| 1. |
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| 2. |
- Gomez, L. F., et al.
(author)
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Shapes and vorticities of superfluid helium nanodroplets
- 2014
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 345:6199, s. 906-909
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Journal article (peer-reviewed)abstract
- Helium nanodroplets are considered ideal model systems to explore quantum hydrodynamics in self-contained, isolated superfluids. However, exploring the dynamic properties of individual droplets is experimentally challenging. In this work, we used single-shot femtosecond x-ray coherent diffractive imaging to investigate the rotation of single, isolated superfluid helium-4 droplets containing ~108 to 1011 atoms. The formation of quantum vortex lattices inside the droplets is confirmed by observing characteristic Bragg patterns from xenon clusters trapped in the vortex cores. The vortex densities are up to five orders of magnitude larger than those observed in bulk liquid helium. The droplets exhibit large centrifugal deformations but retain axially symmetric shapes at angular velocities well beyond the stability range of viscous classical droplets.
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| 3. |
- Legendre, C. M., et al.
(author)
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Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic-Uremic Syndrome
- 2013
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In: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 368:23, s. 2169-2181
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Journal article (peer-reviewed)abstract
- Background Atypical hemolytic-uremic syndrome is a genetic, life-threatening, chronic disease of complement-mediated thrombotic microangiopathy. Plasma exchange or infusion may transiently maintain normal levels of hematologic measures but does not treat the underlying systemic disease. Methods We conducted two prospective phase 2 trials in which patients with atypical hemolytic-uremic syndrome who were 12 years of age or older received eculizumab for 26 weeks and during long-term extension phases. Patients with low platelet counts and renal damage (in trial 1) and those with renal damage but no decrease in the platelet count of more than 25% for at least 8 weeks during plasma exchange or infusion (in trial 2) were recruited. The primary end points included a change in the platelet count (in trial 1) and thrombotic microangiopathy event-free status (no decrease in the platelet count of >25%, no plasma exchange or infusion, and no initiation of dialysis) (in trial 2). Results A total of 37 patients (17 in trial 1 and 20 in trial 2) received eculizumab for a median of 64 and 62 weeks, respectively. Eculizumab resulted in increases in the platelet count; in trial 1, the mean increase in the count from baseline to week 26 was 73x10(9) per liter (P<0.001). In trial 2, 80% of the patients had thrombotic microangiopathy event-free status. Eculizumab was associated with significant improvement in all secondary end points, with continuous, time-dependent increases in the estimated glomerular filtration rate (GFR). In trial 1, dialysis was discontinued in 4 of 5 patients. Earlier intervention with eculizumab was associated with significantly greater improvement in the estimated GFR. Eculizumab was also associated with improvement in health-related quality of life. No cumulative toxicity of therapy or serious infection-related adverse events, including meningococcal infections, were observed through the extension period. Conclusions Eculizumab inhibited complement-mediated thrombotic microangiopathy and was associated with significant time-dependent improvement in renal function in patients with atypical hemolytic-uremic syndrome.
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| 4. |
- Rolles, D., et al.
(author)
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Femtosecond x-ray photoelectron diffraction on gas-phase dibromobenzene molecules
- 2014
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In: Journal of Physics B: Atomic, Molecular and Optical Physics. - : IOP Publishing. - 0953-4075 .- 1361-6455. ; 47:12
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Journal article (peer-reviewed)abstract
- We present time-resolved femtosecond photoelectron momentum images and angular distributions of dissociating, laser-aligned 1,4-dibromobenzene (C6H4Br2) molecules measured in a near-infrared pump, soft-x-ray probe experiment performed at an x-ray free-electron laser. The observed alignment dependence of the bromine 2p photoelectron angular distributions is compared to density functional theory calculations and interpreted in terms of photoelectron diffraction. While no clear time-dependent effects are observed in the angular distribution of the Br(2p) photoelectrons, other, low-energy electrons show a pronounced dependence on the time delay between the near-infrared laser and the x-ray pulse.
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| 5. |
- Armbrecht, G., et al.
(author)
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Vertebral Scheuermann's disease in Europe: prevalence, geographic variation and radiological correlates in men and women aged 50 and over
- 2015
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In: Osteoporosis International. - : Springer Science and Business Media LLC. - 1433-2965 .- 0937-941X. ; 26:10, s. 2509-2519
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Journal article (peer-reviewed)abstract
- The Summary In 27 centres across Europe, the prevalence of deforming spinal Scheuermann's disease in age-stratified population-based samples of over 10,000 men and women aged 50+ averaged 8 % in each sex, but was highly variable between centres. Low DXA BMD was un-associated with Scheuermann's, helping the differential diagnosis from osteoporosis. Introduction This study aims to assess the prevalence of Scheuermann's disease of the spine across Europe in men and women over 50 years of age, to quantitate its association with bone mineral density (BMD) and to assess its role as a confounder for the radiographic diagnosis of osteoporotic fracture. Methods In 27 centres participating in the population-based European Vertebral Osteoporosis Study (EVOS), standardised lateral radiographs of the lumbar and of the thoracic spine from T4 to L4 were assessed in all those of adequate quality. The presence of Scheuermann's disease, a confounder for prevalent fracture in later life, was defined by the presence of at least one Schmorl's node or irregular endplate together with kyphosis (sagittal Cobb angle > 40A degrees between T4 and T12) or a wedged-shaped vertebral body. Alternatively, the (rare) Edgren-Vaino sign was taken as diagnostic. The 6-point-per-vertebral-body (13 vertebrae) method was used to assess osteoporotic vertebral shape and fracture caseness. DXA BMD of the L2-L4 and femoral neck regions was measured in subsets. We also assessed the presence of Scheuermann's by alternative published algorithms when these used the radiographic signs we assessed. Results Vertebral radiographic images from 4486 men and 5655 women passed all quality checks. Prevalence of Scheuermann's varied considerably between centres, and based on random effect modelling, the overall European prevalence using our method was 8 % with no significant difference between sexes. The highest prevalences were seen in Germany, Sweden, the UK and France and low prevalences were seen in Hungary, Poland and Slovakia. Centre-level prevalences in men and women were highly correlated. Scheuermann's was not associated with BMD of the spine or hip. Conclusions Since most of the variation in population impact of Scheuermann's was unaccounted for by the radiological and anthropometric data, the search for new genetic and environmental determinants of this disease is encouraged.
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| 6. |
- Delmonte, B., et al.
(author)
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Geographic provenance of aeolian dust in East Antarctica during Pleistocene glaciations : preliminary results from Talos Dome and comparison with East Antarctic and new Andean ice core data
- 2010
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In: Quaternary Science Reviews. - : Elsevier BV. - 0277-3791 .- 1873-457X. ; 29:02-jan, s. 256-264
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Journal article (peer-reviewed)abstract
- The strontium and neodymium isotopic signature of aeolian mineral particles archived in polar ice cores provides constraints on the geographic provenance of dust and paleo-atmospheric circulation patterns. Data from different ice cores drilled in the centre of the East Antarctic plateau such as EPICA-Dome C (EDC, 75 degrees 06'S: 123 degrees 21'E) and Vostok (78 degrees 28'S, 106 degrees 48'E) suggested a uniform geographic provenance for dust during Pleistocene glacial ages, likely from southern South America (SSA). In this work the existing dust isotopic data from EDC have been integrated with new data from Marine Isotopic Stage (MIS) 14 (about 536 ka before 1950AD) and in parallel some first results are shown for the new TALDICE ice core which was drilled on the edge of the East Antarctic Plateau (Talos Dome, 72 degrees 48'S, 159 degrees 06'E) on the opposite side with respect to SSA. Interestingly, the isotopic composition of TALDICE glacial dust is remarkably similar to that obtained from glacial dust from sites located in the East Antarctic interior. Overall, the glacial dust isotopic field obtained from six East Antarctic ice cores matches well South American data obtained from target areas. In this respect, it was recently suggested that dust exported long-range from South America originates from Patagonia and from the Puna-Altiplano plateau. To test this hypothesis, we analysed the isotopic composition of dust from an ice core drilled on the Illimani glacier (Bolivia, 16 degrees 37'S, 67 degrees 46'W; 6350 m a.s.l.) in order to obtain information on the isotopic composition of regional mineral aerosol uplifted from the Altiplano area and likely transported over a long distance. Altogether, ice core and source data strongly suggest that the westerly circulation pattern allowed efficient transfer of dust from South America to the East Antarctic plateau under cold Quaternary climates. Isotopic data support the hypothesis of a possible mixing of dust from Patagonia and from the Puna-Altiplano plateau. Interestingly, high glacial dust inputs to Antarctica are characterized by less radiogenic Nd values, an issue suggesting that enhanced dust production in Patagonia was associated with the activation of a secondary source. Still, Patagonia was the most important supplier for dust to central East Antarctica during Quaternary glaciations.
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| 7. |
- Armbrecht, Gabriele, et al.
(author)
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Degenerative inter-vertebral disc disease osteochondrosis intervertebralis in Europe : Prevalence, geographic variation and radiological correlates in men and women aged 50 and over
- 2017
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In: Rheumatology. - : Oxford University Press (OUP). - 1462-0324 .- 1462-0332. ; 56:7, s. 1189-1199
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Journal article (peer-reviewed)abstract
- Objectives. To assess the prevalences across Europe of radiological indices of degenerative inter-vertebral disc disease (DDD); and to quantify their associations with, age, sex, physical anthropometry, areal BMD (aBMD) and change in aBMD with time. Methods. In the population-based European Prospective Osteoporosis Study, 27 age-stratified samples of men and women from across the continent aged 50+ years had standardized lateral radiographs of the lumbar and thoracic spine to evaluate the severity of DDD, using the Kellgren-Lawrence (KL) scale. Measurements of anterior, mid-body and posterior vertebral heights on all assessed vertebrae from T4 to L4 were used to generate indices of end-plate curvature. Results. Images from 10 132 participants (56% female, mean age 63.9 years) passed quality checks. Overall, 47% of men and women had DDD grade 3 or more in the lumbar spine and 36% in both thoracic and lumbar spine. Risk ratios for DDD grades 3 and 4, adjusted for age and anthropometric determinants, varied across a three-fold range between centres, yet prevalences were highly correlated in men and women. DDD was associated with flattened, non-ovoid inter-vertebral disc spaces. KL grade 4 and loss of inter-vertebral disc space were associated with higher spine aBMD. Conclusion. KL grades 3 and 4 are often used clinically to categorize radiological DDD. Highly variable European prevalences of radiologically defined DDD grades 3+ along with the large effects of age may have growing and geographically unequal health and economic impacts as the population ages. These data encourage further studies of potential genetic and environmental causes.
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| 8. |
- Charpentier Ljungqvist, Fredrik, 1982-, et al.
(author)
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Regional Patterns of Late Medieval and Early Modern European Building Activity Revealed by Felling Dates
- 2022
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In: Frontiers in Ecology and Evolution. - : Frontiers Media SA. - 2296-701X. ; 9
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Journal article (peer-reviewed)abstract
- Although variations in building activity are a useful indicator of societal well-being and demographic development, historical datasets for larger regions and longer periods are still rare. Here, we present 54,045 annually precise dendrochronological felling dates from historical construction timber from across most of Europe between 1250 and 1699 CE to infer variations in building activity. We use geostatistical techniques to compare spatiotemporal dynamics in past European building activity against independent demographic, economic, social and climatic data. We show that the felling dates capture major geographical patterns of demographic trends, especially in regions with dense data coverage. A particularly strong negative association is found between grain prices and the number of felling dates. In addition, a significant positive association is found between the number of felling dates and mining activity. These strong associations, with well-known macro-economic indicators from pre-industrial Europe, corroborate the use of felling dates as an independent source for exploring large-scale fluctuations of societal well-being and demographic development. Three prominent examples are the building boom in the Hanseatic League region of northeastern Germany during the 13th century, the onset of the Late Medieval Crisis in much of Europec. 1300, and the cessation of building activity in large parts of central Europe during armed conflicts such as the Thirty Years’ War (1618–1648 CE). Despite new insights gained from our European-wide felling date inventory, further studies are needed to investigate changes in construction activity of high versus low status buildings, and of urban versus rural buildings, and to compare those results with a variety of historical documentary sources and natural proxy archives.
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| 11. |
- Ismail, AA, et al.
(author)
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Incidence of limb fracture across Europe: Results from the European Prospective Osteoporosis Study (EPOS)
- 2002
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In: Osteoporosis International. - : Springer Science and Business Media LLC. - 1433-2965 .- 0937-941X. ; 13:7, s. 565-571
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Journal article (peer-reviewed)abstract
- The aim of this population-based prospective study was to determine the incidence of limb fracture by site and gender in different regions of Europe. Men and women aged 50-79 years were recruited from population registers in 31 European centers. Subjects were invited to attend for an interviewer-administered questionnaire and lateral spinal radiographs. Subjects were subsequently followed up using an annual postal questionnaire which included questions concerning the occurrence of new fractures. Self-reported fractures were confirmed where possible by radiograph, attending physician or subject interview. There were 6451 men and 6936 women followed for a median of 3.0 years. During this time there were 140 incident limb fractures in men and 391 in women. The age-adjusted incidence of any limb fracture was 7,3/1000 person-years [pyrs] in men and 19 per 1000 pyrs in women, equivalent to a 2,5 times excess in women. Among women, the incidence of hip, humerus and distal forearm fracture, though not 'other' limb fracture, increased with age, while in men only the incidence of hip and humerus fracture increased with age. Among women, there was evidence of significant variation in the occurrence of hip, distal forearm and humerus fractures across Europe, with incidence rates higher in Scandinavia than in other European regions. though for distal forearm fracture the incidence in east Europe was similar to that observed in Scandinavia. Among men, there was no evidence of significant geographic variation in the occurrence of these fractures. This is the first large population-based study to characterize the incidence of limb fracture in men and women over 50 years of age across Europe. There are substantial differences in the descriptive epidemiology of limb fracture by region and gender.
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| 21. |
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| 22. |
- Delmas, M., et al.
(author)
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HOT MWIR T2SL detectors to reduce system : Size, weight, and power
- 2021
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In: Sensors, Systems, and Next-Generation Satellites XXV. - : SPIE - International Society for Optical Engineering.
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Conference paper (peer-reviewed)abstract
- In 2019, IRnova launched a full-scale production of a reduced size, weight and power integrated detector dewar cooler assemblies (Oden MW; VGA format with 15 μm pixel pitch) covering the full mid-wavelength infrared spectral domain (3.7 μm - 5.1 μm). Oden MW exhibits excellent performance with operating temperatures up to 110 K at F/5.5 with typical values of temporal and spatial noise equivalent temperature of 22 mK and 7 mK, respectively, and an operability higher than 99.85%. More recently, IRnova developed a new detector design with a cut-off wavelength of 5.3 μm which can potentially allow an operating temperature of the detector up to 150K with excellent performance demonstrated on single pixels with a quantum efficiency as high as 46% at 4 μm without antireflection coating, a turn on bias lower than -100 mV and a dark current density as low as 8 × 10-6 A/cm2, which is a factor of < 5 higher than Rule07. The dark current was also found independent of the device size ranging from 10 μm to 223 μm indicating that surface leakage currents are not limiting the dark current. The achievable operating temperature of an FPA made of this new detector design has been estimated to be <150 K with F/5.5 optics. These outstanding results demonstrate that this new generation of detector design is an excellent candidate for future high operating temperature and high-definition focal plane array.
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| 23. |
- Delmas, RJ, et al.
(author)
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Bomb-test Cl-36 measurements in Vostok snow (Antarctica) and the use of Cl-36 as a dating tool for deep ice cores
- 2004
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In: Tellus. Series B: Chemical and Physical Meteorology. - : Stockholm University Press. - 0280-6509. ; 56:5, s. 492-498
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Journal article (peer-reviewed)abstract
- A large pulse of atmospheric Cl-36 generated by a limited number of nuclear tests peaked in the late 1950s to early 1960s. The corresponding enhanced Cl-36 deposition is seen in various glaciological archives in the Northern Hemisphere. The profile of the bomb spike recorded in firn layers at Vostok Station, central East Antarctica. has been measured by employing accelerator mass spectrometry (AMS). The records obtained front two well-dated data sets collected in snow pits in 1997 and 1998 show a broad Cl-36 peak, beginning as early as the 1940s and reaching its maximum in the 1960s. The signal is followed by a long-lasting tail up to the surface. This pattern is totally unexpected. We show that the results, unlike the Greenland data, can be explained by a mobility of HCl in the Antarctic firn. This experiment demonstrates the instability of gaseous Cl- deposits. a phenomenon which has important implications for the use of natural cosmogenic Cl-36 radionuclides as a reliable dating tool for deep ice cores from low-accumulation areas. However, during glacial times, under favourable atmospheric chemistry conditions this dating method may still be applicable. Snow metamorphism and ventilation are assumed to be the two main physical processes responsible for the observed patterns.
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| 27. |
- Karlsson, M K, et al.
(author)
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Indicators of bone formation in weight lifters
- 1995
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In: Calcified Tissue International. - 1432-0827. ; 56:3, s. 177-180
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Journal article (peer-reviewed)abstract
- Physical activity has been suggested to be one of the determinants of bone turnover and to prevent age-related bone loss. To examine this we measured the serum levels of osteocalcin (bone Gla-protein, BGP), C-terminal procollagen peptide (PICP), serum alkaline phosphatase, bone-specific alkaline phosphatase, and S-calcium as indices of bone formation in 19 actively performing and 15 ex-lifters. All were nationally or internationally ranked male athletes. Their values were compared with those from 38 age- and gender-matched controls. Actively performing weight lifters had 35% higher (P < 0.05) serum concentration of osteocalcin than the controls. The ex-lifters did not differ from the age-matched controls. Also serum calcium was elevated in active lifters (6%) (P < 0.01) but not in ex-lifters. No difference was found for serum-ALP, B-ALP, or PICP in either of the groups. Our study indicates that in addition to an already documented and well-known higher bone mineral density in heavily exercising athletes, they have an indication of higher bone formation as measured by biochemical markers. In athletes who have retired from competitional training, however, the bone formation does not differ from that of more sedentary controls.
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| 30. |
- Ramos Santesmases, David, et al.
(author)
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Optical concentration in fully delineated mid-wave infrared T2SL detectors arrays
- 2023
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In: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 123:18
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Journal article (peer-reviewed)abstract
- The dependence of quantum efficiency (QE) on fill factor and pixel pitch is studied theoretically and experimentally in fully delineated type-II superlattice (T2SL) detectors. Theoretically, a 2-dimensional simulation model is used to compute the absorption in the array geometry, which shows an insensitivity of the optical response to the fill factor. This is a result of the photodiode array (PDA) geometry concentrating the light in the pixel area. QE measurements on PDAs with varying pixel pitch (from 225 to 10 μm) and fill factors (from 98% to 64%) confirm this independence of the QE on the fill factor and results in a 50% increase in the photocurrent density in 10 μm pitch PDAs compared to 225 μm pitch PDAs. Furthermore, measurements of the dark current density vs pixel size revealed an absence of surface leakage in these PDAs, which, combined with the increased photocurrent density results in an improved signal-to-noise ratio when reducing the pitch in these T2SL detectors. Finally, this result resolves the QE-modulation transfer function trade-off, as the electrical isolation of the pixel is carried out without impacting the QE of the array.
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| 31. |
- Ramos Santesmases, David, et al.
(author)
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Quasi-3-dimensional simulations and experimental validation of surface leakage currents in high operating temperature type-II superlattice infrared detectors
- 2022
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In: Journal of Applied Physics. - : AIP Publishing. - 0021-8979 .- 1089-7550. ; 132:20, s. 204501-
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Journal article (peer-reviewed)abstract
- The surface leakage in InAs/GaSb type-II superlattice (T2SL) is studied experimentally and theoretically for photodiodes with small sizes down to 10 x 10 mu m(2). The dependence of dark current density on mesa size is studied at 110 and 200 K, and surface leakage is shown to impact both generation-recombination (GR) and diffusion dark current mechanisms. A quasi-3-dimensional model to simulate the fabrication process using surface traps on the pixel's sidewall is presented and is used to accurately represent the dark current of large and small pixels with surface leakage in the different temperature regimes. The simulations confirmed that the surface leakage current has a GR and diffusion component at low and high temperature, respectively. Finally, the surface leakage current has been correlated with the change in minority carrier concentration at the surface due to the presence of donor traps.
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| 32. |
- Ramos Santesmases, David, et al.
(author)
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Simulation and Characterization of the Modulation Transfer Function in Fully Delineated Type-II Superlattices Infrared Detectors
- 2024
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In: IEEE Transactions on Electron Devices. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9383 .- 1557-9646. ; 71:4, s. 2459-2464
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Journal article (peer-reviewed)abstract
- The modulation transfer function (MTF) in fully delineated 15 μ m pitch type-II superlattice (T2SL) mid-wave infrared (IR) detectors is studied theoretically and experimentally. Theoretically, a 2-D model to simulate the spot scan (SS) profile is presented and used to compute the MTF as a function of the wavelength and the array geometry (pitch size, trench width). The dependence of the detector trench on the MTF is also evaluated experimentally by the edge spread function (ESF) method according to the ISO12233 standard. The experimental results show an excellent agreement with the theoretical model, reporting an MTF of 0.61 and 0.60 at the Nyquist frequency for 1 and 2 μ m trench, respectively. With the simulation model, the effect of the increased optical crosstalk for smaller pixel pitch is discussed as a function of the trench width (0.5, 1, and 2 μ m) and incidence angle up to ± 30 ∘ . Simulation results show MTF values at the Nyquist frequency between 0.61–0.62, 0.58–0.60, and 0.55–0.57 with an average degradation of 1%, 2%, and 7% at an angle of ± 30 ∘ compared to normal incidence for the 10, 7.5, and 5 μ m pitch, respectively.
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| 33. |
- Reginster, JY, et al.
(author)
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Recommendations for an update of the current (2001) regulatory requirements for registration of drugs to be used in the treatment of osteoporosis in postmenopausal women and in men
- 2006
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In: Osteoporosis International. - : Springer Science and Business Media LLC. - 1433-2965 .- 0937-941X. ; 17:1, s. 41281-41281
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Journal article (other academic/artistic)abstract
- Recent advances in the understanding of the epidemiology of osteoporosis suggest that certain parts of the current European guidelines for the registration of drugs in osteoporosis might be no longer substantiated. The object of this review is to provide the European regulatory authorities with an evidence-based working document providing suggestions for the revision of the "Note for guidance for the approval of drugs to be used in postmenopausal osteoporosis" (CPMP/EWP/552/95). Following an extensive review of the literature (1990-2004), the Group for the Respect of Ethics and Excellence in Science (GREES) organized a workshop including European regulators, academic scientists and representatives of the pharmaceutical industry. The outcomes of this meeting reflect the personal views of those who attended and should not, in any case, be seen as an official position paper of any regulatory agency. The group identified a certain number of points that deserve discussion. They mainly relate to the nature of the indication being granted to new chemical entities (treatment of osteoporosis in women at high risk of fracture instead of prevention and treatment of osteoporosis), the requirements of showing an anti-fracture efficacy on all or on major nonvertebral fractures (instead of the hip), the duration of pivotal trials (2 years instead of 3) and the possibility of considering bridging studies for new routes of administration, new doses or new regimens of previously approved drugs. The group also recommends that an indication could be granted for the treatment of osteoporosis in males on the basis of a placebo-controlled study, with bone mineral density changes after 1 year as the primary endpoint, for medications approved in the treatment of osteoporosis in women at high risk of fractures.
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| 34. |
- Sanjuan-Delmás, David, et al.
(author)
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Environmental assessment of copper production in Europe: an LCA case study from Sweden conducted using two conventional software-database setups
- 2022
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In: The International Journal of Life Cycle Assessment. - : Springer. - 0948-3349 .- 1614-7502. ; 27:2, s. 255-266
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Journal article (peer-reviewed)abstract
- PurposeThis study focuses on the environmental assessment of European copper production. Life cycle assessment is applied to analyse copper cathode production in Sweden, including its mining (an open-pit mine) and refining (pyrometallurgy), and using two combinations of software and databases: SimaPro software with ecoinvent database and GaBi software with GaBi database. The results are compared with results from other case studies from literature.MethodsA cradle-to-gate LCA was conducted considering 1 tonne of copper as functional unit. The inventory for the foreground system was elaborated using primary data gathered by the staff from the mine, the concentrator and the smelter. For the background data, LCA databases are used considering datasets for the Swedish market whenever possible. As the smelter has multiple useful outputs, economic allocation was applied at the inventory level. The calculation method CML-IA baseline 3.5 was considered for both combinations of software and database, reporting all the impact categories of the method plus the Cumulative Energy Demand.Results and discussionThe inventory of the system and the main environmental hotspots were presented, such as the explosives for blasting (due to their supply chain) or the electricity used in the concentrator. The results obtained with the two combinations of LCA software and databases yield large differences for categories such as abiotic depletion (7.5 times higher for SimaPro and ecoinvent), possibly due to differences in the system boundaries of the databases and the characterisation factors of the method. Although the case study has a relatively high cumulative energy demand (140/168 kMJ/tonne Cu) compared to other mines, its performance in global warming (3.5/4.7 tonne CO2eq/tonne Cu) is much better due to the low greenhouse gas emissions from electricity, which shows that the electricity mix is a key aspect.ConclusionsThe environmental performance of mining depends partially on the specific conditions of the deposit, e.g., the ore grade and the mining type. LCA practitioners should consider the potential different results that can be obtained using different combinations of software and database and exert caution when comparing cases, especially for abiotic depletion, human toxicity and ecotoxicity categories. Finally, the use of renewable energies can be key to improve the environmental sustainability of copper production.
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