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| 2. |
- Cope, Henry, et al.
(författare)
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Routine omics collection is a golden opportunity for European human research in space and analog environments
- 2022
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Ingår i: PATTERNS. - : Elsevier BV. - 2666-3899. ; 3:10, s. 100550-
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Tidskriftsartikel (refereegranskat)abstract
- Widespread generation and analysis of omics data have revolutionized molecular medicine on Earth, yet its power to yield new mechanistic insights and improve occupational health during spaceflight is still to be fully realized in humans. Nevertheless, rapid technological advancements and ever-regular spaceflight programs mean that longitudinal, standardized, and cost-effective collection of human space omics data are firmly within reach. Here, we consider the practicality and scientific return of different sampling methods and omic types in the context of human spaceflight, We also appraise ethical and legal considerations pertinent to omics data derived from European astronauts and spaceflight participants (SFPs). Ultimately, we propose that a routine omics collection program in spaceflight and analog environments presents a golden opportunity. Unlocking this bright future of artificial intelligence (AI)-driven analyses and personalized medicine approaches will require further investigation into best practices, including policy design and standardization of omics data, metadata, and sampling methods.
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| 3. |
- Manzano, Aránzazu, et al.
(författare)
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Enhancing European capabilities for application of multi-omics studies in biology and biomedicine space research
- 2023
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Ingår i: iScience. - : Elsevier BV. - 2589-0042. ; 26:9
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Forskningsöversikt (refereegranskat)abstract
- Following on from the NASA twins’ study, there has been a tremendous interest in the use of omics techniques in spaceflight. Individual space agencies, NASA's GeneLab, JAXA's ibSLS, and the ESA-funded Space Omics Topical Team and the International Standards for Space Omics Processing (ISSOP) groups have established several initiatives to support this growth. Here, we present recommendations from the Space Omics Topical Team to promote standard application of space omics in Europe. We focus on four main themes: i) continued participation in and coordination with international omics endeavors, ii) strengthening of the European space omics infrastructure including workforce and facilities, iii) capitalizing on the emerging opportunities in the commercial space sector, and iv) capitalizing on the emerging opportunities in human subjects research.
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| 4. |
- Overbey, Eliah G., et al.
(författare)
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Challenges and considerations for single-cell and spatially resolved transcriptomics sample collection during spaceflight
- 2022
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Ingår i: CELL REPORTS METHODS. - : Elsevier BV. - 2667-2375. ; 2:11
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Forskningsöversikt (refereegranskat)abstract
- Single-cell RNA sequencing (scRNA-seq) and spatially resolved transcriptomics (SRT) have experienced rapid development in recent years. The findings of spaceflight-based scRNA-seq and SRT investigations are likely to improve our understanding of life in space and our comprehension of gene expression in various cell systems and tissue dynamics. However, compared to their Earth-based counterparts, gene expression experiments conducted in spaceflight have not experienced the same pace of development. Out of the hundreds of spaceflight gene expression datasets available, only a few used scRNA-seq and SRT. In this perspective piece, we explore the growing importance of scRNA-seq and SRT in space biology and discuss the challenges and considerations relevant to robust experimental design to enable growth of these methods in the field.
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| 5. |
- Rutter, Lindsay A., et al.
(författare)
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Astronaut omics and the impact of space on the human body at scale
- 2024
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
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Forskningsöversikt (refereegranskat)abstract
- Future multi-year crewed planetary missions will motivate advances in aerospace nutrition and telehealth. On Earth, the Human Cell Atlas project aims to spatially map all cell types in the human body. Here, we propose that a parallel Human Cell Space Atlas could serve as an openly available, global resource for space life science research. As humanity becomes increasingly spacefaring, high-resolution omics on orbit could permit an advent of precision spaceflight healthcare. Alongside the scientific potential, we consider the complex ethical, cultural, and legal challenges intrinsic to the human space omics discipline, and how philosophical frameworks may benefit from international perspectives. High-resolution omics data have facilitated the ongoing Human Cell Atlas project. In this Perspective, Rutter and colleagues propose that a parallel Human Cell Space Atlas initiative would provide a platform for spaceflight-associated research and healthcare.
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| 6. |
- Rutter, Lindsay, et al.
(författare)
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A New Era for Space Life Science : International Standards for Space Omics Processing
- 2020
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Ingår i: PATTERNS. - : Elsevier BV. - 2666-3899. ; 1:9, s. 100148-
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Forskningsöversikt (refereegranskat)abstract
- Space agencies have announced plans for human missions to the Moon to prepare for Mars. However, the space environment presents stressors that include radiation, microgravity, and isolation. Understanding how these factors affect biology is crucial for safe and effective crewed space exploration. There is a need to develop countermeasures, to adapt plants and microbes for nutrient sources and bioregenerative life support, and to limit pathogen infection. Scientists across the world are conducting space omics experiments onmodel organisms and, more recently, on humans. Optimal extraction of actionable scientific discoveries fromtheseprecious datasets will only occur at the collective level with improved standardization. To address this shortcoming, we established ISSOP (International Standards for Space Omics Processing), an international consortium of scientists who aim to enhance standard guidelines between space biologists at a global level. Here we introduce our consortium and share past lessons learned and future challenges related to spaceflight omics.
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| 7. |
- Rutter, Lindsay A., et al.
(författare)
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Protective alleles and precision healthcare in crewed spaceflight
- 2024
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
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Forskningsöversikt (refereegranskat)abstract
- Common and rare alleles are now being annotated across millions of human genomes, and omics technologies are increasingly being used to develop health and treatment recommendations. However, these alleles have not yet been systematically characterized relative to aerospace medicine. Here, we review published alleles naturally found in human cohorts that have a likely protective effect, which is linked to decreased cancer risk and improved bone, muscular, and cardiovascular health. Although some technical and ethical challenges remain, research into these protective mechanisms could translate into improved nutrition, exercise, and health recommendations for crew members during deep space missions. As space travel promises to become a reality for more humans, insights from human genetics could serve to inform space medicine. Here, the authors overview genetic variants that might confer a protective effect in space, and ethical and technical challenges to translating these findings.
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| 8. |
- Glasbey, JC, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 9. |
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| 10. |
- Bravo, L, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 11. |
- Tabiri, S, et al.
(författare)
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- 2021
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swepub:Mat__t
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