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1.
  • Balázsi, Ágnes, et al. (author)
  • Understanding cultural ecosystem services related to farmlands : Expert survey in Europe
  • 2021
  • In: Land Use Policy. - : Elsevier BV. - 0264-8377. ; 100
  • Journal article (peer-reviewed)abstract
    • Cultural ecosystem services (CES) are nonmaterial benefits that people obtain from ecosystems. The CES subcategories cover a wide range of domains (e.g. recreation, conservation of cultural heritage, human-nature relations). The CES concept has been proposed to acknowledge the nonmaterial values linking people and nature in social-ecological systems. Agricultural landscapes are outstanding examples of complex social-ecological systems where synergies and trade-offs between production and conservation determine the CES values. Europe is still rich in such landscapes/systems with outstanding cultural and natural values that deliver a multitude of CES. In this paper, we address the knowledge and perceptions of identified experts on the role of CES in the management of European agricultural landscapes. To achieve this goal, we developed a questionnaire on CES which was answered by experts working with various issues of European agricultural landscapes, including sustainable agriculture, landscape ecology, grassland management, nature conservation, cultural heritage conservation, environmental policy, sustainability research and rural development. The results show a wide knowledge and acceptance of the CES concept within such expert communities. Especially the aesthetic, cultural heritage, educational and recreational values were considered the most relevant CES subcategories. Interdisciplinary approaches, landscape planning and integrative science-policy approaches were perceived as the most promising methodologies to improve the CES approach for policy and management. Our results also show that according to experts the CES concept is still far from practical implementation in policies that target agricultural landscapes. In order to sustain such systems, we suggest the better implementation of inter- and transdisciplinary research for the development of CES-integrative policy and decision-making.
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  • Ebersole, Charles R., et al. (author)
  • Many Labs 5: Testing Pre-Data-Collection Peer Review as an Intervention to Increase Replicability
  • 2020
  • In: Advances in Methods and Practices in Psychological Science. - : Sage. - 2515-2467 .- 2515-2459. ; 3:3, s. 309-331
  • Journal article (peer-reviewed)abstract
    • Replication studies in psychological science sometimes fail to reproduce prior findings. If these studies use methods that are unfaithful to the original study or ineffective in eliciting the phenomenon of interest, then a failure to replicate may be a failure of the protocol rather than a challenge to the original finding. Formal pre-data-collection peer review by experts may address shortcomings and increase replicability rates. We selected 10 replication studies from the Reproducibility Project: Psychology (RP:P; Open Science Collaboration, 2015) for which the original authors had expressed concerns about the replication designs before data collection; only one of these studies had yielded a statistically significant effect (p < .05). Commenters suggested that lack of adherence to expert review and low-powered tests were the reasons that most of these RP:P studies failed to replicate the original effects. We revised the replication protocols and received formal peer review prior to conducting new replication studies. We administered the RP:P and revised protocols in multiple laboratories (median number of laboratories per original study = 6.5, range = 3-9; median total sample = 1,279.5, range = 276-3,512) for high-powered tests of each original finding with both protocols. Overall, following the preregistered analysis plan, we found that the revised protocols produced effect sizes similar to those of the RP:P protocols (Delta r = .002 or .014, depending on analytic approach). The median effect size for the revised protocols (r = .05) was similar to that of the RP:P protocols (r = .04) and the original RP:P replications (r = .11), and smaller than that of the original studies (r = .37). Analysis of the cumulative evidence across the original studies and the corresponding three replication attempts provided very precise estimates of the 10 tested effects and indicated that their effect sizes (median r = .07, range = .00-.15) were 78% smaller, on average, than the original effect sizes (median r = .37, range = .19-.50).
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  • Lee, Nigel, et al. (author)
  • Caesarean delivery rates and analgesia effectiveness following injections of sterile water for back pain in labour : A multicentre, randomised placebo controlled trial
  • 2020
  • In: eClinicalMedicine. - : Elsevier. - 2589-5370. ; 25
  • Journal article (peer-reviewed)abstract
    • BackgroundAbout a third of women experience severe back pain during labour. Injecting small volumes of intracutaneous sterile water into the lumbar region can be used to relieve this pain, however the procedure is controversial and previous reviews call for high quality trials to establish efficacy. We evaluated the impact on birth outcomes and analgesic effects of sterile water injections.MethodsA multicentre, double-blind trial undertaken between December 2012 and December 2017 in one British and 15 Australian maternity units. Women experiencing severe back-pain in labour were assigned (1:1) by an independently generated randomisation schedule stratified by site to injections of either sterile water or saline placebo. Participants and caregivers were blinded to group allocation. The primary outcome was caesarean delivery rate. Main secondary outcomes included at least 30% or 50% reduction in self-reported pain scores at 30, 60 and 90 minutes after treatment. Intention to treat analysis were used and the level of significance for the multiple clinical outcomes was set at p<0.001 with the Bonferroni correction applied. The study is registered with the ACTRN Registry number, ACTRN1261100022195FindingsBetween December 9, 2012, and December 15, 2017, 1166 women were recruited and randomised: 587 women received sterile water injections (SWI) and 579 a saline placebo. Seven women in the SWI group and 12 in the placebo group were excluded as consent was not completed, leaving 580 and 567, respectively, included in the analysis. The proportions of caesarean delivery were 17·1% (82 of 580) in the SWI group and 14·8% (82 of 567) in the placebo (RR 1·16, 95% CI 0·88–1.51; p = 0·293). At 30 min post treatment 60·8% (330 of 543) of women in the SWI group reported a 30% reduction in self-reported pain compared to 31·4% (163 of 520) placebo (RR 1·94, 95% CI 1·68–2·24; p=<0·001) and 43·3% (235 of 534) SWI reported a 50% reduction versus 18·1% (94 of 520) placebo (RR 2·39, 95% CI 1·95–2·94; p=<0·001). The analgesic effect of SWI compared to placebo remained significant at 60 and 90 min post-treatment. There were no significant differences in other maternal or neonatal outcomes.InterpretationCompared to placebo, injections of sterile water did not reduce rates of caesarean delivery. For the main secondary outcome of pain relief the intervention did result in significantly more women reporting at least 30% and 50% reduction in pain for up to 90 min. Water injections have no effect on birth outcomes though can be an effective treatment for the relief of labour-related back pain.
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5.
  • Maes, Dirk, et al. (author)
  • Integrating national Red Lists for prioritising conservation actions for European butterflies
  • 2019
  • In: Journal of Insect Conservation. - : Springer Science and Business Media LLC. - 1366-638X .- 1572-9753. ; 23:2, s. 301-330
  • Journal article (peer-reviewed)abstract
    • Red Lists are very valuable tools in nature conservation at global, continental and (sub-) national scales. In an attempt to prioritise conservation actions for European butterflies, we compiled a database with species lists and Red Lists of all European countries, including the Macaronesian archipelagos (Azores, Madeira and Canary Islands). In total, we compiled national species lists for 42 countries and national Red Lists for 34 of these. The most species-rich countries in Europe are Italy, Russia and France with more than 250 species each. Endemic species are mainly found on the Macaronesian archipelagos and on the Mediterranean islands. By attributing numerical values proportionate to the threat statuses in the different national Red List categories, we calculated a mean Red List value for every country (cRLV) and a weighted Red List value for every species (wsRLV) using the square root of the country’s area as a weighting factor. Countries with the highest cRLV were industrialised (NW) European countries such as the Netherlands, Belgium, the Czech Republic and Denmark, whereas large Mediterranean countries such as Spain and Italy had the lowest cRLV. Species for which a Red List assessment was available in at least two European countries and with a relatively high wsRLV (≥ 50) are Colias myrmidone, Pseudochazara orestes, Tomares nogelii, Colias chrysotheme and Coenonympha oedippus. We compared these wsRLVs with the species statuses on the European Red List to identify possible mismatches. We discuss how this complementary method can help to prioritise butterfly conservation on the continental and/or the (sub-)national scale.
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6.
  • Riegert, Kristina, 1964-, et al. (author)
  • Politainment
  • 2016
  • In: The international encyclopedia of political communication. - Oxford : John Wiley & Sons. - 9781118290750
  • Book chapter (peer-reviewed)abstract
    • The term politainment refers to the intertwining of politics and entertainment, and encompasses two processes: (1) political entertainment—how the entertainment industry exploits political topics in various entertainment formats; and (2) entertaining politics—how political actors capitalize on their celebrity (staging photo-ops, party convention spectacle, talk-show appearances, etc.) in order to enhance their images and to promote certain issues. When broadly defined, politainment moves beyond its association with infotainment to consider popular culture as a potential space for political insight and activity, and to acknowledge entertainment formats as sources of political knowledge, value orientation, and civic engagement. As a growing body of international scholarship attests, new hybrid media formats increasingly engage “political reality” across genres, conventional and new, in new television formats such as political satire and reality TV, fictionalized realism (in film, television, telenovelas, and interactive video games), and new variations of the celebrity media event genre. Such research recognizes that pleasures found in popular cultural formats of everyday life can also be ways of cultivating audiences' conscious motivations for political participation.
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10.
  • van Swaay, Chris, et al. (author)
  • The European Grassland Butterfly Indicator: 1990–2011
  • 2013
  • Reports (other academic/artistic)abstract
    • This report presents the European Grassland Butterfly Indicator, based on national Butterfly Monitoring Schemes (BMS) in 19 countries across Europe, most of them in the European Union. The indicator shows that since 1990 till 2011 butterfly populations have declined by almost 50 %, indicating a dramatic loss of grassland biodiversity. This also means the situation has not improved since the first version of the indicator published in 2005. Of the 17 species, 8 have declined in Europe, 2 have remained stable and 1 increased. For six species the trend is uncertain. The main driver behind the decline of grassland butterflies is the change in rural land use: agricultural intensification where the land is relatively flat and easy to cultivate, and abandonment in mountains and wet areas, mainly in eastern and southern Europe. Agricultural intensification leads to uniform, almost sterile grasslands for biodiversity. Grassland butterflies thus mainly survive in traditionally farmed low‑input systems (High Nature Value (HNV) Farmland) as well as nature reserves, and on marginal land such as road verges and amenity areas.
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11.
  • Wiseman, Frances K, et al. (author)
  • Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP.
  • 2018
  • In: Brain : a journal of neurology. - : Oxford University Press (OUP). - 1460-2156. ; 141:8, s. 2457-2474
  • Journal article (peer-reviewed)abstract
    • Down syndrome, caused by trisomy of chromosome 21, is the single most common risk factor for early-onset Alzheimer's disease. Worldwide approximately 6 million people have Down syndrome, and all these individuals will develop the hallmark amyloid plaques and neurofibrillary tangles of Alzheimer's disease by the age of 40 and the vast majority will go on to develop dementia. Triplication of APP, a gene on chromosome 21, is sufficient to cause early-onset Alzheimer's disease in the absence of Down syndrome. However, whether triplication of other chromosome 21 genes influences disease pathogenesis in the context of Down syndrome is unclear. Here we show, in a mouse model, that triplication of chromosome 21 genes other than APP increases amyloid-β aggregation, deposition of amyloid-β plaques and worsens associated cognitive deficits. This indicates that triplication of chromosome 21 genes other than APP is likely to have an important role to play in Alzheimer's disease pathogenesis in individuals who have Down syndrome. We go on to show that the effect of trisomy of chromosome 21 on amyloid-β aggregation correlates with an unexpected shift in soluble amyloid-β 40/42 ratio. This alteration in amyloid-β isoform ratio occurs independently of a change in the carboxypeptidase activity of the γ-secretase complex, which cleaves the peptide from APP, or the rate of extracellular clearance of amyloid-β. These new mechanistic insights into the role of triplication of genes on chromosome 21, other than APP, in the development of Alzheimer's disease in individuals who have Down syndrome may have implications for the treatment of this common cause of neurodegeneration.
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  • Result 1-11 of 11
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journal article (6)
reports (4)
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peer-reviewed (7)
other academic/artistic (4)
Author/Editor
Collins, Sue (7)
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