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- Mishra, A., et al.
(author)
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Stroke genetics informs drug discovery and risk prediction across ancestries
- 2022
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 611, s. 115-123
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Journal article (peer-reviewed)abstract
- Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry(1,2). Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis(3), and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach(4), we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry(5). Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.
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7. |
- Aaltonen, T., et al.
(author)
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Combination of Tevatron Searches for the Standard Model Higgs Boson in the W+W- Decay Mode
- 2010
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In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 104:6, s. 061802-
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Journal article (peer-reviewed)abstract
- We combine searches by the CDF and D0 Collaborations for a Higgs boson decaying to W+W-. The data correspond to an integrated total luminosity of 4.8 (CDF) and 5.4 (D0) fb(-1) of p (p) over bar collisions at root s = 1.96 TeV at the Fermilab Tevatron collider. No excess is observed above background expectation, and resulting limits on Higgs boson production exclude a standard model Higgs boson in the mass range 162-166 GeV at the 95% C.L.
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8. |
- Blokland, G. A. M., et al.
(author)
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Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders
- 2022
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In: Biological Psychiatry. - : Elsevier BV. - 0006-3223 .- 1873-2402. ; 91:1, s. 102-117
-
Journal article (peer-reviewed)abstract
- Background: Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across disorders suggest possible shared sex-dependent genetic risk. Methods: We conducted the largest to date genome-wide genotype-by-sex (G×S) interaction of risk for these disorders using 85,735 cases (33,403 SCZ, 19,924 BIP, and 32,408 MDD) and 109,946 controls from the PGC (Psychiatric Genomics Consortium) and iPSYCH. Results: Across disorders, genome-wide significant single nucleotide polymorphism–by-sex interaction was detected for a locus encompassing NKAIN2 (rs117780815, p = 3.2 × 10−8), which interacts with sodium/potassium-transporting ATPase (adenosine triphosphatase) enzymes, implicating neuronal excitability. Three additional loci showed evidence (p < 1 × 10−6) for cross-disorder G×S interaction (rs7302529, p = 1.6 × 10−7; rs73033497, p = 8.8 × 10−7; rs7914279, p = 6.4 × 10−7), implicating various functions. Gene-based analyses identified G×S interaction across disorders (p = 8.97 × 10−7) with transcriptional inhibitor SLTM. Most significant in SCZ was a MOCOS gene locus (rs11665282, p = 1.5 × 10−7), implicating vascular endothelial cells. Secondary analysis of the PGC-SCZ dataset detected an interaction (rs13265509, p = 1.1 × 10−7) in a locus containing IDO2, a kynurenine pathway enzyme with immunoregulatory functions implicated in SCZ, BIP, and MDD. Pathway enrichment analysis detected significant G×S interaction of genes regulating vascular endothelial growth factor receptor signaling in MDD (false discovery rate-corrected p < .05). Conclusions: In the largest genome-wide G×S analysis of mood and psychotic disorders to date, there was substantial genetic overlap between the sexes. However, significant sex-dependent effects were enriched for genes related to neuronal development and immune and vascular functions across and within SCZ, BIP, and MDD at the variant, gene, and pathway levels. © 2021 Society of Biological Psychiatry
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10. |
- Abazov, V. M., et al.
(author)
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Measurement of the Angular and Lifetime Parameters of the Decays B-d(0) -> J/psi K*(0) and B-s(0) -> J/psi phi
- 2009
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In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 102:3, s. 032001-:102, s. 032001-
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Journal article (peer-reviewed)abstract
- We present measurements of the linear polarization amplitudes and the strong relative phases that describe the flavor-untagged decays B-d(0) --> J/psi K*(0) and B-s(0) --> J/psi phi in the transversity basis. We also measure the mean lifetime (tau) over bar (s) of the B-s(0) mass eigenstates and the lifetime ratio (tau) over bar (s)/tau(d). The analyses are based on approximately 2.8 fb(-1) of data recorded with the D0 detector. From our measurements of the angular parameters we conclude that there is no evidence for a deviation from flavor SU( 3) symmetry for these decays and that the factorization assumption is not valid for the B-d(0) --> J/psi K*(0) decay.
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11. |
- Abazov, V. M., et al.
(author)
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Search for Large Extra Spatial Dimensions in the Dielectron and Diphoton Channels in p(p)over-bar Collisions at root s=1.96 TeV
- 2009
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In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 102:5, s. 051601-:102, s. 051601-
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Journal article (peer-reviewed)abstract
- We report on a search for large extra spatial dimensions in the dielectron and diphoton channels using a data sample of 1: 05 fb(-1) of p (p) over bar collisions at a center-of-mass energy of 1.96 TeV collected by the D0 detector at the Fermilab Tevatron Collider. The invariant mass spectrum of the data agrees well with the prediction of the standard model. We find the most restrictive 95% C. L. lower limits on the effective Planck scale between 2.1 and 1.3 TeV for 2 to 7 extra dimensions.
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12. |
- Abazov, V. M., et al.
(author)
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Measurement of sigma(p(p)over-bar -> Z plus X)Br(Z -> tau(+)tau(-)) at root s=1.96 TeV
- 2009
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In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 670:4-5, s. 292-299
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Journal article (peer-reviewed)abstract
- We present a measurement of the cross section for Z boson production times the branching fraction to tau lepton pairs sigma(p (p) over bar -> Z + X)Br(Z -> tau(+)tau(-)) in p (p) over bar collisions at root s = 1.96 TeV. The measurement is performed in the channel in which one tau lepton decays into a muon and neutrinos. and the other tau lepton decays hadronically or into an electron and neutrinos. The data sample corresponds to an integrated luminosity of 1.0 fb(-1) collected with the DO detector at the Fermilab Tevatron Collider. The sample contains 1511 candidate events with an estimated 20% background from jets or muons misidentified as tau leptons. We obtain sigma . Br = 240 +/- 8 (star) +/- 12 (sys) +/- 15 (lum) pb, which is consistent with the standard model prediction.
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13. |
- Abazov, V. M., et al.
(author)
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Search for Associated W and Higgs Boson Production in p(p)over-bar Collisions at root s=1.96 TeV
- 2009
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In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 102:5, s. 051803-:102, s. 051803-
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Journal article (peer-reviewed)abstract
- We present results of a search for WH -> l nu b (b) over bar production in p (p) over bar collisions based on the analysis of 1.05 fb(-1) of data collected by the D0 experiment at the Fermilab Tevatron, using a neural network for separating the signal from backgrounds. No signal-like excess is observed, and we set 95% C. L. upper limits on the WH production cross section multiplied by the branching ratio for H -> b (b) over bar for Higgs boson masses between 100 and 150 GeV. For a mass of 115 GeV, we obtain an observed (expected) limit of 1.5 (1.4) pb, a factor of 11.4 (10.7) times larger than the standard model prediction.
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14. |
- Abazov, V. M., et al.
(author)
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Search for pair production of second generation scalar leptoquarks
- 2009
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In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 671:2, s. 224-232
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Journal article (peer-reviewed)abstract
- We report on a search for the pair production of second generation scalar leptoquarks (LQ) in p (p) over bar collisions at the center of mass energy root s- = 1.96 TeV using a data set corresponding to an integrated luminosity of 1.0 fb(-1) collected with the D empty set experiment at the Fermilab Tevatron Collider. Topologies arising from the LQ (LQ) over bar -> mu q nu q and LQ (LQ) over bar -> mu q mu q decay modes are investigated. No excess of data over the standard model prediction is observed and upper limits on the leptoquark pair production cross section are derived at the 95% C.L. as a function of the leptoquark mass and the branching fraction beta for the decay LQ -> mu q. These are interpreted as lower limits on the leptoquark mass as a function of beta. For beta = 1 (0.5), scalar second generation leptoquarks with masses up to 316 GeV (270 GeV) are excluded.
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15. |
- Abazov, V. M., et al.
(author)
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Evidence for the Decay B-s(0)->(DsDs(*))-D-(*) and a Measurement of Delta Gamma(CP)(s)/Gamma(s)
- 2009
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In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 102:9, s. 091801-
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Journal article (peer-reviewed)abstract
- We search for the semi-inclusive process B-s(0)->(DsDs(*))-D-(*) using 2.8 fb(-1) of pp collisions at s=1.96 TeV recorded by the D0 detector operating at the Fermilab Tevatron Collider. We observe 26.6 +/- 8.4 signal events with a significance above background of 3.2 standard deviations yielding a branching ratio of B(B-s(0)->(DsDs(*))-D-(*))=0.035 +/- 0.010(stat.)+/- 0.011(syst.). Under certain theoretical assumptions, these double-charm final states saturate CP-even eigenstates in the B-s(0) decays resulting in a width difference of Delta Gamma(CP)(s)/Gamma(s)=0.072 +/- 0.021(stat.)+/- 0.022(syst.).
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16. |
- Abazov, V. M., et al.
(author)
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Observation of ZZ Production in p(p)over-bar Collisions at root s=1.96 TeV
- 2008
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In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 101:17, s. 171803-:101, s. 171803-
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Journal article (peer-reviewed)abstract
- We present an observation for ZZ -> l(+) l(-) l'(+) l'(-) (l, l' =e or mu) production in p (p) over bar collisions at a center-of-mass energy of root s = 1.96 TeV. Using 1.7 fb(-1) of data collected by the D0 experiment at the Fermilab Tevatron Collider, we observe three candidate events with an expected background of 0.14(-0.02)(+0.03) events. The significance of this observation is 5.3 standard deviations. The combination of D0 results in this channel, as well as in ZZ -> l(+) l(-) v (v) over bar yields a significance of 5.7 standard deviations and a combined cross section of sigma(ZZ) = 1.60 +/- 0.63(stat)(-0.17)(+0.16)(syst) pb.
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17. |
- Abazov, V. M., et al.
(author)
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Search for Anomalous Top-Quark Couplings with the D0 Detector
- 2009
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In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 102:9, s. 092002-
-
Journal article (peer-reviewed)abstract
- Anomalous Wtb couplings modify the angular correlations of the top-quark decay products and change the single top-quark production cross section. We present limits on anomalous top-quark couplings by combining information from W boson helicity measurements in top-quark decays and anomalous coupling searches in the single top-quark final state. We set limits on right-handed vector couplings as well as left-handed and right-handed tensor couplings based on about 1 fb(-1) of data collected by the D0 experiment.
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18. |
- Abazov, V. M., et al.
(author)
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Search for large extra dimensions via single photon plus missing energy final states at root s=1.96 TeV
- 2008
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In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 101:1, s. 011601-:101, s. 011601-
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Journal article (peer-reviewed)abstract
- We report on a search for large extra dimensions in a data sample of approximately 1 fb(-1) of p (p) over bar collisions at root s=1.96 TeV. We investigate Kaluza-Klein graviton production with a photon and missing transverse energy in the final state. At the 95% C.L. we set limits on the fundamental mass scale M-D from 884 to 778 GeV for two to eight extra dimensions.
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19. |
- Abazov, V. M., et al.
(author)
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Search for Neutral Higgs Bosons at High tan beta in the b(h/H/A) -> b tau(+)tau(-) Channel
- 2009
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In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 102:5, s. 051804-:102, s. 051804-
-
Journal article (peer-reviewed)abstract
- The first search in p (p) over bar collisions at root s = 1.96 TeV for the production of neutral Higgs bosons in association with bottom quarks and decaying in two tau leptons is presented. The cross section for this process is enhanced in many extensions of the standard model, such as its minimal supersymmetric extension (MSSM) at large tan beta. The data, corresponding to an integrated luminosity of 328 pb(-1), were collected with the D0 detector at the Fermilab Tevatron Collider. An upper limit is set on the production cross section of neutral Higgs bosons in the mass range of 90 to 150 GeV, and this limit is used to exclude part of the MSSM parameter space.
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20. |
- Franceschini, N., et al.
(author)
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GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
- 2018
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1
-
Journal article (peer-reviewed)abstract
- Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4. LD score regression reveals significant genetic correlations between cIMT and plaque traits, and both cIMT and plaque with CHD, any stroke subtype and ischemic stroke. Our study provides insights into genes and tissue-specific regulatory mechanisms linking atherosclerosis both to its functional genomic origins and its clinical consequences in humans. © 2018, The Author(s).
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21. |
- Abazov, M, et al.
(author)
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Search for Long-Lived Charged Massive Particles with the D0 Detector
- 2009
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In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 102:16, s. 161802-
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Journal article (peer-reviewed)abstract
- We search for long-lived charged massive particles using 1.1 fb(-1) of data collected by the D0 detector at the Fermilab Tevatron pp Collider. Time-of-flight information is used to search for pair produced long-lived tau sleptons, gauginolike charginos, and Higgsino-like charginos. We find no evidence of a signal and set 95% C.L. cross section upper limits for staus, which vary from 0.31 to 0.04 pb for stau masses between 60 and 300 GeV. We also set lower mass limits of 206 GeV (171 GeV) for pair produced charged gauginos (Higgsinos).
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22. |
- Abazov, M, et al.
(author)
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Search for the Standard Model Higgs Boson in the Missing Energy and Acoplanar b-Jet Topology at root s=1.96 TeV
- 2008
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In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 101:25, s. 251802-
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Journal article (peer-reviewed)abstract
- We report a search for the standard model Higgs boson in the missing energy and acoplanar b-jet topology, using an integrated luminosity of 0.93 fb(-1) recorded by the D0 detector at the Fermilab Tevatron p (p) over bar Collider. The analysis includes signal contributions from p (p) over bar -> ZH -> v (v) over barb (b) over bar, as well as from WH production in which the charged lepton from the W boson decay is undetected. Neural networks are used to separate signal from background. In the absence of a signal, we set limits on sigma(p (p) over bar -> VH) x B(H -> b (b) over bar) at the 95% C.L. of 2.6-2.3 pb, for Higgs boson masses in the range 105-135 GeV, where V W, Z. The corresponding expected limits range from 2.8 to 2.0 pb.
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23. |
- Abazov, V. M., et al.
(author)
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Measurement of the top quark mass in final states with two leptons
- 2009
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In: Physical Review D - Particles, Fields, Gravitation and Cosmology. - 1550-7998 .- 1550-2368. ; 80, s. 092006-
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Journal article (peer-reviewed)abstract
- We present measurements of the top quark mass (m(t)) in tt candidate events with two final state leptons using 1 fb(-1) of data collected by the D0 experiment. Our data sample is selected by requiring two fully identified leptons or by relaxing one lepton requirement to an isolated track if at least one jet is tagged as a b jet. The top quark mass is extracted after reconstructing the event kinematics under the tt hypothesis using two methods. In the first method, we integrate over expected neutrino rapidity distributions, and in the second we calculate a weight for the possible top quark masses based on the observed particle momenta and the known parton distribution functions. We analyze 83 candidate events in the data and obtain m(t)=176.2 +/- 4.8(stat)+/- 2.1(sys) GeV and m(t)=173.2 +/- 4.9(stat)+/- 2.0(sys) GeV for the two methods, respectively. Accounting for correlations between the two methods, we combine the measurements to obtain m(t)=174.7 +/- 4.4(stat)+/- 2.0(sys) GeV.
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24. |
- Abazov, V. M., et al.
(author)
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Search for CP violation in B-s(0) -> mu(+) D-s(-) X decays in p(p)over-bar collisions at root s=1.96 TeV
- 2010
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In: Physical Review D - Particles, Fields, Gravitation and Cosmology. - 1550-7998 .- 1550-2368. ; 82:1, s. 012003-
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Journal article (peer-reviewed)abstract
- We have performed a search for CP violation in a sample of B-s(0) -> mu+Ds-X decays corresponding to 5 fb(-1) of proton-antiproton collisions collected by the D0 detector in Run II at the Fermilab Tevatron Collider. New physics in B-s(0) mixing could contribute a significant CP violating weak phase, which would be observed as a difference in the decay-time distribution for B-s(0) -> (B) over bar (0)(s) oscillated states versus that for (B) over bar (0)(s) -> B-s(0). A fit to the decay-time distributions of the B-s(0)/(B) over bar (0)(s) candidates yields the flavor-specific asymmetry as a(fs)(s) = [-1.7 +/- 9.1(stat)(-1.5)(+1.4)(syst) x 10(-3), which excludes CP violation due to new physics within the experimental sensitivity.
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25. |
- Abazov, M, et al.
(author)
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Measurement of differential Z/gamma* plus jet plus X cross sections in p(p)over-bar collisions at root S=1.96 TeV
- 2008
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In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 669:5, s. 278-286
-
Journal article (peer-reviewed)abstract
- We present new measurements of differential cross sections for Z/gamma* (-> mu mu) + jet + X production in a 1 fb(-1) data sample collected with the DO detector in p (p) over bar collisions at root s = 1.96 TeV. Results include the first measurements differential in the Z/gamma* transverse momentum and rapidity, as well as new measurements differential in the leading jet transverse momentum and rapidity. Next-to-leading order perturbative QCD predictions are compared to the measurements, and reasonable agreement is observed, except in the region of low Z/gamma* transverse momentum. Predictions from two event generators based on matrix elements and parton showers, and one pure parton shower event generator are also compared to the measurements. These show significant overall normalization differences to the data and have varied success in describing the shape of the distributions.
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26. |
- Abazov, M, et al.
(author)
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Search for admixture of scalar top quarks in the t(t)over-bar lepton + jets final state at root s=1.96 TeV
- 2009
-
In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 674:1, s. 4-10
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Journal article (peer-reviewed)abstract
- A search for pair production of the lightest supersymmetric partner of the top quark, (t) over tilde (1), is performed in the lepton + jets channel using 0.9 fb(-1) of data collected by the D circle divide experiment. Kinematic differences between (t) over tilde (1)(t) over tilde (1) and the dominant top quark pair production background are used to separate the two processes. First limits from Run II of the Fermilab Tevatron Collider for the scalar top quark decaying to a chargino and a b quark ((t) over tilde1 -> (chi) over tilde (+)(1)b) are obtained for scalar top quark masses of 130-190 GeV and chargino masses of 90-150 GeV.
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27. |
- Abazov, V. M., et al.
(author)
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Measurement of the t-channel single top quark production cross section
- 2010
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In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 682:4-5, s. 363-369
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Journal article (peer-reviewed)abstract
- The DO Collaboration reports direct evidence for electroweak production of single top quarks through the t-channel exchange of a virtual W boson. This is the first analysis to isolate an individual single top quark production channel. We select events containing an isolated electron or muon, missing transverse energy, and two, three or four jets from 2.3 fb(-1) of p (p) over bar collisions at the Fermilab Tevatron Collider. One or two of the jets are identified as containing a b hadron. We combine three multivariate techniques optimized for the t-channel process to measure the t- and s-channel cross sections simultaneously. We measure cross sections of 3.14(-0.80)(+0.94) pb for the t-channel and 1.05 +/- 0.81 pb for the s-channel. The measured t-channel result is found to have a significance of 4.8 standard deviations and is consistent with the standard model prediction.
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28. |
- Abazov, M, et al.
(author)
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Evidence of WW and WZ Production with lepton plus jets Final States in pp Collisions at root s=1.96 TeV
- 2009
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In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 102:16, s. 161801-
-
Journal article (peer-reviewed)abstract
- We present first evidence for WW+WZ production in lepton+jets final states at a hadron collider. The data correspond to 1.07 fb(-1) of integrated luminosity collected with the D0 detector at the Fermilab Tevatron in pp collisions at root s=1.96 TeV. The observed cross section for WW+WZ production is 20.2 +/- 4.5 pb, consistent with the standard model and more precise than previous measurements in fully leptonic final states. The probability that background fluctuations alone produce this excess is < 5.4x10(-6), which corresponds to a significance of 4.4 standard deviations.
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29. |
- Abazov, M, et al.
(author)
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Measurement of the t(t)over-bar production cross section and top quark mass extraction using dilepton events in p(p)over-bar collisions
- 2009
-
In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 679:3, s. 177-185
-
Journal article (peer-reviewed)abstract
- We present a measurement of the top quark pair production cross section in p (p) over bar collisions at root s = 1.96 TeV using approximately 1 fb(-1) collected with the DO detector. We consider decay channels containing two high p(T) charged leptons where one lepton is identified as an electron or a muon while the other lepton can be an electron, a muon or a hadronically decaying tau lepton. For a mass of the top quark of 170 GeV, the measured cross section is 7.5(-1.0)(+1.0)(stat)(-0.6)(+0.7)(syst)(-0.5)(+0.6)(lumi) pb. Using l tau events only, we measure: sigma(t (t) over bar) x B(t (t) over bar -> l tau b (b) over bar) = 0.13(-0.08)(+0.09)(stat)(-0.06)(+0.06)(syst)(-0.02)(+0.02)(lumi) pb. Comparing the measured cross section as a function of the mass of the top quark with a partial next-to-next-to leading order Quantum Chroniodynamics theoretical prediction, we extract a mass of the top quark of 171.5(-8.8)(+9-9) GeV, in agreement with direct measurements.
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30. |
- Abazov, M, et al.
(author)
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Search for associated production of charginos and neutralinos in the trilepton final state using 2.3 fb(-1) of data
- 2009
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In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 680:1, s. 34-43
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Journal article (peer-reviewed)abstract
- We report the results of a search for associated production of charginos and neutralinos using a data set corresponding to an integrated luminosity of 2.3 fb(-1) collected with the Demptyset experiment during Run II of the Tevatron proton-antiproton collider. Final states containing three charged leptons and missing transverse energy are probed for a signal from supersymmetry with four dedicated trilepton event selections. No evidence for a signal is observed, and we set limits on the product of production cross section and leptonic branching fraction. Within minimal supergravity, these limits translate into bounds on m(0) and m(1/2) that are well beyond existing limits.
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31. |
- Abazov, M, et al.
(author)
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Search for Resonant Diphoton Production with the D0 Detector
- 2009
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In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 102:23, s. 231801-
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Journal article (peer-reviewed)abstract
- We present a search for a narrow resonance in the inclusive diphoton final state using similar to 2.7 fb(-1) of data collected with the D0 detector at the Fermilab Tevatron p (p) over bar Collider. We observe good agreement between the data and the background prediction, and set the first 95% C. L. upper limits on the production cross section times the branching ratio for decay into a pair of photons for resonance masses between 100 and 150 GeV. This search is also interpreted in the context of several models of electroweak symmetry breaking with a Higgs boson decaying into two photons.
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32. |
- Abazov, V. M., et al.
(author)
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Dependence of the t(t)over-bar production cross section on the transverse momentum of the top quark
- 2010
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In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 693:5, s. 515-521
-
Journal article (peer-reviewed)abstract
- We present a measurement of the differential cross section for t (t) over bar events produced in p (p) over bar collisions at root s = 1.96 TeV as a function of the transverse momentum (p(T)) of the top quark. The selected events contain a high-p(T) lepton (l), a large imbalance in p(T). four or more jets with at least one candidate for a b jet, and correspond to 1 fb(-1) of integrated luminosity recorded with the D0 detector. Objects in the event are associated through a constrained kinematic fit to the t (t) over bar -> WbW (b) over bar -> lvbq (q) over bar' (b) over bar process. Results from next and next-to-next-to-leading-order perturbative QCD calculations agree with the measured differential cross section. Comparisons are also provided to predictions from Monte Carlo event generators using QCD calculations at different levels of precision. (C) 2010 Elsevier B.V. All rights reserved.
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33. |
- Abazov, V. M., et al.
(author)
-
Measurement of Z/gamma* plus jet plus X angular distributions in p(p)over-bar collisions at root s=1.96 TeV
- 2010
-
In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 682:4-5, s. 370-380
-
Journal article (peer-reviewed)abstract
- We present the first measurements at a hadron collider of differential cross sections for Z/gamma* + jet + X production in Delta phi(Z. jet), vertical bar Delta y(Z, jet)vertical bar and vertical bar y(boost)(Z + jet)vertical bar. Vector boson production in association with jets is an excellent probe of QCD and constitutes the main background to many small cross section processes, such as associated Higgs production. These measurements are crucial tests of the predictions of perturbative QCD and current event generators, which have varied success in describing the data. Using these measurements as inputs in tuning event generators will increase the experimental sensitivity to rare signals.
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34. |
- Abazov, V. M., et al.
(author)
-
Search for charged Higgs bosons in top quark decays
- 2009
-
In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 682:3, s. 278-286
-
Journal article (peer-reviewed)abstract
- We present a search for charged Higgs bosons in top quark decays. We analyze the e + jets, mu + jets, ee, e mu, mu mu, tau e and tau mu final states from top quark pair production events, using data from about 1 fb (1) of integrated luminosity recorded by the DO experiment at the Fermilab Tevatron Collider. We consider different scenarios of possible charged Higgs boson decays, one where the charged Higgs boson decays purely hadronically into a charm and a strange quark, another where it decays into a tau lepton and a tau neutrino and a third one where both decays appear. We extract limits on the branching ratio B(t -> H(+)b) for all these models. We use two methods, one where the t (t) over bar production cross section is fixed, and one where the cross section is fitted simultaneously with B(t -> H(+)b). Based on the extracted limits, we exclude regions in the charged Higgs boson mass and tan beta parameter space for different scenarios of the minimal supersymmetric standard model.
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35. |
- Abazov, V. M., et al.
(author)
-
Search for single top quarks in the tau plus jets channel using 4.8 fb(-1) of p(p)over-bar collision data
- 2010
-
In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 690:1, s. 5-14
-
Journal article (peer-reviewed)abstract
- We present the first direct search for single top quark production using reconstructed tau leptons in the final state. The search is based on 4.8 fb(-1) of integrated luminosity collected in p (p) over bar collisions at root s= 1.96 TeV with the D0 detector at the Fermilab Tevatron Collider. We select events with a final state including an isolated tau lepton. missing transverse energy, two or three jets, one or two of them being identified as b quark jet. We use a multivariate technique to discriminate signal from background. The number of events observed in data in this final state is consistent with the signal plus background expectation. We set in the tau + jets channel an upper limit on the single top quark cross section of 7.3 pb at the 95% C.L. This measurement allows a gain of 4% in expected sensitivity for the observation of single top production when combining it with electron + jets and muon + jets channels already published by the DO Collaboration with 2.3 fb(-1) of data. We measure a combined cross section of 3.84(-0.83)(+0.89) pb, which is the most precise measurement to date.
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36. |
- Abazov, V. M., et al.
(author)
-
Search for the Standard Model Higgs Boson in the ZH -> v(v)over-barb(b)over-bar Channel in 5.2 fb(-1) of p(p)over-bar Collisions at root s=1.96 TeV
- 2010
-
In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 104:7, s. 071801-
-
Journal article (peer-reviewed)abstract
- A search is performed for the standard model Higgs boson in 5.2 fb(-1) of p (p) over bar collisions at root s = 1.96 TeV, collected with the D0 detector at the Fermilab Tevatron Collider. The final state considered is a pair of b jets and large missing transverse energy, as expected from p (p) over bar -> ZH -> v (v) over barb (b) over bar production. The search is also sensitive to the WH -> lvb (b) over bar channel when the charged lepton is not identified. For a Higgs boson mass of 115 GeV, a limit is set at the 95% C.L. on the cross section multiplied by branching fraction for [p (p) over bar -> (Z/W)H](H -> b (b) over bar) that is a factor of 3.7 larger than the standard model value, consistent with the factor of 4.6 expected.
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37. |
- Abazov, M, et al.
(author)
-
Measurement of gamma + b + X and gamma + c + X Production Cross Sections in pp > Collisions at s=1.96 TeV
- 2009
-
In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 102:19, s. 192002-
-
Journal article (peer-reviewed)abstract
- First measurements of the differential cross sections d(3)sigma/(dp(T)(gamma)dy(gamma)dy(jet)) for the inclusive production of a photon in association with a heavy quark (b, c) jet are presented, covering photon transverse momenta 30 < p(T)(gamma)< 150 GeV, photon rapidities |y(gamma)|< 1.0, jet rapidities |y(jet)|< 0.8, and jet transverse momenta p(T)(jet)> 15 GeV. The results are based on an integrated luminosity of 1 fb(-1) in pp collisions at s=1.96 TeV recorded with the D0 detector at the Fermilab Tevatron Collider. The results are compared with next-to-leading order perturbative QCD predictions.
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38. |
- Abazov, M, et al.
(author)
-
Observation of Single Top-Quark Production
- 2009
-
In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 103:9, s. 092001-
-
Journal article (peer-reviewed)abstract
- We report observation of the electroweak production of single top quarks in pp collisions at s=1.96 TeV based on 2.3 fb(-1) of data collected by the D0 detector at the Fermilab Tevatron Collider. Using events containing an isolated electron or muon and missing transverse energy, together with jets originating from the fragmentation of b quarks, we measure a cross section of sigma(pp -> tb+X,tqb+X)=3.94 +/- 0.88 pb. The probability to measure a cross section at this value or higher in the absence of signal is 2.5x10(-7), corresponding to a 5.0 standard deviation significance for the observation.
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39. |
- Abazov, M, et al.
(author)
-
Search for the lightest scalar top quark in events with two leptons in p(p)over-bar collisions at root s=1.96 TeV
- 2009
-
In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 675:3-4, s. 289-296
-
Journal article (peer-reviewed)abstract
- We report results of a search for the pair production of the lightest supersymmetric partner of the top quark, (t) over bar (1), using a data set corresponding to an integrated luminosity of 1 fb(-1) collected by the D circle divide detector at a p (p) over bar center-of-mass energy of 1.96 TeV at the Fermilab Tevatron collider. Both scalar top quarks are assumed to decay into a b quark, a charged lepton and a scalar neutrino. The search is performed in the electron Plus muon and dielectron final states. The signal topology consists of two isolated leptons, missing transverse energy, and jets. We find no evidence for this process and exclude regions of parameter space in the framework of the minimal supersymmetric standard model.
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40. |
- Abazov, V. M., et al.
(author)
-
Determination of the strong coupling constant from the inclusive jet cross section in pp collisions at s=1.96 TeV
- 2009
-
In: PHYS REV D. - 1550-7998 .- 1550-2368. ; 80, s. 111107-
-
Journal article (peer-reviewed)abstract
- We determine the strong coupling constant alpha(s) and its energy dependence from the p(T) dependence of the inclusive jet cross section in pp collisions at s=1.96 TeV. The strong coupling constant is determined over the transverse momentum range 50 < p(T)< 145 GeV. Using perturbative QCD calculations to order O(alpha(3)(s)) combined with O(alpha(4)(s)) contributions from threshold corrections, we obtain alpha(s)(M-Z)=0.1161(-0.0048)(+0.0041). This is the most precise result obtained at a hadron-hadron collider.
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41. |
- Abazov, V. M., et al.
(author)
-
Double parton interactions in gamma+3 jet events in p(p)over-bar collisions at root s=1.96 TeV
- 2010
-
In: Physical Review D. - 1550-7998 .- 1550-2368. ; 81:5, s. 052012-
-
Journal article (peer-reviewed)abstract
- We have used a sample of gamma + 3 jets events collected by the D0 experiment with an integrated luminosity of about 1 fb(-1) to determine the fraction of events with double parton scattering (f(DP)) in a single p (p) over bar collision at root s = 1.96 TeV. The DP fraction and effective cross section (sigma(eff)), a process-independent scale parameter related to the parton density inside the nucleon, are measured in three intervals of the second (ordered in p(T)) jet transverse momentum p(T)(jet2) within the range 15 <= p(T)(jet2) <= 30 GeV. In this range, f(DP) varies between 0.23 <= f(DP) <= 0.47, while sigma(eff) has the average value sigma(ave)(eff) = 16.4 +/- 0.3(stat) +/- 2.3(syst) mb.
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42. |
- Abazov, V. M., et al.
(author)
-
Measurement of the t(t)over-bar cross section using high-multiplicity jet events
- 2010
-
In: Physical Review D. - 1550-7998 .- 1550-2368. ; 82, s. 032002-
-
Journal article (peer-reviewed)abstract
- We present a measurement of the t (t) over bar cross section using high-multiplicity jet events produced in p (p) over bar collisions at root s = 1.96 TeV. These data were recorded at the Fermilab Tevatron Collider with the D0 detector. Events with at least six jets, two of them identified as b jets, were selected from a 1 fb(-1) data set. The measured cross section, assuming a top quark mass of 175 GeV/c(2), is 6.9 +/- 2.0 pb, in agreement with theoretical expectations.
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43. |
- Abazov, V. M., et al.
(author)
-
Search for a Resonance Decaying into WZ Boson Pairs in p(p)over-bar Collisions
- 2010
-
In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 104:6, s. 061801-
-
Journal article (peer-reviewed)abstract
- We present the first search for an electrically charged resonance W' decaying to a WZ boson pair using 4.1 fb(-1) of integrated luminosity collected with the D0 detector at the Fermilab Tevatron p (p) over bar collider. The WZ pairs are reconstructed through their decays into three charged leptons (l = e, mu). A total of 9 data events is observed in good agreement with the background prediction. We set 95% C.L. limits on the W'WZ coupling and on the W' production cross section multiplied by the branching fractions. We also exclude W' masses between 188 and 520 GeV within a simple extension of the standard model and set the most restrictive limits to date on low-scale technicolor models.
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44. |
- Abazov, V. M., et al.
(author)
-
Search for Higgs Boson Production in Dilepton and Missing Energy Final States with 5.4 fb(-1) of p(p)over-bar Collisions at root s=1.96 TeV
- 2010
-
In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 104:6, s. 061804-
-
Journal article (peer-reviewed)abstract
- A search for the standard model Higgs boson is presented using events with two charged leptons and large missing transverse energy selected from 5.4 fb(-1) of integrated luminosity in p ($) over bar collisions at root s = 1.96 TeV collected with the D0 detector at the Fermilab Tevatron collider. No significant excess of events above background predictions is found, and observed (expected) upper limits at 95% confidence level on the rate of Higgs boson production are derived that are a factor of 1.55 (1.36) above the predicted standard model cross section at m(H) = 165 GeV.
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45. |
- Abazov, V. M., et al.
(author)
-
Search for the Associated Production of a b Quark and a Neutral Supersymmetric Higgs Boson that Decays into τ Pairs
- 2010
-
In: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 104:15
-
Journal article (peer-reviewed)abstract
- We report results from a search for production of a neutral Higgs boson in association with a b quark. We search for Higgs decays to tau pairs with one tau subsequently decaying to a muon and the other to hadrons. The data correspond to 2: 7 fb(-1) of p (p) over bar collisions recorded by the D0 detector at.. root s = 1.96 TeV. The data are found to be consistent with background predictions. The result allows us to exclude a significant region of parameter space of the minimal supersymmetric model.
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46. |
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47. |
- Abazov, M, et al.
(author)
-
Combination of t(t)over-bar cross section measurements and constraints on the mass of the top quark and its decays into charged Higgs bosons
- 2009
-
In: Physical Review D. - 1550-7998 .- 1550-2368. ; 80, s. 071102-
-
Journal article (peer-reviewed)abstract
- We combine measurements of the top quark pair production cross section in p (p) over bar collisions in the l + jets, ll, and tau l final states ( where l is an electron or muon) at a center of mass energy of root s = 1.96 TeV in 1 fb(-1) of data collected with the D0 detector. For a top quark mass of 170 GeV/c(2), we obtain sigma(t (t) over bar) = 8.18(-0.87)(+0.98) pb in agreement with the theoretical prediction. Based on predictions from higher order quantum chromodynamics, we extract a mass for the top quark from the combined t (t) over bar cross section, consistent with the world average of the top quark mass. In addition, the ratios of t (t) over bar cross sections in different final states are used to set upper limits on the branching fractions B(t -> H(+)b -> tau(+) vb) and B(t -> H(+)b -> c (s) over barb) as a function of the charged Higgs boson mass.
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48. |
- Abazov, M, et al.
(author)
-
Measurement of the WW Production Cross Section with Dilepton Final States in pp Collisions at s=1.96 TeV and Limits on Anomalous Trilinear Gauge Couplings
- 2009
-
In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 103:19, s. 191801-
-
Journal article (peer-reviewed)abstract
- We provide the most precise measurement of the WW production cross section in pp collisions to date at a center of mass energy of 1.96 TeV, and set limits on the associated trilinear gauge couplings. The WW -> l nu l(')nu (l, l(')=e, mu) decay channels are analyzed in 1 fb(-1) of data collected by the D0 detector at the Fermilab Tevatron Collider. The measured cross section is sigma(pp -> WW)=11.5 +/- 2.1(stat+syst)+/- 0.7(lumi) pb. One- and two-dimensional 95% C.L. limits on trilinear gauge couplings are provided.
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49. |
- Abazov, M, et al.
(author)
-
Measurement of the Z gamma -> nu(nu)over-bar gamma Production Cross Section and Limits on Anomalous ZZ gamma and Z gamma gamma Couplings in p(p)over-bar Collisions at root s=1.96 TeV
- 2009
-
In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 102:20, s. 201802-
-
Journal article (peer-reviewed)abstract
- We present the first observation of the Z gamma -> nu(nu) over bar gamma process at the Fermilab Tevatron at 5.1 standard deviations significance, based on 3.6 fb(-1) of integrated luminosity collected with the D0 detector at the Fermilab Tevatron p (p) over bar Collider at root s = 1.96 TeV. The measured Z gamma production cross section multiplied by the branching fraction of Z -> nu(nu) over bar is 32 +/- 9(stat + syst) +/- 2(lumi) fb for the photon E-T > 90 GeV. It is in agreement with the standard model prediction of 39 +/- 4 fb. We set limits on anomalous trilinear Z gamma gamma and ZZ gamma gauge boson couplings, most of which are the most restrictive to date.
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50. |
- Abazov, M, et al.
(author)
-
Measurements of differential cross sections of Z/gamma* plus jets plus X events in p(p)over-bar collisions at root s=1.96 TeV
- 2009
-
In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 678:1, s. 45-54
-
Journal article (peer-reviewed)abstract
- We present cross section measurements for Z/gamma* + jets + X production, differential in the transverse momenta of the three leading jets. The data sample was collected with the DO detector at the Fermilab Tevatron p (p) over bar collider at a center-of-mass energy of 1.96 TeV and corresponds to an integrated luminosity of 1 fb(-1). Leading and next-to-leading order perturbative QCD predictions are compared with the measurements. and agreement is found within the theoretical and experimental uncertainties. We also make comparisons with the predictions of four event generators. Two parton-shower-based generators show significant shape and normalization differences with respect to the data. In contrast, two generators combining tree-level matrix elements with a parton shower give a reasonable description of the shapes observed in data. but the predicted normalizations show significant differences with respect to the data, reflecting large scale Uncertainties. For specific choices of scales, the normalizations for either generator can be made to agree with the measurements.
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