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1.	Kanai, M, et al. (author) 2023 swepub:Mat__t
2.	Niemi, MEK, et al. (author) 2021 swepub:Mat__t
3.	Ridker, PM, et al. (author) Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients 2017 In: The New England journal of medicine. - 1533-4406 .- 0028-4793. ; 376:16, s. 1527-1539 Journal article (peer-reviewed)
4.	Alvarez, Mariano J., et al. (author) A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors 2018 In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:7, s. 979-989 Journal article (peer-reviewed)abstract We introduce and validate a new precision oncology framework for the systematic prioritization of drugs targeting mechanistic tumor dependencies in individual patients. Compounds are prioritized on the basis of their ability to invert the concerted activity of master regulator proteins that mechanistically regulate tumor cell state, as assessed from systematic drug perturbation assays. We validated the approach on a cohort of 212 gastroenteropancreatic neuroendocrine tumors (GEP-NETs), a rare malignancy originating in the pancreas and gastrointestinal tract. The analysis identified several master regulator proteins, including key regulators of neuroendocrine lineage progenitor state and immunoevasion, whose role as critical tumor dependencies was experimentally confirmed. Transcriptome analysis of GEP-NET-derived cells, perturbed with a library of 107 compounds, identified the HDAC class I inhibitor entinostat as a potent inhibitor of master regulator activity for 42% of metastatic GEP-NET patients, abrogating tumor growth in vivo. This approach may thus complement current efforts in precision oncology.
5.	Kim, Dae-Kyum, et al. (author) EVpedia: A Community Web Portal for Extracellular Vesicles Research 2015 In: Bioinformatics. - : Oxford University Press (OUP). - 1367-4803 .- 1367-4811. ; 31:6, s. 933-939 Journal article (peer-reviewed)abstract Motivation: Extracellular vesicles (EVs) are spherical bilayered proteolipids, harboring various bioactive molecules. Due to the complexity of the vesicular nomenclatures and components, online searches for EV-related publications and vesicular components are currently challenging. Results: We present an improved version of EVpedia, a public database for EVs research. This community web portal contains a database of publications and vesicular components, identification of orthologous vesicular components, bioinformatic tools and a personalized function. EVpedia includes 6879 publications, 172 080 vesicular components from 263 high-throughput datasets, and has been accessed more than 65 000 times from more than 750 cities. In addition, about 350 members from 73 international research groups have participated in developing EVpedia. This free web-based database might serve as a useful resource to stimulate the emerging field of EV research.

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Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Brown, J. (2); Clark, A. (2); Cole, S. (2); Davies, M. (2); Endo, M. (2); Erdmann, J. (2); show more...; Fox, H. (2); Hasegawa, Y. (2); Hughes, G. (2); Jackson, M. (2); Jackson, P. (2); Karthik, K. (2); Lee, H. (2); Lewis, A. (2); Maeno, T. (2); Price, D. (2); Saleem, M. (2); Suzuki, Y. (2); Walker, R. (2); White, S. (2); Williams, S. (2); Wilson, A. (2); Wright, M. (2); Wu, Y. (2); Yamada, M. (2); Nagata, K. (2); Davidson, N. (2); Dobson, E. (2); Harvey, A. (2); Lange, C. (2); Oliveira, M. (2); Rose, A. (2); Grau, N. (2); Haider, S. (2); Tokunaga, K. (2); Davies, E (2); Suzuki, S (2); Gupta, A. (2); Robinson, M. (2); Dennis, C. (2); Marshall, R. (2); Smith, M. (2); Martin, J. (2); Mbarek, H (2); Davies, G (2); Harris, C (2); Kumar, S (2); Brown, A. (2); Brown, E. (2); Clark, M. (2); show less...

University: Lund University (2); Karolinska Institutet (2); University of Gothenburg (1); Umeå University (1); Stockholm University (1)

Language: English (5)

Research subject (UKÄ/SCB): Natural sciences (2); Medical and Health Sciences (2)

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