| 1. |
- Aad, G., et al.
(author)
-
Commissioning of the ATLAS Muon Spectrometer with cosmic rays
- 2010
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 70:3, s. 875-916
-
Journal article (peer-reviewed)abstract
- The ATLAS detector at the Large Hadron Collider has collected several hundred million cosmic ray events during 2008 and 2009. These data were used to commission the Muon Spectrometer and to study the performance of the trigger and tracking chambers, their alignment, the detector control system, the data acquisition and the analysis programs. We present the performance in the relevant parameters that determine the quality of the muon measurement. We discuss the single element efficiency, resolution and noise rates, the calibration method of the detector response and of the alignment system, the track reconstruction efficiency and the momentum measurement. The results show that the detector is close to the design performance and that the Muon Spectrometer is ready to detect muons produced in high energy proton-proton collisions.
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Aad, G., et al.
(author)
-
Readiness of the ATLAS Tile Calorimeter for LHC collisions
- 2010
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 70:4, s. 1193-1236
-
Journal article (peer-reviewed)abstract
- The Tile hadronic calorimeter of the ATLAS detector has undergone extensive testing in the experimental hall since its installation in late 2005. The readout, control and calibration systems have been fully operational since 2007 and the detector has successfully collected data from the LHC single beams in 2008 and first collisions in 2009. This paper gives an overview of the Tile Calorimeter performance as measured using random triggers, calibration data, data from cosmic ray muons and single beam data. The detector operation status, noise characteristics and performance of the calibration systems are presented, as well as the validation of the timing and energy calibration carried out with minimum ionising cosmic ray muons data. The calibration systems' precision is well below the design value of 1%. The determination of the global energy scale was performed with an uncertainty of 4%.
|
|
| 5. |
- Aad, G., et al.
(author)
-
Studies of the performance of the ATLAS detector using cosmic-ray muons
- 2011
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 71:3
-
Journal article (peer-reviewed)abstract
- Muons from cosmic-ray interactions in the atmosphere provide a high-statistics source of particles that can be used to study the performance and calibration of the ATLAS detector. Cosmic-ray muons can penetrate to the cavern and deposit energy in all detector subsystems. Such events have played an important role in the commissioning of the detector since the start of the installation phase in 2005 and were particularly important for understanding the detector performance in the time prior to the arrival of the first LHC beams. Global cosmic-ray runs were undertaken in both 2008 and 2009 and these data have been used through to the early phases of collision data-taking as a tool for calibration, alignment and detector monitoring. These large datasets have also been used for detector performance studies, including investigations that rely on the combined performance of different subsystems. This paper presents the results of performance studies related to combined tracking, lepton identification and the reconstruction of jets and missing transverse energy. Results are compared to expectations based on a cosmic-ray event generator and a full simulation of the detector response.
|
|
| 6. |
- Aad, G., et al.
(author)
-
The ATLAS Inner Detector commissioning and calibration
- 2010
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 70:3, s. 787-821
-
Journal article (peer-reviewed)abstract
- The ATLAS Inner Detector is a composite tracking system consisting of silicon pixels, silicon strips and straw tubes in a 2 T magnetic field. Its installation was completed in August 2008 and the detector took part in data-taking with single LHC beams and cosmic rays. The initial detector operation, hardware commissioning and in-situ calibrations are described. Tracking performance has been measured with 7.6 million cosmic-ray events, collected using a tracking trigger and reconstructed with modular pattern-recognition and fitting software. The intrinsic hit efficiency and tracking trigger efficiencies are close to 100%. Lorentz angle measurements for both electrons and holes, specific energy-loss calibration and transition radiation turn-on measurements have been performed. Different alignment techniques have been used to reconstruct the detector geometry. After the initial alignment, a transverse impact parameter resolution of 22.1 +/- 0.9 mu m and a relative momentum resolution sigma (p) /p=(4.83 +/- 0.16)x10(-4) GeV(-1)xp (T) have been measured for high momentum tracks.
|
|
| 7. |
- Aad, G., et al.
(author)
-
The ATLAS Simulation Infrastructure
- 2010
-
In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 70:3, s. 823-874
-
Journal article (peer-reviewed)abstract
- The simulation software for the ATLAS Experiment at the Large Hadron Collider is being used for large-scale production of events on the LHC Computing Grid. This simulation requires many components, from the generators that simulate particle collisions, through packages simulating the response of the various detectors and triggers. All of these components come together under the ATLAS simulation infrastructure. In this paper, that infrastructure is discussed, including that supporting the detector description, interfacing the event generation, and combining the GEANT4 simulation of the response of the individual detectors. Also described are the tools allowing the software validation, performance testing, and the validation of the simulated output against known physics processes.
|
|
| 8. |
- Abata, E., et al.
(author)
-
Study of energy response and resolution of the ATLAS barrel calorimeter to hadrons of energies from 20 to 350 GeV
- 2010
-
In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier. - 0168-9002 .- 1872-9576 .- 0167-5087. ; 621:1-3, s. 134-150
-
Journal article (peer-reviewed)abstract
- A fully instrumented slice of the ATLAS detector was exposed to test beams from the SPS (Super Proton Synchrotron) at CERN in 2004. In this paper, the results of the measurements of the response of the barrel calorimeter to hadrons with energies in the range 20-350 GeV and beam impact points and angles corresponding to pseudo-rapidity values in the range 0.2-0.65 are reported. The results are compared to the predictions of a simulation program using the Geant 4 toolkit. (C) 2010 Published by Elsevier B.V.
|
|
| 9. |
- Anselm, Jonas, et al.
(author)
-
Bannlys alla politiska beslut som ger mer klimatutsläpp
- 2014
-
In: Dagens Nyheter.
-
Journal article (other academic/artistic)abstract
- Torftig valdebatt. Dagspolitiken klarar inte att hantera ödesfrågan om klimatet, vilket oroar oss. Vi föreslår därför ett ”utsläppsmoratorium”: inga beslut får tas som ökar utsläppen av växthusgaser. Principen måste kopplas till mål om exempelvis förnybar energi och grön infrastruktur, skriver 23 forskare och debattörer.
|
|
| 10. |
|
|
| 11. |
|
|
| 12. |
- Danielsson, Jonas, 1973-
(author)
-
Skräckskönt : en etnologisk studie
- 2006
-
Doctoral thesis (other academic/artistic)abstract
- The aim of the present study is to explore how horror movie fans use the films to gain access to certain emotions, and the discussions to which the movies give rise. Through this, I hope to attain a deeper understanding of how the horror movie fan chooses to view the genre. While horror movie fans experience a raft of emotions as they watch, this is not the whole story; they also reflect upon these emotions and question certain responses, eg. why laugh at one form of violence but not the next, or how can one killer elicit empathy in the viewer while others do not. In order to understand this popular genre I have based my thesis mainly on interviews with the actual horror film fan, here represented by 9 women and 11 men. Special emphasis in the theoretical body is placed on Bakhtin’s notion of the grotesque, a ”world turned upside-down”, and dialogical truth. The horror movie fan might be described in the same fashion – as someone who through the films he watches sees and acknowledges an alternative cultural system which is otherwise suppressed. They can experiment with ideas of other kinds of rules, norms and hierarchies than those already in place in society. The horror movie fans talk about special themes as more important than others, and these “key symbols” have helped in constructing the thesis. I have for that reason formed the analysis in the region of emotions like fear, disgust and desires, but also more intellectual discussions on film violence and evil. It is clear that a controlled sense of fear is one of the main forces sparking the initial interest the informants felt for horror and urging them forward in their quest for more. It is also clear that feelings of disgust the horror movies evoke are a part of the fans’ discussions about the world and the evil therein. The horror movie fans speak about evil as something inherent in everyone, and something which must be acknowledged in order to live a “full” life. Despite of all this I consider pure enjoyment and entertainment to be the very foundation of their shared interest, and that the horror movie fans try to make strong distinctions between “fact” and “fiction”. These conscious distinctions could also be one of the reasons that the fans find these types of movies entertaining. Those who are incapable to make these clear distinctions are therefore, more or less, unable to see the purpose of the fascination with horror narratives.
|
|
| 13. |
- Danielsson, Louise, 1979, et al.
(author)
-
To sense and make sense of anxiety: Physiotherapists' perceptions of their treatment for patients with generalized anxiety.
- 2013
-
In: Physiotherapy theory and practice. - : Informa UK Limited. - 1532-5040 .- 0959-3985. ; 29:8, s. 604-615
-
Journal article (peer-reviewed)abstract
- The generalized anxiety is characterized by long-term psychological and physiological discomfort. Pharmacological and psychotherapeutic interventions have been extensively examined, whereas knowledge is scant regarding other professional perspectives. This article focuses on the physiotherapeutic perspective on anxiety, exploring physiotherapists' perceptions of their treatment for patients with generalized anxiety. Semi-structured interviews were conducted with 10 physiotherapists working in psychiatry or primary health care. Data were analysed using qualitative content analysis, resulting in one main category and five subcategories. The main category "To sense and make sense of one's anxiety" reflects the idea that physiotherapy works through immediate, tangible bodily experiences to help a person understand and handle his or her anxiety better. Five subcategories reflected different aspects of this main category: (1) the body is the arena of anxiety, (2) to get in touch with oneself, (3) to get down-to-earth with oneself, (4) to make sense of bodily sensations, and (5) to gain trust in one's capability to handle anxiety. In conclusion, the gradual bodily awareness of sensations, to sense and make sense of anxiety in physiotherapy treatment, becomes an opportunity to find ways to withstand and to manage symptoms of anxiety, encouraging an embodied self-trust. The emphasis on the immediately lived body involves the potential to learn how to endure anxiety instead of running away from it, to discern and to understand different sensations, leading to an integration of anxiety as being part of oneself rather than overflowing oneself.
|
|
| 14. |
|
|
| 15. |
|
|
| 16. |
- Danielsson, Marianne, 1968-, et al.
(author)
-
En vänbok till en vän av det goda samtalet
- 2024
-
In: Samtal om idéer, utvärdering och samhällsförändring. - Uppsala : Acta Universitatis Upsaliensis. - 9789151320083 ; , s. 9-15
-
Book chapter (other academic/artistic)
|
|
| 17. |
- Danielsson, Marianne, 1968-
(author)
-
Fängslande idéer : Svensk miljöpolitik och teorier om policyproduktion
- 2010
-
Doctoral thesis (other academic/artistic)abstract
- This thesis investigates the role of ideas in policy processes. It does so using three theories as a starting point, selected for being alike yet unique in their description of how ideas may “get stuck” in the organization’s production and reproduction of policy. The theories are Discourse Coalition Framework, Advocacy Coalition Framework, and Punctuated Equilibrium Theory. These theories have very different emphases but share constructivist traits and an interest in how social processes of meaning making take form in a rather “traditional” organizational setting, thus paying attention to, if not reducing the study to, the institutions of representative democracy.Two theoretical problems are identified within these theories. They concern 1) the mechanism and 2) the object of analysis. The theoretical question addressed in part I is: How are we to understand the proposition that ideas may cause stability in policy processes? What is the underlying mechanism? It is argued that the cognitive mechanism which the theories use should be substituted with a social psychological one. The assumption that stability is created when political actors conform to the ideas of others when they are confronted with apparent unanimity among policy makers, rather than that they internalize these ideas, makes both greater stability and instability in policy processes more plausible.Part II poses the question; if we are to investigate policy stability and instability using the discussed theoretical perspective, what unit of analysis should we use? In other words, what is a policy? It is argued that if ideological stability is seen as an effect of how policy formulation is organized (as is argued in part I), then close attention must be paid to processual factors when it is decided what unit of policy, on what level, might be explained. It is furthermore argued that although we may theoretically form an idea about substantially coherent patterns of policy recognizable as a policy, which should result from stable organizational patterns of communication in the policy process, it remains an empirical question if and where these patterns can actually be found. An analysis of Swedish environmental policy is performed to allow for observations of the degree to which empirical evidence is consistent with the policy patterns predicted by the theoretical assumptions outlined in part one.
|
|
| 18. |
- Danielsson, Marianne, 1968-
(author)
-
Fängslande idéer i politik och teori : En teoretisk granskning
- 2008
-
Licentiate thesis (other academic/artistic)abstract
- I den snabbt växande litteraturen om idéer i policyprocessen, som ibland kallats ”the ideational turn” tänker man sig ofta att idéer och språk styr politikens aktörer, snarare än styrs av dem. Hur politiska problem formuleras styr vilka lösningar som ter sig rimliga. Intresset riktas mot politik som intellektuell verksamhet. Dessutom tänker man sig att de resulterande tänkesätten kring problem och lösningar – tolkningsramarna eller problembilderna – tenderar att börja leva sitt eget liv, och utanför aktörernas direkta kontroll påverka det politiska beslutsfattandet. Påståenden om verkligheten och värderingspåståenden blir alltså med ett sådant perspektiv väsentliga, eftersom de antas utgöra utgångspunkt och ram för den fortsatta formuleringen av den offentliga politiken. De stänger in och riktar blicken. I den här avhandlingen ska ett antal teorier, med stor tilltro till slagkraftiga idéers förmåga att styra och organisera tanke och handling vid utformning och upprätthållande av offentlig politik, skärskådas och prövas teoretiskt. Målet är att urskilja huruvida dessa innehåller empiriskt prövvärda teoretiska påståenden om idéers funktion i policyprocesser. Med utgångspunkt i en teorigenomgång argumenterar jag för att det verkar rimligt att förvänta sig att stabila eller instängande idéstrukturer hänger samman med stabil interaktion i policyprocesser. I så fall är det likaledes rimligt att undersöka hur reproduktion av idéer, och tröghet i förändring av policy, förhåller sig till det sätt på vilket politiken och policyproduktionen är organiserad. Ett sådant perspektiv innebär alltså att policyproduktion bör undersökas utifrån de organisatoriska och institutionella villkor som präglar den konkreta intellektuella verksamhet som krävs för att policybeslut ska materialiseras. Teorier som tycks svara mot detta krav är Maarten Hajers Discourse Coalition Framework, Paul Sabatier och Hank Jenkins-Smiths Advocacy Coalition Framework och Frank Baumgartners och Bryan Jones Punctuated Equilibrium Theory. De valda teoretikerna beskriver idéer som mer eller mindre trögrörliga sociala konstruktioner, som både är förankrade i och organiserar policyprocessen – även om de inte själva uttrycker det så. De kan alltså ses som olika teoribildningar inom samma teoriperspektiv. I avhandlingen identifieras flera problem i detta teorperspektiv. De handlar alla om de kognitiva låsningar som teorierna förutsätter som förklaringar till stabil policyproduktion. Jag menar att teorierna, för det första, inte på ett tillfredställande sätt lyckas lösa struktur-aktörproblemet utan glider mellan en föreställning om individen som ömsom strukturernas slav och ömsom dess herre, mer beroende på vad som behövs för att lösa förklaringsekvationen än på vad som verkar rimligt och troligt. För det andra ifrågasätter jag, mot bakgrund av det begränsade sociala sammanhang som en policysektor oftast är, rimligheten i att anta att det normala är att den diskurs som präglar ett politikområde förmår definiera världen för policyprocessens aktörer. För det tredje argumenterar jag för att sättet att beskriva de politiska aktörerna som i tanken ”infärgade” av en organisatoriskt, institutionellt eller socialt förankrad diskurs begränsar möjligheten att göra policyanalys till politisk maktanalys. Ett särskilt kapitel ägnas därför åt olika möjligheter att konceptualisera idéstrukturernas relation till aktörerna i policyprocesser. Detta hänger också ihop med förståelsen av makt. Jag menar nämligen att frågan om vad idéstrukturerna gör med aktörerna i policyprocessen är nära sammankopplad med hur vi ska förstå maktrelationerna i denna process. I centrum för avsnittet står den idéernas sociala praktik som är språk, kommunikation och samtal: den språkliga praktik där idéer kommer till uttryck. Frågan som ställs i detta kapitel är om det finns andra sätt än teoriernas antagande om ”kognitiv inlåsning” att tala om politiska idéer som en faktor för makt och inflytande. Detta i sin tur beror på huruvida det finns alternativa sätt att förstå idéstrukturers effekter på policyprocessens aktörer. Och om det går att på ett rimligare och mer konsistent sätt beskriva hur idéer kan skapa maktrelationer, kan vi därmed omvärdera Baumgartner och Jones, Sabatier och Jenkins Smiths, och Hajers teorier i ljuset av dessa insikter? I föreliggande text argumenterar jag för att svaret är ja på båda dessa frågor. Det nästföljande kapitlet ägnas därför åter dessa teorier, nu med fokus på hur de ska prövas empiriskt. Jag diskuterar dels olikheter mellan teorierna beträffande vilka konkreta arenor och aktörer de menar spelar roll för stabilitet i och förändring av policy, dels hur dessa påståenden kan ”översättas” till en prövning i svensk kontext. Diskussionen summeras i ett antal ur teorierna härledda prövbara, delvis konkurrerande, påståenden om hur idéer strukturerar policyprocessen. Det femte avslutande kapitlet summerar hela avhandlingen.
|
|
| 19. |
|
|
| 20. |
|
|
| 21. |
|
|
| 22. |
|
|
| 23. |
- Danielsson Malmros, Ingmarie, 1959-, et al.
(author)
-
Women, gender, and the fight for gender equality in Europe
- 2022. - 1
-
In: Re-imagining the Teaching of European History. - London : Routledge. - 9781032294278 - 9781032294261 ; , s. 193-205
-
Book chapter (peer-reviewed)abstract
- This chapter proposes the theme of the history of travel and travelers for a comprehensive approach to teaching and learning history for active citizenship education. In particular, we analyze briefly on the historical ways: itineraries, routes, and cultures. From the routes of faith to the itineraries and routes of trade to the routes of conflict (European explorations and conquests in the Americas, from the crusades to the world wars) and their participants; your travel and trade. Over the millennia, the sea has been the main vector of trade and the Mediterranean ports have been crucial places for the economy. Networks of exchanges from foodstuffs to metals, from timber to grain, spices and textiles, men, women, slaves, yesterday as still today; the journeys and mirages of forced nomads. These are contents that through an active methodology can offer a critical approach to the phenomenon of travel considered decisive for the elaboration of European societies and make students acquire a vision of the complex relationships existing between different cultures through an approach by outcomes of history. Knowing the fundamental moments and processes of the European history of time travel with glances at world history starting also from personal and local history and expounding historical knowledge by making connections and arguing one’s own reflections, we believe can develop education for democratic citizenship through critical and responsible behavior inspired by the values of freedom and solidarity at all levels of organized life (local, national, European, and world).
|
|
| 24. |
- Danielsson, Tatiana
(author)
-
Further Investigations of Convergence Results for Homogenization Problems with Various Combinations of Scales
- 2020
-
Doctoral thesis (other academic/artistic)abstract
- This thesis is based on six papers. We study the homogenization of selected parabolic problems with one or more microscopic scales in space and time, respectively. The approaches are prepared by means of certain methods, like two-scale convergence, multiscale convergence and also the evolution setting of multiscale convergence and very weak multiscale convergence. Paper I treats a linear parabolic homogenization problem with rapid spatial and temporal oscillations in perforated domains. Suitable results of two-scale convergence type are established. Paper II deals with further development of compactness results which can be used in the homogenization procedure engaging a certain limit condition. The homogenization procedure deals with a parabolic problem with a certain matching between a fast spatial and a fast temporal scale and a coefficient passing to zero that the time derivative is multiplied with. Papers III and IV are further generalizations of Paper II and investigate homogenization problems with different types of matching between the microscopic scales. Papers III and IV deal with one and two rapid scales in both space and time respectively. Paper V treats the nonlinearity of monotone parabolic problems with an arbitrary number of spatial and temporal scales by applying the perturbed test functions method together with multiscale convergence and very weak multiscale convergence adapted to the evolution setting. In Paper VI we discuss the relation between two-scale convergence and the unfolding method and potential extensions of existing results. The papers above are summarized in Chapter 4. Chapter 1 gives a brief introduction to the topic and Chapters 2 and 3 are surveys over some important previous results.
|
|
| 25. |
- Danielsson, Tatiana, et al.
(author)
-
Homogenization of monotone parabolic problems with an arbitrary number of spatial and temporal scales
- 2024
-
In: Applications of Mathematics. - : Institute of Mathematics, Czech Academy of Sciences. - 0862-7940 .- 1572-9109. ; 69:1, s. 1-24
-
Journal article (peer-reviewed)abstract
- In this paper we prove a general homogenization result for monotone parabolic problems with an arbitrary number of microscopic scales in space as well as in time, where the scale functions are not necessarily powers of epsilon. The main tools for the homogenization procedure are multiscale convergence and very weak multiscale convergence, both adapted to evolution problems. At the end of the paper an example is given to concretize the use of the main result.
|
|
| 26. |
|
|
| 27. |
- Denvall, Verner, et al.
(author)
-
Forskningens relevans, användbarhet, användning och nytta – 30 år senare
- 2024
-
In: Samtal om idéer, utvärdering och samhällsförändring. : En vänbok till Evert Vedung - En vänbok till Evert Vedung. - 9789151320083 ; 2, s. 51-51
-
Book chapter (other academic/artistic)abstract
- Kapitlet ingår i en festskrift till professor emeritus Evert Vedung och har publicerats i Acta Universitatis Upsaliensis vid Uppsala universitet som ett av 25 kapitel i en forskarantlogi om utvärdering. I kapitlet återvänder jag till Vedungs rapport "Forskningens relevans, användbarhet, användning och nytta" från 1993. Det är en delrapport från ett treårigt FoU-projekt finansierat av Byggforskningsrådet (BFR) med syfte att utveckla en modell för att underlätta bedömning av FoU-kunskap. Ambitionen var att skapa checklistor som skulle kunna rutinisera ansökningar, beredning och utvärdering av forskning och därmed avgöra vad som var samhällsrelevant. Evert Vedung ville utreda hur forskningsresultat kan mätas med utgångspunkten att forskning måste vara användbar även utanför forskarsamhället. I kapitlet undersöker jag hur hans argument om vad som gör forskning relevant står sig trettio år senare. Framställningen präglas av dagens diskussioner om forskningens användbarhet med begrepp som kunskaps- och faktaresistens.
|
|
| 28. |
|
|
| 29. |
|
|
| 30. |
|
|
| 31. |
|
|
| 32. |
|
|
| 33. |
- Kimbung, Siker, et al.
(author)
-
Contrasting breast cancer molecular subtypes across serial tumor progression stages: biological and prognostic implications.
- 2015
-
In: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 6:32, s. 33306-18
-
Journal article (peer-reviewed)abstract
- The relevance of the intrinsic subtypes for clinical management of metastatic breast cancer is not comprehensively established. We aimed to evaluate the prevalence and prognostic significance of drifts in tumor molecular subtypes during breast cancer progression. A well-annotated cohort of 304 women with advanced breast cancer was studied. Tissue microarrays of primary tumors and synchronous lymph node metastases were constructed. Conventional biomarkers were centrally assessed and molecular subtypes were assigned following the 2013 St Gallen guidelines. Fine-needle aspirates of asynchronous metastases were transcriptionally profiled and subtyped using PAM50. Discordant expression of individual biomarkers and molecular subtypes was observed during tumor progression. Primary luminal-like tumors were relatively unstable, frequently adopting a more aggressive subtype in the metastases. Notably, loss of ER expression and a luminal to non-luminal subtype conversion was associated with an inferior post-recurrence survival. In addition, ER and molecular subtype assessed at all tumor progression stages were independent prognostic factors for post-recurrence breast cancer mortality in multivariable analyses. Our results demonstrate that drifts in tumor molecular subtypes may occur during tumor progression, conferring adverse consequences on outcome following breast cancer relapse.
|
|
| 34. |
- Kimbung, Siker, et al.
(author)
-
Transcriptional Profiling of Breast Cancer Metastases Identifies Liver Metastasis-Selective Genes Associated with Adverse Outcome in Luminal A Primary Breast Cancer
- 2016
-
In: Clinical Cancer Research. - : AMER ASSOC CANCER RESEARCH. - 1078-0432 .- 1557-3265. ; 22:1, s. 146-157
-
Journal article (peer-reviewed)abstract
- Purpose: The complete molecular basis of the organ-specificity of metastasis is elusive. This study aimed to provide an independent characterization of the transcriptional landscape of breast cancer metastases with the specific objective to identify liver metastasis-selective genes of prognostic importance following primary tumor diagnosis. Experimental Design: A cohort of 304 women with advanced breast cancer was studied. Associations between the site of recurrence and clinicopathologic features were investigated. Fine-needle aspirates of metastases (n = 91) were subjected to whole-genome transcriptional profiling. Liver metastasis-selective genes were identified by significance analysis of microarray (SAM) analyses and independently validated in external datasets. Finally, the prognostic relevance of the liver metastasis-selective genes in primary breast cancer was tested. Results: Liver relapse was associated with estrogen receptor (ER) expression (P = 0.002), luminal B subtype (P = 0.01), and was prognostic for an inferior postrelapse survival (P = 0.01). The major variation in the transcriptional landscape of metastases was also associated with ER expression and molecular subtype. However, liver metastases displayed unique transcriptional fingerprints, characterized by down-regulation of extracellular matrix (i.e., stromal) genes. Importantly, we identified a 17-gene liver metastasis-selective signature, which was significantly and independently prognostic for shorter relapse-free (P < 0.001) and overall (P = 0.001) survival in ER-positive tumors. Remarkably, this signature remained independently prognostic for shorter relapse-free survival (P = 0.001) among luminal A tumors. Conclusions: Extracellular matrix (stromal) genes can be used to partition breast cancer by site of relapse and may be used to further refine prognostication in ER positive primary breast cancer. (C)2015 AACR.
|
|
| 35. |
|
|
| 36. |
- Mickwitz, Per, et al.
(author)
-
Att använda eller inte använda: det är frågan
- 2024
-
In: Samtal om idéer, utvärdering och samhällsförändring : En vänbok till Evert Vedung - En vänbok till Evert Vedung. - 9789151320083 ; , s. 147-158
-
Book chapter (other academic/artistic)
|
|
| 37. |
|
|
| 38. |
|
|
| 39. |
- Aad, G., et al.
(author)
-
- 2012
-
In: Nuclear Physics, Section B. - : Elsevier BV. - 0550-3213 .- 1873-1562. ; 864:3, s. 341-381
-
Journal article (peer-reviewed)
|
|
