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1.	Church, Timothy W., et al. (author) AKAP79 enables calcineurin to directly suppress protein kinase A activity 2021 In: eLIFE. - : eLIFE SCIENCES PUBL LTD. - 2050-084X. ; 10 Journal article (peer-reviewed)abstract Interplay between the second messengers cAMP and Ca2+ is a hallmark of dynamic cellular processes. A common motif is the opposition of the Ca2+-sensitive phosphatase calcineurin and the major cAMP receptor, protein kinase A (PKA). Calcineurin dephosphorylates sites primed by PKA to bring about changes including synaptic long-term depression (LTD). AKAP79 supports signaling of this type by anchoring PKA and calcineurin in tandem. In this study, we discovered that AKAP79 increases the rate of calcineurin dephosphorylation of type II PKA regulatory subunits by an order of magnitude. Fluorescent PKA activity reporter assays, supported by kinetic modeling, show how AKAP79-enhanced calcineurin activity enables suppression of PKA without altering cAMP levels by increasing PKA catalytic subunit capture rate. Experiments with hippocampal neurons indicate that this mechanism contributes toward LTD. This non-canonical mode of PKA regulation may underlie many other cellular processes.
2.	Sumaila, U. Rashid, et al. (author) WTO must ban harmful fisheries subsidies 2021 In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 374:6567, s. 544-544 Journal article (other academic/artistic)

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Type of publication: journal article (2)

Type of content: other academic/artistic (1); peer-reviewed (1)

Author/Editor: Hellgren Kotaleski, ... (1); Folke, Carl (1); Fanzo, Jessica (1); Troell, Max (1); Ramirez, Jorge (1); Akpalu, Wisdom (1); show more...; Stage, Jesper, 1972- (1); Pascual, Unai (1); Armitage, Derek (1); Campbell, Donovan (1); Bennett, Nathan J. (1); Yang, Hong (1); Amon, Diva J (1); Anderies, John M. (1); Tol, Richard S.J. (1); Obura, David (1); Gjerde, Kristina (1); Dewitte, Boris (1); Crépin, Anne-Sophie (1); Asche, Frank (1); Jouffray, Jean-Bapti ... (1); Bailey, Megan (1); Jacquet, Jennifer (1); Weber, Elke U. (1); Peterson, Garry (1); Levin, Simon A. (1); Barnes, Colin (1); Barrett, Scott (1); Chapin, F. Stuart (1); Polasky, Stephen (1); Scheffer, Marten (1); Gordon, Line (1); Basurto, Xavier (1); Österblom, Henrik (1); Blasiak, Robert (1); Villasante, Sebastia ... (1); List, John (1); Bennett, Elena (1); Murray, Grant (1); Jensen, Olaf P. (1); Limburg, Karin E. (1); Seto, Karen C. (1); Tewatia, Parul (1); Wabnitz, Colette C. ... (1); Yagi, Nobuyuki (1); Flaaten, Ola (1); Duarte, Carlos M. (1); Daily, Gretchen C. (1); Breitburg, Denise (1); Garçon, Véronique (1); show less...

University: Royal Institute of Technology (1); Luleå University of Technology (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Natural sciences (1); Medical and Health Sciences (1); Social Sciences (1)

Year: 2021 (2)

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