| 1. |
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| 2. |
- Bombarda, F., et al.
(author)
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Runaway electron beam control
- 2019
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In: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 1361-6587 .- 0741-3335. ; 61:1
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Journal article (peer-reviewed)
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| 3. |
- Fenstermacher, M.E., et al.
(author)
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DIII-D research advancing the physics basis for optimizing the tokamak approach to fusion energy
- 2022
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In: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 62:4
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Journal article (peer-reviewed)abstract
- DIII-D physics research addresses critical challenges for the operation of ITER and the next generation of fusion energy devices. This is done through a focus on innovations to provide solutions for high performance long pulse operation, coupled with fundamental plasma physics understanding and model validation, to drive scenario development by integrating high performance core and boundary plasmas. Substantial increases in off-axis current drive efficiency from an innovative top launch system for EC power, and in pressure broadening for Alfven eigenmode control from a co-/counter-I p steerable off-axis neutral beam, all improve the prospects for optimization of future long pulse/steady state high performance tokamak operation. Fundamental studies into the modes that drive the evolution of the pedestal pressure profile and electron vs ion heat flux validate predictive models of pedestal recovery after ELMs. Understanding the physics mechanisms of ELM control and density pumpout by 3D magnetic perturbation fields leads to confident predictions for ITER and future devices. Validated modeling of high-Z shattered pellet injection for disruption mitigation, runaway electron dissipation, and techniques for disruption prediction and avoidance including machine learning, give confidence in handling disruptivity for future devices. For the non-nuclear phase of ITER, two actuators are identified to lower the L-H threshold power in hydrogen plasmas. With this physics understanding and suite of capabilities, a high poloidal beta optimized-core scenario with an internal transport barrier that projects nearly to Q = 10 in ITER at ∼8 MA was coupled to a detached divertor, and a near super H-mode optimized-pedestal scenario with co-I p beam injection was coupled to a radiative divertor. The hybrid core scenario was achieved directly, without the need for anomalous current diffusion, using off-axis current drive actuators. Also, a controller to assess proximity to stability limits and regulate β N in the ITER baseline scenario, based on plasma response to probing 3D fields, was demonstrated. Finally, innovative tokamak operation using a negative triangularity shape showed many attractive features for future pilot plant operation.
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| 4. |
- Meyer, H., et al.
(author)
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Overview of progress in European medium sized tokamaks towards an integrated plasma-edge/wall solution
- 2017
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In: Nuclear Fusion. - : Institute of Physics Publishing (IOPP). - 0029-5515 .- 1741-4326. ; 57:10
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Journal article (peer-reviewed)abstract
- Integrating the plasma core performance with an edge and scrape-off layer (SOL) that leads to tolerable heat and particle loads on the wall is a major challenge. The new European medium size tokamak task force (EU-MST) coordinates research on ASDEX Upgrade (AUG), MAST and TCV. This multi-machine approach within EU-MST, covering a wide parameter range, is instrumental to progress in the field, as ITER and DEMO core/pedestal and SOL parameters are not achievable simultaneously in present day devices. A two prong approach is adopted. On the one hand, scenarios with tolerable transient heat and particle loads, including active edge localised mode (ELM) control are developed. On the other hand, divertor solutions including advanced magnetic configurations are studied. Considerable progress has been made on both approaches, in particular in the fields of: ELM control with resonant magnetic perturbations (RMP), small ELM regimes, detachment onset and control, as well as filamentary scrape-off-layer transport. For example full ELM suppression has now been achieved on AUG at low collisionality with n = 2 RMP maintaining good confinement H-H(98,H-y2) approximate to 0.95. Advances have been made with respect to detachment onset and control. Studies in advanced divertor configurations (Snowflake, Super-X and X-point target divertor) shed new light on SOL physics. Cross field filamentary transport has been characterised in a wide parameter regime on AUG, MAST and TCV progressing the theoretical and experimental understanding crucial for predicting first wall loads in ITER and DEMO. Conditions in the SOL also play a crucial role for ELM stability and access to small ELM regimes.
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| 5. |
- Meyer, H., et al.
(author)
-
Overview of progress in European medium sized tokamaks towards an integrated plasma-edge/wall solution
- 2017
-
In: Nuclear Fusion. - : Institute of Physics Publishing (IOPP). - 0029-5515 .- 1741-4326. ; 57:10
-
Journal article (peer-reviewed)abstract
- Integrating the plasma core performance with an edge and scrape-off layer (SOL) that leads to tolerable heat and particle loads on the wall is a major challenge. The new European medium size tokamak task force (EU-MST) coordinates research on ASDEX Upgrade (AUG), MAST and TCV. This multi-machine approach within EU-MST, covering a wide parameter range, is instrumental to progress in the field, as ITER and DEMO core/pedestal and SOL parameters are not achievable simultaneously in present day devices. A two prong approach is adopted. On the one hand, scenarios with tolerable transient heat and particle loads, including active edge localised mode (ELM) control are developed. On the other hand, divertor solutions including advanced magnetic configurations are studied. Considerable progress has been made on both approaches, in particular in the fields of: ELM control with resonant magnetic perturbations (RMP), small ELM regimes, detachment onset and control, as well as filamentary scrape-off-layer transport. For example full ELM suppression has now been achieved on AUG at low collisionality with n = 2 RMP maintaining good confinement H-H(98,H-y2) approximate to 0.95. Advances have been made with respect to detachment onset and control. Studies in advanced divertor configurations (Snowflake, Super-X and X-point target divertor) shed new light on SOL physics. Cross field filamentary transport has been characterised in a wide parameter regime on AUG, MAST and TCV progressing the theoretical and experimental understanding crucial for predicting first wall loads in ITER and DEMO. Conditions in the SOL also play a crucial role for ELM stability and access to small ELM regimes.
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| 6. |
- Magrini, L., et al.
(author)
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The Gaia -ESO survey: Mixing processes in low-mass stars traced by lithium abundance in cluster and field stars
- 2021
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 651
-
Journal article (peer-reviewed)abstract
- Aims. We aim to constrain the mixing processes in low-mass stars by investigating the behaviour of the Li surface abundance after the main sequence. We take advantage of the data from the sixth internal data release of Gaia-ESO, IDR6, and from the Gaia Early Data Release 3, EDR3s. Methods. We selected a sample of main-sequence, sub-giant, and giant stars in which the Li abundance is measured by the Gaia-ESO survey. These stars belong to 57 open clusters with ages from 130 Myr to about 7 Gyr and to Milky Way fields, covering a range in [Fe/H] between -1.0and +0.5 dex, with few stars between -1.0 and -2.5dex. We studied the behaviour of the Li abundances as a function of stellar parameters. We inferred the masses of giant stars in clusters from the main-sequence turn-off masses, and for field stars through comparison with stellar evolution models using a maximum likelihood technique. We compared the observed Li behaviour in field giant stars and in giant stars belonging to individual clusters with the predictions of a set of classical models and of models with mixing induced by rotation and thermohaline instability. Results. The comparison with stellar evolution models confirms that classical models cannot reproduce the observed lithium abundances in the metallicity and mass regimes covered by the data. The models that include the effects of both rotation-induced mixing and thermohaline instability account for the Li abundance trends observed in our sample in all metallicity and mass ranges. The differences between the results of the classical models and of the rotation models largely differ (up to 2 dex), making lithium the best element with which to constrain stellar mixing processes in low-mass stars. We discuss the nature of a sample of Li-rich stars. Conclusions. We demonstrate that the evolution of the surface abundance of Li in giant stars is a powerful tool for constraining theoretical stellar evolution models, allowing us to distinguish the effect of different mixing processes. For stars with well-determined masses, we find a better agreement of observed surface abundances and models with rotation-induced and thermohaline mixing. Rotation effects dominate during the main sequence and the first phases of the post-main-sequence evolution, and the thermohaline induced mixing after the bump in the luminosity function.
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| 7. |
- Magrini, L., et al.
(author)
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The Gaia-ESO survey : Mapping the shape and evolution of the radial abundance gradients with open clusters
- 2023
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 669
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Journal article (peer-reviewed)abstract
- Context: The spatial distribution of elemental abundances and their time evolution are among the major constraints to disentangling the scenarios of formation and evolution of the Galaxy.Aims: In this paper we used the sample of open clusters available in the final release of the Gaia-ESO survey to trace the Galactic radial abundance and abundance-to-iron ratio gradients, and their time evolution.Methods: We selected member stars in 62 open clusters, with ages from 0.1 to about 7 Gyr, located in the Galactic thin disc at galactocentric radii (R-GC) from about 6 to 21 kpc. We analysed the shape of the resulting [Fe/H] gradient, the average gradients [El/H] and [El/Fe] combining elements belonging to four different nucleosynthesis channels, and their individual abundance and abundance ratio gradients. We also investigated the time evolution of the gradients dividing open clusters in three age bins.Results: The [Fe/H] gradient has a slope of -0.054 dex kpc(-1). It can be better approximated with a two-slope shape, steeper for R-GC <= 11.2 kpc and flatter in the outer regions. We saw different behaviours for elements belonging to different channels. For the time evolution of the gradient, we found that the youngest clusters (age < 1 Gyr) in the inner disc have lower metallicity than their older counterparts and that they outline a flatter gradient. We considered some possible explanations, including the effects of gas inflow and migration. We suggest that the most likely one may be related to a bias introduced by the standard spectroscopic analysis producing lower metallicities in the analysis of low-gravity stars.Conclusions: To delineate the shape of the 'true' gradient, we should most likely limit our analysis to stars with low surface gravity log g> 2.5 and microturbulent parameter xi< 1.8 km s(-1). Based on this reduced sample, we can conclude that the gradient has minimally evolved over the time-frame outlined by the open clusters, indicating a slow and stationary formation of the thin disc over the last 3 Gyr. We found a secondary role of cluster migration in shaping the gradient, with a more prominent role of migration for the oldest clusters.
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| 8. |
- Baratella, M., et al.
(author)
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The Gaia-ESO Survey: A new approach to chemically characterising young open cluster : II. Abundances of the neutron-capture elements Cu, Sr, Y, Zr, Ba, La, and Ce
- 2021
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 653
-
Journal article (peer-reviewed)abstract
- Context. Young open clusters (ages of less than 200 Myr) have been observed to exhibit several peculiarities in their chemical compositions. These anomalies include a slightly sub-solar iron content, super-solar abundances of some atomic species (e.g. ionised chromium), and atypical enhancements of [Ba/Fe], with values up to ~0.7 dex. Regarding the behaviour of the other s-process elements like yttrium, zirconium, lanthanum, and cerium, there is general disagreement in the literature: some authors claim that they follow the same trend as barium, while others find solar abundances at all ages. Aims. In this work we expand upon our previous analysis of a sample of five young open clusters (IC 2391, IC 2602, IC 4665, NGC 2516, and NGC 2547) and one star-forming region (NGC 2264), with the aim of determining abundances of different neutron-capture elements, mainly Cu I, Sr I, Sr II, Y II, Zr II, Ba II, La II, and Ce II. For NGC 2264 and NGC 2547 we present the measurements of these elements for the first time. Methods. We analysed high-resolution, high signal-to-noise spectra of 23 solar-type stars observed within the Gaia-ESO survey. After a careful selection, we derived abundances of isolated and clean lines via spectral synthesis computations and in a strictly differential way with respect to the Sun. Results. We find that our clusters have solar [Cu/Fe] within the uncertainties, while we confirm that [Ba/Fe] is super-solar, with values ranging from +0.22 to +0.64 dex. Our analysis also points to a mild enhancement of Y, with [Y/Fe] ratios covering values between 0 and +0.3 dex. For the other s-process elements we find that [X/Fe] ratios are solar at all ages. Conclusions. It is not possible to reconcile the anomalous behaviour of Ba and Y at young ages with standard stellar yields and Galactic chemical evolution model predictions. We explore different possible scenarios related to the behaviour of spectral lines, from the dependence on the different ionisation stages and the sensitivity to the presence of magnetic fields (through the Landé factor) to the first ionisation potential effect. We also investigate the possibility that they may arise from alterations of the structure of the stellar photosphere due to the increased levels of stellar activity that affect the spectral line formation, and consequently the derived abundances. These effects seem to be stronger in stars at ages of less than ∼ 100 Myr. However, we are still unable to explain these enhancements, and the Ba puzzle remains unsolved. With the present study we suggest that other elements, for example Sr, Zr, La, and Ce, might be more reliable tracer of the s-process at young ages, and we strongly encourage further critical observations.
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| 9. |
- Casali, G., et al.
(author)
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The Gaia-ESO survey : Calibrating a relationship between age and the [C/N] abundance ratio with open clusters
- 2019
-
In: Astronomy and Astrophysics. - : EDP SCIENCES S A. - 0004-6361 .- 1432-0746. ; 629
-
Journal article (peer-reviewed)abstract
- Context: In the era of large high-resolution spectroscopic surveys such as Gaia-ESO and APOGEE, high-quality spectra can contribute to our understanding of the Galactic chemical evolution by providing abundances of elements that belong to the different nucleosynthesis channels, and also by providing constraints to one of the most elusive astrophysical quantities: stellar age.Aims: Some abundance ratios, such as [C/N], have been proven to be excellent indicators of stellar ages. We aim at providing an empirical relationship between stellar ages and [C/N] using open star clusters, observed by the Gaia-ESO and APOGEE surveys, as calibrators.Methods: We used stellar parameters and abundances from the Gaia-ESO Survey and APOGEE Survey of the Galactic field and open cluster stars. Ages of star clusters were retrieved from the literature sources and validated using a common set of isochrones. We used the same isochrones to determine for each age and metallicity the surface gravity at which the first dredge-up and red giant branch bump occur. We studied the effect of extra-mixing processes in our sample of giant stars, and we derived the mean [C/N] in evolved stars, including only stars without evidence of extra mixing. By combining the Gaia-ESO and APOGEE samples of open clusters, we derived a linear relationship between [C/N] and (logarithmic) cluster ages.Results: We apply our relationship to selected giant field stars in the Gaia-ESO and APOGEE surveys. We find an age separation between thin-and thick-disc stars and age trends within their populations, with an increasing age towards lower metallicity populations.Conclusions: With this empirical relationship, we are able to provide an age estimate for giant stars in which C and N abundances are measured. For giant stars, the isochrone fitting method is indeed less sensitive than for dwarf stars at the turn-off. Our method can therefore be considered as an additional tool to give an independent estimate of the age of giant stars. The uncertainties in their ages is similar to those obtained using isochrone fitting for dwarf stars.
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| 10. |
- Casali, G., et al.
(author)
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The Gaia-ESO survey : the non-universality of the age-chemical-clocks-metallicity relations in the Galactic disc
- 2020
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 639
-
Journal article (peer-reviewed)abstract
- Context. In the era of large spectroscopic surveys, massive databases of high-quality spectra coupled with the products of the Gaia satellite provide tools to outline a new picture of our Galaxy. In this framework, an important piece of information is provided by our ability to infer stellar ages, and consequently to sketch a Galactic timeline.Aims. We aim to provide empirical relations between stellar ages and abundance ratios for a sample of stars with very similar stellar parameters to those of the Sun, namely the so-called solar-like stars. We investigate the dependence on metallicity, and we apply our relations to independent samples, that is, the Gaia-ESO samples of open clusters and of field stars.Methods. We analyse high-resolution and high-signal-to-noise-ratio HARPS spectra of a sample of solar-like stars to obtain precise determinations of their atmospheric parameters and abundances for 25 elements and/or ions belonging to the main nucleosynthesis channels through differential spectral analysis, and of their ages through isochrone fitting.Results. We investigate the relations between stellar ages and several abundance ratios. For the abundance ratios with a steeper dependence on age, we perform multivariate linear regressions, in which we include the dependence on metallicity, [Fe/H]. We apply our best relations to a sample of open clusters located from the inner to the outer regions of the Galactic disc. Using our relations, we are able to recover the literature ages only for clusters located at R-GC > 7 kpc. The values that we obtain for the ages of the inner-disc clusters are much greater than the literature ones. In these clusters, the content of neutron capture elements, such as Y and Zr, is indeed lower than expected from chemical evolution models, and consequently their [Y/Mg] and [Y/Al] are lower than in clusters of the same age located in the solar neighbourhood. With our chemical evolution model and a set of empirical yields, we suggest that a strong dependence on the star formation history and metallicity-dependent stellar yields of s-process elements can substantially modify the slope of the [s/alpha]-[Fe/H]-age relation in different regions of the Galaxy.Conclusions. Our results point towards a non-universal relation [s/alpha]-[Fe/H]-age, indicating the existence of relations with different slopes and intercepts at different Galactocentric distances or for different star formation histories. Therefore, relations between ages and abundance ratios obtained from samples of stars located in a limited region of the Galaxy cannot be translated into general relations valid for the whole disc. A better understanding of the s-process at high metallicity is necessary to fully understand the origin of these variations.
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| 11. |
- Magrini, L., et al.
(author)
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Gaia -ESO survey : Lithium abundances in open cluster Red Clump stars
- 2021
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 655
-
Journal article (peer-reviewed)abstract
- Context. It has recently been suggested that all giant stars with masses below 2 M? suffer an episode of surface lithium enrichment between the tip of the red giant branch (RGB) and the red clump (RC). Aims. We test if the above result can be confirmed in a sample of RC and RGB stars that are members of open clusters. Methods. We discuss Li abundances in six open clusters with ages between 1.5 and 4.9 Gyr (turn-off masses between 1.1 and 1.7 M? ). We compare these observations with the predictions of different models that include rotation-induced mixing, thermohaline instability, mixing induced by the first He flash, and energy losses by neutrino magnetic moment. Results. In six clusters, we find close to 35% of RC stars have Li abundances that are similar or higher than those of upper RGB stars. This can be a sign of fresh Li production. Because of the extra-mixing episode connected to the luminosity bump, the expectation has been for RC stars to have systematically lower surface Li abundances. However, we cannot confirm that this possible Li production is ubiquitous. For about 65% of RC giants, we can only determine upper limits in abundances that could be hiding very low Li content. Conclusions. Our results indicate the possibility that Li is being produced in the RC, at levels that would not typically permit the classification of these the stars as Li rich. The determination of their carbon isotopic ratio would help to confirm that the RC giants have suffered extra mixing followed by subsequent Li enrichment. The Li abundances of the RC stars can be qualitatively explained by the models including an additional mixing episode close to the He flash.
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| 12. |
- Magrini, L., et al.
(author)
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The Gaia-ESO Survey : The N/O abundance ratio in the Milky Way
- 2018
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In: Astronomy and Astrophysics. - : EDP SCIENCES S A. - 0004-6361 .- 1432-0746. ; 618
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Journal article (peer-reviewed)abstract
- Context. The abundance ratio N/O is a useful tool to study the interplay of galactic processes, for example star formation efficiency, timescale of infall, and outflow loading factor. Aims. We aim to trace log(N/O) versus [Fe/H] in the Milky Way and to compare this ratio with a set of chemical evolution models to understand the role of infall, outflow, and star formation efficiency in the building up of the Galactic disc. Methods. We used the abundances from IDR2-3, IDR4, IDR5 data releases of the Gaia-ESO Survey both for Galactic field and open cluster stars. We determined membership and average composition of open clusters and we separated thin and thick disc field stars. We considered the effect of mixing in the abundance of N in giant stars. We computed a grid of chemical evolution models, suited to reproduce the main features of our Galaxy, exploring the effects of the star formation efficiency, infall timescale, and differential outflow. Results. With our samples, we map the metallicity range -0. 6 <= [Fe/H] <= 0.3 with a corresponding -1.2 <= log(N/O) <= -0.2, where the secondary production of N dominates. Thanks to the wide range of Galactocentric distances covered by our samples, we can distinguish the behaviour of log(N/O) in different parts of the Galaxy. Conclusions. Our spatially resolved results allow us to distinguish differences in the evolution of N/O with Galactocentric radius. Comparing the data with our models, we can characterise the radial regions of our Galaxy. A shorter infall timescale is needed in the inner regions, while the outer regions need a longer infall timescale, coupled with a higher star formation efficiency. We compare our results with nebular abundances obtained in MaNGA galaxies, finding in our Galaxy a much wider range of log(N/O) than in integrated observations of external galaxies of similar stellar mass, but similar to the ranges found in studies of individual H II regions.
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| 13. |
- Romano, D., et al.
(author)
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The Gaia-ESO Survey : Galactic evolution of lithium from iDR6
- 2021
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 653
-
Journal article (peer-reviewed)abstract
- Context. After more than 50 years, astronomical research still struggles to reconstruct the history of lithium enrichment in the Galaxy and to establish the relative importance of the various 7Li sources in enriching the interstellar medium (ISM) with this fragile element.Aims. To better trace the evolution of lithium in the Milky Way discs, we exploit the unique characteristics of a sample of open clusters (OCs) and field stars for which high-precision 7Li abundances and stellar parameters are homogeneously derived by the Gaia-ESO Survey (GES).Methods. We derive possibly un-depleted 7Li abundances for 26 OCs and star forming regions with ages from young (∼3 Myr) to old (∼4.5 Gyr), spanning a large range of galactocentric distances, 5 < RGC/kpc < 15, which allows us to reconstruct the local late Galactic evolution of lithium as well as its current abundance gradient along the disc. Field stars are added to look further back in time and to constrain 7Li evolution in other Galactic components. The data are then compared to theoretical tracks from chemical evolution models that implement different 7Li forges.Results. Thanks to the homogeneity of the GES analysis, we can combine the maximum average 7Li abundances derived for the clusters with 7Li measurements in field stars. We find that the upper envelope of the 7Li abundances measured in field stars of nearly solar metallicities (−0.3 < [Fe/H]/dex < +0.3) traces very well the level of lithium enrichment attained by the ISM as inferred from observations of cluster stars in the same metallicity range. We confirm previous findings that the abundance of 7Li in the solar neighbourhood does not decrease at super-solar metallicity. The comparison of the data with the chemical evolution model predictions favours a scenario in which the majority of the 7Li abundance in meteorites comes from novae. Current data also seem to suggest that the nova rate flattens out at later times. This requirement might have implications for the masses of the white dwarf nova progenitors and deserves further investigation. Neutrino-induced reactions taking place in core-collapse supernovae also produce some fresh lithium. This likely makes a negligible contribution to the meteoritic abundance, but could be responsible for a mild increase in the 7Li abundance in the ISM of low-metallicity systems that would counterbalance the astration processes.
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| 14. |
- Spina, L., et al.
(author)
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The Gaia -ESO Survey : Chemical tagging in the thin disk: Open clusters blindly recovered in the elemental abundance space
- 2022
-
In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 668
-
Journal article (peer-reviewed)abstract
- Context. The chemical makeup of a star provides the fossil information of the environment where it formed. Under this premise, it should be possible to use chemical abundances to tag stars that formed within the same stellar association. This idea - known as chemical tagging - has not produced the expected results, especially within the thin disk where open stellar clusters have chemical patterns that are difficult to disentangle. Aims. The ultimate goal of this study is to probe the feasibility of chemical tagging within the thin disk population using high-quality data from a controlled sample of stars. We also aim at improving the existing techniques of chemical tagging and giving some kind of guidance on different strategies of clustering analysis in the elemental abundance space. Methods. Here we develop the first blind search of open clusters'members through clustering analysis in the elemental abundance space using the OPTICS algorithm applied to data from the Gaia-ESO survey. First, we evaluate different strategies of analysis (e.g., choice of the algorithm, data preprocessing techniques, metric, space of data clustering), determining which ones are more performing. Second, we apply these methods to a data set including both field stars and open clusters attempting a blind recover of as many open clusters as possible. Results. We show how specific strategies of data analysis can improve the final results. Specifically, we demonstrate that open clusters can be more efficaciously recovered with the Manhattan metric and on a space whose dimensions are carefully selected. Using these (and other) prescriptions we are able to recover open clusters hidden in our data set and find new members of these stellar associations (i.e., escapers, binaries). Conclusions. Our results indicate that there are chances of recovering open clusters'members via clustering analysis in the elemental abundance space, albeit in a data set that has a very high fraction of cluster members compared to an average field star sample. Presumably, the performances of chemical tagging will further increase with higher quality data and more sophisticated clustering algorithms, which will likely became available in the near future.
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| 15. |
- Viscasillas Vázquez, C., et al.
(author)
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The Gaia -ESO survey : Age-chemical-clock relations spatially resolved in the Galactic disc
- 2022
-
In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 660
-
Journal article (peer-reviewed)abstract
- Context. The last decade has seen a revolution in our knowledge of the Galaxy thanks to the Gaia and asteroseismic space missions and the ground-based spectroscopic surveys. Aims. To complete this picture, it is necessary to map the ages of its stellar populations. During recent years, the dependence on time of abundance ratios involving slow (s) neutron-capture and α elements (called chemical-clocks) has been used to provide estimates of stellar ages, usually in a limited volume close to the Sun. We aim to analyse the relations of chemical clocks in the Galactic disc extending the range to RGC∼ 6- 20 kpc. Methods. Using the sixth internal data release of the Gaia-ESO survey, we calibrated several relations between stellar ages and abundance ratios [s/α] using a sample of open clusters, the largest one so far used with this aim (62 clusters). Thanks to their wide galactocentric coverage, we investigated the radial variations of the shape of these relations, confirming their non-universality. Results. The multi-variate relations allowed us to infer stellar ages for field stars. We estimated our accuracy (ranging from 0.0 to -0.9 Gyr) and precision (from 0.4 to 2.3 Gyr) in recovering the global ages of open clusters, and the ages of their individual members. We applied the relations with the highest correlation coefficients to the field star population, finding an older population at lower metallicity and higher [α/Fe] in the thin disc, and a younger one at higher [Fe/H] and low [α/Fe], as expected. Conclusion. We confirm that there is no single age-chemical clock relationship valid for the whole disc, but that there is a dependence on the galactocentric position, which is related to the radial variation of the star formation history combined with the non-monotonic dependence on metallicity of the yields of the s-process elements from low- and intermediate-mass stars. Finally, the abundance ratios [Ba/α] are more sensitive to age than those with [Y/α] for young disc stars, and their slopes vary less with galactocentric distance. We remind the reader that the application of such relationships to field stars is only of statistical value.
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| 16. |
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| 17. |
- Dittrich, Christian, et al.
(author)
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ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016
- 2016
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In: ESMO Open. - : Elsevier BV. - 2059-7029. ; 1:5
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Journal article (peer-reviewed)abstract
- The European Society for Medical Oncology (ESMO) and the American Society of Clinical Oncology (ASCO) are publishing a new edition of the ESMO/ ASCO Global Curriculum (GC) thanks to contribution of 64 ESMOappointed and 32 ASCO-appointed authors. First published in 2004 and updated in 2010, the GC edition 2016 answers to the need for updated recommendations for the training of physicians in medical oncology by defining the standard to be fulfilled to qualify as medical oncologists. At times of internationalisation of healthcare and increased mobility of patients and physicians, the GC aims to provide state-of-the-art cancer care to all patients wherever they live. Recent progress in the field of cancer research has indeed resulted in diagnostic and therapeutic innovations such as targeted therapies as a standard therapeutic approach or personalised cancer medicine specialised training for medical oncology trainees. Thus, several new chapters on technical contents such as molecular pathology, translational research or molecular imaging and on conceptual attitudes towards human principles like genetic counselling or survivorship have been integrated in the GC. The GC edition 2016 consists of 12 sections with 17 subsections, 44 chapters and 35 subchapters, respectively. Besides renewal in its contents, the GC underwent a principal formal change taking into consideration modern didactic principles. It is presented in a template-based format that subcategorises the detailed outcome requirements into learning objectives, awareness, knowledge and skills. Consecutive steps will be those of harmonising and implementing teaching and assessment strategies.
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| 18. |
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| 19. |
- Reichardt, P., et al.
(author)
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Adjuvant therapy in primary GIST: state-of-the-art
- 2012
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In: Annals of Oncology. - : Elsevier BV. - 1569-8041 .- 0923-7534. ; 23:11, s. 2776-2781
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Research review (peer-reviewed)abstract
- The management of primary gastrointestinal stromal tumours (GISTs) has evolved with the introduction of adjuvant therapy. Recently reported results of the SSG XVIII/AIO trial by the Scandinavian Sarcoma Group (SSG) and the German Working Group on Medical Oncology (AIO) represent a significant change in the evidence for adjuvant therapy duration. The objectives of this European Expert Panel meeting were to describe the optimal management and best practice for the systemic adjuvant treatment of patients with primary GISTs. A panel of medical oncology experts from European sarcoma research groups were invited to a 1-day workshop. Several questions and discussion points were selected by the organising committee prior to the conference. The experts reviewed the current literature of all clinical trials available on adjuvant therapy for primary GISTs, considered the quality evidence and formulated recommendations for each discussion point. Clinical issues were identified and provisional clinical opinions were formulated for adjuvant treatment patient selection, imatinib dose, duration and patient recall, mutational analysis and follow-up of primary GIST patients. Adjuvant imatinib 400 mg/day for 3 years duration is a standard treatment in all patients with significant risk of recurrence following resection of primary GISTs. Patient selection for adjuvant therapy should be based on any of the three commonly used patient risk stratification schemes. R1 surgery (versus R0) alone is not an indication for adjuvant imatinib in low-risk GIST. Recall and imatinib restart could be proposed in patients who discontinued 1-year adjuvant imatinib within the previous 3 months and may be considered on a case-by-case basis in patients who discontinued within the previous year. Mutational analysis is recommended in all cases of GISTs using centralised laboratories with good quality control. Treatment is not recommended in an imatinib-insensitive D842V-mutated GIST. During adjuvant treatment, patients are recommended to be clinically assessed at 1- to 3-month intervals. Upon discontinuation, computed tomography scan (CT) scans are recommended every 3 to 4 months for 2 years when the risk of relapse is highest, followed by every 6 months until year 5 and annually until year 10 after treatment discontinuation. Key points in systemic adjuvant treatment and clinical management of primary GISTs as well as open questions were identified during this European Expert Panel meeting on GIST management.
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| 20. |
- Stacchiotti, S., et al.
(author)
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Epithelioid hemangioendothelioma, an ultra-rare cancer : a consensus paper from the community of experts
- 2021
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In: ESMO Open. - : Elsevier BV. - 2059-7029. ; 6:3
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Research review (peer-reviewed)abstract
- Epithelioid hemangioendothelioma (EHE) is an ultra-rare, translocated, vascular sarcoma. EHE clinical behavior is variable, ranging from that of a low-grade malignancy to that of a high-grade sarcoma and it is marked by a high propensity for systemic involvement. No active systemic agents are currently approved specifically for EHE, which is typically refractory to the antitumor drugs used in sarcomas. The degree of uncertainty in selecting the most appropriate therapy for EHE patients and the lack of guidelines on the clinical management of the disease make the adoption of new treatments inconsistent across the world, resulting in suboptimal outcomes for many EHE patients. To address the shortcoming, a global consensus meeting was organized in December 2020 under the umbrella of the European Society for Medical Oncology (ESMO) involving >80 experts from several disciplines from Europe, North America and Asia, together with a patient representative from the EHE Group, a global, disease-specific patient advocacy group, and Sarcoma Patient EuroNet (SPAEN). The meeting was aimed at defining, by consensus, evidence-based best practices for the optimal approach to primary and metastatic EHE. The consensus achieved during that meeting is the subject of the present publication.
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