spectra, and is optically thin to visible-light continuum photons that come either from downscattered X-rays or from the shock-heated ejecta. Calculations show that this scenario is self-consistent.
35.	Langereis, A, et al. (author) Experimental study of single- and double-electron transfer in slow Ne8++Hecollisions using photon and electron spectroscopy 1999 In: PHYSICAL REVIEW A. - : AMERICAN PHYSICAL SOC. - 1050-2947. ; 60:4, s. 2917-2930 Journal article (other academic/artistic)abstract Single- and double-electron transfer from He to the Ne8+(ls(2))S-0(1) ion has been studied at 80 keV by extreme ultraviolet (EUV) spectroscopy and zero-degree electron spectroscopy. Signals originating from the stabilization after two-electron capture are
36.	Langereis, A, et al. (author) Experimental study of single and double electron transfer processes in slow Ne8++H-2 collisions using photon spectroscopy 1997 In: PHYSICA SCRIPTA. - : ROYAL SWEDISH ACAD SCIENCES. - 0281-1847. ; T73, s. 83-84 Journal article (other academic/artistic)abstract We have performed high resolution EUV spectroscopy on the Ne8+ + H-2 system at 80keV impact energy. New transitions have been identified. The analysis is supported by extensive theoretical calculations. A detailed picture of the decay path of the doubly e
37.	Langereis, A, et al. (author) Experimental study of single and double electron transfer processes in slow Ne8++He collisions using photon- and electron spectroscopy 1997 In: PHYSICA SCRIPTA. - : ROYAL SWEDISH ACAD SCIENCES. - 0281-1847. ; T73, s. 85-86 Journal article (other academic/artistic)abstract We have performed high resolution EUV and Auger electron spectroscopy on the Ne8+ + He system at 80 keV impact energy. New transitions both in the Auger and the EW spectra have been identified The analysis is supported by extensive theoretical calculation
38.	Roblick, U, et al. (author) Sequential alterations of the proteome during genesis and progression of sporadic colon cancer 2004 In: DISEASES OF THE COLON & RECTUM. - 0012-3706. ; 47:6, s. 1069-1070 Conference paper (other academic/artistic)
39.	Strotjohann, Nora L., et al. (author) Bright, Months-long Stellar Outbursts Announce the Explosion of Interaction-powered Supernovae 2021 In: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 907:2 Journal article (peer-reviewed)abstract Interaction-powered supernovae (SNe) explode within an optically thick circumstellar medium (CSM) that could be ejected during eruptive events. To identify and characterize such pre-explosion outbursts, we produce forced-photometry light curves for 196 interacting SNe, mostly of Type IIn, detected by the Zwicky Transient Facility between early 2018 and 2020 June. Extensive tests demonstrate that we only expect a few false detections among the 70,000 analyzed pre-explosion images after applying quality cuts and bias corrections. We detect precursor eruptions prior to 18 Type IIn SNe and prior to the Type Ibn SN 2019uo. Precursors become brighter and more frequent in the last months before the SN and month-long outbursts brighter than magnitude -13 occur prior to 25% (5-69%, 95% confidence range) of all Type IIn SNe within the final three months before the explosion. With radiative energies of up to 10(49) erg, precursors could eject similar to 1 M of material. Nevertheless, SNe with detected precursors are not significantly more luminous than other SNe IIn, and the characteristic narrow hydrogen lines in their spectra typically originate from earlier, undetected mass-loss events. The long precursor durations require ongoing energy injection, and they could, for example, be powered by interaction or by a continuum-driven wind. Instabilities during the neon- and oxygen-burning phases are predicted to launch precursors in the final years to months before the explosion; however, the brightest precursor is 100 times more energetic than anticipated.

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