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- Cochius-den Otter, S, et al.
(author)
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The CoDiNOS trial protocol: an international randomised controlled trial of intravenous sildenafil versus inhaled nitric oxide for the treatment of pulmonary hypertension in neonates with congenital diaphragmatic hernia
- 2019
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In: BMJ open. - : BMJ. - 2044-6055. ; 9:11, s. e032122-
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Journal article (peer-reviewed)abstract
- Congenital diaphragmatic hernia (CDH) is a developmental defect of the diaphragm that impairs normal lung development, causing pulmonary hypertension (PH). PH in CDH newborns is the main determinant for morbidity and mortality. Different therapies are still mainly based on ‘trial and error’. Inhaled nitric oxide (iNO) is often the drug of first choice. However, iNO does not seem to improve mortality. Intravenous sildenafil has reduced mortality in newborns with PH without CDH, but prospective data in CDH patients are lacking.Methods and analysisIn an open label, multicentre, international randomised controlled trial in Europe, Canada and Australia, 330 newborns with CDH and PH are recruited over a 4-year period (2018–2022). Patients are randomised for intravenous sildenafil or iNO. Sildenafil is given in a loading dose of 0.4 mg/kg in 3 hours; followed by continuous infusion of 1.6 mg/kg/day, iNO is dosed at 20 ppm. Primary outcome is absence of PH on day 14 without pulmonary vasodilator therapy and/or absence of death within the first 28 days of life. Secondary outcome measures include clinical and echocardiographic markers of PH in the first year of life. We hypothesise that sildenafil gives a 25% reduction in the primary outcome from 68% to 48% on day 14, for which a sample size of 330 patients is needed. An intention-to-treat analysis will be performed. A p-value (two-sided) <0.05 is considered significant in all analyses.Ethics and disseminationEthics approval has been granted by the ethics committee in Rotterdam (MEC-2017-324) and the central Committee on Research Involving Human Subjects (NL60229.078.17) in the Netherlands. The principles of the Declaration of Helsinki, the Medical Research Involving Human Subjects Act and the national rules and regulations on personal data protection will be used. Parental informed consent will be obtained.Trial registration numberNTR6982; Pre-results.
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| 2. |
- Gray, I., et al.
(author)
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A novel approach for the autonomous inspection and repair of aircraft composite structures
- 2019
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In: <em>18<sup>th</sup> European Conference on Composite Materials </em>(ECCM). - : Applied Mechanics Laboratory.
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Conference paper (other academic/artistic)abstract
- The paper presents the results obtained in the first two years of the H2020 CompInnova project which deals with the development of an innovative approach for inspection and repair of damage in aeronautical composites. The development of a newly designed robotic platform for autonomous inspection using combined infrared thermography (IRT) and phased array (PA) non-destructive investigation for damage detection and characterization, while integrated with laser repair capabilities. PA and IRT are combined in order to detect near-surface and sub-surface damages. Development of a novel thermographic technique termed Pulsed Phase-informed Lock-In Thermography, enables for the first time the rapid and quantitative assessment of damage in the materials. Furthermore, the results are fused using machine learning and image processing techniques for detection and sizing in real time. This will provide the information needed for an automatic laser repair procedure capable of removing precisely ply-by-ply the material. This method allows to have a well-treated surface to apply a repair patch. The three different modules (PA, IRT and laser repair) are integrated on an autonomous robotic platform. The robot is going to be able to attach and move on surfaces of different orientations via the use of a vortex-based actuation system, thus providing the ability to autonomously access, scan and repair the different sections of an aircraft fuselage. © CCM 2020 - 18th European Conference on Composite Materials. All rights reserved.
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| 3. |
- Kostopoulos, V., et al.
(author)
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Autonomous Inspection and Repair of Aircraft Composite Structures
- 2018
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In: 18th IFAC Conference on Technology, Culture and International Stability TECIS 2018. - : Elsevier. ; , s. 554-557, s. 554-557
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Conference paper (peer-reviewed)abstract
- This paper deals with the development of an innovative approach for inspection and repair of damage in aeronautical composites that took place in the first two years of the H2020 Compinnova project which. The aim is a newly designed robotic platform for autonomous inspection using combined infrared thermography (IRT) and phased array (PA) non-destructive investigation for damage detection and characterization, while integrated with laser repaircapabilities. This will affect the increasing societal need for safer aircraft in the lowest possible cost, while new and effective techniques of inspection are needed because of the rapidly expanding use of composites in the aerospace industry.
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