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- Glasbey, JC, et al.
(author)
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- 2021
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swepub:Mat__t
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- Fung, P. P. L., et al.
(author)
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Time to onset of bisphosphonate-related osteonecrosis of the jaws : a multicentre retrospective cohort study
- 2017
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In: Oral Diseases. - : WILEY. - 1354-523X .- 1601-0825. ; 23:4, s. 477-483
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Journal article (peer-reviewed)abstract
- Objectives: Osteonecrosis of the jaw (ONJ) is a potentially severe adverse effect of bisphosphonates (BP). Although the risk of ONJ increases with increasing duration of BP treatment, there are currently no reliable estimates of the ONJ time to onset (TTO). The objective of this study was to estimate the TTO and associated risk factors in BP-treated patients.Subjects and Methods: Retrospective analysis of data from 22 secondary care centres in seven countries relevant to 349 patients who developed BP-related ONJ between 2004 and 2012.Results: The median (95%CI) TTO was 6.0 years in patients treated with alendronate (n=88) and 2.2years in those treated with zoledronate (n=218). Multivariable Cox regression showed that dentoalveolar surgery was inversely associated, and the use of antiangiogenics directly associated, with the TTO in patients with cancer treated with zoledronate.Conclusions: The incidence of ONJ increases with the duration of BP therapy, with notable differences observed with respect to BP type and potency, route of administration and underlying disease. When data are stratified by BP type, a time of 6.0 and 2.2years of oral alendronate and intravenous zoledronate therapy, respectively, is required for 50% of patients to develop ONJ. After stratification by disease, a time of 5.3 and 2.2years of BP therapy is required for 50% of patients with osteoporosis and cancer, respectively, to develop ONJ. These findings have significant implications for the design of future clinical studies and the development of risk-reduction strategies aimed at either assessing or modulating the risk of ONJ associated with BP.
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- S, Syrjänen, et al.
(author)
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Human papillomaviruses in oral carcinoma and oral potentially malignant disorders: a systematic review.
- 2011
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In: Oral diseases. - : Wiley. - 1354-523X. ; 17:Suppl 1, s. 58-72
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Journal article (peer-reviewed)abstract
- Abstract OBJECTIVES: Human papillomavirus (HPV) in oral carcinoma (OSCC) and potentially malignant disorders (OPMD) is controversial. The primary aim was to calculate pooled risk estimates for the association of HPV with OSCC and OPMD when compared with healthy oral mucosa as controls. We also examined the effects of sampling techniques on HPV detection rates. METHODS: Systematic review was performed using PubMed (January 1966-September 2010) and EMBASE (January 1990-September 2010). Eligible studies included randomized controlled, cohort and cross-sectional studies. Pooled data were analysed by calculating odds ratios, using a random effects model. Risk of bias was based on characteristics of study group, appropriateness of the control group and prospective design. RESULTS: Of the 1121 publications identified, 39 cross-sectional studies met the inclusion criteria. Collectively, 1885 cases and 2248 controls of OSCC and 956 cases and 675 controls of OPMD were available for analysis. Significant association was found between pooled HPV-DNA detection and OSCC (OR = 3.98; 95% CI: 2.62-6.02) and even for HPV16 only (OR = 3.86; 95% CI: 2.16-6.86). HPV was also associated with OPMD (OR = 3.87; 95% CI: 2.87-5.21). In a subgroup analysis of OPMD, HPV was also associated with oral leukoplakia (OR = 4.03; 95% CI: 2.34-6.92), oral lichen planus (OR = 5.12; 95% CI: 2.40-10.93), and epithelial dysplasia (OR = 5.10; 95% CI: 2.03-12.80). CONCLUSIONS: The results suggest a potentially important causal association between HPV and OSCC and OPMD.
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- Wolff, A., et al.
(author)
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Electrostimulation of the lingual nerve by an intraoral device may lead to salivary gland regeneration: A case series study
- 2018
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In: Medicina Oral Patologia Oral Y Cirugia Bucal. - : Medicina Oral, S.L.. - 1698-6946. ; 23:5
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Journal article (peer-reviewed)abstract
- Background: Salivary gland function is controlled by the salivary reflex, whose efferent arm is composed by the parasympathetic and the sympathetic divisions of the autonomic nervous system. Parenchymal injury is the main salivary gland involvement of Sjögren’s syndrome and head and neck radiotherapy, but neural damage has been reported as well. Recently an intraoral device for electrostimulation of the lingual nerve in vicinity to the lower third molar has been introduced. At this point this nerve carries efferent fibers for the innervation of the submandibular, sublingual and several minor salivary glands and afferent fibers of the salivary reflex. Therefore, excitation of these fibers potentially leads to increased secretion of all salivary glands. Thus, the study objective was to assess whether comprehensive neural activation by electrostimulation of the lingual nerve carries the potential to induce the regeneration of damaged salivary glands. Material and Methods: The device was tested on three patients with no collectable resting and stimulated secretion of saliva during a double blind, sham controlled period of two months and nine open-label months. Results: All three subjects developed the capacity to spit saliva, not only in direct response to the electrostimulation but also after free intervals without electrostimulation. In addition, their symptoms of dry mouth severity and frequency improved. Conclusions: This recovery is probably due to the combined effect of increase in secretory functional gland mass and regain of nervous control of the secretory elements and blood vessels. Both are phenomena that would contribute to gland regeneration.
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- Campisi, T., et al.
(author)
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Perceived Pedestrian Level of Service : The case of Thessaloniki, Greece
- 2022
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In: Transportation Research Procedia. - : Elsevier BV. - 2352-1465. ; , s. 124-131
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Conference paper (peer-reviewed)abstract
- Level of Service (LOS) is one of the most crucial components for the assessment of pedestrian facilities by mainly concerning the effective width as well as pedestrians’ flows. However, current research reveals that qualitative characteristics can also contribute to LOS estimation as perceived by pedestrians. Specifically, socio-demographic characteristics (i.e., age, gender) as well as characteristics related with perceived comfort and safety can be related with perceived LOS. A Revealed Preference (RP) face to face questionnaire-based survey (including 301 interviewees) was realized during October 2019 at a central pedestrian facility in the city of Thessaloniki, Greece. RP questionnaire survey assisted in gaining valuable knowledge concerning the factors that mainly affect pedestrians’ perceived LOS across the pedestrian facility. The examined pedestrian facility is one of the most important in Thessaloniki since it facilitates high pedestrian flows within the city center daily. The present survey considered pedestrians’ general mobility characteristics such as walking frequency along the facility and trip purpose. Additionally, the evaluation of the greater facility’ area in terms of land use attractiveness, comfort, personal and road safety, public transport, parking conditions and traffic delays, accessibility, pedestrians and bicycles were concerned as well. Ordinal regression was the main tool for the development of the ordinal regression model, and therefore, for the conclusions’ drawing of the present research. The findings regarding perceived LOS can pave the way towards the design of sustainable policy concerning pedestrian facilities as well as the encouragement of active transport in urban areas.
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- di Summa, Pietro G., et al.
(author)
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Collagen (NeuraGen(®)) nerve conduits and stem cells for peripheral nerve gap repair
- 2014
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In: Neuroscience Letters. - : Elsevier. - 0304-3940 .- 1872-7972. ; 572, s. 26-31
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Journal article (peer-reviewed)abstract
- Collagen nerve guides are used clinically for peripheral nerve defects, but their use is generally limited to lesions up to 3cm. In this study we combined collagen conduits with cells as an alternative strategy to support nerve regeneration over longer gaps. In vitro cell adherence to collagen conduits (NeuraGen(®) nerve guides) was assessed by scanning electron microscopy. For in vivo experiments, conduits were seeded with either Schwann cells (SC), SC-like differentiated bone marrow-derived mesenchymal stem cells (dMSC), SC-like differentiated adipose-derived stem cells (dASC) or left empty (control group), conduits were used to bridge a 1cm gap in the rat sciatic nerve and after 2-weeks immunohistochemical analysis was performed to assess axonal regeneration and SC infiltration. The regenerative cells showed good adherence to the collagen walls. Primary SC showed significant improvement in distal stump sprouting. No significant differences in proximal regeneration distances were noticed among experimental groups. dMSC and dASC-loaded conduits showed a diffuse sprouting pattern, while SC-loaded showed an enhanced cone pattern and a typical sprouting along the conduits walls, suggesting an increased affinity for the collagen type I fibrillar structure. NeuraGen(®) guides showed high affinity of regenerative cells and could be used as efficient vehicle for cell delivery. However, surface modifications (e.g. with extracellular matrix molecule peptides) of NeuraGen(®) guides could be used in future tissue-engineering applications to better exploit the cell potential.
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