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1.	Sandahl, Julie Damgaard, et al. (author) t(6;9)(p22; q34)/DEK-NUP214-rearranged pediatric myeloid leukemia : an international study of 62 patients 2014 In: Haematologica. - : Ferrata Storti Foundation (Haematologica). - 0390-6078 .- 1592-8721. ; 99:5, s. 865-872 Journal article (peer-reviewed)abstract Acute myeloid leukemia with t(6; 9)(p22; q34) is listed as a distinct entity in the 2008 World Health Organization classification, but little is known about the clinical implications of t(6; 9)-positive myeloid leukemia in children. This international multicenter study presents the clinical and genetic characteristics of 62 pediatric patients with t(6; 9)/DEKNUP214-rearranged myeloid leukemia; 54 diagnosed as having acute myeloid leukemia, representing <1% of all childhood acute myeloid leukemia, and eight as having myelodysplastic syndrome. The t(6; 9)/DEK-NUP214 was associated with relatively late onset (median age 10.4 years), male predominance (sex ratio 1.7), French-American-British M2 classification (54%), myelodysplasia (100%), and FLT3-ITD (42%). Outcome was substantially better than previously reported with a 5-year event-free survival of 32%, 5-year overall survival of 53%, and a 5-year cumulative incidence of relapse of 57%. Hematopoietic stem cell transplantation in first complete remission improved the 5-year event-free survival compared with chemotherapy alone (68% versus 18%; P<0.01) but not the overall survival (68% versus 54%; P=0.48). The presence of FLT3-ITD had a non-significant negative effect on 5-year overall survival compared with non-mutated cases (22% versus 62%; P=0.13). Gene expression profiling showed a unique signature characterized by significantly higher expression of EYA3, SESN1, PRDM2/RIZ, and HIST2H4 genes. In conclusion, t(6; 9)/DEK-NUP214 represents a unique subtype of acute myeloid leukemia with a high risk of relapse, high frequency of FLT3-ITD, and a specific gene expression signature.
2.	Damgaard-Sandahl, J, et al. (author) Hyperdiploidy in Childhood AML Associated with Low Age and AML-M7. A NOPHO-AML Study and Literature Review 2011 In: Blood. ; 118:21, s. 1505-1505 Conference paper (peer-reviewed)

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Type of publication: conference paper (1); journal article (1)

Type of content: peer-reviewed (2)

Author/Editor: Hasle, Henrik (2); Forestier, Erik (2); Abrahamsson, Jonas, ... (1); Zeller, Bernward (1); Jonsson, Olafur G. (1); Kaspers, Gertjan J. ... (1); show more...; Lausen, Birgitte (1); Heldrup, Jesper (1); Jahnukainen, Kirsi (1); Palle, Josefine (1); Johansson, Bertil (1); Kjeldsen, Eigil (1); Raimondi, Susana C (1); Harbott, Jochen (1); Auvrignon, Anne (1); Beverloo, H Berna (1); Harrison, Christine ... (1); Perot, Christine (1); Tomizawa, Daisuke (1); Zwaan, C Michel (1); van den Heuvel-Eibri ... (1); Locatelli, Franco (1); de Haas, Valerie (1); Masetti, Riccardo (1); Liang, Der-Cherng (1); Coenen, Eva A (1); Damgaard-Sandahl, J (1); Chilton, Lucy (1); Kerndrup, Gitte (1); Zecca, Marco (1); Inaba, Hiroto (1); Adachi, Souichi (1); Cayuela, Jean Michel (1); Sandahl, Julie Damga ... (1); von Neuhoff, Nils (1); Fornerod, Maarten (1); Reinhardt, Katarina (1); show less...

University: Umeå University (2); University of Gothenburg (1); Lund University (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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