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1.	Berntell, Ellen, et al. (author) Mid-Pliocene West African Monsoon rainfall as simulated in the PlioMIP2 ensemble 2021 In: Climate of the Past. - : Copernicus GmbH. - 1814-9324 .- 1814-9332. ; 17:4, s. 1777-1794 Journal article (peer-reviewed)abstract The mid-Pliocene warm period (mPWP; ∼3.2 million years ago) is seen as the most recent time period characterized by a warm climate state, with similar to modern geography and ∼400 ppmv atmospheric CO2 concentration, and is therefore often considered an interesting analogue for near-future climate projections. Paleoenvironmental reconstructions indicate higher surface temperatures, decreasing tropical deserts, and a more humid climate in West Africa characterized by a strengthened West African Monsoon (WAM). Using model results from the second phase of the Pliocene Modelling Intercomparison Project (PlioMIP2) ensemble, we analyse changes of the WAM rainfall during the mPWP by comparing them with the control simulations for the pre-industrial period. The ensemble shows a robust increase in the summer rainfall over West Africa and the Sahara region, with an average increase of 2.5 mm/d, contrasted by a rainfall decrease over the equatorial Atlantic. An anomalous warming of the Sahara and deepening of the Saharan Heat Low, seen in >90 % of the models, leads to a strengthening of the WAM and an increased monsoonal flow into the continent. A similar warming of the Sahara is seen in future projections using both phase 3 and 5 of the Coupled Model Intercomparison Project (CMIP3 and CMIP5). Though previous studies of future projections indicate a west–east drying–wetting contrast over the Sahel, PlioMIP2 simulations indicate a uniform rainfall increase in that region in warm climates characterized by increasing greenhouse gas forcing. We note that this effect will further depend on the long-term response of the vegetation to the CO2 forcing.
2.	Burke, Michael J., et al. (author) Transplant Outcomes for Children with T Cell Acute Lymphoblastic Leukemia in Second Remission : A Report from the Center for International Blood and Marrow Transplant Research 2015 In: Biology of blood and marrow transplantation. - : Elsevier BV. - 1083-8791 .- 1523-6536. ; 21:12, s. 2154-2159 Journal article (peer-reviewed)abstract Survival for children with relapsed T cell acute lymphoblastic leukemia (T-ALL) is poor when treated with chemotherapy alone, and outcomes after allogeneic hematopoietic cell transplantation (HCT) is not well described. Two hundred twenty-nine children with T-ALL in second complete remission (CR2) received an HCT after myeloablative conditioning between 2000 and 2011 and were reported to the Center for International Blood and Marrow Transplant Research. Median age was 10 years (range, 2 to 18). Donor source was umbilical cord blood (26%), matched sibling bone marrow (38%), or unrelated bone marrow/peripheral blood (36%). Acute (grades II to IV) and chronic graft-versus-host disease occurred in, respectively, 35% (95% confidence interval [CI], 27% to 45%) and 26% (95% CI, 20% to 33%) of patients. Transplant-related mortality at day 100 and 3-year relapse rates were 13% (95% CI, 9% to 18%) and 30% (95% CI, 24% to 37%), respectively. Three-year overall survival and disease-free survival rates were 48% (95% CI, 41% to 55%) and 46% (95% CI, 39% to 52%), respectively. In multivariate analysis, patients with bone marrow relapse, with or without concurrent extramedullary relapse before HCT, were most likely to relapse (hazard ratio, 3.94; P =.005) as compared with isolated extramedullary disease. In conclusion, HCT for pediatric T-ALL in CR2 demonstrates reasonable and durable outcomes, and consideration for HCT is warranted. (c) 2015 American Society for Blood and Marrow Transplantation.
3.	Cramwinckel, Margot J., et al. (author) Global and Zonal-Mean Hydrological Response to Early Eocene Warmth 2023 In: Paleoceanography and Paleoclimatology. - 2572-4517 .- 2572-4525. ; 38:6 Journal article (peer-reviewed)abstract Earth's hydrological cycle is expected to intensify in response to global warming, with a wet-gets-wetter, dry-gets-drier response anticipated over the ocean. Subtropical regions (similar to 15 degrees-30 degrees N/S) are predicted to become drier, yet proxy evidence from past warm climates suggests these regions may be characterized by wetter conditions. Here we use an integrated data-modeling approach to reconstruct global and zonal-mean rainfall patterns during the early Eocene (similar to 56-48 million years ago). The Deep-Time Model Intercomparison Project (DeepMIP) model ensemble indicates that the mid-(30 degrees-60 degrees N/S) and high-latitudes (>60 degrees N/S) are characterized by a thermodynamically dominated hydrological response to warming and overall wetter conditions. The tropical band (0 degrees-15 degrees N/S) is also characterized by wetter conditions, with several DeepMIP models simulating narrowing of the Inter-Tropical Convergence Zone. However, the latter is not evident from the proxy data. The subtropics are characterized by negative precipitation-evaporation anomalies (i.e., drier conditions) in the DeepMIP models, but there is surprisingly large inter-model variability in mean annual precipitation (MAP). Intriguingly, we find that models with weaker meridional temperature gradients (e.g., CESM, GFDL) are characterized by a reduction in subtropical moisture divergence, leading to an increase in MAP. These model simulations agree more closely with our new proxy-derived precipitation reconstructions and other key climate metrics and imply that the early Eocene was characterized by reduced subtropical moisture divergence. If the meridional temperature gradient was even weaker than suggested by those DeepMIP models, circulation-induced changes may have outcompeted thermodynamic changes, leading to wetter subtropics. This highlights the importance of accurately reconstructing zonal temperature gradients when reconstructing past rainfall patterns. As the world warms, the atmosphere is able to hold more moisture however, this moisture will not fall evenly across the globe. Some regions are expected to become wetter, whereas other regions will become drier. This is the basis of the familiar paradigm wet-gets-wetter, dry-gets-drier and is largely supported by future model projections. However, evidence from the geological record contradicts this hypothesis and suggests that a warmer world could be characterized by wetter (rather than drier) subtropics. Here, we use an integrated data-modeling approach to investigate the hydrological response to warming during an ancient warm interval (the early Eocene, 56-48 million years ago). We show that models with weaker latitudinal temperature gradients are characterized by a reduction in subtropical moisture divergence. However, this was not sufficient to induce subtropical wetting. If the meridional temperature gradient was weaker than suggested by the models, circulation-induced changes may have lead to wetter subtropics. This work shows that the latitudinal temperature gradient is a key factor that influences hydroclimate in the subtropics, especially in past warm climates.
4.	de Nooijer, Wesley, et al. (author) Evaluation of Arctic warming in mid-Pliocene climate simulations 2020 In: Climate of the Past. - : Copernicus GmbH. - 1814-9324 .- 1814-9332. ; 16:6, s. 2325-2341 Journal article (peer-reviewed)abstract Palaeoclimate simulations improve our understanding of the climate, inform us about the performance of climate models in a different climate scenario, and help to identify robust features of the climate system. Here, we analyse Arctic warming in an ensemble of 16 simulations of the mid-Pliocene Warm Period (mPWP), derived from the Pliocene Model Intercomparison Project Phase 2 (PlioMIP2). The PlioMIP2 ensemble simulates Arctic (60-90 degrees N) annual mean surface air temperature (SAT) increases of 3.7 to 11.6 degrees C compared to the pre-industrial period, with a multimodel mean (MMM) increase of 7.2 degrees C. The Arctic warming amplification ratio relative to global SAT anomalies in the ensemble ranges from 1.8 to 3.1 (MMM is 2.3). Sea ice extent anomalies range from -3.0 to -10.4 x 10(6) km(2), with a MMM anomaly of -5.6 x 10 6 km(2), which constitutes a decrease of 53 % compared to the pre-industrial period. The majority (11 out of 16) of models simulate summer seaice-free conditions (<= 1 x 10(6) km(2)) in their mPWP simulation. The ensemble tends to underestimate SAT in the Arctic when compared to available reconstructions, although the degree of underestimation varies strongly between the simulations. The simulations with the highest Arctic SAT anomalies tend to match the proxy dataset in its current form better. The ensemble shows some agreement with reconstructions of sea ice, particularly with regard to seasonal sea ice. Large uncertainties limit the confidence that can be placed in the findings and the compatibility of the different proxy datasets. We show that while reducing uncertainties in the reconstructions could decrease the SAT data-model discord substantially, further improvements are likely to be found in enhanced boundary conditions or model physics. Lastly, we compare the Arctic warming in the mPWP to projections of future Arctic warming and find that the PlioMIP2 ensemble simulates greater Arctic amplification than CMIP5 future climate simulations and an increase instead of a decrease in Atlantic Meridional Overturning Circulation (AMOC) strength compared to pre-industrial period. The results highlight the importance of slow feedbacks in equilibrium climate simulations, and that caution must be taken when using simulations of the mPWP as an analogue for future climate change.
5.	Feng, Ran, et al. (author) Past terrestrial hydroclimate sensitivity controlled by Earth system feedbacks 2022 In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1 Journal article (peer-reviewed)abstract Despite tectonic conditions and atmospheric CO2 levels (pCO2) similar to those of present-day, geological reconstructions from the mid-Pliocene (3.3-3.0 Ma) document high lake levels in the Sahel and mesic conditions in subtropical Eurasia, suggesting drastic reorganizations of subtropical terrestrial hydroclimate during this interval. Here, using a compilation of proxy data and multi-model paleoclimate simulations, we show that the mid-Pliocene hydroclimate state is not driven by direct CO2 radiative forcing but by a loss of northern high-latitude ice sheets and continental greening. These ice sheet and vegetation changes are long-term Earth system feedbacks to elevated pCO2. Further, the moist conditions in the Sahel and subtropical Eurasia during the mid-Pliocene are a product of enhanced tropospheric humidity and a stationary wave response to the surface warming pattern, which varies strongly with land cover changes. These findings highlight the potential for amplified terrestrial hydroclimate responses over long timescales to a sustained CO2 forcing.
6.	Goudsmit-Harzevoort, Barbara, et al. (author) The Relationship Between the Global Mean Deep-Sea and Surface Temperature During the Early Eocene 2023 In: Paleoceanography and Paleoclimatology. - 2572-4517 .- 2572-4525. ; 38:3 Journal article (peer-reviewed)abstract Estimates of global mean near-surface air temperature (global SAT) for the Cenozoic era rely largely on paleo-proxy data of deep-sea temperature (DST), with the assumption that changes in global SAT covary with changes in the global mean deep-sea temperature (global DST) and global mean sea-surface temperature (global SST). We tested the validity of this assumption by analyzing the relationship between global SST, SAT, and DST using 25 different model simulations from the Deep-Time Model Intercomparison Project simulating the early Eocene Climatic Optimum (EECO) with varying CO2 levels. Similar to the modern situation, we find limited spatial variability in DST, indicating that local DST estimates can be regarded as a first order representative of global DST. In line with previously assumed relationships, linear regression analysis indicates that both global DST and SAT respond stronger to changes in atmospheric CO2 than global SST by a similar factor. Consequently, this model-based analysis validates the assumption that changes in global DST can be used to estimate changes in global SAT during the early Cenozoic. Paleo-proxy estimates of global DST, SST, and SAT during EECO show the best fit with model simulations with a 1,680 ppm atmospheric CO2 level. This matches paleo-proxies of EECO atmospheric CO2, indicating a good fit between models and proxy-data.
7.	Guo, Donglin, et al. (author) Highly restricted near-surface permafrost extent during the mid-Pliocene warm period 2023 In: Proceedings of the National Academy of Sciences of the United States of America. - 0027-8424 .- 1091-6490. ; 120:36 Journal article (peer-reviewed)abstract Accurate understanding of permafrost dynamics is critical for evaluating and mitigating impacts that may arise as permafrost degrades in the future; however, existing projections have large uncertainties. Studies of how permafrost responded historically during Earth's past warm periods are helpful in exploring potential future permafrost behavior and to evaluate the uncertainty of future permafrost change projections. Here, we combine a surface frost index model with outputs from the second phase of the Pliocene Model Intercomparison Project to simulate the near-surface (similar to 3 to 4 m depth) permafrost state in the Northern Hemisphere during the mid-Pliocene warm period (mPWP, similar to 3.264 to 3.025 Ma). This period shares similarities with the projected future climate. Constrained by proxy-based surface air temperature records, our simulations demonstrate that near-surface permafrost was highly spatially restricted during the mPWP and was 93 +/- 3% smaller than the preindustrial extent. Near-surface permafrost was present only in the eastern Siberian uplands, Canadian high Arctic Archipelago, and northernmost Greenland. The simulations are similar to near-surface permafrost changes projected for the end of this century under the SSP5-8.5 scenario and provide a perspective on the potential permafrost behavior that may be expected in a warmer world.
8.	Haywood, Alan M., et al. (author) The Pliocene Model Intercomparison Project Phase 2 : large-scale climate features and climate sensitivity 2020 In: Climate of the Past. - : Copernicus GmbH. - 1814-9324 .- 1814-9332. ; 16:6, s. 2095-2123 Journal article (peer-reviewed)abstract The Pliocene epoch has great potential to improve our understanding of the long-term climatic and environmental consequences of an atmospheric CO2 concentration near similar to 400 parts per million by volume. Here we present the large-scale features of Pliocene climate as simulated by a new ensemble of climate models of varying complexity and spatial resolution based on new reconstructions of boundary conditions (the Pliocene Model Intercomparison Project Phase 2; PlioMIP2). As a global annual average, modelled surface air temperatures increase by between 1.7 and 5.2 degrees C relative to the pre-industrial era with a multi-model mean value of 3.2 degrees C. Annual mean total precipitation rates increase by 7 % (range: 2 %-13 %). On average, surface air temperature (SAT) increases by 4.3 degrees C over land and 2.8 degrees C over the oceans. There is a clear pattern of polar amplification with warming polewards of 60 degrees N and 60 degrees S exceeding the global mean warming by a factor of 2.3. In the Atlantic and Pacific oceans, meridional temperature gradients are reduced, while tropical zonal gradients remain largely unchanged. There is a statistically significant relationship between a model's climate response associated with a doubling in CO2 (equilibrium climate sensitivity; ECS) and its simulated Pliocene surface temperature response. The mean ensemble Earth system response to a doubling of CO2 (including ice sheet feedbacks) is 67 % greater than ECS; this is larger than the increase of 47 % obtained from the PlioMIP1 ensemble. Proxy-derived estimates of Pliocene sea surface temperatures are used to assess model estimates of ECS and give an ECS range of 2.6-4.8 degrees C. This result is in general accord with the ECS range presented by previous Intergovernmental Panel on Climate Change (IPCC) Assessment Reports.
9.	Kelemen, Fanni Dora, et al. (author) Meridional Heat Transport in the DeepMIP Eocene Ensemble : Non-CO2 and CO2 Effects 2023 In: Paleoceanography and Paleoclimatology. - 2572-4517 .- 2572-4525. ; 38:8 Journal article (peer-reviewed)abstract The total meridional heat transport (MHT) is relatively stable across different climates. Nevertheless, the strength of individual processes contributing to the total transport are not stable. Here we investigate the MHT and its main components especially in the atmosphere, in five coupled climate model simulations from the Deep-Time Model Intercomparison Project (DeepMIP). These simulations target the early Eocene climatic optimum, a geological time period with high CO2 concentrations, analog to the upper range of end-of-century CO2 projections. Preindustrial and early Eocene simulations, at a range of CO2 levels are used to quantify the MHT changes in response to both CO2 and non-CO2 related forcings. We found that atmospheric poleward heat transport increases with CO2, while oceanic poleward heat transport decreases. The non-CO2 boundary conditions cause more MHT toward the South Pole, mainly through an increase in the southward oceanic heat transport. The changes in paleogeography increase the heat transport via transient eddies at the northern mid-latitudes in the Eocene. The Eocene Hadley cells do not transport more heat poleward, but due to the warmer atmosphere, especially the northern cell, circulate more heat in the tropics, than today. The monsoon systems' poleward latent heat transport increases with rising CO2 concentrations, but this change is counterweighted by the globally smaller Eocene monsoon area. Our results show that the changes in the monsoon systems' latent heat transport is a robust feature of CO2 warming, which is in line with the currently observed precipitation increase of present day monsoon systems.
10.	Lunt, Daniel J., et al. (author) DeepMIP : model intercomparison of early Eocene climatic optimum (EECO) large-scale climate features and comparison with proxy data 2021 In: Climate of the Past. - : Copernicus GmbH. - 1814-9324 .- 1814-9332. ; 17:1, s. 203-227 Journal article (peer-reviewed)abstract We present results from an ensemble of eight climate models, each of which has carried out simulations of the early Eocene climate optimum (EECO, similar to 50 million years ago). These simulations have been carried out in the framework of the Deep-Time Model Intercomparison Project (DeepMIP; http://www.deepmip.org , last access: 10 January 2021); thus, all models have been configured with the same paleogeographic and vegetation boundary conditions. The results indicate that these non-CO2 boundary conditions contribute between 3 and 5 degrees C to Eocene warmth. Compared with results from previous studies, the DeepMIP simulations generally show a reduced spread of the global mean surface temperature response across the ensemble for a given atmospheric CO2 concentration as well as an increased climate sensitivity on average. An energy balance analysis of the model ensemble indicates that global mean warming in the Eocene compared with the preindustrial period mostly arises from decreases in emissivity due to the elevated CO2 concentration (and associated water vapour and long-wave cloud feedbacks), whereas the reduction in the Eocene in terms of the meridional temperature gradient is primarily due to emissivity and albedo changes owing to the non-CO2 boundary conditions (i.e. the removal of the Antarctic ice sheet and changes in vegetation). Three of the models (the Community Earth System Model, CESM; the Geophysical Fluid Dynamics Laboratory, GFDL, model; and the Norwegian Earth System Model, NorESM) show results that are consistent with the proxies in terms of the global mean temperature, meridional SST gradient, and CO2, without prescribing changes to model parameters. In addition, many of the models agree well with the first-order spatial patterns in the SST proxies. However, at a more regional scale, the models lack skill. In particular, the modelled anomalies are substantially lower than those indicated by the proxies in the southwest Pacific; here, modelled continental surface air temperature anomalies are more consistent with surface air temperature proxies, implying a possible inconsistency between marine and terrestrial temperatures in either the proxies or models in this region. Our aim is that the documentation of the large-scale features and model-data comparison presented herein will pave the way to further studies that explore aspects of the model simulations in more detail, for example the ocean circulation, hydrological cycle, and modes of variability, and encourage sensitivity studies to aspects such as paleogeography, orbital configuration, and aerosols.
11.	Mueller, Stefanie H., et al. (author) Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry 2023 In: Genome Medicine. - : BioMed Central (BMC). - 1756-994X. ; 15 Journal article (peer-reviewed)abstract Background: Low-frequency variants play an important role in breast cancer (BC) susceptibility. Gene-based methods can increase power by combining multiple variants in the same gene and help identify target genes.Methods: We evaluated the potential of gene-based aggregation in the Breast Cancer Association Consortium cohorts including 83,471 cases and 59,199 controls. Low-frequency variants were aggregated for individual genes' coding and regulatory regions. Association results in European ancestry samples were compared to single-marker association results in the same cohort. Gene-based associations were also combined in meta-analysis across individuals with European, Asian, African, and Latin American and Hispanic ancestry.Results: In European ancestry samples, 14 genes were significantly associated (q < 0.05) with BC. Of those, two genes, FMNL3 (P = 6.11 x 10(-6)) and AC058822.1 (P = 1.47 x 10(-4)), represent new associations. High FMNL3 expression has previously been linked to poor prognosis in several other cancers. Meta-analysis of samples with diverse ancestry discovered further associations including established candidate genes ESR1 and CBLB. Furthermore, literature review and database query found further support for a biologically plausible link with cancer for genes CBLB, FMNL3, FGFR2, LSP1, MAP3K1, and SRGAP2C.Conclusions: Using extended gene-based aggregation tests including coding and regulatory variation, we report identification of plausible target genes for previously identified single-marker associations with BC as well as the discovery of novel genes implicated in BC development. Including multi ancestral cohorts in this study enabled the identification of otherwise missed disease associations as ESR1 (P = 1.31 x 10(-5)), demonstrating the importance of diversifying study cohorts.
12.	Niezgodzki, Igor, et al. (author) Simulation of Arctic sea ice within the DeepMIP Eocene ensemble : Thresholds, seasonality and factors controlling sea ice development 2022 In: Global and Planetary Change. - : Elsevier BV. - 0921-8181 .- 1872-6364. ; 214 Journal article (peer-reviewed)abstract The early Eocene greenhouse climate maintained by high atmospheric CO2 concentrations serves as a testbed for future climate changes dominated by increasing CO2 forcing. In particular, the early Eocene Arctic region is important in the context of future CO2 driven climate warming in the northern polar region and associated shrinking Arctic sea ice. Here, we present early Eocene Arctic sea ice simulations carried out by six coupled climate models within the framework of the Deep-Time Model Intercomparison Project (DeepMIP). We find differences in sea ice responses to CO2 changes across the ensemble and compare the results with available proxy-based sea ice reconstructions from the Arctic Ocean. Most of the models simulate seasonal sea ice presence at high CO2 levels (≥ 840 ppmv = 3× pre-industrial (PI) level of 280 ppmv). However, the threshold when sea ice permanently disappears from the ocean varies considerably between the models (from <840 ppmv to >1680 ppmv). Based on a one-dimensional energy balance model analysis we find that the greenhouse effect likely caused by increased atmospheric water vapor concentration plays an important role in the inter-model spread in Arctic winter surface temperature changes in response to a CO2 rise from 1× to 3× the PI level. Furthermore, differences in simulated surface salinity in the Arctic Ocean play an important role in the control of local sea ice formation. These differences result from different implementations of river run-off between the models, but also from differences in the exchange of waters between a brackish Arctic and a more saline North Atlantic Ocean that are controlled by the width of the gateway between both basins. As there is no geological evidence for Arctic sea ice in the early Eocene, its presence in most of the simulations with 3× PI CO2 level indicates either a higher CO2 level and/or an overly weak polar sensitivity in these models.
13.	Oldeman, Arthur M., et al. (author) Reduced El Niño variability in the mid-Pliocene according to the PlioMIP2 ensemble 2021 In: Climate of the Past. - : Copernicus GmbH. - 1814-9324 .- 1814-9332. ; 17:6, s. 2427-2450 Journal article (peer-reviewed)abstract The mid-Pliocene warm period (3.264–3.025 Ma) is the most recent geological period during which atmospheric CO2 levels were similar to recent historical values (∼400 ppm). Several proxy reconstructions for the mid-Pliocene show highly reduced zonal sea surface temperature (SST) gradients in the tropical Pacific Ocean, indicating an El Niño-like mean state. However, past modelling studies do not show these highly reduced gradients. Efforts to understand mid-Pliocene climate dynamics have led to the Pliocene Model Intercomparison Project (PlioMIP). Results from the first phase (PlioMIP1) showed clear El Niño variability (albeit significantly reduced) and did not show the greatly reduced time-mean zonal SST gradient suggested by some of the proxies.In this work, we study El Niño–Southern Oscillation (ENSO) variability in the PlioMIP2 ensemble, which consists of additional global coupled climate models and updated boundary conditions compared to PlioMIP1. We quantify ENSO amplitude, period, spatial structure and “flavour”, as well as the tropical Pacific annual mean state in mid-Pliocene and pre-industrial simulations. Results show a reduced ENSO amplitude in the model-ensemble mean (−24 %) with respect to the pre-industrial, with 15 out of 17 individual models showing such a reduction. Furthermore, the spectral power of this variability considerably decreases in the 3–4-year band. The spatial structure of the dominant empirical orthogonal function shows no particular change in the patterns of tropical Pacific variability in the model-ensemble mean, compared to the pre-industrial. Although the time-mean zonal SST gradient in the equatorial Pacific decreases for 14 out of 17 models (0.2 ∘C reduction in the ensemble mean), there does not seem to be a correlation with the decrease in ENSO amplitude. The models showing the most “El Niño-like” mean state changes show a similar ENSO amplitude to that in the pre-industrial reference, while models showing more “La Niña-like” mean state changes generally show a large reduction in ENSO variability. The PlioMIP2 results show a reasonable agreement with both time-mean proxies indicating a reduced zonal SST gradient and reconstructions indicating a reduced, or similar, ENSO variability.
14.	Pontes, Gabriel M., et al. (author) Drier tropical and subtropical Southern Hemisphere in the mid-Pliocene Warm Period 2020 In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1 Journal article (peer-reviewed)abstract Thermodynamic arguments imply that global mean rainfall increases in a warmer atmosphere; however, dynamical effects may result in more significant diversity of regional precipitation change. Here we investigate rainfall changes in the mid-Pliocene Warm Period (similar to 3 Ma), a time when temperatures were 2-3 degrees C warmer than the pre-industrial era, using output from the Pliocene Model Intercomparison Projects phases 1 and 2 and sensitivity climate model experiments. In the Mid-Pliocene simulations, the higher rates of warming in the northern hemisphere create an interhemispheric temperature gradient that enhances the southward cross-equatorial energy flux by up to 48%. This intensified energy flux reorganizes the atmospheric circulation leading to a northward shift of the Inter-Tropical Convergence Zone and a weakened and poleward displaced Southern Hemisphere Subtropical Convergences Zones. These changes result in drier-than-normal Southern Hemisphere tropics and subtropics. The evaluation of the mid-Pliocene adds a constraint to possible future warmer scenarios associated with differing rates of warming between hemispheres.
15.	Pontes, Gabriel M., et al. (author) Mid-Pliocene El Niño/Southern Oscillation suppressed by Pacific intertropical convergence zone shift 2022 In: Nature Geoscience. - : Springer Science and Business Media LLC. - 1752-0894 .- 1752-0908. ; 15:9, s. 726-734 Journal article (peer-reviewed)abstract The El Niño/Southern Oscillation (ENSO), the dominant driver of year-to-year climate variability in the equatorial Pacific Ocean, impacts climate pattern across the globe. However, the response of the ENSO system to past and potential future temperature increases is not fully understood. Here we investigate ENSO variability in the warmer climate of the mid-Pliocene (~3.0–3.3 Ma), when surface temperatures were ~2–3 °C above modern values, in a large ensemble of climate models—the Pliocene Model Intercomparison Project. We show that the ensemble consistently suggests a weakening of ENSO variability, with a mean reduction of 25% (±16%). We further show that shifts in the equatorial Pacific mean state cannot fully explain these changes. Instead, ENSO was suppressed by a series of off-equatorial processes triggered by a northward displacement of the Pacific intertropical convergence zone: weakened convective feedback and intensified Southern Hemisphere circulation, which inhibit various processes that initiate ENSO. The connection between the climatological intertropical convergence zone position and ENSO we find in the past is expected to operate in our warming world with important ramifications for ENSO variability.
16.	Ren, Xin, et al. (author) The hydrological cycle and ocean circulation of the Maritime Continent in the Pliocene : results from PlioMIP2 2023 In: Climate of the Past. - 1814-9324 .- 1814-9332. ; 19:10, s. 2053-2077 Journal article (peer-reviewed)abstract The Maritime Continent (MC) forms the western boundary of the tropical Pacific Ocean, and relatively small changes in this region can impact the climate locally and remotely. In the mid-Piacenzian warm period of the Pliocene (mPWP; 3.264 to 3.025 Ma) atmospheric CO2 concentrations were ∼ 400 ppm, and the subaerial Sunda and Sahul shelves made the land–sea distribution of the MC different to today. Topographic changes and elevated levels of CO2, combined with other forcings, are therefore expected to have driven a substantial climate signal in the MC region at this time. By using the results from the Pliocene Model Intercomparison Project Phase 2 (PlioMIP2), we study the mean climatic features of the MC in the mPWP and changes in Indonesian Throughflow (ITF) with respect to the preindustrial. Results show a warmer and wetter mPWP climate of the MC and lower sea surface salinity in the surrounding ocean compared with the preindustrial. Furthermore, we quantify the volume transfer through the ITF; although the ITF may be expected to be hindered by the subaerial shelves, 10 out of 15 models show an increased volume transport compared with the preindustrial.In order to avoid undue influence from closely related models that are present in the PlioMIP2 ensemble, we introduce a new metric, the multi-cluster mean (MCM), which is based on cluster analysis of the individual models. We study the effect that the choice of MCM versus the more traditional analysis of multi-model mean (MMM) and individual models has on the discrepancy between model results and data. We find that models, which reproduce modern MC climate well, are not always good at simulating the mPWP climate anomaly of the MC. By comparing with individual models, the MMM and MCM reproduce the preindustrial sea surface temperature (SST) of the reanalysis better than most individual models and produce less discrepancy with reconstructed sea surface temperature anomalies (SSTA) than most individual models in the MC. In addition, the clusters reveal spatial signals that are not captured by the MMM, so that the MCM provides us with a new way to explore the results from model ensembles that include similar models.
17.	Weiffenbach, Julia E., et al. (author) Unraveling the mechanisms and implications of a stronger mid-Pliocene Atlantic Meridional Overturning Circulation (AMOC) in PlioMIP2 2023 In: Climate of the Past. - : COPERNICUS GESELLSCHAFT MBH. - 1814-9324 .- 1814-9332. ; 19:1, s. 61-85 Journal article (peer-reviewed)abstract The mid-Pliocene warm period (3.264-3.025 Ma) is the most recent geological period in which the atmospheric CO2 concentration was approximately equal to the concentration we measure today (ca. 400 ppm). Sea surface temperature (SST) proxies indicate above-average warming over the North Atlantic in the mid-Pliocene with respect to the pre-industrial period, which may be linked to an intensified Atlantic Meridional Overturning Circulation (AMOC). Earlier results from the Pliocene Model Intercomparison Project Phase 2 (PlioMIP2) show that the ensemble simulates a stronger AMOC in the mid-Pliocene than in the pre-industrial. However, no consistent relationship between the stronger mid-Pliocene AMOC and either the Atlantic northward ocean heat transport (OHT) or average North Atlantic SSTs has been found. In this study, we look further into the drivers and consequences of a stronger AMOC in mid-Pliocene compared to pre-industrial simulations in PlioMIP2. We find that all model simulations with a closed Bering Strait and Canadian Archipelago show reduced freshwater transport from the Arctic Ocean into the North Atlantic. This contributes to an increase in salinity in the subpolar North Atlantic and Labrador Sea that can be linked to the stronger AMOC in the mid-Pliocene. To investigate the dynamics behind the ensembles variable response of the total Atlantic OHT to the stronger AMOC, we separate the Atlantic OHT into two components associated with either the overturning circulation or the wind-driven gyre circulation. While the ensemble mean of the overturning component is increased significantly in magnitude in the mid-Pliocene, it is partly compensated by a reduction in the gyre component in the northern subtropical gyre region. This indicates that the lack of relationship between the total OHT and AMOC is due to changes in OHT by the subtropical gyre. The overturning and gyre components should therefore be considered separately to gain a more complete understanding of the OHT response to a stronger mid-Pliocene AMOC. In addition, we show that the AMOC exerts a stronger influence on North Atlantic SSTs in the mid-Pliocene than in the pre-industrial, providing a possible explanation for the improved agreement of the PlioMIP2 ensemble mean SSTs with reconstructions in the North Atlantic.
18.	Williams, Charles J. R., et al. (author) African Hydroclimate During the Early Eocene From the DeepMIP Simulations 2022 In: Paleoceanography and Paleoclimatology. - 2572-4517 .- 2572-4525. ; 37:5 Journal article (peer-reviewed)abstract The early Eocene (∼56–48 Myr ago) is characterized by high CO2 estimates (1,200–2,500 ppmv) and elevated global temperatures (∼10°C–16°C higher than modern). However, the response of the hydrological cycle during the early Eocene is poorly constrained, especially in regions with sparse data coverage (e.g., Africa). Here, we present a study of African hydroclimate during the early Eocene, as simulated by an ensemble of state-of-the-art climate models in the Deep-time Model Intercomparison Project (DeepMIP). A comparison between the DeepMIP pre-industrial simulations and modern observations suggests that model biases are model- and geographically dependent, however, these biases are reduced in the model ensemble mean. A comparison between the Eocene simulations and the pre-industrial suggests that there is no obvious wetting or drying trend as the CO2 increases. The results suggest that changes to the land sea mask (relative to modern) in the models may be responsible for the simulated increases in precipitation to the north of Eocene Africa. There is an increase in precipitation over equatorial and West Africa and associated drying over northern Africa as CO2 rises. There are also important dynamical changes, with evidence that anticyclonic low-level circulation is replaced by increased south-westerly flow at high CO2 levels. Lastly, a model-data comparison using newly compiled quantitative climate estimates from paleobotanical proxy data suggests a marginally better fit with the reconstructions at lower levels of CO2.
19.	Zhang, Ke, et al. (author) Revisiting the physical processes controlling the tropical atmospheric circulation changes during the Mid-Piacenzian Warm Period 2024 In: Quaternary International. - 1040-6182 .- 1873-4553. ; 682, s. 46-59 Journal article (peer-reviewed)abstract The Mid-Piacenzian Warm Period (MPWP; 3.0–3.3 Ma), a warm geological period about three million years ago, has been deemed as a good past analog for understanding the current and future climate change. Based on 12 climate model outputs from Pliocene Model Intercomparison Project Phase 2 (PlioMIP2), we investigate tropical atmospheric circulation (TAC) changes under the warm MPWP and associated underlying mechanisms by diagnosing both atmospheric static stability and diabatic processes. Our findings underscore the advantage of analyzing atmospheric diabatic processes in elucidating seasonal variations of TAC compared to static stability assessments. Specifically, by diagnosing alterations in diabatic processes, we achieve a quantitative understanding and explanation the following TAC changes (incl. Strength and edge) during the MPWP: the weakened (annual, DJF, JJA) Northern Hemisphere and (DJF) Southern Hemisphere Hadley circulation (HC), reduced (annual, DJF) Pacific Walker circulation (PWC) and enhanced (annual, JJA) Southern Hemisphere HC and (JJA) PWC, and westward shifted (annual, DJF, JJA) PWC. We further addressed that the increasing bulk subtropical static stability and/or decreasing vertical shear of subtropical zonal wind - two crucial control factors for changes in subtropical baroclinicity - may promote HC widening, and vice versa. Consequently, our study of spatial diabatic heating and cooling, corresponding to upward and downward motions within the TAC, respectively, provides a new perspective for understanding the processes controlling seasonal TAC changes in response to surface warming.
20.	Zhang, Yurui, et al. (author) Early Eocene Ocean Meridional Overturning Circulation : The Roles of Atmospheric Forcing and Strait Geometry 2022 In: Paleoceanography and Paleoclimatology. - 2572-4517 .- 2572-4525. ; 37:3 Journal article (peer-reviewed)abstract Here, we compare the ocean overturning circulation of the early Eocene (47–56 Ma) in eight coupled climate model simulations from the Deep-Time Model Intercomparison Project (DeepMIP) and investigate the causes of the observed inter-model spread. The most common global meridional overturning circulation (MOC) feature of these simulations is the anticlockwise bottom cell, fed by sinking in the Southern Ocean. In the North Pacific, one model (GFDL) displays strong deepwater formation and one model (CESM) shows weak deepwater formation, while in the Atlantic two models show signs of weak intermediate water formation (MIROC and NorESM). The location of the Southern Ocean deepwater formation sites varies among models and relates to small differences in model geometry of the Southern Ocean gateways. Globally, convection occurs in the basins with smallest local freshwater gain from the atmosphere. The global MOC is insensitive to atmospheric CO2 concentrations from 1× (i.e., 280 ppm) to 3× (840 ppm) pre-industrial levels. Only two models have simulations with higher CO2 (i.e., CESM and GFDL) and these show divergent responses, with a collapsed and active MOC, respectively, possibly due to differences in spin-up conditions. Combining the multiple model results with available proxy data on abyssal ocean circulation highlights that strong Southern Hemisphere-driven overturning is the most likely feature of the early Eocene. In the North Atlantic, unlike the present day, neither model results nor proxy data suggest deepwater formation in the open ocean during the early Eocene, while the evidence for deepwater formation in the North Pacific remains inconclusive.
21.	Zhang, Zijian, et al. (author) Impact of Mountains in Southern China on the Eocene Climates of East Asia 2022 In: Journal of Geophysical Research - Atmospheres. - 2169-897X .- 2169-8996. ; 127:17 Journal article (peer-reviewed)abstract Inconsistencies in the Eocene climates of East Asia have been revealed in both geological studies and simulations. Several earlier reconstructions showed an arid zonal band in mid-latitude China, but others showed a humid climate in the same region. Moreover, previous Eocene modeling studies have demonstrated that climate models can simulate both scenarios in China. Therefore, it is essential to investigate the cause of this model spread. We conducted a series of experiments using Norwegian Earth System Model 1-F and examined the impact of mountains in Southern China on the simulated Eocene climate. These mountains, including the Gangdese and Southeast Mountains, are located along the main path of water vapor transport to East Asia. Our results reveal that the Southeast Mountains play the dominant role in controlling the simulated precipitation in Eastern China during the Eocene. When the heights of the Southeast Mountains exceed similar to 2,000 m, an arid zonal band appears in mid-latitude China, whereas humid climates appear in Eastern China when the elevation of the Southeast Mountains is relatively low.
22.	Zhang, Zhongshi, et al. (author) Mid-Pliocene Atlantic Meridional Overturning Circulation simulated in PlioMIP2 2021 In: Climate of the Past. - : Copernicus GmbH. - 1814-9324 .- 1814-9332. ; 17:1, s. 529-543 Journal article (peer-reviewed)abstract In the Pliocene Model Intercomparison Project Phase 2 (PlioMIP2), coupled climate models have been used to simulate an interglacial climate during the mid-Piacenzian warm period (mPWP; 3.264 to 3.025 Ma). Here, we compare the Atlantic Meridional Overturning Circulation (AMOC), poleward ocean heat transport and sea surface warming in the Atlantic simulated with these models. In PlioMIP2, all models simulate an intensified mid-Pliocene AMOC. How- ever, there is no consistent response in the simulated Atlantic ocean heat transport nor in the depth of the Atlantic overturning cell. The models show a large spread in the simulated AMOC maximum, the Atlantic ocean heat transport and the surface warming in the North Atlantic. Although a few models simulate a surface warming of similar to 8-12 degrees C in the North Atlantic, similar to the reconstruction from Pliocene Research, Interpretation and Synoptic Mapping (PRISM) version 4, most models appear to underestimate this warming. The large model spread and model-data discrepancies in the PlioMIP2 ensemble do not support the hypothesis that an intensification of the AMOC, together with an increase in northward ocean heat transport, is the dominant mechanism for the mid-Pliocene warm climate over the North Atlantic.

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