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Sökning: WFRF:(Chrcanovic Bruno)

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1.
  • Abdel-Halim, Maha, et al. (författare)
  • The Impact of Dental Implant Length on Failure Rates : A Systematic Review and Meta-Analysis
  • 2021
  • Ingår i: Materials. - : MDPI. - 1996-1944. ; 14:14
  • Forskningsöversikt (refereegranskat)abstract
    • The present review aimed to evaluate the impact of implant length on failure rates between short (<10 mm) and long (>= 10 mm) dental implants. An electronic search was undertaken in three databases, as well as a manual search of journals. Implant failure was the outcome evaluated. Meta-analysis was performed in addition to a meta-regression in order to verify how the risk ratio (RR) was associated with the follow-up time. The review included 353 publications. Altogether, there were 25,490 short and 159,435 long implants. Pairwise meta-analysis showed that short implants had a higher failure risk than long implants (RR 2.437, p < 0.001). There was a decrease in the probability of implant failure with longer implants when implants of different length groups were compared. A sensitivity analysis, which plotted together only studies with follow-up times of 7 years or less, resulted in an estimated increase of 0.6 in RR for every additional month of follow-up. In conclusion, short implants showed a 2.5 times higher risk of failure than long implants. Implant failure is multifactorial, and the implant length is only one of the many factors contributing to the loss of an implant. A good treatment plan and the patient's general health should be taken into account when planning for an implant treatment.
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2.
  • Abdul Rahim, Maha, et al. (författare)
  • Influence of Crown-Implant Ratio and Implant Inclination on Marginal Bone Loss around Dental Implants Supporting Single Crowns in the Posterior Region : A Retrospective Clinical Study.
  • 2023
  • Ingår i: Journal of Clinical Medicine. - : MDPI. - 2077-0383. ; 12:9
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of this present record-based retrospective study was to investigate the influence of the crown-implant ratio (CIR) and implant inclination in relation to the occlusal plane on the marginal bone loss (MBL) around dental implants supporting single crowns in the posterior region of the jaws. All the cases of implant-supported single crowns in the premolar and molar regions were initially considered for inclusion. Only implants not lost, with baseline radiographs taken within 12 months after implant placement and with a minimum of 36 months of radiological follow-up, were considered for the analysis of MBL. Univariate linear regression models were used to compare MBL over time between 12 clinical covariates, after which a linear mixed-effects model was built. After the exclusion of 49 cases, a total of 316 implant-supported single crowns in 234 patients were included. The results from the statistical models suggested that implant inclination and anatomical- and clinical CIR (the main related factors investigated in the study) were not statistically significantly related to MBL over time. Age (older people), tooth region (premolar), and bruxism (bruxers) had a statistically significant influence on MBL over time.
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3.
  • Al Ansari, Yasmin, et al. (författare)
  • Diabetes Mellitus and Dental Implants : A Systematic Review and Meta-Analysis
  • 2022
  • Ingår i: Materials. - : MDPI. - 1996-1944. ; 15:9
  • Forskningsöversikt (refereegranskat)abstract
    • The present review aimed to evaluate the impact of diabetes mellitus on dental implant failure rates and marginal bone loss (MBL). An electronic search was undertaken in three databases, plus a manual search of journals. Meta-analyses were performed as well as meta-regressions in order to verify how the odds ratio (OR) and MBL were associated with follow-up time. The review included 89 publications. Altogether, there were 5510 and 62,780 implants placed in diabetic and non-diabetic patients, respectively. Pairwise meta-analysis showed that implants in diabetic patients had a higher failure risk in comparison to non-diabetic patients (OR 1.777, p < 0.001). Implant failures were more likely to occur in type 1 diabetes patients than in type 2 (OR 4.477, p = 0.032). The difference in implant failure between the groups was statistically significant in the maxilla but not in the mandible. The MBL mean difference (MD) between the groups was 0.776 mm (p = 0.027), with an estimated increase of 0.032 mm in the MBL MD between groups for every additional month of follow-up (p < 0.001). There was an estimated decrease of 0.007 in OR for every additional month of follow-up (p = 0.048). In conclusion, implants in diabetic patients showed a 77.7% higher risk of failure than in non-diabetic patients.
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4.
  • Al-Kilani, Josef, et al. (författare)
  • Difference in marginal bone loss around implants between short implant-supported partial fixed prostheses with and without cantilever : a retrospective clinical study
  • 2023
  • Ingår i: International Journal of Implant Dentistry. - : Springer. - 2198-4034. ; 9:1
  • Tidskriftsartikel (refereegranskat)abstract
    • PURPOSE: To investigate the influence of cantilever prosthetic arm on the marginal bone loss (MBL) over time around dental implants supporting short fixed partial dentures (FPDs), in a record-based retrospective study.METHODS: All cases of 3-unit implant-supported FPDs, supported by 2-3 implants, from the database of cases treated at one specialist clinic were considered for inclusion. Only implants with a minimum of 36 months of radiological follow-up were considered. Univariate linear regression models were used to compare MBL over time between 12 clinical covariates, after which a linear mixed-effects model was built.RESULTS: One-hundred-thirty-nine patients (64 men, 75 women) with 164 3-unit implant-supported FPDs (333 implants supporting non-cantilevered FPDs, 94 supporting cantilevered FPDs) were included in the study. The patients were followed up clinically and radiographically for a mean of 154.1 ± 78.0 (min-max, 37.3-364.6) and 132.9 ± 77.3 months (min-max, 36.8-329.9), respectively. The total number of marginal bone level double measurements (mesial and distal sides of each implant) was 2909. FPDs with cantilever presented an estimated greater MBL over time compared to FPDs without cantilever. Bruxism, sex (women), implant (modified) surface, and (poor) bone quality were also associated with higher MBL over time.CONCLUSIONS: The use of a cantilever extension is suggested to negatively affect the bone marginal level over time around implants supporting 3-unit FPDs. Due to the small difference of the estimated MBL over long periods of follow-up between the groups, it is a matter of debate if the observed negative effect may be of clinical significance.
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5.
  • Al-Moraissi, Essam, et al. (författare)
  • Three-dimensional versus standard miniplate fixation in the management of mandibular angle fractures : a systematic review and meta-analysis
  • 2014
  • Ingår i: International Journal of Oral and Maxillofacial Surgery. - : Elsevier. - 0901-5027 .- 1399-0020. ; 43:6, s. 708-716
  • Forskningsöversikt (refereegranskat)abstract
    • The aim of the present study was to test whether there is a significant difference in the clinical outcomes between standard and three-dimensional (3D) miniplate fixation in the management of mandibular angle fractures (MAFs). An electronic search without date and language restrictions was performed in October 2013. Inclusion criteria were studies in humans including randomized controlled trials, controlled clinical trials, and retrospective studies, with the aim of comparing the two techniques. Six studies were included. The meta-analyses revealed statistically significant differences for the incidence of hardware failure and postoperative trismus. There were no significant differences in the incidence of postoperative infection, malocclusion, wound dehiscence, non-union/malunion, or paresthesia. The cumulative odds ratio was 0.42, meaning that the use of 3D miniplates in the fixation of MAFs decreases the risk of the event (postoperative complication) by 58%. The results of this meta-analysis showed lower postoperative complication rates with the use of 3D miniplate fixation in comparison with the use of standard miniplate fixation in the management of MAFs.
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6.
  • Albrektsson, Tomas, et al. (författare)
  • Foreign body reactions, marginal bone loss and allergies in relation to titanium implants
  • 2018
  • Ingår i: European Journal of Oral Implantology. - : Quintessence. - 1756-2406 .- 1756-2414. ; 11, s. 37-46
  • Tidskriftsartikel (refereegranskat)abstract
    • Aim: To describe general observations of immunological reactions to foreign materials and to realize that CP titanium gives rise to a foreign body reaction with subsequent bone embedment when placed as oral implants. To analyse the possibility of titanium allergy. Materials and methods: The present paper is of a narrative review type. Hand and Medline searches were performed to evaluate marginal bone loss of oral implants and the potential of titanium allergy. Results: Immunological reactions to foreign substances include Type I hypersensitivity reactions such as allergy, Type II hypersensitivity reactions characterised by IgM or IgG antibodies that may react with blood group antigens at transfusion, and Type III hypersensitivity caused by antigen-antibody immune complexes exemplified by acute serum sickness. There is also Type IV hypersensitivity, or delayed hypersensitivity, which is typically found in drug and foreign body reactions. It proved very difficult to find a universally acceptable definition of reasons for marginal bone loss around oral implants, which lead to most varying figures of so-called peri-implantitis being 1% to 2% in some 10-year follow-up papers to between 28% and 56% of all placed implants in other papers. It was recognised that bone resorption to oral as well as orthopaedic implants may be due to immunological reactions. Today, osseointegration is seen as an immune-modulated inflammatory process where the immune system is locally either up- or downregulated. Titanium implant allergy is a rare condition, if it exists. The authors found only two papers presenting strong evidence of allergy to CP titanium, but with the lack of universally accepted and tested patch tests, the precise diagnosis is difficult. Conclusions: CP titanium acts as a foreign body when placed in live tissues. There may be immunological reasons behind marginal bone loss. Titanium allergy may exist in rare cases, but there is a lack of properly designed and analysed patch tests at present.
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7.
  • Albrektsson, Tomas, 1945, et al. (författare)
  • Initial and long-term crestal bone responses to modern dental implants
  • 2017
  • Ingår i: Periodontology 2000. - : Wiley. - 0906-6713 .- 1600-0757. ; 73:1, s. 41-50
  • Forskningsöversikt (refereegranskat)abstract
    • Successful osseointegration is the result of a controlled foreign body reaction to dental implants. Osseointegrated implants have demonstrated excellent long-term survivability, although they may be subject to limited marginal bone loss. Marginal bone loss during the first few years after implant placement seldom represents disease, but is instead the result of an adaptive bone response to surgical trauma and implant loading. It is not uncommon for implants with early marginal bone loss to enter a long-lasting state of bone stability. Extensive bone resorption after the first year is generally due to an exacerbation of adverse body reactions caused by non-optimal implant components, adverse surgery or prosthodontics and/or compromised patient factors. Disease in the form of peri-implantitis is a late complication that affects some implants with suppuration and rapid loss of crestal bone, and is probably caused by bacterial pathogens and immunological reactions. Unfortunately, the literature is not consistent with respect to the type or magnitude of clinical implant problems, including how they are defined and diagnosed. If the peri-implantitis diagnosis is confined to cases with infection, suppuration and significant bone loss, the frequency of the disease is relatively low, which is in sharp contrast to the frequencies reported with unrealistic definitions of peri-implantitis. We suggest that when modern implants are placed by properly trained individuals, only 1–2% of implants show true peri-implantitis during follow-up periods of 10 years or more. Peri-implantitis must be separated from the initial and self-limiting marginal bone loss.
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8.
  • Albrektsson, Tomas, et al. (författare)
  • Osseointegration of Implants : A Biological and Clinical Overview
  • 2017
  • Ingår i: JSM Dental Surgery. - : SciMedCentral. - 2573-1548. ; 2:3
  • Forskningsöversikt (refereegranskat)abstract
    • Osseointegration was discovered in 1962 and coined as a term in 1977. Original definitions implied direct contact between foreign materials and bone without any interposed soft tissue layers. Today, osseointegration is regarded to be a foreign body response to separate foreign elements from bone. A new definition of the term is suggested in this paper; “Osseointegration is a foreign body reaction where interfacial bone is formed as a defense reaction to shield off the implant from the tissues”. Excellent clinical results of osseointegrated implants have been reported from dentistry and Ear Nose Throat surgery, the latter with the indications of a stable anchorage of hearing aids or facial epistheses in cases of facial trauma. In Orthopaedic surgery a randomized controlled clinical trial has been undertaken demonstrating very good clinical results supported by positive radiostereo-photogrammetical data.
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9.
  • Alenezi, Ali, et al. (författare)
  • Characteristics of 2 Different Commercially Available Implants with or without Nanotopography
  • 2013
  • Ingår i: International Journal of Dentistry. - : Hindawi Limited. - 1687-8736 .- 1687-8728. ; 2013:Art. no. 769768
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of this study was to assess histologically and histomorphometrically the early bone forming properties after 3 weeks for 2 commercially available implants, one supposedly possessing nanotopography and one without, in a rabbit femur model. Twenty-four implants divided equally into 2 groups were utilized in this study. The first group (P-I MICRO+NANO) was a titanium oxide (TiO2) microblasted and noble gas ion bombarded surface while the second group (Ospol) was anodic oxidized surface with calcium and phosphate incorporation. The implants were placed in the rabbit femur unicortically and were allowed to heal for 3 weeks. After euthanasia, the samples were subjected to histologic sectioning and bone-implant contact and bone area were evaluated histomorphometrically under an optical microscope. The histomorphometric evaluation presented that the P-I MICRO+NANO implants demonstrated significantly higher new bone formation as compared to the Ospol implants. Within the limitations of this study, the results suggested that nanostructures presented significantly higher bone formation after 3 weeks in vivo, and the effect of chemistry was limited, which is indicative that nanotopography is effective at early healing periods.
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10.
  • Alenezi, Ali, et al. (författare)
  • Effects of Local Drug and Chemical Compound Delivery on Bone Regeneration Around Dental Implants in Animal Models : A Systematic Review and Meta-Analysis
  • 2018
  • Ingår i: International Journal of Oral & Maxillofacial Implants. - : Quintessence. - 0882-2786 .- 1942-4434. ; 33:1, s. e1-e18
  • Forskningsöversikt (refereegranskat)abstract
    • Purpose: One of the suggested methods for enhancing osseointegration is the local application of drug agents around implant surfaces. The aim of this review was to evaluate the methods most commonly used for local drug and chemical compound delivery to implant sites and assess their influence on osseointegration. Materials and Methods: An electronic search was undertaken in three databases (PubMed, Scopus, Embase). The search was limited to animal experiments using endosseous implants combined with local drug delivery systems. Meta-analyses were performed for the outcome bone-to-implant contact (BIC). Results: Sixty-one studies met the inclusion criteria. Calcium phosphate (CaP), bisphosphonates (BPs), and bone morphogenetic proteins (BMPs) were the most commonly used chemical compounds. There were two main methods for local drug delivery at the bone-implant interface: (1) directly from an implant surface by coating or immobilizing techniques, and (2) the local application of drugs to the implant site, using carriers. There was a statistically significant increase in BIC for both local drug delivery methods (P = .02 and P < .0001, respectively) compared with the control methods. There was a statistically significant increase in BIC when CaP (P = .0001) and BMPs (P = .02) were either coating implants or were delivered to the implant site, in comparison to when drugs were not used. The difference was not significant for the use of BPs (P = .15). Conclusion: It is suggested that the use of local chemical compound delivery systems around implants could significantly improve implant osseointegration in animal models. It is a matter of debate whether these in vivo results might have some significant effect in the human clinical setting in the long term.
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11.
  • Alenezi, Ali, et al. (författare)
  • Effects of the local administration of antibiotics on bone formation on implant surface in animal models : A systematic review and meta-analysis
  • 2020
  • Ingår i: Japanese Dental Science Review. - : Elsevier. - 1882-7616. ; 56:1, s. 177-183
  • Forskningsöversikt (refereegranskat)abstract
    • Purpose: This review aimed to evaluate the effects of the local delivery of antibiotics incorporated in implant surfaces on some quantitative parameters of bone formation. Materials and methods: An electronic search was undertaken in three databases (PubMed, Scopus, Embase) in addition to hand searching. The search was limited to animal experiments using endosseous implants combined with localized antibiotics release. Meta-analyses were performed for the percentages of bone volume (BV) and bone-to-implant contact (BIC). Results: Nine studies met the inclusion criteria. Several methods were identified for local delivery of antibiotics at the bone-implant interface, but the most commonly used method was by coating (incorporating the implant surface with the antibiotic agents). Different antibiotic agents were used, namely bacitracin, doxycycline, enoxacin, gentamicin, minocycline, tobramycin, and vancomycin. There was no statistically significant difference in the percentage of BIC between implants with or without localized antibiotic release (P = 0.59). The meta-analysis revealed higher BV around implants coated with antibiotics compared to control groups (without antibiotics) (P < 0.01). Conclusion: It is suggested that the local administration of antibiotics around implants did not adversely affect the percentage of direct bone contact around implants, with a tendency for a slightly better bone formation around implants when combined with local administration of antibiotics. It is a matter of debate whether these in vivo results will have the same effect in the clinical setting. However, the risk of bias of these studies may, to some extent, question the validity of these results. (C) 2020 The Author. Published by Elsevier Ltd on behalf of The Japanese Association for Dental Science.
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12.
  • Alenezi, Ali, et al. (författare)
  • Long-Term Survival and Complication Rates of Porcelain Laminate Veneers in Clinical Studies : A Systematic Review
  • 2021
  • Ingår i: Journal of Clinical Medicine. - : MDPI. - 2077-0383. ; 10:5
  • Tidskriftsartikel (refereegranskat)abstract
    • The presented study aimed to assess the survival rate of porcelain laminate veneers (PLV) based on a systematic review of the literature. An electronic search was last updated in February 2021. Eligibility criteria included clinical series of patients rehabilitated with PLVs published in the last 25 years, with a minimum follow-up of 3 years. Survival analysis methods were applied. Twenty-five studies were included, with 6500 PLVs. The 10-year estimated cumulative survival rate (CSR) of PLVs was 95.5%. The 10-year CSR of PLVs when fracture, debonding, occurrence of secondary caries, and need of endodontic treatment were considered as isolated reasons for failure were 96.3%, 99.2%, 99.3%, and 99.0%, respectively. PLVs without incisal coverage had a higher failure rate than PLVs with incisal coverage. Non-feldspathic PLVs performed better than feldspathic PLVs. As a conclusion, the 10-year CSR of PLVs was 95.5%, when fracture, debonding, occurrence of secondary caries, and need of endodontic treatment were considered as reasons for restoration failure. Fracture seems to be most common complication of PLVs, followed by debonding, with both more commonly happening within the first years after PLV cementation. PLVs with incisal coverage and non-feldspathic PLVs presented lower failure rates than PLVs without incisal coverage and feldspathic PLVs.
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13.
  • Ali, Amir, et al. (författare)
  • Frequency of Smoking and Marginal Bone Loss around Dental Implants : A Retrospective Matched-Control Study
  • 2023
  • Ingår i: Journal of Clinical Medicine. - : MDPI. - 2077-0383. ; 12:4
  • Tidskriftsartikel (refereegranskat)abstract
    • This dental record-based retrospective study aimed to compare the marginal bone loss (MBL) around dental implants in a group of smokers in relation to a matched group of non-smokers, with a special focus on five different frequencies of daily smoking (non-smokers, and frequency of 1-5, 6-10, 11-15, and 20 cig./day). Only implants with a minimum of 36 months of radiological follow-up were considered. Univariate linear regression models were used to compare MBL over time between 12 clinical covariates, after which a linear mixed-effects model was built. After matching of the patients, the study included 340 implants in 104 smokers, and 337 implants in 100 non-smokers. The results suggested that smoking degree (greater MBL for higher degrees of smoking), bruxism (greater MBL for bruxers), jaw (greater MBL in maxilla), prosthesis fixation (greater MBL for screw-retained prosthesis), and implant diameter (greater MBL for 3.75-4.10 mm) had a significant influence on MBL over time. There appears to be a positive correlation between the degree of smoking and the degree of MBL, meaning, the higher the degree of smoking, the greater the MBL. However, the difference is not apparent for different degrees of smoking when this is high, namely above 10 cigarettes per day.
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14.
  • Ayele, Sarah, et al. (författare)
  • Marginal bone loss around dental implants : comparison between diabetic and non-diabetic patients-a retrospective clinical study
  • 2023
  • Ingår i: Clinical Oral Investigations. - : Springer. - 1432-6981 .- 1436-3771. ; 27:6, s. 2833-2841
  • Tidskriftsartikel (refereegranskat)abstract
    • ObjectivesThe aim of the present retrospective study was to compare the marginal bone loss (MBL) around dental implants in a group of diabetic patients in relation to a matched group of non-diabetic patients.Materials and methodsThe present dental record-based retrospective study included patients selected from individuals treated with dental implants at one specialist clinic in Malmo, Sweden. Patients were excluded if they had history of periodontitis and/or were treated for periodontal disease. The study group included 710 implants installed in 180 patients (mean age 60.3 +/- 13.0 years), 349 implants in 90 diabetic (21 T1DM and 69 T2DM patients), and 361 implants in 90 non-diabetic patients.ResultsThe results suggested that jaw (greater MBL in the maxilla), diabetes (greater MBL for diabetic patients, and worse for T1DM patients), bruxism (greater MBL for bruxers), and smoking (greater MBL for smokers and former smokers) had a statistically significant influence on MBL over time.ConclusionsPatients with diabetes have an estimated greater MBL over time compared to non-diabetic patients. The difference was greater in patients with diabetes type 1 compared to patients with diabetes type 2. Bruxism, smoking, and implant location (maxilla) were also associated with a higher loss of marginal bone around implants over time.
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15.
  • Botermans, Anna, et al. (författare)
  • Immediate implant placement in the maxillary aesthetic zone : A cone beam computed tomography study
  • 2021
  • Ingår i: Journal of Clinical Medicine. - : MDPI. - 2077-0383. ; 10:24
  • Tidskriftsartikel (refereegranskat)abstract
    • This study aimed to investigate the factors that could be associated with the risk of labial cortical bone wall perforation with immediate implant placement (IIP) in the maxillary aesthetic zone, in a cone-beam computed tomography (CBCT) virtual study. CBCT exams from 126 qualified subjects (756 teeth) were included. Implants were virtually positioned in two different positions: in the long axis of the tooth (prosthetically-driven position) and in an ideal position in relation to adjacent anatomical structures (bone-driven position). Two different implant diameters were planned for each tooth position, namely, 3.75 and 4.3 mm for central incisors and canines, and 3.0 and 3.3 mm for lateral incisors. The incidence of perforation was nearly 80% and 5% for prostheticallyand bone-driven position, respectively. Factors associated with a higher risk of cortical bone wall perforation (bone-driven position), according to logistic regression analysis, were women, wider implants, Sagittal Root Position class IV, and decrease of the labial concavity angle. Perforation of the labial cortical bone wall can be greatly minimized when the implant is placed in a bone-driven position compared to a prosthetically-driven position. It is important to preoperatively evaluate the morphological features of the implant site for risk assessment and to individualize the treatment plan. 
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16.
  • Bredberg, Clara, et al. (författare)
  • Marginal bone loss around dental implants : comparison between matched groups of bruxer and non-bruxer patients
  • 2023
  • Ingår i: Clinical Implant Dentistry and Related Research. - : John Wiley & Sons. - 1523-0899 .- 1708-8208. ; 25:1, s. 124-132
  • Tidskriftsartikel (refereegranskat)abstract
    • PURPOSE: To compare marginal bone loss (MBL) around dental implants in a group of bruxers in relation to a matched group of non-bruxers.METHODS: The present record-based retrospective study included patients selected from individuals treated with dental implants at one specialist clinic in Malmö. Only implants not lost and with baseline radiographs taken within 12 months after implant placement and with a minimum of 36 months of radiological follow-up were considered for inclusion. Univariate linear regression models and a linear mixed-effects model were performed.RESULTS: Two hundred and four patients (104 bruxers, 100 non-bruxers), with a total of 811 implants (416 in bruxers, 395 in non-bruxers) were included in the study. The results of the linear mixed-effects model suggested that bruxism, smoking, age, region of the jaws, implant diameter, and prosthesis type had a statistically significant influence on MBL over time. Individuals who are both bruxers and smokers showed greater MBL when compared to individuals who are either a bruxer or smoker, or neither (p < 0.001).CONCLUSIONS: Bruxism is suggested to increase the risk of MBL over time, as well as higher age, smoking, and the combination of bruxism and smoking. Other factors that showed a correlation with increased MBL were implant diameter, region of the jaws, and prosthesis type, but it is not possible to draw robust conclusions for these factors, as the categories of these variables were very unbalanced.
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17.
  • Chaves, Roberta Rayra Martins, et al. (författare)
  • KRAS mutations in implant‐associated peripheral giant cell granuloma
  • 2020
  • Ingår i: Oral Diseases. - : John Wiley & Sons. - 1354-523X .- 1601-0825. ; 26:2, s. 334-340
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives: To investigate the molecular pathogenesis of implant‐associated peripheral giant cell granuloma (IA‐PGCG). Methods: A convenience sample of 15 IA‐PGCG cases was selected. Hotspot mutations of KRAS, FGFR1, and TRPV4 genes, previously reported in conventional giant cell lesions of the jaws, were investigated by Sanger sequencing. As these mutations could activate MAPK/ERK pathway, the expression of phospho‐ERK1/2 was also evaluated by immunohistochemistry. Results: KRAS mutations were detected in 8/15 (53.4%) samples. Similar to conventional peripheral giant cell granuloma, the KRAS mutations most frequently occurred in codon 146 (p.A146V, n = 3), followed by codon 12 (p.G12A and p.G12D, n = 1 each) and codon 14 (p.V14L, n = 1). Variants of unknown significance (VUS) were also detected in two cases, affecting codons 37 (p.E37K) and 127 (p.T127I). All samples showed wild‐type (WT) sequences for FGFR1 and TRPV4 genes. Consistent with MAPK/ERK pathway activation, all mononuclear cells of the lesion showed strong staining for phospho‐ERK1/2 protein in the immunohistochemical analysis. Conclusions: KRAS mutations and activation of the MAPK‐ERK signaling pathway occur in IA‐PGCG. This is the first study to demonstrate cancer‐associated gene mutations in a non‐neoplastic reactive condition associated with dental implants.
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18.
  • Chrcanovic, Bruno (författare)
  • A History of Periodontitis Suggests a Higher Risk for Implant Loss
  • 2015
  • Ingår i: Journal of Evidence-Based Dental Practice. - : Elsevier. - 1532-3382 .- 1532-3390. ; 15:4, s. 185-186
  • Tidskriftsartikel (refereegranskat)abstract
    • ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Periodontitis, implant loss and peri-implantitis. A meta-analysis. Sgolastra F, Petrucci A, Severino M, Gatto R, Monaco A.Clin Oral Implants Res 2015;26(4):e8-16. REVIEWER: Bruno Ramos Chrcanovic, DDS, MSc, PhD student PURPOSE/QUESTION: To compare the risks of implant loss, implant bone loss, and peri-implantitis between subjects with and without a history of periodontal disease. SOURCE OF FUNDING: The authors reported that no external funding sources directly supported this study TYPE OF STUDY/DESIGN: Systematic review with meta-analysis of data LEVEL OF EVIDENCE: Level 2: Limited-quality, patient-oriented evidence STRENGTH OF RECOMMENDATION GRADE: Grade B: Inconsistent or limited-quality patient-oriented evidence.
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19.
  • Chrcanovic, Bruno, et al. (författare)
  • A morphometric analysis of the mandibular canal by cone beam computed tomography and its relevance to the sagittal split ramus osteotomy
  • 2016
  • Ingår i: Oral and Maxillofacial Surgery. - : Springer. - 1865-1550 .- 1865-1569. ; 20:2, s. 183-190
  • Tidskriftsartikel (refereegranskat)abstract
    • PURPOSE: The aim of the present study was to morphometrically analyze the mandibular canal through the mandibular ramus by cone beam computed tomography (CBCT) and to relate the findings to performing sagittal split ramus osteotomy. METHODS: CBCT of 200 patients were analyzed. Five parameters were measured at the axial scan, from the mandibular foramen to 21 mm below it (3-mm intervals). The canal was classified according to the position within the bone marrow space. Variations were evaluated according to age, sex, side, and number of mandibular teeth. RESULTS/CONCLUSIONS: The following measurements increased gradually towards the most inferior level of measurement: the total thickness of the mandibular ramus through the center of the mandibular canal, the width of the bone marrow space (both buccal and lingual), and the narrowest width from the mandibular canal inner cortical to the mandibular ramus external cortical. The inner diameter of the mandibular canal slightly decreased to the same direction. Concerning the mandibular canal position within the bone marrow space, the percentage of the separate type increased towards the most inferior level of measurement, and the contact and fusion types decreased. Age, number of teeth, and sex had no significant influence on the total thickness of the mandibular ramus and on the narrowest width from the mandibular canal inner cortical to the mandibular ramus external cortical.
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20.
  • Chrcanovic, Bruno, et al. (författare)
  • A retrospective study on clinical and radiological outcomes of oral implants in patients followed up for a minimum of 20 years
  • 2018
  • Ingår i: Clinical Implant Dentistry and Related Research. - : John Wiley & Sons. - 1523-0899 .- 1708-8208. ; 20:2, s. 199-207
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Very long-term follow-up of oral implants is seldom reported in the literature. Purpose: To assess oral implant failure rates and marginal bone loss (MBL) of patients followed up for a minimum of 20 years. Materials and Methods: Implants placed in patients followed up for 20+ years were included. Descriptive statistics, survival analyses, generalized estimating equations were performed. Three-hundred implants were randomly selected for MBL. Results: 1,045 implants (227 patients) were included. Implant location, irradiation, and bruxism affected the implant survival rate. Thirty-five percent of the failures occurred within the first year after implantation, and another 26.8% in the second/third year. There was a cumulative survival rate of 87.8% after 36 years of follow-up. In the last radiological follow up, 35 implants (11.7%) had bone gain, and 35 implants (11.7%) presented at least 3 mm of MBL. Twenty-six out of 86 failed implants with available radiograms presented severe MBL in the last radiological register before implant failure. Conclusions: Most of the implant failures occurred at the first few years after implantation, regardless of a very long follow up. MBL can be insignificant in long-term observations, but it may, nevertheless, be the cause of secondary failure of oral implants in some cases.
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21.
  • Chrcanovic, Bruno, et al. (författare)
  • Adenomatoid odontogenic tumor : an updated analysis of the cases reported in the literature
  • 2019
  • Ingår i: Journal of Oral Pathology & Medicine. - : John Wiley & Sons. - 0904-2512 .- 1600-0714. ; 48:1, s. 10-16
  • Forskningsöversikt (refereegranskat)abstract
    • Purpose. To review the clinical and radiographic features of the available data published on adenomatoid odontogenic tumor (AOT) with special emphasis on the comparison of its variants. Methods. An electronic search was undertaken in July/2018. Eligibility criteria included publications having enough clinical/radiological/histological information to confirm the diagnosis. Results. 436 publications reporting 1558 cases were included, of which 739 follicular, 247 extrafollicular, and 30 peripheral AOTs. Impacted canine is associated with follicular AOTs in almost 70% of the cases. AOTs were more prevalent in females, in the second decade of life, in maxillae, in anterior region of the jaws, and most are asymptomatic, with a considerable number of lesions presenting cortical bone perforation. Most of the lesions were treated by enucleation. Some cases of recurrence were reported in the literature, but only one was well documented. No difference was found when comparing the clinical/radiological features of the follicular, extrafollicular and peripheral variants. Conclusions. AOT variants do not show distinctive clinical radiological features. Recurrence of AOT is very rare, which justify its conservative management.
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22.
  • Chrcanovic, Bruno, et al. (författare)
  • Ameloblastic fibrodentinoma and ameloblastic fibro-odontoma : an updated systematic review of cases reported in the literature
  • 2017
  • Ingår i: Journal of oral and maxillofacial surgery (Print). - : Elsevier. - 0278-2391 .- 1531-5053. ; 75:7, s. 1425-1437
  • Forskningsöversikt (refereegranskat)abstract
    • Purpose: To integrate the available data published on ameloblastic fibrodentinoma (AFD) and ameloblastic fibro-odontoma (AFO) into a comprehensive analysis of its clinical/radiologic features. Methods: An electronic search was undertaken in August/2016. Eligibility criteria included publications reporting cases of AFD and/or AFO having enough clinical, radiological and histological information to confirm the diagnosis. Demographic data, lesion site and size, treatment approach, and recurrence were analyzed and compared between AFD and AFO. Results: 55 publications reporting 64 AFDs (60 central, 4 peripheral) and 137 publications reporting 215 AFOs (211 central, 3 peripheral, 1 unknown) were included. The difference in recurrence rate (when the information about recurrence was provided) was not statistically significant. The mean age of the patients affected by AFD was not statistically significantly different from those affected by AFO. Conclusions: AFD and AFO presented several similarities: higher prevalence in males and in mandibles, similar patients’ mean age, rate of cortical bone perforation and of the lesions’ association with displaced/unerupted teeth and tooth root resorption, mean lesion size, and recurrence rate. The lesions differed with regard to the presence of radiopacities and locularity. Taken together, our data do not support the concept of progressive maturation of these tumoral conditions.
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23.
  • Chrcanovic, Bruno, et al. (författare)
  • Ameloblastic fibrodentinosarcoma and ameloblastic fibro-odontosarcoma : a systematic review
  • 2018
  • Ingår i: Journal of Stomatology, Oral and Maxillofacial Surgery. - : Elsevier. - 2468-7855. ; 119:5, s. 401-406
  • Forskningsöversikt (refereegranskat)abstract
    • The purpose of the present review was to integrate the available data published on ameloblastic fibrodentinosarcoma (AFDS) and ameloblastic fibro-odontosarcoma (AFOS) into a comprehensive analysis of their clinical/radiologic features. An electronic search was undertaken in July/2017. Eligibility criteria included publications having enough clinical/radiological/histological information to confirm the diagnosis. 17 publications (8 AFDS, 9 AFOS) were included. The patients with the two different lesions had a similar mean age. The lesions were both more prevalent in mandibles than in maxillae, all showed bone expansion and similar rates of cortical bone perforation, tooth displacement, and locular appearance at radiological exams. Mean follow-up time was higher for AFDS, and the mean size of the lesions were larger for AFDS, although without a statistically significant difference. None of AFDS recurred, while 2 AFOS recurred. As only few cases of AFDS and AFOS have been reported, additional reports are necessary to add evidence to the study of clinical and radiologic features of these lesions.
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24.
  • Chrcanovic, Bruno, et al. (författare)
  • Ameloblastic fibroma and ameloblastic fibrosarcoma : a systematic review
  • 2018
  • Ingår i: Journal of Oral Pathology & Medicine. - : John Wiley & Sons. - 0904-2512 .- 1600-0714. ; 47:4, s. 315-325
  • Forskningsöversikt (refereegranskat)abstract
    • Purpose. To integrate the available data published to date on ameloblastic fibromas (AF) and ameloblastic fibrosarcomas (AFS) into a comprehensive analysis of their clinical/radiologic features. Methods. An electronic search was undertaken in July/2017. Eligibility criteria included publications having enough clinical, radiological and histological information to confirm a definite diagnosis. Results. 244 publications (279 central AF tumours, 10 peripheral AF, 103 AFS) were included. AF and AFS differed significantly with regard to the occurrence of patients’ mean age, bone expansion, cortical bone perforation and lesion size. Recurrence rates were: central AF (19.2%), peripheral AF (12.5%), AFS (all lesions, 35%), primary (de novo) AFS (28.8%), secondary AFS (occurring after an AF, 50%). Larger lesions and older patients were more often treated by surgical resections for central AF. Segmental resection resulted in the lowest rate of recurrence for most of the lesion types. AFS treated by segmental resection had a 70.5% lower probability to recur (OR 0.295; p=0.049) than marginal resection. 21.3% of the AFS-patients died due to complications related to the lesion. Conclusions. Very long follow-up is recommended for AF lesions, due to the risk of recurrence and malignant change into AFS. Segmental resection is the most recommended therapy for AFS.
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25.
  • Chrcanovic, Bruno, et al. (författare)
  • Analysis of risk factors for cluster behavior of dental implant failures
  • 2017
  • Ingår i: Clinical Implant Dentistry and Related Research. - : Wiley. - 1523-0899 .- 1708-8208. ; 19:4, s. 632-642
  • Tidskriftsartikel (refereegranskat)abstract
    • BackgroundSome studies indicated that implant failures are commonly concentrated in few patients. PurposeTo identify and analyze cluster behavior of dental implant failures among subjects of a retrospective study. Materials and MethodsThis retrospective study included patients receiving at least three implants only. Patients presenting at least three implant failures were classified as presenting a cluster behavior. Univariate and multivariate logistic regression models and generalized estimating equations analysis evaluated the effect of explanatory variables on the cluster behavior. ResultsThere were 1406 patients with three or more implants (8337 implants, 592 failures). Sixty-seven (4.77%) patients presented cluster behavior, with 56.8% of all implant failures. The intake of antidepressants and bruxism were identified as potential negative factors exerting a statistically significant influence on a cluster behavior at the patient-level. The negative factors at the implant-level were turned implants, short implants, poor bone quality, age of the patient, the intake of medicaments to reduce the acid gastric production, smoking, and bruxism. ConclusionsA cluster pattern among patients with implant failure is highly probable. Factors of interest as predictors for implant failures could be a number of systemic and local factors, although a direct causal relationship cannot be ascertained.
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26.
  • Chrcanovic, Bruno, et al. (författare)
  • Assessment of hematologic parameters before and after bimaxillary orthognathic surgery
  • 2016
  • Ingår i: Oral and Maxillofacial Surgery. - : Springer. - 1865-1550 .- 1865-1569. ; 20:1, s. 35-43
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose: The purpose of the study was to evaluate changes of hematologic parameters in bimaxillary surgery. Methods: Fifty-three patients were prospectively evaluated and divided into groups based on the surgical procedure and sex (predictor variables). Hemoglobin, red blood cells, hematocrit, and platelet were the primary outcome variables, operation time the secondary outcome, and the patients’ age and weight the other variables. Trial registration: NCT02364765 (U.S. National Institutes of Health, clinicaltrials.gov). Results: There was statistically significant difference between all hematologic parameters before and after surgery, for both men and women, and for all surgical groups. There was a positive correlation between operative time and the decrease (in %) of the hematologic parameters. Linear regression analysis suggested that the Hb values decrease 0.083 % for every minute increase in the operation time, and 0.066, 0.066, and 0.010 % for RBC, Hct, and platelet count, respectively. There was a negative correlation between weight and all hematologic parameters. Correlations between age and hematologic parameters were not statistically significant. Almost all correlations between age, weight, sex, and the surgery group and the hematologic parameters were considered as very weak. Only one patient was transfused. Conclusions: It is suggested that operation time and patient’s weight play a bigger role than patient’s age and sex in the decrease of hematologic parameters after bimaxillary surgery.
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27.
  • Chrcanovic, Bruno, et al. (författare)
  • Bisphosphonates and dental implants : A meta-analysis
  • 2016
  • Ingår i: Quintessence International. - : Quintessence. - 0033-6572. ; 47:4, s. 329-42
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: To test the null hypothesis of no difference in the implant failure rates, marginal bone loss, and postoperative infection for patients receiving or not receiving bisphosphonates, against the alternative hypothesis of a difference. METHOD AND MATERIALS: An electronic search was undertaken in October 2015 in PubMed/Medline, Web of Science, and Embase, plus hand-searching and databases of clinical trials. Eligibility criteria included clinical human studies, either randomized or not. RESULTS: A total of 18 publications were included in the review. Concerning implant failure, the meta-analysis found a risk ratio of 1.73 (95% confidence interval [CI] 1.21-2.48, P = .003) for patients taking bisphosphonates, when compared to patients not taking the medicament. The probability of an implant failure in patients taking bisphosphonates was estimated to be 1.5% (0.015, 95% CI 0.006- 0.023, standard error [SE] 0.004, P < .001). It cannot be suggested that bisphosphonates may affect the marginal bone loss of dental implants, due to a limited number of studies reporting this outcome. Due to a lack of sufficient information, meta-analysis for the outcome "postoperative infection" was not performed. CONCLUSION: The results of the present study cannot suggest that the insertion of dental implants in patients taking BPs affects the implant failure rates, due to a limited number of published studies, all characterized by a low level of specificity, and most of them dealing with a limited number of cases without a proper control group. Therefore, the real effect of BPs on the osseointegration and survival of dental implants is still not well established.
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28.
  • Chrcanovic, Bruno, et al. (författare)
  • Bone Quality and Quantity and Dental Implant Failure: A Systematic Review and Meta-analysis
  • 2017
  • Ingår i: International Journal of Prosthodontics. - : Quintessence Publishing. - 0893-2174 .- 1942-4426 .- 1139-9791. ; 30:3, s. 219-237
  • Forskningsöversikt (refereegranskat)abstract
    • Purpose: The aim of this study was to test the null hypothesis that there is no difference in implant failure rates, marginal bone loss, and postoperative infection for implants inserted in bone with different qualities and quantities according to the classification of Lekholm and Zarb. Materials and Methods: An electronic search was undertaken in January 2015 for randomized and nonrandomized human clinical studies. Results: A total of 94 publications were included. When bone sites of different qualities were considered, the results suggested the following comparative implant failure rates: 1 > 2, 1 > 3, 3 > 2, 4 > 1, 4 > 2, and 4 > 3. Sensitivity analyses suggested that when implants inserted in bone qualities 1 and 2 and 1 and 3 were compared, oxidized and sandblasted/acid-etched surfaces showed a decrease in significant difference in failures compared with turned implants. The same is not true for failure of implants inserted in bone quality 4 compared to failure of implants in all other bone qualities. When bone sites of different quantities were considered, the following comparative implant failure rates were observed: A > B, A > C, A < D, B < C, B < D, C < D, E > A, E > B, E > C, E > D. Due to insufficient information, meta-analyses for the outcomes postoperative infection and marginal bone loss were not performed. Conclusion: Sites with poorer bone quality and lack of bone volume may statistically affect implant failure rates. Implant surfaces may play a role in failure of implants in different bone qualities.
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29.
  • Chrcanovic, Bruno, et al. (författare)
  • Bruxism and dental implant failures: a multilevel mixed effects parametric survival analysis approach
  • 2016
  • Ingår i: Journal of Oral Rehabilitation. - : Wiley. - 0305-182X .- 1365-2842. ; 43:11, s. 813-823
  • Tidskriftsartikel (refereegranskat)abstract
    • Recent studies have suggested that the insertion of dental implants in patients being diagnosed with bruxism negatively affected the implant failure rates. The aim of the present study was to investigate the association between the bruxism and the risk of dental implant failure. This retrospective study is based on 2670 patients who received 10 096 implants at one specialist clinic. Implant- and patient-related data were collected. Descriptive statistics were used to describe the patients and implants. Multilevel mixed effects parametric survival analysis was used to test the association between bruxism and risk of implant failure adjusting for several potential confounders. Criteria from a recent international consensus (Lobbezoo et al., J Oral Rehabil, 40, 2013, 2) and from the International Classification of Sleep Disorders (International classification of sleep disorders, revised: diagnostic and coding manual, American Academy of Sleep Medicine, Chicago, 2014) were used to define and diagnose the condition. The number of implants with information available for all variables totalled 3549, placed in 994 patients, with 179 implants reported as failures. The implant failure rates were 130% (24/185) for bruxers and 46% (155/3364) for non-bruxers (P < 0001). The statistical model showed that bruxism was a statistically significantly risk factor to implant failure (HR 3396; 95% CI 1314, 8777; P = 0012), as well as implant length, implant diameter, implant surface, bone quantity D in relation to quantity A, bone quality 4 in relation to quality 1 (Lekholm and Zarb classification), smoking and the intake of proton pump inhibitors. It is suggested that the bruxism may be associated with an increased risk of dental implant failure.
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30.
  • Chrcanovic, Bruno, et al. (författare)
  • Bruxism and dental implant treatment complications: a retrospective comparative study of 98 bruxer patients and a matched group.
  • 2017
  • Ingår i: Clinical oral implants research. - : Wiley. - 1600-0501 .- 0905-7161. ; 28:7
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives To analyze the complications of dental implant treatment in a group of patients with bruxism in comparison with a matched group of non‐bruxers. Material and methods Patients being diagnosed as bruxers were identified within a group of patients consecutively treated with implant‐supported prostheses at one specialist clinic, based on the most recent listed sign and symptoms of bruxism according to the International Classification of Sleep Disorders. A diagnostic grading system of “possible,” “probable,” and “definite” sleep or awake bruxism was used, according to a recent published international consensus. A case–control matching model was used to match the bruxers with a group of non‐bruxers, based on five variables. Implant‐, prosthetic‐, and patient‐related data were collected, as well as 14 mechanical complications, and compared between groups. Results Ninety‐eight of 2670 patients were identified as bruxers. The odds ratio of implant failure in bruxers in relation to non‐bruxers was 2.71 (95% CI 1.25, 5.88). Considering the same number of patients with the same total number of implants equally distributed between groups, the bruxers group had a higher prevalence of mechanical complications in comparison with the non‐bruxers group. Conclusions This study suggests that bruxism may significantly increase both the implant failure rate and the rate of mechanical and technical complications of implant‐supported restorations. Other risk factors may also have influenced the results.
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31.
  • Chrcanovic, Bruno, et al. (författare)
  • Bruxism and Dental Implants: A Meta-Analysis.
  • 2015
  • Ingår i: Implant dentistry. - : Lippincott Williams & Wilkins. - 1538-2982 .- 1056-6163. ; 24:5, s. 505-516
  • Tidskriftsartikel (refereegranskat)abstract
    • To test the null hypothesis of no difference in the implant failure rates, postoperative infection, and marginal bone loss after the insertion of dental implants in bruxers compared with the insertion in non-bruxers against the alternative hypothesis of a difference.
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32.
  • Chrcanovic, Bruno, et al. (författare)
  • Calcifying epithelial odontogenic tumor : An updated analysis of 339 cases reported in the literature
  • 2017
  • Ingår i: Journal of Cranio-Maxillofacial Surgery. - : Elsevier. - 1010-5182 .- 1878-4119. ; 45:8, s. 1117-1123
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose: The aim of this study was to integrate the available data published on calcifying epithelial odontogenic tumors (CEOT) into a comprehensive analysis of its clinical and radiologic features. Materials and Methods: An electronic search was undertaken in May 2016. Eligibility criteria were publications having enough clinical, radiological and/or histological information to confirm definite diagnosis. Results: A total of 362 lesions were found, 339 with enough information were analyzed. Variants clear cells (n=33) and Langerhans cells (n=10) were rarely described in the literature, as well as lesions with malignant transformation (n=8). Central lesions (n=264) were more prevalent than their peripheral counterparts (n=24). A higher prevalence characterized the mandible, posterior region, and third and fourth decades. About 40% of the peripheral lesions showed signs of underlying bone erosion, and about half of the central ones showed signs of cortical bone perforation. Recurrence was found in all lesions (12.6%), peripheral lesions (18.8%), central lesions (11.6%), clear cell (10.7%), Langerhans cell (0%), and those with malignant transformation (42.9%). Excision or curettage was associated with the highest recurrence rate. None of the variables showed a statistically significant influence on the recurrence rate. Conclusions: The possible locally aggressive behavior of the lesions recommends a less conservative management than simple curettage. The clear cell variant shows similar demographic data and biological behavior compared to the non-variant lesions, suggesting that the presence of clear cells does not have an important clinical significance.
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33.
  • Chrcanovic, Bruno, et al. (författare)
  • Cementoblastoma : an updated analysis of 258 cases reported in the literature
  • 2017
  • Ingår i: Journal of Cranio-Maxillofacial Surgery. - : Elsevier. - 1010-5182 .- 1878-4119. ; 45:10, s. 1759-1766
  • Forskningsöversikt (refereegranskat)abstract
    • Purpose: To investigate the recurrence rate of cementoblastomas for different variables aside from the clinical/radiologic features. Methods: An electronic search was undertaken in November/2016. Eligibility criteria included publications having enough clinical/radiological/histological information to confirm the diagnosis. Results: 141 publications (258 cementoblastomas) were included. There was an equal sex distribution. There was a high prevalence in the second/third decades of life, in the posterior regions, and in mandibular first molars. Lesions were commonly associated with bone expansion (74.9%), presence of clinical symptoms (70.2%), vital teeth (78%), root resorption (59.8%). Observations not as frequent: cortical bone perforation (16.3%), inferior displacement of the mandibular canal (23.6%). Treatment was reported for 229 cases. Twenty (11.8%) out of 170 recurred. Preservation of the involved teeth and location seem to not influence the recurrence rate, but there was a 687% higher probability (odds ratio 7.875; p=0.048) of recurrence for lesions associated with bone expansion, and a 217% higher probability (odds ratio 3.173; p=0.023) of recurrence for lesions presenting cortical bone perforation. Conclusions: Although the recurrence rate of cementoblastomas is not as high as previously believed, it is a relevant phenomenon (11.8%). The presence of bone expansion and cortical bone perforation seem to influence the recurrence rate.
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34.
  • Chrcanovic, Bruno, et al. (författare)
  • Central giant cell lesion of the jaws : an updated analysis of 2270 cases reported in the literature
  • 2018
  • Ingår i: Journal of Oral Pathology & Medicine. - : John Wiley & Sons. - 0904-2512 .- 1600-0714. ; 47:8, s. 731-739
  • Forskningsöversikt (refereegranskat)abstract
    • Purpose. To review all available data published on central giant cell lesion (CGCL) of the jaws into a comprehensive analysis of its clinical/radiologic features, with emphasis on the predictive factors associated with its recurrence. Methods. Electronic search undertaken in 5 databases (February/2018), looking for publications reporting cases of CGCLs. Results. 365 publications were included, comprising 2270 lesions. CGCLs were more prevalent in women and in the mandible, being usually asymptomatic. Cortical bone perforation occurred in 50% of the cases. Marginal/segmental resection were more often performed in larger lesions, and drug therapy was more frequent in small lesions. Recurrence was reported in 232/1316 cases (17.6%). The recurrence rate of the aggressive lesions (22.8%) after surgical treatment was higher than non-aggressive lesions (7.8%). Four out of five CGCLs showed partial/total regression with pharmacological treatment. Aggressive lesions showed worse response to corticosteroids than non-aggressive lesions. For the lesions submitted to surgery as the first treatment, curettage, enucleation or marginal resection in relation to segmental resection, aggressive lesions, cortical bone perforation, and tooth root resorption were associated with increased recurrence rate. Recurrence related to combination of surgical/pharmacological treatment could not be evaluated due to the variety of protocols. Conclusions. Aggressive CGCLs recur more often than the non-aggressive ones. Despite sometimes showing poor response to corticosteroid injection or surgical curettage, a combination of both treatment strategies should be considered in these aggressive cases in order to reduce morbidities associated with radical surgery. The best protocol to manage aggressive and non-aggressive lesions remains to be determined.
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35.
  • Chrcanovic, Bruno, et al. (författare)
  • Clinical factors associated with the recurrence of central giant cell lesions.
  • 2019
  • Ingår i: Journal of Oral Pathology & Medicine. - : John Wiley & Sons. - 0904-2512 .- 1600-0714. ; 48:9, s. 799-802
  • Tidskriftsartikel (refereegranskat)abstract
    • Central giant cell lesion of the jaws (CGCLJ) is a destructive condition that shows a varied and unpredictable biological behaviour. In the present study, we aimed to evaluate factors associated with the recurrence of CGCLJ. Based on the data of a previous systematic review of 2,270 CGCLJ, we used the multiple imputation to deal with the missing data. The dependent variable was the recurrence after the first treatment (yes/no). The dichotomic covariates were sex, upper or lower jaw location, size (up to or larger than 4 cm), pain, cortical bone perforation (yes/no), locularity (uni-/multilocular), tooth displacement (yes/no), treatment type (curettage or enucleation) and root resorption (yes/no). The final logistic model indicated that the tumours associated with tooth displacement, root resorption, and treated with curettage had a more significant chance of recurrence. In conclusion, our study suggests that tooth displacement, root resorption, and the type of treatment are potentially useful in the future construction of an algorithm for patient's treatment. This article is protected by copyright. All rights reserved.
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36.
  • Chrcanovic, Bruno, et al. (författare)
  • Dental implants in irradiated versus non-irradiated patients : a meta-analysis
  • 2016
  • Ingår i: Head and Neck. - : John Wiley & Sons. - 1043-3074 .- 1097-0347. ; 38:3, s. 448-481
  • Forskningsöversikt (refereegranskat)abstract
    • Background/Methods. The purpose of the present meta-analysis was to test the null hypothesis of no difference in dental implant failure rates, postoperative infection, and marginal bone loss for patients being rehabilitated by dental implants and being previously irradiated in the head and neck region versus non-irradiated patients, against the alternative hypothesis of a difference. Results/Conclusion. The study suggests that irradiation negatively affects the survival of implants, as well as the difference in implant location (maxilla vs. mandible), but there is no statistically significant difference in survival when implants are inserted before or after 12 months after radiotherapy. The study failed to support the effectiveness of hyperbaric oxygen therapy in irradiated patients. It was observed a tendency to lower survival rates of implants inserted in the patients submitted to higher irradiation doses. The results should be interpreted with caution due to the presence of uncontrolled confounding factors in the included studies.
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37.
  • Chrcanovic, Bruno, et al. (författare)
  • Dental Implants in Patients Receiving Chemotherapy : A Meta-Analysis
  • 2016
  • Ingår i: Implant Dentistry. - : Lippincott Williams & Wilkins. - 1056-6163 .- 1538-2982. ; 25:2, s. 261-271
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose: To test the null hypothesis of no difference in the implant failure rates, postoperative infection, and marginal bone loss for patients being rehabilitated by dental implants and being versus not being submitted to chemotherapy, against the alternative hypothesis of a difference. Methods: An electronic search without time or language restrictions was undertaken in May 2014 in PubMed/MEDLINE, Web of Science, Cochrane Oral Health Group Trials Register plus hand-searching. Eligibility criteria included clinical human studies, either randomized or not. Results: Nine publications were included. The results suggested that the insertion of dental implants in patients submitted or not submitted to chemotherapy did not affect the implant failure rates (risk ratio 1.02, 95% confidence interval 0.56-1.85; P = 0.95). Because of lack of enough information, meta-analyses for the outcomes "postoperative infection" and "marginal bone loss" were not performed. Conclusion: These results cannot suggest that the insertion of dental implants in patients submitted to chemotherapy may or may not affect the implant failure rates, because of a limited number of published studies, most of them characterized by a low level of specificity and dealing with a limited number of cases without a control group. The reliability and validity of the data collected and the potential for biases and confounding factors are some of the shortcomings of the present study.
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38.
  • Chrcanovic, Bruno (författare)
  • Dental implants in patients with ectodermal dysplasia : a systematic review
  • 2018
  • Ingår i: Journal of Cranio-Maxillofacial Surgery. - : Elsevier. - 1010-5182 .- 1878-4119. ; 46:8, s. 1211-1217
  • Forskningsöversikt (refereegranskat)abstract
    • Purpose. To assess the clinical outcome and survival rate of oral implants placed in individuals with ectodermal dysplasia (ED), based on previously published studies. Methods. An electronic search without time restrictions was undertaken in 5 databases (PubMed/Medline, Web of Science, ScienceDirect, J-Stage, Lilacs). Descriptive statistics, Kaplan Meier estimator and implant failure probability were calculated. Results. 90 publications included, reporting 228 ED patients that received 1472 implants (1392 conventional, 47 zygomatic, 33 mini-implants). Mean age of the patients was 20.2±6.8 years (2-56). Patients had a mean of 3.2±2.5 maxillary and 2.1±2.6 mandibular permanent teeth (min-max, 0-14). Patients received a mean of 8.2±3.8 implants (1-20). Most implants were placed in the third decade of life, 24.6% of the implants were placed in children (0-17 years of age). 1391 implants had information on follow-up (72 failures, 5.2%). The 20-year CSR was 84.6%. The probability of failure was 4.5% (95%CI 3.5%-5.6%, p<0.001). Additional treatments performed: Le Fort I (99 implants, 20 patients, 3.5% failed), grafting (497 implants, 77 patients, 5.2% failed), distraction osteogenesis (79 implants, 16 patients, 10.1% failed). Mean follow-up 42.9±41.9 months (min-max, 2-240). Conclusions. Dental implants placed in ED patients, either infants or adults, present a high survival rate (20-year CSR 84.6%).
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39.
  • Chrcanovic, Bruno, et al. (författare)
  • Dental implants in patients with epidermolysis bullosa : a systematic review
  • 2019
  • Ingår i: Oral and Maxillofacial Surgery. - : Springer. - 1865-1550 .- 1865-1569. ; 23:4, s. 389-394
  • Forskningsöversikt (refereegranskat)abstract
    • PURPOSE: To integrate the available data published on patients with epidermolysis bullosa (EB) rehabilitated with dental implants, as well as to review the recommendations for EB patients receiving implants. METHODS: An electronic search was undertaken in February 2019 in five databases. RESULTS: Sixteen publications were included, reporting 28 patients with EB, rehabilitated with 161 dental implants. The mean ± SD patients' age at implant surgery was 34.7 ± 12.1 years (range, 13-56). Only one implant was placed in the molar region, all other implants were placed in the incisor, canine, and premolar regions. Patients received a mean ± SD of 5.8 ± 2.8 implants (range, 2-11). Most of the patients received implant-supported fixed prostheses (fixed partial 14.3%, fixed full-arch 60.7%, overdenture 25%). Implant and prosthesis failure rates were 1.3% and 0%, respectively. The two implant failures were detected before or at the abutment connection. The mean ± SD follow-up time was of 39.2 ± 24.5 months (range, 6-111). The EB patient quality-of-life improved considerably as a result of treatment with dental implants. There is a series of dental care considerations that should be followed to smooth the implant treatment in EB patients. CONCLUSIONS: The dental implant failure rate in EB patients seems to be very low, although the few cases reported in the literature were followed up for a short mean period, i.e., just a little bit longer than 3 years. More cases followed up for a long period are needed in order to be able to make a more reliable prognosis for the long-term oral rehabilitation of EB patients with dental implants.
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40.
  • Chrcanovic, Bruno, et al. (författare)
  • Dental implants inserted in fresh extraction sockets versus healed sites : a systematic review and meta-analysis
  • 2015
  • Ingår i: Journal of Dentistry. - : Elsevier. - 0300-5712 .- 1879-176X. ; 43:1, s. 16-41
  • Forskningsöversikt (refereegranskat)abstract
    • OBJECTIVES: The purpose of the present review was to test the null hypothesis of no difference in the implant failure rates, postoperative infection and marginal bone loss for the insertion of dental implants in fresh extraction sockets compared to the insertion in healed sites, against the alternative hypothesis of a difference. METHODS: An electronic search was undertaken in July 2014. Eligibility criteria included clinical human studies, either randomized or not. RESULTS: The search strategy resulted in 73 publications, with 8241 implants inserted in sockets (330 failures, 4.00%), and 19,410 in healed sites (599 failures, 3.09%). The difference between the procedures significantly affected the failure rates (RR 1.58, 95% CI 1.27-1.95, P<0.0001). The difference was not statistically significant when studies evaluating implants inserted in maxillae or in mandibles were pooled, or when the studies using implants to rehabilitate patients with full-arch prostheses were pooled; however, it was significant for the studies that rehabilitated patients with implant-supported single crowns and for the controlled studies. There was no apparent significant effect of implants inserted in fresh extraction sockets on the occurrence of postoperative infection or on the magnitude of marginal bone loss. CONCLUSION: It is suggested that the insertion of implants in fresh extraction sockets affects the failure rates. However, it does not affect the marginal bone loss or the occurrence of postoperative infection. The results should be interpreted with caution due to the potential for biases and to the presence of uncontrolled confounding factors in the included studies, most of them not randomized. CLINICAL SIGNIFICANCE: The question whether immediate implants are more at risk for failure than implants placed in mature bone has received increasing attention in the last years. As the philosophies of treatment alter over time, a periodic review of the different concepts is necessary to refine techniques and eliminate unnecessary procedures. This would form a basis for optimum treatment.
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41.
  • Chrcanovic, Bruno, et al. (författare)
  • Dental implants inserted in male versus female patients: a systematic review and meta-analysis.
  • 2015
  • Ingår i: Journal of oral rehabilitation. - : Wiley. - 1365-2842 .- 0305-182X. ; 42:9, s. 709-722
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of this meta-analysis was to test the null hypothesis of no difference in the failure rates, marginal bone loss (MBL) and post-operative infection for implants inserted in male or female patients, against the alternative hypothesis of a difference. An electronic search without time or language restrictions was undertaken in December 2014. Eligibility criteria included clinical human studies, either randomized or not. Ninety-one publications were included, with a total of 27203 implants inserted in men (1185 failures), and 25154 implants inserted in women (1039 failures). The results suggest that the insertion of dental implants in male patients statistically affected the implant failure rates (RR 1·21, 95% CI 1·07-1·37, P=0·002). Due to the limited number of studies reporting results on MBL, it is difficult to estimate the real effect of the insertion of implants in different sexes on the marginal bone level. Due to lack of satisfactory information, meta-analysis for the outcome 'post-operative infection' was not performed. The results have to be interpreted with caution due to the presence of several confounding factors in the included studies.
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42.
  • Chrcanovic, Bruno, et al. (författare)
  • Desmoplastic ameloblastoma : a systematic review of the cases reported in the literature
  • 2020
  • Ingår i: International Journal of Oral and Maxillofacial Surgery. - : Elsevier. - 0901-5027 .- 1399-0020. ; 49:6, s. 709-716
  • Forskningsöversikt (refereegranskat)abstract
    • The purpose was to integrate the available data published on desmoplastic ameloblastoma (DA) into a comprehensive analysis of its clinical/radiographic features. As it is not clear if the hybrid ameloblastoma has a unique biological behavior, the clinical/radiographic features of conventional DA with the hybrid variant were compared. An electronic search was undertaken in May/2019. Eligibility criteria included publications having enough clinical/radiographic/histological information to confirm the diagnosis. 128 publications reporting 285 DAs were included (246 central non-hybrid, 33 central hybrid, 6 peripheral). There was a statistically significant difference between non-hybrid and hybrid cases concerning lesion location, radiographic limits and size. In contrast to non-hybrid tumors that showed similar distribution in mandible and maxilla, a highly predominant mandible location was observed in the hybrid tumors. Also, non-hybrid lesions more often showed ill-defined radiographic margins, and were larger tumors than hybrid DAs. Enucleation with an additional therapy (either curettage or peripheral osteotomy) or resection led to a lower recurrence risk in comparison to curettage or enucleation without additional therapy. Location of the lesion and type of treatment are related to tumor recurrence. There are important differences in location and radiographic limits between hybrid and non-hybrid DAs, which support their classification as distinct lesions.
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43.
  • Chrcanovic, Bruno, et al. (författare)
  • Diabetes and oral implant failure : a systematic review
  • 2014
  • Ingår i: Journal of Dental Research. - : Sage Publications. - 0022-0345 .- 1544-0591. ; 93:9, s. 859-867
  • Forskningsöversikt (refereegranskat)abstract
    • The aim of this systematic review and meta-analysis was to investigate whether there are any effects of diabetes mellitus on implant failure rates, postoperative infections, and marginal bone loss. An electronic search without time or language restrictions was undertaken in March 2014. The present review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Eligibility criteria included clinical human studies. The search strategy resulted in 14 publications. The I (2) statistic was used to express the percentage of total variation across studies due to heterogeneity. The inverse variance method was used for the random effects model when heterogeneity was detected or for the fixed effects model when heterogeneity was not detected. The estimates of an intervention for dichotomous outcomes were expressed in risk ratio and in mean difference in millimeters for continuous outcomes, both with a 95% confidence interval. There was a statistically significant difference (p = .001; mean difference = 0.20, 95% confidence interval = 0.08, 0.31) between diabetic and non-diabetic patients concerning marginal bone loss, favoring non-diabetic patients. A meta-analysis was not possible for postoperative infections. The difference between the patients (diabetic vs. non-diabetic) did not significantly affect implant failure rates (p = .65), with a risk ratio of 1.07 (95% confidence interval = 0.80, 1.44). Studies are lacking that include both patient types, with larger sample sizes, and that report the outcome data separately for each group. The results of the present meta-analysis should be interpreted with caution because of the presence of uncontrolled confounding factors in the included studies.
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44.
  • Chrcanovic, Bruno, et al. (författare)
  • Factors Influencing Early Dental Implant Failures
  • 2016
  • Ingår i: Journal of Dental Research. - : SAGE Publications. - 0022-0345 .- 1544-0591. ; 95:9, s. 995-1002
  • Tidskriftsartikel (refereegranskat)abstract
    • The purpose of the present study was to assess the influence of local and systemic factors on the occurrence of dental implant failures up to the second-stage surgery (abutment connection). This retrospective study is based on 2,670 patients who received 10,096 implants and were consecutively treated with implant-supported prostheses between 1980 and 2014 at 1 specialist clinic. Several anatomic-, patient-, health-, and implant-related factors were collected. Descriptive statistics were used to describe the patients and implants. Univariate and multivariate logistic regression models were used at the patient level as well as the implant level to evaluate the effect of explanatory variables on the failure of implants up to abutment connection. A generalized estimating equation method was used for the implant-level analysis to account for the fact that repeated observations (several implants) were available for a single patient. Overall, 642 implants (6.36%) failed, of which 176 (1.74%) in 139 patients were lost up to second-stage surgery. The distribution of implants in sites of different bone quantities and qualities was quite similar between implants lost up to and after abutment connection. Smoking and the intake of antidepressants were the statistically significant predictors in the multivariate model (ClinicalTrials. gov NCT02369562).
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45.
  • Chrcanovic, Bruno, et al. (författare)
  • Factors influencing the fracture of dental implants
  • 2018
  • Ingår i: Clinical Implant Dentistry and Related Research. - : John Wiley & Sons. - 1523-0899 .- 1708-8208. ; 20:1, s. 58-67
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Implant fractures are rare but offer a challenging clinical situation. Purpose: To determine the prevalence of implant fracture and the possible risk factors predisposing an implant to a higher fracture risk. Materials and Methods: This retrospective study is based on 2670 patients consecutively treated with implant-supported prostheses. Anatomical-, patient-, and implant-related factors were collected. Descriptive statistics and survival analyses were performed. Generalized estimating equations (GEE) evaluated the effect of explanatory variables on implant fracture. Results: Forty-four implants (out of 10 099; 0.44%) fractured. The mean ± standard deviation time for fracture to occur was 95.1 ± 58.5 months (min-max, 3.8-294.7). Half of the occurrences of fracture happened between 2 and 8 years after implantation. Five factors had a statistically significant influence on the fracture of implants (increase/decrease in fracture probability): use of higher grades of titanium (decrease 72.9%), bruxism (increase 1819.5%), direct adjacency to cantilever (increase 247.6%), every 1 mm increase in implant length (increase 22.3%), every 1 mm increase in implant diameter (decrease 96.9%). Conclusions: It is suggested that 5 factors could influence the incidence of implant fractures: grade of titanium, implant diameter and length, cantilever, bruxism.
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46.
  • Chrcanovic, Bruno (författare)
  • Fixation of mandibular angle fractures : clinical studies
  • 2014
  • Ingår i: Oral and Maxillofacial Surgery. - : Springer. - 1865-1550 .- 1865-1569. ; 18:2, s. 123-152
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose The purpose of this study was to review the literature regarding the evolution of current thoughts on fixation of mandibular angle fractures (MAFs). Methods An electronic search in PubMed was undertaken in August 2012. The titles and abstracts from these results were read to identify studies within the selection criteria. Eligibility criteria included studies from the last 30 years (from 1983 onwards) reporting clinical studies of MAFs. Results The search strategy initially identified 767 studies. The references from 1983 onwards totaled 727 articles. Fifty-four studies were identified without repetition within the selection criteria. Two articles showing significance in the development of treatment techniques were included. Additional hand-searching yielded 13 additional papers. Thus, a total of 69 studies were included. Conclusions Prospective randomized controlled studies of MAFs repair techniques are scarce. The available data at best predict that complications are associated with all kinds of fixation techniques. The similar results of complications in studies using different methods of fixation indicate that biomechanics are only one factor to be considered when treating MAFs. A second fracture in the mandible (which was observed in the majority of the studies’ population) can confound the outcome data because the fixation requirements of a double fracture are often different from those for an isolated fracture. It can be necessary additional effort intended for increase of stability when using biodegradable plate system to fixate MAFs. The use of 1.3 mm malleable miniplates was associated with an unacceptable incidence of plate fracture, suggesting that this is not the most adequate system to treat MAFs. The use of the 3D grid plates has shown good clinical results. The efficiency of locking miniplate system is yet to be proven because there are few clinical studies with its use to fixate MAFs, although they have shown good results. When considering the use of semirigid or rigid fixation systems, the use of two miniplates outweigh the advantages of the use of one reconstruction plate, although the use of miniplates is not recommended for displaced comminuted MAFs. Although it has been shown that absolute rigid fixation is not necessary for fracture healing, any system that provides superior stability without impacting negatively on other aspects of the procedure, i.e., time, exposure, and cost, should be favored. MAFs can be treated in a highly effective way and with a relatively low rate of complications with monocortical miniplate fixation. The large number of studies on the treatment of MAF reflects the fact that a consensus has not been reached for a single, ideal treatment method.
  •  
47.
  • Chrcanovic, Bruno (författare)
  • Fixation of mandibular angle fractures : in vitro biomechanical assessments and computer-based studies
  • 2012
  • Ingår i: Oral and Maxillofacial Surgery. - : Springer. - 1865-1550 .- 1865-1569. ; 17:4, s. 251-268
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose The purpose of this study was to review the literature regarding the evolution of current thoughts on fixation of mandibular angle fractures (MAFs), based on in vitro biomechanical assessments and computer-based studies. Methods An electronic search in PubMed was undertaken in August 2012. The titles and abstracts from these results were read to identify studies within the selection criteria. Eligibility criteria included studies from the last 30 years (from 1983 onwards). Results The search strategy initially identified 767 studies. Thirty-one studies were identified without repetition within the selection criteria. Two articles showing significance in the development of treatment techniques was included. Additional hand searching yielded five additional papers. Thus, a total of 38 studies were included. Conclusions The osteosynthesis positions as well as the plating technique play important roles in the stability of MAF repair. The only in vitro study evaluating the use of wire osteosynthesis concluded that wires placed through the lower border approach would provide greater stability than those at the upper border. Many studies indicate that the use of two miniplates avoids (or decreases) lateral displacement of the lower mandibular border and opening of the inferior fracture gap. Some studies even suggest that the use of two miniplates may be considered a more “rigid” fixation technique for MAFs than the use of a reconstruction plate. When using two miniplates, the biplanar plate orientation provides greater biomechanical stability than the monoplanar one. However, despite its greater biomechanical stability, the two-miniplate technique has some disadvantages that should also be taken into account. Studies with biodegradable plates suggest the use of at least two plates for each MAF. There are few studies with compression plates, and they have not yet reached a consensus. The solitary lag screw proved to withstand the functional loading of the mandible; however, only few biomechanical assessments were performed. In vitro studies have shown good biomechanical stability with the use of 3-D grid plates. The use of malleable miniplates alone is not sufficient to withstand the early postoperative bite force. Some studies suggest that the segment of the tension band miniplate located at the distal fragment of the MAF should be fixed with three screws. The studies also showed some limitations. None considered the stabilization of the fracture site afforded by the masseter–pterygoid muscle pouch. Most of the studies did not evaluate plating system strength in the long term and therefore did not observe the effect of resorption on the strength of the different biodegradable plating systems. Another limitation of many studies is the absence of a control group. A confounding factor that could not be tested in in vitro investigations is the additional resistance to displacement of jagged fracture margins present in the human fracture.
  •  
48.
  • Chrcanovic, Bruno, et al. (författare)
  • Flapless versus conventional flapped dental implant surgery : a meta-analysis
  • 2014
  • Ingår i: PLOS ONE. - : Public Library of Science. - 1932-6203. ; 9:6
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of this study was to test the null hypothesis of no difference in the implant failure rates, postoperative infection, and marginal bone loss for patients being rehabilitated by dental implants being inserted by a flapless surgical procedure versus the open flap technique, against the alternative hypothesis of a difference. An electronic search without time or language restrictions was undertaken in March 2014. Eligibility criteria included clinical human studies, either randomized or not. The search strategy resulted in 23 publications. The I2 statistic was used to express the percentage of the total variation across studies due to heterogeneity. The inverse variance method was used for random-effects model or fixed-effects model, when indicated. The estimates of relative effect were expressed in risk ratio (RR) and mean difference (MD) in millimeters. Sixteen studies were judged to be at high risk of bias, whereas two studies were considered of moderate risk of bias, and five studies of low risk of bias. The funnel plots indicated absence of publication bias for the three outcomes analyzed. The test for overall effect showed that the difference between the procedures (flapless vs. open flap surgery) significantly affect the implant failure rates (P = 0.03), with a RR of 1.75 (95% CI 1.07-2.86). However, a sensitivity analysis revealed differences when studies of high and low risk of bias were pooled separately. Thus, the results must be interpreted carefully. No apparent significant effects of flapless technique on the occurrence of postoperative infection (P = 0.96; RR 0.96, 95% CI 0.23-4.03) or on the marginal bone loss (P = 0.16; MD -0.07 mm, 95% CI -0.16-0.03) were observed.
  •  
49.
  • Chrcanovic, Bruno, et al. (författare)
  • Gingival cyst of the adult, lateral periodontal cyst, and botryoid odontogenic cyst : an updated systematic review
  • 2019
  • Ingår i: Oral Diseases. - : John Wiley & Sons. - 1354-523X .- 1601-0825. ; 25:1, s. 26-33
  • Forskningsöversikt (refereegranskat)abstract
    • Objective. To integrate the available data published on gingival cyst of the adult (GCA), lateral periodontal cyst (LPC) and botryoid odontogenic cyst (BOC) into a comprehensive analysis of their clinical/radiologic features. Methods. An electronic search was undertaken in July/2017. Eligibility criteria included publications having enough clinical/radiological/histological information to confirm the diagnosis. Results. 146 publications (157 GCAs, 213 LPCs, 96 BOCs) were included. GCA and LPC presented highest prevalence in the sixth/fifth decades; BOC in the sixth/seventh decades. LPCs were larger lesions than GCAs and GCAs appeared at an older age than LPC. There was no statistically significant difference between them for other factors (location, symptoms, recurrence, follow-up time). In comparison to LPC, BOC lesions were larger, appeared more often in mandible and in older subjects, had more often a multilocular appearance, and presented a higher recurrence rate. Recurrence rates: GCA (3.2%), LPC (2.4%), BOC (21.7%). No factor seems to influence the recurrence rate of GCA or LPC. Multilocular radiological appearance seems to affect the recurrence rate of BOCs. Conclusions. Conservative surgical approaches seem to be enough for GCA/LPC. BOC presents a more aggressive behavior than GCA/LPC. Therefore, treatment of this lesion might involve some kind of adjunctive therapy after enucleation.
  •  
50.
  • Chrcanovic, Bruno, et al. (författare)
  • Glandular odontogenic cyst : an updated analysis of 169 cases reported in the literature
  • 2018
  • Ingår i: Oral Diseases. - : John Wiley & Sons. - 1354-523X .- 1601-0825. ; 24:5, s. 717-724
  • Forskningsöversikt (refereegranskat)abstract
    • OBJECTIVE: To integrate the available data published on glandular odontogenic cyst (GOC) into a comprehensive analysis of its clinical/radiologic and histopathological features. METHODS: An electronic search was undertaken in May/2017. Eligibility criteria included publications having enough clinical/radiological/histological information to confirm the diagnosis. RESULTS: 58 publications (169 GOCs) were included. The lesion was slightly more prevalent in men than in women. There was a high prevalence in the fifty/sixth decades of life, in the anterior regions, and in mandibles. Lesions were commonly associated with bone expansion (73%) and unilocular radiological appearance (61.5%). GOC was found to be associated with tooth displacement or an unerupted tooth (30.9%), cortical bone perforation (26%), presence of clinical symptoms (24.3%), root resorption (13.9%). Microscopic parameters most commonly observed in GOCs - in at least 95% of the lesions: presence of hobnail cells, intraepithelial microcysts, epithelial lining with variable thickness. The presence of apocrine snouting was the microscopic parameter less often found (40.4%). CONCLUSIONS: Although the recurrence rate of GOCs is not as high as previously believed, it is a relevant phenomenon (21.6%). Adjunctive procedures after enucleation should be considered. None of the clinical/radiologic and histopathological features evaluated had a statistically significant effect on the recurrence rate.
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