| 1. |
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| 2. |
- Plainaki, C., et al.
(author)
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Towards a Global Unified Model of Europa’s Tenuous Atmosphere
- 2018
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In: Space Science Reviews. - : Springer Netherlands. - 0038-6308 .- 1572-9672. ; 214:1
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Research review (peer-reviewed)abstract
- Despite the numerous modeling efforts of the past, our knowledge on the radiation-induced physical and chemical processes in Europa’s tenuous atmosphere and on the exchange of material between the moon’s surface and Jupiter’s magnetosphere remains limited. In lack of an adequate number of in situ observations, the existence of a wide variety of models based on different scenarios and considerations has resulted in a fragmentary understanding of the interactions of the magnetospheric ion population with both the moon’s icy surface and neutral gas envelope. Models show large discrepancy in the source and loss rates of the different constituents as well as in the determination of the spatial distribution of the atmosphere and its variation with time. The existence of several models based on very different approaches highlights the need of a detailed comparison among them with the final goal of developing a unified model of Europa’s tenuous atmosphere. The availability to the science community of such a model could be of particular interest in view of the planning of the future mission observations (e.g., ESA’s JUpiter ICy moons Explorer (JUICE) mission, and NASA’s Europa Clipper mission). We review the existing models of Europa’s tenuous atmosphere and discuss each of their derived characteristics of the neutral environment. We also discuss discrepancies among different models and the assumptions of the plasma environment in the vicinity of Europa. A summary of the existing observations of both the neutral and the plasma environments at Europa is also presented. The characteristics of a global unified model of the tenuous atmosphere are, then, discussed. Finally, we identify needed future experimental work in laboratories and propose some suitable observation strategies for upcoming missions.
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| 3. |
- Zamora-Ros, R., et al.
(author)
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Dietary intakes and food sources of phytoestrogens in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24-hour dietary recall cohort
- 2012
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In: European Journal of Clinical Nutrition. - : Springer Science and Business Media LLC. - 0954-3007 .- 1476-5640. ; 66:8, s. 932-941
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Journal article (peer-reviewed)abstract
- BACKGROUND/OBJECTIVES: Phytoestrogens are estradiol-like natural compounds found in plants that have been associated with protective effects against chronic diseases, including some cancers, cardiovascular diseases and osteoporosis. The purpose of this study was to estimate the dietary intake of phytoestrogens, identify their food sources and their association with lifestyle factors in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. SUBJECTS/METHODS: Single 24-hour dietary recalls were collected from 36 037 individuals from 10 European countries, aged 35-74 years using a standardized computerized interview programe (EPIC-Soft). An ad hoc food composition database on phytoestrogens (isoflavones, lignans, coumestans, enterolignans and equol) was compiled using data from available databases, in order to obtain and describe phytoestrogen intakes and their food sources across 27 redefined EPIC centres. RESULTS: Mean total phytoestrogen intake was the highest in the UK health-conscious group (24.9 mg/day in men and 21.1 mg/day in women) whereas lowest in Greece (1.3 mg/day) in men and Spain-Granada (1.0 mg/day) in women. Northern European countries had higher intakes than southern countries. The main phytoestrogen contributors were isoflavones in both UK centres and lignans in the other EPIC cohorts. Age, body mass index, educational level, smoking status and physical activity were related to increased intakes of lignans, enterolignans and equol, but not to total phytoestrogen, isoflavone or coumestan intakes. In the UK cohorts, the major food sources of phytoestrogens were soy products. In the other EPIC cohorts the dietary sources were more distributed, among fruits, vegetables, soy products, cereal products, non-alcoholic and alcoholic beverages. CONCLUSIONS: There was a high variability in the dietary intake of total and phytoestrogen subclasses and their food sources across European regions.
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| 7. |
- Aleksandrovskii, A.N., et al.
(author)
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On the polyamorphism of fullerite-based orientational glasses.
- 2005
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In: Low Temperature Physics. - : AIP Publishing. - 1063-777X .- 1090-6517. ; 31:5, s. 429-444
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Journal article (peer-reviewed)abstract
- The dilatometric investigation in the temperature range of 2–28 K shows that a first-orderpolyamorphous transition occurs in the orientational glasses based on C60 doped with H2, D2 andXe. A polyamorphous transition was also detected in C60 doped with Kr and He. It is observed thatthe hysteresis of thermal expansion caused by the polyamorphous transition (and, hence, the transitiontemperature) is essentially dependent on the type of doping gas. Both positive and negativecontributions to the thermal expansion were observed in the low-temperature phase of the glasses.The relaxation time of the negative contribution occurs to be much longer than that of the positivecontribution. The positive contribution is found to be due to phonon and libron modes, whilst thenegative contribution is attributed to tunneling states of the C60 molecules. The characteristictime of the phase transformation from the low-T phase to the high-T phase has been found for theC60–H2 system at 12 K. A theoretical model is proposed to interpret these observed phenomena.The theoretical model proposed, includes a consideration of the nature of polyamorphism inglasses, as well as the thermodynamics and kinetics of the transition. A model of noninteractingtunneling states is used to explain the negative contribution to the thermal expansion. The experimentaldata obtained is considered within the framework of the theoretical model. From the theoreticalmodel the order of magnitude of the polyamorphous transition temperature has been estimated.It is found that the late stage of the polyamorphous transformation is described well by theKolmogorov law with an exponent of n = 1. At this stage of the transformation, the two-dimensionalphase boundary moves along the normal, and the nucleation is not important.
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| 8. |
- Prokhvatilov, A.I., et al.
(author)
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Hysteretic phenomena in Xe-doped C60 from X-ray diffraction
- 2005
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In: Low Temperature Physics. - : AIP Publishing. - 1063-777X .- 1090-6517. ; 31:5, s. 585-589
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Journal article (peer-reviewed)abstract
- Polycrystalline fullerite C60 intercalated with Xe atoms at 575 K and a pressure of 200 MPa was studied by powder x-ray diffraction. The integrated intensities of a few brighter reflections have been utilized to evaluate the occupancy of the octahedral interstitial sites in C60 crystals, which turned out to be (34±4)%, and in good agreement with another independent estimate. It is found that reflections of the (h00) type become observable in Xe-doped C60. The presence of xenon in the octahedral sites affects both the orientational phase transition as well as the glassification process, decreasing both characteristic temperatures as well as smearing the phase transition over a greater temperature range. Considerable hysteretic phenomena have been observed close to the phase transition and the glassification temperature. The signs of the two hysteresis loops are opposite. There is reliable evidence that at the lowest temperatures studied the thermal expansion of the doped crystal is negative under cool-down.
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| 11. |
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| 12. |
- Cassidy, A, et al.
(author)
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Critical review of health effects of soyabean phyto-oestrogens in post-menopausal women
- 2006
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In: The Proceedings of the Nutrition Society. - : Cambridge University Press (CUP). - 0029-6651. ; 65:1, s. 76-92
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Journal article (peer-reviewed)abstract
- A consensus view of soyabean phyto-oestrogens in clinical interventions in post-menopausal women is presented that is based on data from the EU-funded project Phytohealth. The phyto-oestrogens, primarily genistein and daidzein, were given as soyabean-protein isolates, whole-soyabean foods or extracts, supplements or pure compounds. A comprehensive literature search was conducted with well-defined inclusion or exclusion criteria. For areas for which substantial research exists only placebo-controlled double-blind randomised controlled trials (RCT) conducted on healthy post-menopausal women were included. For emerging areas all available human studies in post-menopausal women were reviewed. In order to make cross comparisons between studies the doses of isoflavones were calculated as aglycone equivalents. There is a suggestion, but no conclusive evidence, that isoflavones from the sources studied so far have a beneficial effect on bone health. The consumption of whole-soyabean foods and soyabean-protein isolates has some beneficial effects on lipid markers of cardiovascular risk. The consumption of isolated isoflavones does not affect blood lipid levels or blood pressure, although it may improve endothelial function. For menopausal symptoms there is currently limited evidence that soyabean-protein isolates, soyabean foods or red-clover (Trifolium pratense L.) extract are effective but soyabean isoflavone extracts may be effective in reducing hot flushes. There are too few RCT studies to reach conclusions on the effects of isoflavones on breast cancer, colon cancer, diabetes or cognitive function. The health benefits of soyabean phyto-oestrogens in healthy post-menopausal women are subtle and even some well-designed studies do not show protective effects. Future studies should focus on high-risk post-menopausal women, especially in the areas of diabetes, CVD, breast cancer and bone health.
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| 13. |
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| 15. |
- Foley, Jonathan A., et al.
(author)
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Solutions for a cultivated planet
- 2011
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 478:7369, s. 337-342
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Journal article (peer-reviewed)abstract
- Increasing population and consumption are placing unprecedented demands on agriculture and natural resources. Today, approximately a billion people are chronically malnourished while our agricultural systems are concurrently degrading land, water, biodiversity and climate on a global scale. To meet the world's future food security and sustainability needs, food production must grow substantially while, at the same time, agriculture's environmental footprint must shrink dramatically. Here we analyse solutions to this dilemma, showing that tremendous progress could be made by halting agricultural expansion, closing 'yield gaps' on underperforming lands, increasing cropping efficiency, shifting diets and reducing waste. Together, these strategies could double food production while greatly reducing the environmental impacts of agriculture.
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| 16. |
- Forslund, Tommie, et al.
(author)
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El Apego Va a Juicio: Problemas de Custodia y Protección Infantil : [Attachment goes to court: Child protection and custody issues]
- 2021
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In: Anuario de psicología jurídica. - : Colegio Oficial de la Psicologia de Madrid. - 1133-0740 .- 2174-0542. ; 32:1, s. 115-139
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Journal article (peer-reviewed)abstract
- Attachment theory and research are drawn upon in many applied settings, including family courts, but misunderstandings are widespread and sometimes result in misapplications. The aim of this consensus statement is, therefore, to enhance understanding, counter misinformation, and steer family-court utilisation of attachment theory in a supportive, evidence-based direction, especially with regard to child protection and child custody decision-making. This article is divided into two parts. In the first part, we address problems related to the use of attachment theory and research in family courts, and discuss reasons for these problems. To this end, we examine family court applications of attachment theory in the current context of the best-interest-of-the-child standard, discuss misunderstandings regarding attachment theory, and identify factors that have hindered accurate implementation. In the second part, we provide recommendations for the application of attachment theory and research. To this end, we set out three attachment principles: the child's need for familiar, non-abusive caregivers; the value of continuity of good-enough care; and the benefits of networks of attachment relationships. We also discuss the suitability of assessments of attachment quality and caregiving behaviour to inform family court decision-making. We conclude that assessments of caregiver behaviour should take center stage. Although there is dissensus among us regarding the use of assessments of attachment quality to inform child custody and child-protection decisions, such assessments are currently most suitable for targeting and directing supportive interventions. Finally, we provide directions to guide future interdisciplinary research collaboration.
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| 17. |
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| 18. |
- Garcia-Larsen, V., et al.
(author)
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Dietary intake of flavonoids and ventilatory function in european adults: A GA2LEN study
- 2018
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In: Nutrients. - Basel : MDPI AG. - 2072-6643. ; 10:1
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Journal article (peer-reviewed)abstract
- Background: Flavonoids exert anti-inflammatory properties and modulate oxidative stress in vitro, suggesting a protective effect on lung function, but epidemiological studies examining this association are scarce. Methods: A stratified random sample was drawn from the GA2LEN screening survey, in which 55,000 adults aged 15 to 75 answered a questionnaire on respiratory symptoms. Post-bronchodilator spirometry was obtained from 2850 subjects. Forced vital capacity (FVC), the ratio between the forced exhaled volume in 1 second (FEV1) and FVC (FEV1/FVC), FVC below lower limit of normal (FVC < LLN), and FEV1/FVC < LLN were calculated. Intake of the six main subclasses of flavonoids was estimated using the GA2LEN Food Frequency Questionnaire. Adjusted associations between outcomes and each subclass of flavonoids were examined with multivariate regressions. Simes’ procedure was used to test for multiple comparisons. Results: A total of 2599 subjects had valid lung function and dietary data. A lower prevalence of FVC < LLN (airway restriction) was observed in those with higher total flavonoid (adjusted odds ratio (aOR), higher vs. lowest quintile intake 0.58, 95% Confidence Interval (CI) 0.36, 0.94), and pro-anthocyanidin intakes (aOR 0.47, 95% CI 0.27, 0.81). A higher FEV1/FVC was associated with higher intakes of total flavonoids and pro-anthocyanidins (adjusted correlation coefficient (a β-coeff 0.33, 0.10, 0.57 and a β-coeff 0.44, 95% CI 0.19, 0.69, respectively). After Simes’ procedure, the statistical significance of each of these associations was attenuated but remained below 0.05, with the exception of total flavonoids and airway restriction. Conclusions: This population-based study in European adults provides cross-sectional evidence of a positive association of total flavonoid intake and pro-anthocyanidins and ventilatory function, and a negative association with spirometric restriction in European adults. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
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| 19. |
- Gurevich, A.M., et al.
(author)
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Low temperature heat capacity of fullerite C60 doped with nitrogen
- 2006
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In: Low Temperature Physics. - : AIP Publishing. - 1063-777X .- 1090-6517. ; 32:10, s. 967-969
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Journal article (peer-reviewed)abstract
- The heat capacity C-m of polycrystalline fullerite C-60 doped with nitrogen is measured in the temperature interval 2-13 K. The contributions to the heat capacity from translational lattice vibrations (Debyc contribution), from orientational vibrations of the C-60 molecules (Einstein contribution), and from the motion of the N-2 molecules in the octahedral cavities of the C-60 lattice are estimated. However, no indications of the first-order phase transformation detected earlier in a dilatometric investigation of the N-2-C-60 orientational glass are found (beyond the experimental error limits). A possible explanation for this fact is proposed.
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| 20. |
- Litt, Dana M., et al.
(author)
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A cross-cultural comparison of factors associated with marijuana use among college students in the United States and Sweden
- 2021
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In: The international journal of alcohol and drug research. - : Ohio State University Press. - 1925-7066. ; 9:2, s. 52-58
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Journal article (peer-reviewed)abstract
- Aims: Marijuana is a popular drug among U.S. college students. In Sweden, the prevalence of marijuana use has been relatively low but is increasing. Brief, personalized interventions have been efficacious in reducing substance use, including marijuana, among college students in the U.S. However, prior to implementation of U.S. interventions in Sweden, it is important to compare factors associated with marijuana use among college students in the two countries. Design, Setting, and Participants: Data are from baseline assessments of two large college student intervention studies in the U.S. (N = 3,753, 39% male) and Sweden (N = 2,280, 35% male). Measures: Past 30-day prevalence and frequency of marijuana use was analyzed in regard to relevant demographic factors. The moderating role of nationality was also examined. Findings: Results support previous findings indicating marijuana use is more common in the U.S. than in Sweden. Most demographic factors were similar across the countries, except for relationship status and work status, in which associations with number of marijuana use days (but not odds of any marijuana use) were stronger for Swedish college students compared to U.S. college students. Conclusions: Based on overall similarities between the U.S. and Sweden, comparable interventions might be recommended in both countries.
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| 21. |
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| 22. |
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| 23. |
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| 24. |
- Subarkah, D., et al.
(author)
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Unraveling the histories of Proterozoic shales through in situ Rb-Sr dating and trace element laser ablation analysis
- 2022
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In: Geology. - : Geological Society of America. - 0091-7613 .- 1943-2682. ; 50:1, s. 66-70
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Journal article (peer-reviewed)abstract
- Authigenic components in marine sediments are important archives for past environment reconstructions. However, defining reliable age constraints and assessing the effects of post depositional overprints in Precambrian sequences are challenging. We demonstrate a new laser-based analytical approach that has the potential to rapidly and accurately evaluate the depositional and alteration histories of Proterozoic shales. Our study employs a novel application of in situ Rb-Sr dating coupled with simultaneous trace-element analysis using reaction-cell laser ablation-inductively coupled plasma-tandem mass spectrometry (LA-ICPMS/MS). We present results from shales sourced from two wells in the Proterozoic McArthur Basin, northern Australia. These rocks have been widely used by previous studies as a key section for ancient biogeochemical and paleo-redox reconstructions. Shales from well UR5 yielded initial Sr-87/Sr-86 ratios, Rb-Sr ages, and rare earth element plus yttrium (REEY) patterns similar to those of a dolerite sampled from the same core. We propose that the UR5 samples chronicle hydrothermal alteration instigated by the dolerite intrusion. In contrast, a correlative shale from well UR6 yielded an age consistent with the expected depositional age (1577 +/- 56 Ma) with REEY and initial Sr-87/Sr-86 ratios similar to ca. 1.5 Ga seawater. We suggest that this sample records the minimum depositional age and early marine diagenetic history for this unit. This new technique can date Proterozoic shales quickly, cheaply, and with minimum sample preparation. Importantly, ages are triaged to differentiate between those recording primary marine versus secondary processes. This novel approach provides a potentially powerful tool for dating and fingerprinting the vast array of ancient marine shales for further studies of Earth systems through deep time.
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| 25. |
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| 26. |
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| 27. |
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| 28. |
- Cancelliere, Carol, et al.
(author)
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Protocol for a systematic review of prognosis after mild traumatic brain injury : an update of the WHO Collaborating Centre Task Force findings
- 2012
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In: Systematic Reviews. - : Springer Science and Business Media LLC. - 2046-4053. ; :1, s. 17-
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Journal article (peer-reviewed)abstract
- Background: Mild traumatic brain injury (MTBI) is a major public-health concern and represents 70-90% of all treated traumatic brain injuries. The last best-evidence synthesis, conducted by the WHO Collaborating Centre for Neurotrauma, Prevention, Management and Rehabilitation in 2002, found few quality studies on prognosis. The objective of this review is to update these findings. Specifically, we aim to describe the course, identify modifiable prognostic factors, determine long-term sequelae, and identify effects of interventions for MTBI. Finally, we will identify gaps in the literature, and make recommendations for future research.Methods: The databases MEDLINE, PsychINFO, Embase, CINAHL and SPORTDiscus were systematically searched (2001 to date). The search terms included 'traumatic brain injury', 'craniocerebral trauma', 'prognosis', and 'recovery of function'. Reference lists of eligible papers were also searched. Studies were screened according to pre-defined inclusion and exclusion criteria. Inclusion criteria included original, published peer-reviewed research reports in English, French, Swedish, Norwegian, Danish and Spanish, and human participants of all ages with an accepted definition of MTBI. Exclusion criteria included publication types other than systematic reviews, meta-analyses, randomized controlled trials, cohort studies, and case-control studies; as well as cadaveric, biomechanical, and laboratory studies. All eligible papers were critically appraised using a modification of the Scottish Intercollegiate Guidelines Network (SIGN) criteria. Two reviewers performed independent, in-depth reviews of each eligible study, and a third reviewer was consulted for disagreements. Data from accepted papers were extracted into evidence tables, and the evidence was synthesized according to the modified SIGN criteria.Conclusion: The results of this study form the basis for a better understanding of recovery after MTBI, and will allow development of prediction tools and recommendation of interventions, as well as informing health policy and setting a future research agenda.
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| 29. |
- Cancelliere, Carol, et al.
(author)
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Systematic review of prognosis and return to play after sport concussion : results of the international collaboration on mild traumatic brain injury prognosis
- 2014
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In: Archives of Physical Medicine and Rehabilitation. - : Elsevier. - 0003-9993 .- 1532-821X. ; 95:3, Suppl, s. S210-S229
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Research review (peer-reviewed)abstract
- ObjectiveTo synthesize the best available evidence on prognosis after sport concussion.Data SourcesMEDLINE and other databases were searched (2001–2012) with terms including “craniocerebral trauma” and “sports.” Reference lists of eligible articles were also searched.Study SelectionRandomized controlled trials and cohort and case-control studies were selected according to predefined criteria. Studies had to have a minimum of 30 concussion cases.Data ExtractionEligible studies were critically appraised using a modification of the Scottish Intercollegiate Guidelines Network (SIGN) criteria. Two reviewers independently reviewed and extracted data from accepted studies into evidence tables.Data SynthesisEvidence was synthesized qualitatively according to modified SIGN criteria, and studies were categorized as exploratory or confirmatory based on the strength of their design and evidence. After 77,914 records were screened, 52 articles were eligible for this review, and 24 articles (representing 19 studies) with a low risk of bias were accepted. Our findings are based on exploratory studies of predominantly male football players at the high school, collegiate, and professional levels. Most athletes recover within days to a few weeks, and American and Australian professional football players return to play quickly after mild traumatic brain injury. Delayed recovery appears more likely in high school athletes, in those with a history of previous concussion, and in those with a higher number and duration of postconcussion symptoms.ConclusionsThe evidence concerning sports concussion course and prognosis is very preliminary, and there is no evidence on the effect of return-to-play guidelines on prognosis. Our findings have implications for further research. Well-designed, confirmatory studies are urgently needed to understand the consequences of sport concussion, including recurrent concussion, across different athletic populations and sports.
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| 30. |
- Cancelliere, Carol, et al.
(author)
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Systematic review of return to work after mild traumatic brain injury : results of the international collaboration on mild traumatic brain injury prognosis
- 2014
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In: Archives of Physical Medicine and Rehabilitation. - : Elsevier. - 0003-9993 .- 1532-821X. ; 95:3, Suppl, s. S201-S209
-
Research review (peer-reviewed)abstract
- ObjectiveTo synthesize the best available evidence on return to work (RTW) after mild traumatic brain injury (MTBI).Data SourcesMEDLINE and other databases were searched (2001–2012) with terms including “craniocerebral trauma” and “employment.” Reference lists of eligible articles were also searched.Study SelectionControlled trials and cohort and case-control studies were selected according to predefined criteria. Studies had to assess RTW or employment outcomes in at least 30 MTBI cases.Data ExtractionEligible studies were critically appraised using a modification of the Scottish Intercollegiate Guidelines Network criteria. Two reviewers independently reviewed and extracted data from accepted studies into evidence tables.Data SynthesisEvidence was synthesized qualitatively according to modified Scottish Intercollegiate Guidelines Network criteria and prioritized according to design as exploratory or confirmatory. After 77,914 records were screened, 299 articles were found eligible and reviewed; 101 (34%) of these with a low risk of bias were accepted as scientifically admissible, and 4 of these had RTW or employment outcomes. This evidence is preliminary and suggests that most workers RTW within 3 to 6 months after MTBI; MTBI is not a significant risk factor for long-term work disability; and predictors of delayed RTW include a lower level of education (<11y of formal education), nausea or vomiting on hospital admission, extracranial injuries, severe head/bodily pain early after injury, and limited job independence and decision-making latitude.ConclusionsOur findings are based on preliminary evidence with varied patient characteristics and MTBI definitions, thus limiting firm conclusions. More well-designed studies are required to understand RTW and sustained employment after MTBI in the longer term (≥2y post-MTBI).
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| 31. |
- Carlen, M., et al.
(author)
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Functional integration of adult-born neurons
- 2002
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In: Current Biology. - 0960-9822 .- 1879-0445. ; 12:7, s. 606-608
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Journal article (peer-reviewed)abstract
- Over the past decade, it has become clear that neural stem cells in the adult mammalian brain continuously generate new neurons, predominantly in the hippocampus and olfactory bulb [1]. However, the central issue of whether these new neurons participate in functional synaptic circuitry has yet to be resolved. Here, we use virus-based transsynaptic neuronal tracing and c-Fos mapping of odor-induced neuronal activity to demonstrate that neurons generated in the adult functionally integrate into the synaptic circuitry of the brain.
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| 32. |
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| 33. |
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| 34. |
- de Roos, Baukje, et al.
(author)
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Targeting the delivery of dietary plant bioactives to those who would benefit most: from science to practical applications
- 2019
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In: European Journal of Nutrition. - : Springer Science and Business Media LLC. - 1436-6207 .- 1436-6215. ; 58:53 (suppl. 2), s. 65-73
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Research review (peer-reviewed)abstract
- Background A healthy diet and optimal lifestyle choices are amongst the most important actions for the prevention of cardiometabolic diseases. Despite this, it appears difficult to convince consumers to select more nutritious foods. Furthermore, the development and production of healthier foods do not always lead to economic profits for the agro-food sector. Most dietary recommendations for the general population represent a "one-size-fits-all approach" which does not necessarily ensure that everyone has adequate exposure to health-promoting constituents of foods. Indeed, we now know that individuals show a high variability in responses when exposed to specific nutrients, foods, or diets. Purpose This review aims to highlight our current understanding of inter-individual variability in response to dietary bioactives, based on the integration of findings of the COST Action POSITIVe. We also evaluate opportunities for translation of scientific knowledge on inter-individual variability in response to dietary bioactives, once it becomes available, into practical applications for stakeholders, such as the agro-food industry. The potential impact from such applications will form an important impetus for the food industry to develop and market new high quality and healthy foods for specific groups of consumers in the future. This may contribute to a decrease in the burden of diet-related chronic diseases. Key messages Individual differences in ADME (Absorption, Digestion, Metabolism and Excretion) is believed to underpin much of the inter-individual variation in responses. Recent developments in the area of food metabolome databases and fast improvements in innovative metabotyping technologies hold great promise for improved profiling of dietary intake, exposure to individual ingredients, foods and dietary patterns, as well as our ability to identify individual responsiveness. The food industry needs well-defined population clusters or targets in order to be able to design "personalized products". There are indeed excellent industrial opportunities for foods that modulate gut microbiota, and thereby enable the delivery of food bioactive metabolites. It is currently not clear whether knowledge on individual nutrient needs, based on genetic or metagenomic data, would affect long-term dietary and health behaviours. Data to support the development of dietary recommendations may need to be generated by new n-of-1-based study designs in the future.
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| 35. |
- Dolbin, Alexander V., et al.
(author)
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Specific features of thermal expansion and polyamorphism in CH4 – C60 solutions at low temperatures
- 2007
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In: Low Temperature Physics. - : AIP Publishing. - 1063-777X .- 1090-6517. ; 33:12, s. 1068-1072
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Journal article (peer-reviewed)abstract
- The temperature dependence of the linear thermal expansion coefficient alpha(T) is investigated in the temperature range of 2.5 to 23 K for two different CH4-C-60 solutions in which CH4 molecules occupy 24 and 50% of the octahedral interstitial sites of the C-60 lattice. In both cases, alpha(T) exhibits hysteresis, suggesting the existence of two types of orientational glass associated with these solutions. The temperature of the first-order phase transition between these two glasses is estimated, and the behavior of these two glasses is compared. The characteristic times of thermalization tau(1), reorientation of the C-60 molecules tau(2), and of the phase transformation between the glasses tau('), are estimated for these solutions. Both the temperature dependence of alpha(T) and the characteristic thermalization time tau(1) are found to have features near the phase transition temperature, and an explanation is put forward to explain these observed features.
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| 36. |
- Dolbin, Alexander V., et al.
(author)
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The effect of the noncentral impurity-matrix interaction upon the thermal expansion and polyamorphism of solid CO-C60 solutions at low temperatures
- 2008
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In: Fizika Nizkikh Temperatur. - : AIP Publishing. - 0132-6414. ; 34:6, s. 592-598
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Journal article (peer-reviewed)abstract
- Orientational glasses with CO molecules occupying 26 and 90% of the octahedral interstitial sites in the C60 lattice have been investigated by the dilatometric method in a temperature interval of 2.5–22 K. At temperatures 4–6 K the glasses undergo a first-order phase transition which is evident from the hysteresis of the thermal expansion and the maxima in the temperature dependences of the linear thermal expansion coefficients a(T), and the thermalization times t1(T) of the samples. The effect of the noncentral CO–C60 interaction upon the thermal expansion and the phase transition in these glasses was clarified by comparing the behavior of the properties of the CO–C60 and N2–C60 solutions.
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| 37. |
- Dolbin, Alexander V., et al.
(author)
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Thermal expansion of solutions of deuteromethane in fullerite C60 at low temperature : Isotopic effect
- 2009
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In: Low temperature physics (Woodbury, N.Y., Print). - : American Institute of Physics. - 1063-777X .- 1090-6517. ; 35:3, s. 226-231
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Journal article (peer-reviewed)abstract
- The thermal expansion of CD4 solutions in the orientational glass C60 with molar concentration of deuteromethane 20 and 50% has been investigated in the temperature range 2.5–23 K. The orientational glass CD4–C60 undergoes a first-order phase transition in the temperature interval 4.5–55 K. This transition is manifested as hysteresis of the linear thermal expansion coefficient alpha as well as maxima in the temperature dependences alpha(T) and tau1(T), where tau1 is the characteristic thermalization time of the experimental samples. The characteristic re-orientation times of the C60 molecules and the characteristic phase transformations occurring in the experimental solutions are determined. The results of the present study are compared with the results of a similar study of the solution CH4–C60. It is concluded that tunneling rotation of the CH4 and CD4 molecules occupying interstitial positions in the fullerite C60 lattice occurs.
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| 38. |
- Falk, A, et al.
(author)
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Gene delivery to adult neural stem cells
- 2002
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In: Experimental Cell Research. - : Elsevier BV. - 1090-2422 .- 0014-4827. ; 279:1, s. 34-39
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Journal article (peer-reviewed)abstract
- Neural stem cells may present an ideal route for gene therapy as well as offer new possibilities for the replacement of neurons lost to injury or disease. However, it has proved difficult to express ectopic genes in stem cells. We report methods to introduce genes into adult neural stem cells using viral and nonviral vectors in vitro and in vivo. Adenoviral and VSV-G-pseudotyped retroviral vectors are more efficient than plasmid transfection or VSV-G lentiviral transduction in vitro. We further show that adult neural stem cells can be directed to a neuronal fate by ectopic expression of neurogenin 2 in vitro. Plasmids can be delivered in vivo when complexed with linear polyethyleneimine, and gene expression can be targeted specifically to neural stem or progenitor cells by the use of specific promoters. These techniques may be utilized both to study the function of various genes in the differentiation of neural stem cells to specific cell fates and, ultimately, for gene therapy or to generate specific differentiated progeny for cell transplantation. (C) 2002 Elsevier Science (USA).
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| 39. |
- Galtsov, N. N., et al.
(author)
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Intercalation of fullerite C60 with N2 molecules : an investigation by X-ray powder diffraction
- 2007
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In: Low temperature physics (Woodbury, N.Y., Print). - : American Institute of Physics (AIP). - 1063-777X .- 1090-6517. ; 33:10, s. 881-885
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Journal article (peer-reviewed)abstract
- The lattice parameter a of fullerite C60 intercalated with N2 molecules is investigated in the temperature interval 6–295K by x-ray diffraction. It is found that the interstitial molecular N2 has a considerable effect on both the orientational phase transition temperature Tc and the orientational glass formation temperature Tg. Hysteresis of a(T) in the Tc and Tg regions is detected, along with an abrupt change in volume over the region defining Tc. Complete intercalation of C60 with N2 molecules results in a 0.2% increase in the lattice parameter, which persists over the whole temperature range. Evidence is also obtained that the interstitial guest molecular N2 induces a slight deformation of the cubic symmetry of the C60 host lattice.
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| 40. |
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| 49. |
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| 50. |
- Holmberg, J, et al.
(author)
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Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis
- 2005
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In: Genes & development. - : Cold Spring Harbor Laboratory. - 0890-9369 .- 1549-5477. ; 19:4, s. 462-471
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Journal article (peer-reviewed)abstract
- The number of cells in an organ is regulated by mitogens and trophic factors that impinge on intrinsic determinants of proliferation and apoptosis. We here report the identification of an additional mechanism to control cell number in the brain: EphA7 induces ephrin-A2 reverse signaling, which negatively regulates neural progenitor cell proliferation. Cells in the neural stem cell niche in the adult brain proliferate more and have a shorter cell cycle in mice lacking ephrin-A2. The increased progenitor proliferation is accompanied by a higher number of cells in the olfactory bulb. Disrupting the interaction between ephrin-A2 and EphA7 in the adult brain of wild-type mice disinhibits proliferation and results in increased neurogenesis. The identification of ephrin-A2 and EphA7 as negative regulators of progenitor cell proliferation reveals a novel mechanism to control cell numbers in the brain.
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