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1.	Brunius, Carl, 1974, et al. (author) Prediction and modeling of pre-analytical sampling errors as a strategy to improve plasma NMR metabolomics data 2017 In: Bioinformatics. - : Oxford University Press (OUP). - 1367-4803 .- 1460-2059 .- 1367-4811. ; 33:22, s. 3567-3574 Journal article (peer-reviewed)abstract Biobanks are important infrastructures for life science research. Optimal sample handling regarding e.g. collection and processing of biological samples is highly complex, with many variables that could alter sample integrity and even more complex when considering multiple study centers or using legacy samples with limited documentation on sample management. Novel means to understand and take into account such variability would enable high-quality research on archived samples. This study investigated whether pre-analytical sample variability could be predicted and reduced by modeling alterations in the plasma metabolome, measured by NMR, as a function of pre-centrifugation conditions (1-36 h pre-centrifugation delay time at 4 A degrees C and 22 A degrees C) in 16 individuals. Pre-centrifugation temperature and delay times were predicted using random forest modeling and performance was validated on independent samples. Alterations in the metabolome were modeled at each temperature using a cluster-based approach, revealing reproducible effects of delay time on energy metabolism intermediates at both temperatures, but more pronounced at 22 A degrees C. Moreover, pre-centrifugation delay at 4 A degrees C resulted in large, specific variability at 3 h, predominantly of lipids. Pre-analytical sample handling error correction resulted in significant improvement of data quality, particularly at 22 A degrees C. This approach offers the possibility to predict pre-centrifugation delay temperature and time in biobanked samples before use in costly downstream applications. Moreover, the results suggest potential to decrease the impact of undesired, delay-induced variability. However, these findings need to be validated in multiple, large sample sets and with analytical techniques covering a wider range of the metabolome, such as LC-MS.
2.	Brunius, G, et al. (author) Bradykinin upregulates IL-8 production in human gingival fibroblasts stimulated by interleukin-1beta and tumor necrosis factor alpha 2005 In: Regulatory peptides. - : Elsevier BV. - 0167-0115. ; 126:3, s. 183-188 Journal article (peer-reviewed)
3.	Brunius, G, et al. (author) Effect of phenytoin on interleukin-1 beta production in human gingival fibroblasts challenged to tumor necrosis factor alpha in vitro 1996 In: European journal of oral sciences. - : Wiley. - 0909-8836 .- 1600-0722. ; 104:1, s. 27-33 Journal article (peer-reviewed)
4.	Modeer, T, et al. (author) Effect of phenytoin on the production of interleukin-6 and interleukin-8 in human gingival fibroblasts 2000 In: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. - : Wiley. - 0904-2512. ; 29:10, s. 491-499 Journal article (peer-reviewed)
5.	Ulaszewska, Marynka M., et al. (author) Nutrimetabolomics: An Integrative Action for Metabolomic Analyses in Human Nutritional Studies 2019 In: Molecular Nutrition and Food Research. - : Wiley. - 1613-4125 .- 1613-4133. ; 63:1 Research review (peer-reviewed)abstract The life sciences are currently being transformed by an unprecedented wave of developments in molecular analysis, which include important advances in instrumental analysis as well as biocomputing. In light of the central role played by metabolism in nutrition, metabolomics is rapidly being established as a key analytical tool in human nutritional studies. Consequently, an increasing number of nutritionists integrate metabolomics into their study designs. Within this dynamic landscape, the potential of nutritional metabolomics (nutrimetabolomics) to be translated into a science, which can impact on health policies, still needs to be realized. A key element to reach this goal is the ability of the research community to join, to collectively make the best use of the potential offered by nutritional metabolomics. This article, therefore, provides a methodological description of nutritional metabolomics that reflects on the state-of-the-art techniques used in the laboratories of the Food Biomarker Alliance (funded by the European Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL)) as well as points of reflections to harmonize this field. It is not intended to be exhaustive but rather to present a pragmatic guidance on metabolomic methodologies, providing readers with useful “tips and tricks” along the analytical workflow.
6.	Yucel-Lindberg, T, et al. (author) Bradykinin enhances IL-8 production in human gingival fibroblasts stimulated with interleukin-1 beta or tumor necrosis factor alpha. 2003 In: JOURNAL OF DENTAL RESEARCH. - 0022-0345. ; 82, s. B225-B225 Conference paper (other academic/artistic)
7.	Yucel-Lindberg, T, et al. (author) Enhanced cyclooxygenase-2 mRNA expression in human gingival fibroblasts induced by cell contact with human lymphocytes 2001 In: European journal of oral sciences. - : Wiley. - 0909-8836. ; 109:3, s. 187-192 Journal article (peer-reviewed)
8.	Yucel-Lindberg, T, et al. (author) Epidermal growth factor synergistically enhances interleukin-8 production in human gingival fibroblasts stimulated with interleukin-1beta 2006 In: Archives of oral biology. - : Elsevier BV. - 0003-9969. ; 51:10, s. 892-898 Journal article (peer-reviewed)

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Type of publication: journal article (6); conference paper (1); research review (1)

Type of content: peer-reviewed (7); other academic/artistic (1)

Author/Editor: Brunius, G (6); Modeer, T (4); Yucel-Lindberg, T (4); Domeij, H (3); Gustavsson, A. (2); Brunius, Carl, 1974 (2); show more...; Anduren, I (2); Mustafa, M (1); Andersson, L.I. (1); Landberg, Rikard, 19 ... (1); Shinoda, K (1); Garcia-Aloy, Mar (1); Andres-Lacueva, Cris ... (1); Karlsson, B Göran, 1 ... (1); Feskens, Edith J. M. (1); Skurk, Thomas (1); Brennan, Lorraine (1); Wishart, David S. (1); Tybring, G (1); Portmann, Reto (1); Manach, Claudine (1); Capozzi, Francesco (1); Kulling, Sabine E. (1); Mattivi, Fulvio (1); Vergeres, Guy (1); Pedersen, Anders, 19 ... (1); Malmodin, Daniel, 19 ... (1); YucelLindberg, B (1); Wondimu, B (1); González-Domínguez, ... (1); Hanhineva, K. (1); Durand, Stephanie (1); Llorach, Rafael (1); Ulaszewska, Marynka ... (1); Hemeryck, Lieselot Y ... (1); Vanhaecke, Lynn (1); Kopka, Joachim (1); Pujos-Guillot, E. (1); Ferrario, Paola G. (1); Weinert, Christoph H ... (1); Trimigno, Alessia (1); Badertscher, René (1); Bub, Achim (1); Cialiè Rosso, Marta (1); Cordero, Chiara E. (1); Daniel, Hannelore (1); Egert, Bjoern (1); Franceschi, Pietro (1); Giacomoni, Franck (1); Giesbertz, Pieter (1); show less...

University: Karolinska Institutet (7); Chalmers University of Technology (2); University of Gothenburg (1); Swedish University of Agricultural Sciences (1)

Language: English (8)

Research subject (UKÄ/SCB): Natural sciences (1); Engineering and Technology (1); Medical and Health Sciences (1); Social Sciences (1); Humanities (1)

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