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1.
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2.
  • Kristan, Matej, et al. (author)
  • The first visual object tracking segmentation VOTS2023 challenge results
  • 2023
  • In: 2023 IEEE/CVF International conference on computer vision workshops (ICCVW). - : Institute of Electrical and Electronics Engineers Inc.. - 9798350307443 - 9798350307450 ; , s. 1788-1810
  • Conference paper (peer-reviewed)abstract
    • The Visual Object Tracking Segmentation VOTS2023 challenge is the eleventh annual tracker benchmarking activity of the VOT initiative. This challenge is the first to merge short-term and long-term as well as single-target and multiple-target tracking with segmentation masks as the only target location specification. A new dataset was created; the ground truth has been withheld to prevent overfitting. New performance measures and evaluation protocols have been created along with a new toolkit and an evaluation server. Results of the presented 47 trackers indicate that modern tracking frameworks are well-suited to deal with convergence of short-term and long-term tracking and that multiple and single target tracking can be considered a single problem. A leaderboard, with participating trackers details, the source code, the datasets, and the evaluation kit are publicly available at the challenge website1
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3.
  • Sun, Jie, 1977, et al. (author)
  • Electrochemical Bubbling Transfer of Graphene Using a Polymer Support with Encapsulated Air Gap as Permeation Stopping Layer
  • 2016
  • In: Journal of Nanomaterials. - : Hindawi Limited. - 1687-4129 .- 1687-4110. ; 2016
  • Journal article (peer-reviewed)abstract
    • Electrochemical bubbling transfer of graphene is a technique with high industrial potential due to its scalability, time- and cost-effectiveness, and ecofriendliness. However, the graphene is often damaged due to the turbulence and the trapped bubbles formed by the direct H2O and H+ permeation through the supporting polymer. We invent a graphene mechanical support of polyethylene terephthalate foil/plastic frame/poly(methyl methacrylate) sandwich, with an encapsulated air gap as the permeation stopping layer. The graphene damage is drastically reduced, as confirmed by the morphology and structural and electrical characterization, ultimately improving the controllability/reproducibility of the bubbling transfer of graphene and other two-dimensional materials.
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5.
  • Ablikim, M., et al. (author)
  • Search for h(c) -> pi(+)pi(-) J/psi via psi(3686) -> pi(0)pi(+)pi(-) J/psi
  • 2018
  • In: Physical Review D. - : American Physical Society. - 2470-0010 .- 2470-0029. ; 97:5
  • Journal article (peer-reviewed)abstract
    • Using a data sample of 448.1 x 10(6) psi(3686) events collected with the BESIII detector operating at the BEPCII, we perform search for the hadronic transition h(c)-> pi(+)pi(-) J/psi via psi (3686) -> pi(0)hc. No signals of the transition are observed, and the upper limit on the product branching fraction B(sigma(3686) -> pi(0)h(c))B(h(c) -> pi(+)pi(-) J/psi) at the 90% confidence level (C. L.) is determined to be 2.0 x 10(-6). This is the most stringent upper limit to date.
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6.
  • Chen, Jie, et al. (author)
  • Antioxidants, minerals and vitamins in relation to Crohn's disease and ulcerative colitis : A Mendelian randomization study
  • 2023
  • In: Alimentary Pharmacology and Therapeutics. - : John Wiley & Sons. - 0269-2813 .- 1365-2036. ; 57:4, s. 399-408
  • Journal article (peer-reviewed)abstract
    • BackgroundEvidence for antioxidants, minerals and vitamins in relation to the risk of Crohn's disease (CD) and ulcerative colitis (UC) is limited and inconsistent. This mendelian randomization (MR) study aimed to examine the causal associations of circulating levels of antioxidants, minerals and vitamins with CD and UC.MethodsSingle-nucleotide polymorphisms associated with antioxidants (beta-carotene, lycopene and uric acid), minerals (copper, calcium, iron, magnesium, phosphorus, zinc and selenium), and vitamins (folate, vitamins A, B6, B12, C, D, E and K1) were employed as instrumental variables. Genetic associations with CD and UC were extracted from the UK Biobank, the FinnGen study and the International Inflammatory Bowel Disease Genetics Consortium. The inverse variance weighted method and sensitivity analyses were performed.ResultsGenetically predicted higher lycopene (OR = 0.94, 95% CI: 0.91–0.97), vitamins D (OR = 0.65, 95% CI: 0.54–0.79) and K1 (OR = 0.93, 95% CI: 0.90–0.97) levels were inversely associated with CD risk, whereas genetically predicted higher magnesium (OR = 1.53, 95% CI: 1.23–1.90) levels were positively associated with CD risk. Higher levels of genetically predicted lycopene (OR = 0.91, 95% CI: 0.88–0.95), phosphorus (OR = 0.69, 95% CI: 0.58–0.82), selenium (OR = 0.91, 95% CI: 0.85–0.97), zinc (OR = 0.91, 95% CI: 0.89–0.94), folate (OR = 0.71, 95% CI: 0.56–0.92) and vitamin E (OR = 0.78, 95% CI: 0.69–0.88) were associated with reduced UC risk, whereas genetically predicted high levels of calcium (OR = 1.46, 95% CI: 1.22–1.76) and magnesium (OR = 1.24, 95% CI: 1.03–1.49) were associated with increased risk of UC.ConclusionsOur study provided evidence that circulating levels of antioxidants, minerals and vitamins might be causally linked to the development of IBD.
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7.
  • Chen, Jie, et al. (author)
  • Sedentary lifestyle, physical activity, and gastrointestinal diseases : evidence from mendelian randomization analysis
  • 2024
  • In: EBioMedicine. - : Elsevier. - 2352-3964. ; 103
  • Journal article (peer-reviewed)abstract
    • Background: The causal associations of physical activity and sedentary behavior with the risk of gastrointestinal disease are unclear. We performed a Mendelian randomization analysis to examine these associations.Methods: Genetic instruments associated with leisure screen time (LST, an indicator of a sedentary lifestyle) and moderate-to-vigorous intensity physical activity (MVPA) at the genome-wide significance (P < 5 x 10-8) level were selected from a genome-wide association study. Summary statistics for gastrointestinal diseases were obtained from the UK Biobank study, the FinnGen study, and large consortia. Multivariable MR analyses were conducted for genetically determined LST with adjustment for MVPA and vice versa. We also performed multivariable MR with adjustment for genetically proxied smoking, body mass index (BMI), waist-to-hip ratio, type 2 diabetes, and fasting insulin for both exposures.Findings: Genetically proxied longer LST was associated with an increased risk of gastrointestinal reflux, gastric ulcer, duodenal ulcer, chronic gastritis, irritable bowel syndrome, diverticular disease, Crohn's disease, ulcerative colitis, non-alcoholic fatty liver disease, alcoholic liver disease, cholangitis, cholecystitis, cholelithiasis, acute pancreatitis, chronic pancreatitis, and acute appendicitis. Most associations remained after adjustment for genetic liability to MVPA. Genetic liability to MVPA was associated with decreased risk of gastroesophageal reflux, gastric ulcer, chronic gastritis, irritable bowel syndrome, cholecystitis, cholelithiasis, acute and chronic pancreatitis. The associations attenuated albeit directionally remained after adjusting for genetically predicted LST. Multivariable MR analysis found that BMI and type 2 diabetes mediated the associations of LST and MVPA with several gastrointestinal diseases.Interpretation: The study suggests that a sedentary lifestyle may play a causal role in the development of many gastrointestinal diseases.
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8.
  • Chu, Audrey Y, et al. (author)
  • Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation
  • 2017
  • In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 49:1, s. 125-130
  • Journal article (peer-reviewed)abstract
    • Variation in body fat distribution contributes to the metabolic sequelae of obesity. The genetic determinants of body fat distribution are poorly understood. The goal of this study was to gain new insights into the underlying genetics of body fat distribution by conducting sample-size-weighted fixed-effects genome-wide association meta-analyses in up to 9,594 women and 8,738 men of European, African, Hispanic and Chinese ancestry, with and without sex stratification, for six traits associated with ectopic fat (hereinafter referred to as ectopic-fat traits). In total, we identified seven new loci associated with ectopic-fat traits (ATXN1, UBE2E2, EBF1, RREB1, GSDMB, GRAMD3 and ENSA; P < 5 × 10(-8); false discovery rate < 1%). Functional analysis of these genes showed that loss of function of either Atxn1 or Ube2e2 in primary mouse adipose progenitor cells impaired adipocyte differentiation, suggesting physiological roles for ATXN1 and UBE2E2 in adipogenesis. Future studies are necessary to further explore the mechanisms by which these genes affect adipocyte biology and how their perturbations contribute to systemic metabolic disease.
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9.
  • de las Fuentes, Lisa, et al. (author)
  • Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci
  • 2021
  • In: Molecular Psychiatry. - : Springer Nature. - 1359-4184 .- 1476-5578. ; 26:6, s. 2111-2125
  • Journal article (peer-reviewed)abstract
    • Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, “Some College” (yes/no) and “Graduated College” (yes/no). Interactions were evaluated using both a 1 degree of freedom (DF) interaction term and a 2DF joint test of genetic and interaction effects. Analyses were performed for systolic BP, diastolic BP, mean arterial pressure, and pulse pressure. We pursued genome-wide interrogation in Stage 1 studies (N = 117 438) and follow-up on promising variants in Stage 2 studies (N = 293 787) in five ancestry groups. Through combined meta-analyses of Stages 1 and 2, we identified 84 known and 18 novel BP loci at genome-wide significance level (P < 5 × 10-8). Two novel loci were identified based on the 1DF test of interaction with educational attainment, while the remaining 16 loci were identified through the 2DF joint test of genetic and interaction effects. Ten novel loci were identified in individuals of African ancestry. Several novel loci show strong biological plausibility since they involve physiologic systems implicated in BP regulation. They include genes involved in the central nervous system-adrenal signaling axis (ZDHHC17, CADPS, PIK3C2G), vascular structure and function (GNB3, CDON), and renal function (HAS2 and HAS2-AS1, SLIT3). Collectively, these findings suggest a role of educational attainment or SES in further dissection of the genetic architecture of BP.
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10.
  • de Vries, Paul S., et al. (author)
  • Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions
  • 2019
  • In: American Journal of Epidemiology. - : Oxford University Press. - 0002-9262 .- 1476-6256. ; 188:6, s. 1033-1054
  • Journal article (peer-reviewed)abstract
    • A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multiancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in stage 1 (genome-wide discovery) and 66 studies in stage 2 (focused follow-up), for a total of 394,584 individuals from 5 ancestry groups. Analyses covered the period July 2014-November 2017. Genetic main effects and interaction effects were jointly assessed by means of a 2-degrees-of-freedom (df) test, and a 1-df test was used to assess the interaction effects alone. Variants at 495 loci were at least suggestively associated (P < 1 x 10(-6)) with lipid levels in stage 1 and were evaluated in stage 2, followed by combined analyses of stage 1 and stage 2. In the combined analysis of stages 1 and 2, a total of 147 independent loci were associated with lipid levels at P < 5 x 10(-8) using 2-df tests, of which 18 were novel. No genome-wide-significant associations were found testing the interaction effect alone. The novel loci included several genes (proprotein convertase subtilisin/kexin type 5 (PCSK5), vascular endothelial growth factor B (VEGFB), and apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (APOBEC1) complementation factor (A1CF)) that have a putative role in lipid metabolism on the basis of existing evidence from cellular and experimental models.
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11.
  • Deng, Jifei, et al. (author)
  • Imbalanced multiclass classification with active learning in strip rolling process
  • 2022
  • In: Knowledge-Based Systems. - : Elsevier. - 0950-7051 .- 1872-7409. ; 255
  • Journal article (peer-reviewed)abstract
    • In the strip rolling process, conventional supervised methods cannot effectively address data with an imbalanced number of normal and faulty instances. In this paper, based on a deep belief network, a resampling method is combined with active learning (AL) to address imbalanced multiclass problems. The support vector machine-based synthetic minority oversampling technique was adapted to enrich the training data, whereas the true data distribution and model generalization were changed. A new selection strategy of AL is proposed that forms a function using uncertainty and diversity. AL uses an optimizing set that has a similar distribution with the whole dataset to calculate the informativeness of instances to optimize the model. Based on this step, the model study instances approach decision boundaries to promote performance. The proposed method is validated by five UCI benchmark datasets and strip rolling data, and experiments show that it outperforms conventional methods in tackling imbalanced multiclass problems.
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12.
  • Deng, Jifei, et al. (author)
  • Mass customization with reinforcement learning : Automatic reconfiguration of a production line
  • 2023
  • In: Applied Soft Computing. - : Elsevier. - 1568-4946 .- 1872-9681. ; 145
  • Journal article (peer-reviewed)abstract
    • This paper addresses the problem of efficient automation system configuration for mass customization in industrial manufacturing. Due to the various demands from customers, production lines need to adjust the process parameters of the machines based on specific quality parameters. Reinforcement learning, which learns from samples, can tackle the problem more efficiently than the currently used methods. Based on the proximal policy optimization and centralized training with decentralized execution, a multi-agent reinforcement learning method (MARL) is proposed to reconfigure process parameters of machines based on the changed specifications. The proposed method has the actor of each agent observing only its own state, the agents are made to collaborate by a centralized critic which observes all the states. To evaluate the method, a steel strip rolling line with six collaborating mills is studied. Simulation results show that the proposed method outperforms the existing methods and state-of-the-art multi-agent reinforcement learning methods in terms of accuracy and computing costs.
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13.
  • Deng, Jifei, et al. (author)
  • Offline reinforcement learning for industrial process control : A case study from steel industry
  • 2023
  • In: Information Sciences. - : Elsevier. - 0020-0255 .- 1872-6291. ; 632, s. 221-231
  • Journal article (peer-reviewed)abstract
    • Flatness is a crucial indicator of strip quality that presents a challenge in regulation due to the high-speed process and the nonlinear relationship between flatness and process parameters. Conventional methods for controlling flatness are based on the first principles, empirical models, and predesigned rules, which are less adaptable to changing rolling conditions. To address this limitation, this paper proposed an offline reinforcement learning (RL) based data-driven method for flatness control. Based on the data collected from a factory, the offline RL method can learn the process dynamics from data to generate a control policy. Unlike online RL methods, the proposed method does not require a simulator for training, the policy can be potentially safer and more accurate since a simulator involves simplifications that can introduce bias. To obtain a steady performance, the proposed method incorporated ensemble Q-functions into policy evaluation to address uncertainty estimation. To address distributional shifts, based on Q-values from ensemble Q-functions, behavior cloning was added to policy improvement. Simulation and comparison results showed that the proposed method outperformed the state-of-the-art offline RL methods and achieved the best performance in producing strips with lower flatness.
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14.
  • Deng, Jifei, et al. (author)
  • Reinforcement learning for industrial process control: A case study in flatness control in steel industry
  • 2022
  • In: Computers in industry (Print). - : Elsevier. - 0166-3615 .- 1872-6194. ; 143
  • Journal article (peer-reviewed)abstract
    • Strip rolling is a typical manufacturing process, in which conventional control approaches are widely applied. Development of the control algorithms requires a mathematical expression of the process by means of the first principles or empirical models. However, it is difficult to upgrade the conventional control approaches in response to the ever-changing requirements and environmental conditions because domain knowledge of control engineering, mechanical engineering, and material science is required. Reinforcement learning is a machine learning method that can make the agent learn from interacting with the environment, thus avoiding the need for the above mentioned mathematical expression. This paper proposes a novel approach that combines ensemble learning with reinforcement learning methods for strip rolling control. Based on the proximal policy optimization (PPO), a multi-actor PPO is proposed. Each randomly initialized actor interacts with the environment in parallel, but only the experience from the actor that obtains the highest reward is used for updating the actors. Simulation results show that the proposed method outperforms the conventional control methods and the state-of-the-art reinforcement learning methods in terms of process capability and smoothness.
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15.
  • Deng, Liying, et al. (author)
  • Can fluorophlogopite mica be used as an alkali metal ion source to boost the growth of two-dimensional molybdenum dioxide?
  • 2023
  • In: Applied Surface Science. - : Elsevier BV. - 0169-4332. ; 612
  • Journal article (peer-reviewed)abstract
    • Everyone familiar with two-dimensional (2D) materials is aware of fluorophlogopite mica (FM), which has an atomic-level flat surface that provides an ideal platform for the growth of 2D materials. Since it has been demonstrated that the alkali metal ions (AMI) can aid in the growth of large-sized 2D materials by chemical vapor deposition (CVD) in recent years, it became a major mystery whether FM which contains AMI benefits from them in the preparation of 2D materials by CVD, too. In this article, we dispelled this ambiguity and discovered that temperature is the key for FM as an AMI source to boost the growth of large-sized 2D materials. We carried out variable temperature experiments and found that FM can indeed be incorporated into the growth of large-sized 2D materials as an AMI source at high temperatures and successfully obtained the highly crystalline MoO2 with a larger size compared to those without FM. This finding is of great importance to the understanding of the growth mechanism of FM for 2D materials by CVD and to better exploit its role in the growth of 2D materials.
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16.
  • Deng, Pan, et al. (author)
  • High purity and viability cell separation of a bacterivorous jakobid flagellate based on a steep velocity gradient induced soft inertial force
  • 2018
  • In: RSC Advances. - : ROYAL SOC CHEMISTRY. - 2046-2069. ; 8:62, s. 35512-35520
  • Journal article (peer-reviewed)abstract
    • Cell separation is one of the key limiting factors for precise analysis of non-axenic microbial lab cultures or environmental samples, and it remains a challenge to isolate target cells with high purity and viability via high-throughput cell sorting. During the past decade, hydrodynamic microfluidic platforms have attracted great attention in cell preparation for their high efficiency, robust performance and low cost. Here, we employ the use of a low-velocity sheath flow with high viscosity near the wall and a high-velocity sheath flow with low viscosity on the other side of the sample flow in a soft inertial separation chip. This not only prevents hard interactions between cells and chip walls but, in comparison to previous inertial separation methods, generates a significant increase in deflection of large cells while keeping the small ones in the original flow. We first conducted experiments on a mixture of small and large fluorescent particles (1.0 and 9.9 m, respectively) and removed over 99% of the small particles. The separation efficiency was then tested on a culture of a bacterivorous jakobid flagellate, Seculamonas ecuadoriensis fed on the live bacterium, Klebsiella sp. Using our microfluidic chip, over 94% of live bacteria were removed while maintaining high jakobid cell viability. For comparison, we also conducted size-based cell sorting of the same culture using flow cytometry, which is widely used as a rapid and automated separation tool. Compared with the latter, our chip showed more than 40% higher separation efficiency. Thus, our device provides high purity and viability for cell separation of a sensitive cell sample (jakobid cells). Potentially, the method can be further used for applications in diagnostics, biological analyses and environmental assessment of mixed microbial samples.
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17.
  • Dong, Y. B., et al. (author)
  • The growth of graphene on Ni–Cu alloy thin films at a low temperature and its carbon diffusion mechanism
  • 2019
  • In: Nanomaterials. - : MDPI AG. - 2079-4991. ; 9:11
  • Journal article (peer-reviewed)abstract
    • Carbon solid solubility in metals is an important factor affecting uniform graphene growth by chemical vapor deposition (CVD) at high temperatures. At low temperatures, however, it was found that the carbon diffusion rate (CDR) on the metal catalyst surface has a greater impact on the number and uniformity of graphene layers compared with that of the carbon solid solubility. The CDR decreases rapidly with decreasing temperatures, resulting in inhomogeneous and multilayer graphene. In the present work, a Ni–Cu alloy sacrificial layer was used as the catalyst based on the following properties. Cu was selected to increase the CDR, while Ni was used to provide high catalytic activity. By plasma-enhanced CVD, graphene was grown on the surface of Ni–Cu alloy under low pressure using methane as the carbon source. The optimal composition of the Ni–Cu alloy, 1:2, was selected through experiments. In addition, the plasma power was optimized to improve the graphene quality. On the basis of the parameter optimization, together with our previously-reported, in-situ, sacrificial metal-layer etching technique, relatively homogeneous wafer-size patterned graphene was obtained directly on a 2-inch SiO2 /Si substrate at a low temperature (~600◦ C).
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18.
  • Dong, Y. B., et al. (author)
  • Transfer-free, lithography-free, and micrometer-precision patterning of CVD graphene on SiO 2 toward all-carbon electronics
  • 2018
  • In: APL Materials. - : AIP Publishing. - 2166-532X. ; 6:2
  • Journal article (peer-reviewed)abstract
    • A method of producing large area continuous graphene directly on SiO 2 by chemical vapor deposition is systematically developed. Cu thin film catalysts are sputtered onto the SiO 2 and pre-patterned. During graphene deposition, high temperature induces evaporation and balling of the Cu, and the graphene "lands onto" SiO 2 . Due to the high heating and growth rate, continuous graphene is largely completed before the Cu evaporation and balling. 60 nm is identified as the optimal thickness of the Cu for a successful graphene growth and μm-large feature size in the graphene. An all-carbon device is demonstrated based on this technique.
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19.
  • Dong, Yibo, et al. (author)
  • In Situ Growth of CVD Graphene Directly on Dielectric Surface toward Application
  • 2020
  • In: ACS Applied Electronic Materials. - : American Chemical Society (ACS). - 2637-6113. ; 2:1, s. 238-246
  • Journal article (peer-reviewed)abstract
    • A technique for the in situ growth of patterned graphene by CVD has been achieved directly on insulating substrates at 800 degrees C. The graphene growth is catalyzed by a Ni-Cu alloy sacrificial layer, which integrates many advantages such as being lithography-free, and almost wrinkle-free, with a high repeatability and rapid growth. The etching method of the metal sacrificial layer is the core of this technique, and the mechanism is analyzed. Graphene has been found to play an important role in accelerating etching speeds. The Ni-Cu alloy exhibits a high catalytic activity, and thus, high-quality graphene can be obtained at a lower temperature. Moreover, the Ni-Cu layer accommodates a limited amount of carbon atoms, which ensures a high monolayer ratio of the graphene. The carbon solid solubility of the alloy is calculated theoretically and used to explain the experimental findings. The method is compatible with the current semiconductor process and is conducive to the industrialization of graphene devices.
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20.
  • Feitosa, Mary F., et al. (author)
  • Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries
  • 2018
  • In: PLOS ONE. - : Public library science. - 1932-6203. ; 13:6
  • Journal article (peer-reviewed)abstract
    • Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci and contribute to the understanding of alcohol-related BP regulation. We conducted a large two-stage investigation incorporating joint testing of main genetic effects and single nucleotide variant (SNV)-alcohol consumption interactions. In Stage 1, genome-wide discovery meta-analyses in approximate to 131 K individuals across several ancestry groups yielded 3,514 SNVs (245 loci) with suggestive evidence of association (P <1.0 x 10(-5)). In Stage 2, these SNVs were tested for independent external replication in individuals across multiple ancestries. We identified and replicated (at Bonferroni correction threshold) five novel BP loci (380 SNVs in 21 genes) and 49 previously reported BP loci (2,159 SNVs in 109 genes) in European ancestry, and in multi-ancestry meta-analyses (P < 5.0 x 10(-8)). For African ancestry samples, we detected 18 potentially novel BP loci (P< 5.0 x 10(-8)) in Stage 1 that warrant further replication. Additionally, correlated meta-analysis identified eight novel BP loci (11 genes). Several genes in these loci (e.g., PINX1, GATA4, BLK, FTO and GABBR2 have been previously reported to be associated with alcohol consumption. These findings provide insights into the role of alcohol consumption in the genetic architecture of hypertension.
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21.
  • Figueroa, Jonine D., et al. (author)
  • Genome-wide association study identifies multiple loci associated with bladder cancer risk
  • 2014
  • In: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 23:5, s. 1387-1398
  • Journal article (peer-reviewed)abstract
    • andidate gene and genome-wide association studies (GWAS) have identified 11 independent susceptibility loci associated with bladder cancer risk. To discover additional risk variants, we conducted a new GWAS of 2422 bladder cancer cases and 5751 controls, followed by a meta-analysis with two independently published bladder cancer GWAS, resulting in a combined analysis of 6911 cases and 11 814 controls of European descent. TaqMan genotyping of 13 promising single nucleotide polymorphisms with P < 1 × 10−5 was pursued in a follow-up set of 801 cases and 1307 controls. Two new loci achieved genome-wide statistical significance: rs10936599 on 3q26.2 (P = 4.53 × 10−9) and rs907611 on 11p15.5 (P = 4.11 × 10−8). Two notable loci were also identified that approached genome-wide statistical significance: rs6104690 on 20p12.2 (P = 7.13 × 10−7) and rs4510656 on 6p22.3 (P = 6.98 × 10−7); these require further studies for confirmation. In conclusion, our study has identified new susceptibility alleles for bladder cancer risk that require fine-mapping and laboratory investigation, which could further understanding into the biological underpinnings of bladder carcinogenesis.
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22.
  • Guo, W., et al. (author)
  • Rapid chemical vapor deposition of graphene on liquid copper
  • 2016
  • In: Synthetic Metals. - : Elsevier BV. - 0379-6779. ; 216, s. 93-97
  • Journal article (peer-reviewed)abstract
    • Molten copper is used to catalyze the graphene synthesis by chemical vapor deposition. The Cu has no grains above melting temperature, which is favorable for graphene growth. Using a vertical cold wall system, the deposition rate is drastically increased as compared with common hot-wall tube furnaces, pushing the method one step forward towards applications. A molybdenum-graphite Joule heater is used to avoid mechanical deformation of the carrier foil for the catalyst to ease the subsequent processes. The rapid deposition makes it possible to observe graphene growth on liquid Cu even at low pressure, where severe Cu evaporation simultaneously occurs.
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23.
  • Jiang, Kui, et al. (author)
  • Suppressed recombination loss in organic photovoltaics adopting a planar-mixed heterojunction architecture
  • 2022
  • In: Nature Energy. - : NATURE PORTFOLIO. - 2058-7546. ; 7:11, s. 1076-1086
  • Journal article (peer-reviewed)abstract
    • At present, high-performance organic photovoltaics mostly adopt a bulk-heterojunction architecture, in which exciton dissociation is facilitated by charge-transfer states formed at numerous donor-acceptor (D-A) heterojunctions. However, the spin character of charge-transfer states originated from recombination of photocarriers allows relaxation to the lowest-energy triplet exciton (T-1) at these heterojunctions, causing photocurrent loss. Here we find that this loss pathway can be alleviated in sequentially processed planar-mixed heterojunction (PMHJ) devices, employing donor and acceptor with intrinsically weaker exciton binding strengths. The reduced D-A intermixing in PMHJ alleviates non-geminate recombination at D-A contacts, limiting the chance of relaxation, thus suppressing T-1 formation without sacrificing exciton dissociation efficiency. This resulted in devices with high power conversion efficiencies of >19%. We elucidate the working mechanisms for PMHJs and discuss the implications for material design, device engineering and photophysics, thus providing a comprehensive grounding for future organic photovoltaics to reach their full promise. Organic solar cells with a bulk-heterojunction architecture suffer from photocurrent loss driven by triplet states. Now, Jiang et al. show that sequentially deposited donor-acceptor planar-mixed heterojunctions suppress triplet formation, enabling efficiencies over 19%.
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24.
  • Jiang, Liang, et al. (author)
  • Formation of Spinel Phases in Oxidized BOF Slag under Different Cooling Conditions
  • 2017
  • In: Steel Research International. - : John Wiley & Sons. - 1611-3683 .- 1869-344X. ; 88:11
  • Journal article (peer-reviewed)abstract
    • To enhance utilization of wastes generated from steelmaking, a BOF slag sample from Ning Steel group in China is treated by oxidizing at 1500 °C for 30 min and then cooled by different methods. The treated samples are characterized, in combination with calculations using FactSage 6.4. XRD results show that iron oxides in BOF slag are converted largely by the oxidation to spinel phases, Fe3O4 and MgFe2O4, which also eliminates free CaO and MgO. EDS analyses show Fe element existing in di-calcium silicate and glass phase, which are Fe3+ ions formed by oxidation. An incorporation of Fe3+ ions into crystal structures has stabilized high temperature polymorph of C2S, β-C2S, and α’-C2S, in the treated slag samples. Fe3+ ions may also act as a network former to facilitate glass formation. This may make it possible for the glass and α’-C2S phase to complement each other, leading to a higher hydraulicity, while the BOF slag, after the spinel separation, is blended in cements. Some suggestions are proposed, based on the present and early studies, to enhance hydraulicity for the BOF slag, as well as grain sizes of spinel phases, which may result in economic and environmental benefits for steel and cement industries.
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25.
  • Kristan, Matej, et al. (author)
  • The Ninth Visual Object Tracking VOT2021 Challenge Results
  • 2021
  • In: 2021 IEEE/CVF INTERNATIONAL CONFERENCE ON COMPUTER VISION WORKSHOPS (ICCVW 2021). - : IEEE COMPUTER SOC. - 9781665401913 ; , s. 2711-2738
  • Conference paper (peer-reviewed)abstract
    • The Visual Object Tracking challenge VOT2021 is the ninth annual tracker benchmarking activity organized by the VOT initiative. Results of 71 trackers are presented; many are state-of-the-art trackers published at major computer vision conferences or in journals in recent years. The VOT2021 challenge was composed of four sub-challenges focusing on different tracking domains: (i) VOT-ST2021 challenge focused on short-term tracking in RGB, (ii) VOT-RT2021 challenge focused on "real-time" short-term tracking in RGB, (iii) VOT-LT2021 focused on long-term tracking, namely coping with target disappearance and reappearance and (iv) VOT-RGBD2021 challenge focused on long-term tracking in RGB and depth imagery. The VOT-ST2021 dataset was refreshed, while VOT-RGBD2021 introduces a training dataset and sequestered dataset for winner identification. The source code for most of the trackers, the datasets, the evaluation kit and the results along with the source code for most trackers are publicly available at the challenge website(1).
  •  
26.
  • Li, Jie, et al. (author)
  • Sphenostylisins A-K : bioactive modified isoflavonoid constituents of the root bark of Sphenostylis marginata ssp. erecta
  • 2013
  • In: Journal of Organic Chemistry. - : American Chemical Society (ACS). - 0022-3263 .- 1520-6904. ; 78:20, s. 10166-10177
  • Journal article (peer-reviewed)abstract
    • Sphenostylisins A-C (1-3), three complex dimeric compounds representing two novel carbon skeletons, along with an additional eight new compounds, sphenostylisins D-K (4-11), were isolated from the active chloroform-soluble extract of the root bark of Sphenostylis marginata ssp. erecta using a bioactivity-guided isolation approach. The structures were elucidated by means of detailed spectroscopic analysis, including NMR and HRESIMS analysis, and tandem MS fragmentation was utilized to further support the structures of 1-3. The absolute configuration of sphenostylisin C (3) was established by electronic circular dichroism analysis. Plausible biogenetic relationships between the modified isoflavonoids 1-11 are proposed, and a cyclization reaction of 9 was conducted to support one of the biogenetic proposals made. All of these pure isolates were evaluated against a panel of in vitro bioassays, and among the results obtained, sphenostylisin A (1) was found to be a very potent NF-κB inhibitor (IC50 = 6 nM).
  •  
27.
  •  
28.
  • Liu, Lihui, 1985, et al. (author)
  • A Mechanism for Highly Efficient Electrochemical Bubbling Delamination of CVD-Grown Graphene from Metal Substrates
  • 2016
  • In: Advanced Materials Interfaces. - : Wiley. - 2196-7350. ; 3:8
  • Journal article (peer-reviewed)abstract
    • In most cases, transfer of chemical-vapor-deposited 2D materials from metallic foil catalysts onto a target substrate is the most necessary step for their promising fundamental studies and applications. Recently, a highly efficient and nondestructive electrochemical delamination method has been proposed as an alternative to the conventional etching transfer method, which alleviates the problem of cost and environment pollution because it eliminates the need to etch away the metals. Here, the mechanism of the electrochemical bubbling delamination process is elucidated by studying the effect of the various electrolytes on the delamination rate. A capacitor-based circuit model is proposed and confirmed by the electrochemical impedance spectroscopy results. A factor of 27 decrease in the time required for complete graphene delamination from the platinum cathodes is found when increasing the NaOH ratio in the electrolyte solution. The opposite trend is observed for delamination at the anode. The surface screening effect induced by nonreactive ions in the vicinity of the electrodes plays a key role in the delamination efficiency. The analysis is generic and can be used as a guideline to describe and design the electrochemical delamination of other 2D materials from their metal catalysts as well.
  •  
29.
  • Liu, Q., et al. (author)
  • High responsivity sensing of unfocused laser and white light using graphene photodetectors grown by chemical vapor deposition
  • 2016
  • In: Optical Materials Express. - 2159-3930. ; 6:7, s. 2158-2164
  • Journal article (peer-reviewed)abstract
    • Graphene photodetectors grown by chemical vapor deposition are fabricated for unfocused laser and white light sensing. The unfocused light enlarges the illuminated graphene area and mimics the real-life sensing conditions, yielding a responsivity of 104 mA/W at room temperature without enhancing absorbance by waveguide and plasmonics. The devices are based on positive photoconductivity from the electron-hole photocarrier pairs and the bolometric-effect-induced negative photoconductivity. The buried off-center local gate induces a net internal potential in the graphene. The relative strength of the two photoconductivities depends on the gate voltage. The technology is scalable, which is a step ahead toward real applications.
  •  
30.
  • Liu, Tao, et al. (author)
  • Prediction model for austenite grains growth during reheating process in Ti micro-alloyed cast steel by coupling precipitates dissolution and coarsening behavior
  • 2019
  • In: Journal of Iron and Steel Research International. - : SPRINGER. - 1006-706X .- 2210-3988. ; 26:2, s. 162-172
  • Journal article (peer-reviewed)abstract
    • A combined model to predict austenite grains growth of titanium micro-alloyed as-cast steel during reheating process was established. The model involves the behaviors of austenite grains growth in continuous heating process and isothermal soaking process, and the variation of boundary pinning efficiency caused by the dissolution and coarsening kinetics of second-phase particles was also considered into the model. Furthermore, the experimental verifications were performed to examine the prediction power of the model. The results revealed that the mean austenite grains size increased with the increase in reheating temperature and soaking time, and the coarsening temperature of austenite grains growth was 1423K under the current titanium content. In addition, the reliability of the predicted results in continuous heating process was validated by continuous heating experiments. Moreover, an optimal regression expression of austenite grains growth in isothermal soaking process was obtained based on the experimental results. The compared results indicated that the combined model in conjunction with precipitates dissolution and coarsening kinetics had good reliability and accuracy to predict the austenite grains growth of titanium micro-alloyed casting steel during reheating process.
  •  
31.
  • Murray, Benjamin, et al. (author)
  • Accessible data curation and analytics for international-scale citizen science datasets
  • 2021
  • In: Scientific Data. - : Springer Science and Business Media LLC. - 2052-4463. ; 8:1
  • Journal article (peer-reviewed)abstract
    • The Covid Symptom Study, a smartphone-based surveillance study on COVID-19 symptoms in the population, is an exemplar of big data citizen science. As of May 23rd, 2021, over 5 million participants have collectively logged over 360 million self-assessment reports since its introduction in March 2020. The success of the Covid Symptom Study creates significant technical challenges around effective data curation. The primary issue is scale. The size of the dataset means that it can no longer be readily processed using standard Python-based data analytics software such as Pandas on commodity hardware. Alternative technologies exist but carry a higher technical complexity and are less accessible to many researchers. We present ExeTera, a Python-based open source software package designed to provide Pandas-like data analytics on datasets that approach terabyte scales. We present its design and capabilities, and show how it is a critical component of a data curation pipeline that enables reproducible research across an international research group for the Covid Symptom Study.
  •  
32.
  • Pan, G. Z., et al. (author)
  • Analysis of optical coupling behavior in two-dimensional implant-defined coherently coupled vertical-cavity surface-emitting laser arrays
  • 2018
  • In: Photonics Research. - 2327-9125. ; 6:11, s. 1048-1055
  • Journal article (peer-reviewed)abstract
    • Optical coupling behavior and associated effects in two-dimensional implant-defined coherently coupled vertical-cavity surface-emitting laser (VCSEL) arrays are studied via both experiments and theoretical calculations. Experiments show that optical coupling between array elements can enhance the array’s output power. Additionally, optical coupling via leaky optical fields can provide extra optical gain for the array elements, which can then reduce the thresholds of these elements. Elements can even be pumped without current injection to emit light by receiving a strong leaky optical field from other array elements. Optical coupling can also cause unusual phenomena: the central elements in large-area coherently coupled VCSEL arrays that lase prior to the outer elements when the arrays are biased, or the average injection current required for each element to lase, which is much lower than the threshold for a single VCSEL. Theoretical calculations are performed to explain the experimental results.
  •  
33.
  • Pan, G. Z., et al. (author)
  • Dependence of Beam Quality on Optical Intensity Asymmetry in In-Phase Coherently Coupled VCSEL Array
  • 2018
  • In: IEEE Journal of Quantum Electronics. - 0018-9197 .- 1558-1713. ; 54:3
  • Journal article (peer-reviewed)abstract
    • Dependence of beam quality on optical intensity asymmetry among elements in in-phase coherently coupled vertical cavity surface emitting lasers array is analyzed using the finite-difference time domain solutions software. The analysis results reveal that the coupling efficiency of in-phased array decreases and the divergence increases as the level of optical intensity asymmetry increases. Furthermore, an addressable separated-contact three-element triangular in-phased array is fabricated and measured to verify the analysis. The array exhibits a relatively high of coupling efficiency of 24% and a near-diffraction-limit divergence of 3.2° (1.12 times of the diffraction limit, D.L.) when the optical intensity of each element is adjusted to be uniform. By degrading the optical intensity symmetry, the coupling efficiency decreases to 17.07% and the divergence increases to 4.03° ( 1.37× D.L.). After that, a much larger 10× 10 array exhibiting in-phase characteristics is produced and its beam quality and optical uniformity are measured and discussed. Analysis and experiment results demonstrate that symmetric optical intensity among elements is essential for in-phased array to achieve high beam quality. Employing separate contacts in the array is proved an effective way to obtain uniform optical intensity and achieve high beam quality.
  •  
34.
  • Pan, G. Z., et al. (author)
  • Large-Scale Proton-Implant-Defined VCSEL Arrays with Narrow Beamwidth
  • 2018
  • In: IEEE Electron Device Letters. - 0741-3106 .- 1558-0563. ; 39:3, s. 390-393
  • Journal article (peer-reviewed)abstract
    • In-phase coherently coupled proton-implant-defined vertical cavity surface emitting laser (VCSEL) arrays face difficulties in current spreading, resulting in small array scale, low output power, and broad beamwidth. Although patterned metal grids can improve the current spreading, the undesirable out-of-phase mode tends to be dominant in the array. In this letter, by means of engineering the implantation and array parameters, in-phase mode is obtained in large-scale proton-implant-defined arrays with metal grids. Experimental results show that these arrays are operating in in-phase mode with a nominal interelement spacing of 8 μm and an implantation depth of 2.22 μm. By using these parameters, a 5 × 5 in-phase array with a narrow beamwidth (far-field full width at half maximum) of 1.61° is realized. Besides, a 10 × 10 in-phase array with a beamwidth of 1.89° and an output power of 10.25 mW for the in-phase mode is achieved. The calculation of far fields is performed to confirm the in-phase operation measured results. Such a simple and low-cost technology provides a promising method for preparing large-scale in-phase coherently coupled VCSEL arrays.
  •  
35.
  • Pan, Kui, et al. (author)
  • Highly effective transfer of micro-LED pixels to the intermediate and rigid substrate with weak and tunable adhesion by thiol modification
  • 2023
  • In: Nanoscale. - : Royal Society of Chemistry (RSC). - 2040-3372 .- 2040-3364. ; 15:9, s. 4420-4428
  • Journal article (peer-reviewed)abstract
    • Based on transfer printing technology, micro-LED pixels can be transferred to different types and sizes of driving substrates to realize displays with different application scenarios. To achieve a successful transfer, GaN-based micro-LEDs first need to be separated from the original epitaxial substrate. Here, micro-LED pixels (each size 25 μm × 30 μm) on the sapphire substrate were transferred to a flexible semiconductor wafer processing (SWP) tape that is strongly sticky by conventional laser lift-off (LLO) techniques. The pixels on the SWP tape were then transferred by using a sacrificial layer of non-crosslinked oligomeric polystyrene (PS) film onto the intermediate and rigid substrate (IRS) with weak and tunable adhesion by thiol (-SH) modification. The electrode of the micro-LED is Au metal, which forms Au-S bonds with the surface of the IRS to fix the pixels. The rigid substrate helps ensure that the pixel spacing is almost unchanged during the stamp transfer process, and the weak and tunable adhesion facilitates the pixels being picked up by the stamp. The experimental results demonstrate that the pixels can be efficiently transferred to the IRS by LLO and sacrificial layer-assistance, which will provide the possibility of achieving the further transfer of pixels to different types and sizes of driving substrates by a suitable transfer stamp. The transfer process details are discussed, which can provide insights into the transfer of micro-nano devices through polymer sacrificial layers.
  •  
36.
  • Pan, Kui, et al. (author)
  • Monolithically and Vertically Integrated LED-on-FET Device Based on a Novel GaN Epitaxial Structure
  • 2023
  • In: IEEE Transactions on Electron Devices. - 1557-9646 .- 0018-9383. ; 70:12, s. 6393-6398
  • Journal article (peer-reviewed)abstract
    • Optoelectronic devices, such as light-emitting diodes (LEDs), based on GaN-based semiconductor compounds are widely used for their advantages of long life, high reliability, and low energy consumption. The persistent challenge is integrating LED with transistors to achieve smaller size, lighter weight, higher speed, and more reliable optoelectronic integrated circuits. Here, we report monolithically and vertically integrated LED-on-FET devices fabricated on a novel GaN epitaxial structure. The designed device structure and fabrication process are simple. It also eliminates the extra area occupied by the transistor, and the shared n-GaN layer between the LED and FET reduces interconnect resistance and improves reliability. The measured threshold voltage (V-Th) of the LED-on-FET device is extrapolated as 3.9 V at the voltage (V-DD) of 5 V, and V-Th decreases with the increase of V-DD . More importantly, the gate voltage (V-GS) shows good performance in modulated electroluminescence (EL) intensity and switching capability of the LED. The integrated LED efficiently emits light modulation with a wavelength of 440 nm at V-DD= 9 V and V-GS=4-9 V (step = 1 V), which are necessary for devices in applications, such as displays and smart lighting. This epitaxy structure and integration scheme is promising in achieving large-scale optoelectronic integrated circuits, such as the next-generation micro-LED and nano-LED with super compact integrated drivers.
  •  
37.
  • Risal, Sanjiv, et al. (author)
  • Transgenerational transmission of reproductive and metabolic dysfunction in the male progeny of polycystic ovary syndrome
  • 2023
  • In: Cell Reports Medicine. - : Cell Press. - 2666-3791. ; 4:5
  • Journal article (peer-reviewed)abstract
    • The transgenerational maternal effects of polycystic ovary syndrome (PCOS) in female progeny are being revealed. As there is evidence that a male equivalent of PCOS may exists, we ask whether sons born to mothers with PCOS (PCOS-sons) transmit reproductive and metabolic phenotypes to their male progeny. Here, in a register-based cohort and a clinical case-control study, we find that PCOS-sons are more often obese and dyslipidemic. Our prenatal androgenized PCOS-like mouse model with or without diet-induced obesity confirmed that reproductive and metabolic dysfunctions in first-generation (F1) male offspring are passed down to F3. Sequencing of F1–F3 sperm reveals distinct differentially expressed (DE) small non-coding RNAs (sncRNAs) across generations in each lineage. Notably, common targets between transgenerational DEsncRNAs in mouse sperm and in PCOS-sons serum indicate similar effects of maternal hyperandrogenism, strengthening the translational relevance and highlighting a previously underappreciated risk of transmission of reproductive and metabolic dysfunction via the male germline. 
  •  
38.
  • Shi, Wenbin, et al. (author)
  • Redox-responsive polymeric membranes via supermolecular host-guest interactions
  • 2015
  • In: Journal of Membrane Science. - : Elsevier BV. - 0376-7388 .- 1873-3123. ; 480, s. 139-152
  • Journal article (peer-reviewed)abstract
    • Redox-responsive materials have attracted much attention, and redox-responsive membrane is strongly desired since enormous numbers of redox reactions carry out in living systems. Herein, a novel polymeric membrane with redox-resposive hydraulic permeability is fabricated by introducing a reversible redox-responsive system based on the host guest complex between ferrocene (Fc) and beta-cyclodextrin (1 CD) into polyethersulfone (PES) membrane. As the result of reversible radox-responsive formation or deformation of the complex, the water flux for the membrane with 18.3 wt% redox-responsive materials was 270 mL/m(2) mmHg h in original state, while increased to 1022 mL/m(2) mmHg h in oxidation state and decreased to 538 mL/m(2) mmHg h in reduction state. In addition, the results of water contact angle, surface zeta potential and the gas flow/liquid displacement confirmed that the origin of the reclox-responsive hydraulic permeability were the change of the pore size and porosity for the modified membranes. The redox-responsive membranes have great potential to be utilized in the Fields of chemical detection, drug delivery, biological treatments and so On.
  •  
39.
  • Sun, Jie, 1977, et al. (author)
  • Mechanism of Electrochemical Delamination of Two-Dimensional Materials from Their Native Substrates by Bubbling
  • 2015
  • In: Sensors. - : MDPI AG. - 1424-8220. ; 15:12, s. 31811-31820
  • Journal article (peer-reviewed)abstract
    • A capacitor-based circuit model is proposed to explain the electrochemical delamination of two-dimensional materials from their native substrates where produced gas bubbles squeeze into the interface. The delamination is actually the electric breakdown of the capacitor formed between the solution and substrate. To facilitate the procedure, the backside of the ubstrate has to be shielded so that the capacitor breakdown voltage can be reached. The screening effect can be induced either by nonreactive ions around the electrode or, more effectively, by an undetachable insulator. This mechanism serves as a guideline for the surface science and applications involving the bubbling delamination.
  •  
40.
  • Sun, Jie, 1977, et al. (author)
  • Synthesis Methods of Two-Dimensional MoS2: A Brief Review
  • 2017
  • In: Crystals. - : MDPI AG. - 2073-4352. ; 7:7, s. Article no 198 -
  • Research review (peer-reviewed)abstract
    • Molybdenum disulfide (MoS2) is one of the most important two-dimensional materials after graphene. Monolayer MoS2 has a direct bandgap (1.9 eV) and is potentially suitable for post-silicon electronics. Among all atomically thin semiconductors, MoS2's synthesis techniques are more developed. Here, we review the recent developments in the synthesis of hexagonal MoS2, where they are categorized into top-down and bottom-up approaches. Micromechanical exfoliation is convenient for beginners and basic research. Liquid phase exfoliation and solutions for chemical processes are cheap and suitable for large-scale production; yielding materials mostly in powders with different shapes, sizes and layer numbers. MoS2 films on a substrate targeting high-end nanoelectronic applications can be produced by chemical vapor deposition, compatible with the semiconductor industry. Usually, metal catalysts are unnecessary. Unlike graphene, the transfer of atomic layers is omitted. We especially emphasize the recent advances in metalorganic chemical vapor deposition and atomic layer deposition, where gaseous precursors are used. These processes grow MoS2 with the smallest building-blocks, naturally promising higher quality and controllability. Most likely, this will be an important direction in the field. Nevertheless, today none of those methods reproducibly produces MoS2 with competitive quality. There is a long way to go for MoS2 in real-life electronic device applications.
  •  
41.
  • Tian, Liang, et al. (author)
  • Electroless Deposition of 4 μm High Ni/Au Bumps for 8 μm Pitch Interconnection
  • 2022
  • In: ACS Applied Electronic Materials. - : American Chemical Society (ACS). - 2637-6113. ; 4:10, s. 4966-4971
  • Journal article (peer-reviewed)abstract
    • We propose that electroless plating is a superb approach to preparing metallic bumps with an ultrafine pitch for the integration of a micro light-emitting diode (micro-LED). Electroless plating does not suffer from lift-off-related issues, which are ubiquitous in thermal evaporation. Besides, it can result in much more uniform bumps than electroplating because the bump height is not affected by the current distribution. This study reports ultrafine pitch Ni/Au bumps fabricated by electroless nickel immersion gold (ENIG) plating. Furthermore, cheap metals iron and nickel are selected to catalyze the electroless nickel process. The results indicate that uniform and consistent Ni/Au bumps can be obtained through the iron sheet and nickel layer method. Besides, no voids and impurities are found inside the bumps, which is beneficial for the following interconnection process. Moreover, the change in Ni bump height values with the electroless plating time is also provided.
  •  
42.
  • Wan, Wenxin, et al. (author)
  • Operating conditions combination analysis method of optimal water management state for PEM fuel cell
  • 2023
  • In: Green Energy and Intelligent Transportation. - 2773-1537 .- 2097-2512. ; 2:4
  • Journal article (peer-reviewed)abstract
    • The water content of proton exchange membrane fuel cells (PEMFCs) affects the transport of reactants and the conductivity of the membrane. Effective water management measures can improve the performance and extend the lifespan of the fuel cell. The water management state of the stack is influenced by various external operating conditions, and optimizing the combination of these conditions can improve the water management state within the stack. Considering that the stack's internal resistance can reflect its water management state, this study first establishes an internal resistance-operating condition model that considers the coupling effect of temperature and humidity to determine the variation trend of total resistance and stack humidity with single-factor operating conditions. Subsequently, the water management state optimization method based on the ANN-HGPSO algorithm is proposed, which not only quantitatively evaluates the influence weights of different operating conditions on the stack's internal resistance but also efficiently and accurately obtains the optimal combination of five operating conditions: working temperature, anode gas pressure, cathode gas pressure, anode gas humidity, and cathode gas humidity to achieve the optimal water management state in the stack, within the entire range of current densities. Finally, the response surface experimental results of the stack also validate the effectiveness and accuracy of the ANN-HGPSO algorithm. The method mentioned in this article can provide effective strategies for efficient water management and output performance optimization control of PEMFC stacks.
  •  
43.
  • Wang, Zhaoming, et al. (author)
  • Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
  • 2014
  • In: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:24, s. 6616-6633
  • Journal article (peer-reviewed)abstract
    • Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.
  •  
44.
  • Xiong, Fangzhu, et al. (author)
  • Transfer-free graphene-like thin films on GaN LED epiwafers grown by PECVD using an ultrathin Pt catalyst for transparent electrode applications
  • 2019
  • In: Materials. - : MDPI AG. - 1996-1944. ; 12:21, s. 1-12
  • Journal article (peer-reviewed)abstract
    • In this work, we grew transfer-free graphene-like thin films (GLTFs) directly on gallium nitride (GaN)/sapphire light-emitting diode (LED) substrates. Their electrical, optical and thermal properties were studied for transparent electrode applications. Ultrathin platinum (2 nm) was used as the catalyst in the plasma-enhanced chemical vapor deposition (PECVD). The growth parameters were adjusted such that the high temperature exposure of GaN wafers was reduced to its minimum (deposition temperature as low as 600 °C) to ensure the intactness of GaN epilayers. In a comparison study of the Pt-GLTF GaN LED devices and Pt-only LED devices, the former was found to be superior in most aspects, including surface sheet resistance, power consumption, and temperature distribution, but not in optical transmission. This confirmed that the as-developed GLTF-based transparent electrodes had good current spreading, current injection and thermal spreading functionalities. Most importantly, the technique presented herein does not involve any material transfer, rendering a scalable, controllable, reproducible and semiconductor industry-compatible solution for transparent electrodes in GaN-based optoelectronic devices.
  •  
45.
  • Xu, K., et al. (author)
  • GaN nanorod light emitting diodes with suspended graphene transparent electrodes grown by rapid chemical vapor deposition
  • 2013
  • In: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 103:22, s. 5-
  • Journal article (peer-reviewed)abstract
    • Ordered and dense GaN light emitting nanorods are studied with polycrystalline graphene grown by rapid chemical vapor deposition as suspended transparent electrodes. As the substitute of indium tin oxide, the graphene avoids complex processing to fill up the gaps between nanorods and subsequent surface flattening and offers high conductivity to improve the carrier injection. The as-fabricated devices have 32% improvement in light output power compared to conventional planar GaN-graphene diodes. The suspended graphene remains electrically stable up to 300 degrees C in air. The graphene can be obtained at low cost and high efficiency, indicating its high potential in future applications.
  •  
46.
  • Xu, K., et al. (author)
  • Graphene GaN-Based Schottky Ultraviolet Detectors
  • 2015
  • In: IEEE Transactions on Electron Devices. - : Institute of Electrical and Electronics Engineers (IEEE). - 1557-9646 .- 0018-9383. ; 62:9, s. 2802-2808
  • Journal article (peer-reviewed)abstract
    • Graphene GaN-based Schottky ultraviolet detectors are fabricated. The monolayer graphene is grown by chemical vapor deposition. The graphene is much more transparent than metals, as confirmed by the fact that our devices retain their high responsivity up to 360-nm wavelength (corresponding to the band edge absorption of GaN). Importantly, by virtue of the tunable work function of graphene, the graphene GaN Schottky barrier height can be greatly enlarged. The built-in field is enhanced, and the detector performance is improved. The current ratio with and without luminescence is up to 1.6 x 10(4). The characteristic time constants of the devices are in the order of a few milliseconds. The device open-circuit voltage and short-circuit current are also increased. At last, special type Schottky devices consisting of GaN nanorods or surface-etched GaN are prepared for complementary study. It is found although the dry etching induced surface defects lead to an increase in the dark current, and these carrier traps also greatly contribute to the photoconductivity under luminescence, resulting in extraordinarily large responsivity (up to 360 A/W at -6 V).
  •  
47.
  • Xu, K., et al. (author)
  • Graphene transparent electrodes grown by rapid chemical vapor deposition with ultrathin indium tin oxide contact layers for GaN light emitting diodes
  • 2013
  • In: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 102:16
  • Journal article (peer-reviewed)abstract
    • By virtue of the small active volume around Cu catalyst, graphene is synthesized by fast chemical vapor deposition (CVD) in a cold wall vertical system. Despite being highly polycrystalline, it is as conductive and transparent as standard graphene and can be used in light emitting diodes as transparent electrodes. 7-10 nm indium tin oxide (ITO) contact layer is inserted between the graphene and p-GaN to enhance hole injection. Devices with forward voltage and transparency comparable to those using traditional 240 nm ITO are achieved with better ultraviolet performances, hinting the promising future for application-oriented graphene by rapid CVD.
  •  
48.
  • You, Fengzhi, et al. (author)
  • Maternal mortality in Henan Province, China: changes between 1996 and 2009.
  • 2012
  • In: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 7:10
  • Journal article (peer-reviewed)abstract
    • Background: Maternal deaths occur mostly in developing countries and the majority of them are preventable. This study analyzes changes in maternal mortality and related causes in Henan Province, China, between 1996 and 2009, in an attempt to provide a reliable basis for introducing effective interventions to reduce the maternal mortality ratio (MMR), part of the fifth Millennium Development Goal. Methods and Findings: This population-based maternal mortality survey in Henan Province was carried out from 1996 to 2009. Basic information was obtained from the health care network for women and children and the vital statistics system, from specially trained monitoring personnel in 25 selected monitoring sites and by household survey in each case of maternal death. This data was subsequently reported to the Henan Provincial Maternal and Child Healthcare Hospital. The total MMR in Henan Province declined by 78.4%, from 80.1 per 100 000 live births in 1996 to 17.3 per 100 000 live births in 2009. The decline was more pronounced in rural than in urban areas. The most common causes of maternal death during this period were obstetric hemorrhage (43.8%), pregnancy-induced hypertension (15.8%), amniotic fluid embolism (13.9%) and heart disease (8.0%). The MMR was higher in rural areas with lower income, less education and poorer health care. Conclusion: There was a remarkable decrease in the MMR in Henan Province between 1996 and 2009 mainly in the rural areas and MMR due to direct obstetric causes such as obstetric hemorrhage. This study indicates that improving the health care network for women, training of obstetric staff at basic-level units, promoting maternal education, and increasing household income are important interventional strategies to reduce the MMR further.
  •  
49.
  • Yu, Xiaoran, et al. (author)
  • Remaining-useful-lifetime prediction of proton exchange membrane fuel cell considering model uncertainty quantification on the full-time scale
  • 2023
  • In: IEEE Transactions on Transportation Electrification. - 2332-7782. ; In Press
  • Journal article (peer-reviewed)abstract
    • A prognostics and health management (PHM) system with prediction at its core optimizes the durability of the proton exchange membrane fuel cell (PEMFC). However, the aging behavior model has some uncertainty due to limited knowledge, affecting the predictive performance in remaining useful life (RUL) prediction. To address this issue, an RUL prediction method based on the Bayesian framework considering uncertainty quantification on the full-time scale is proposed. Firstly, the state of health (SOH) of the PEMFC is estimated, and the behavior of uncertainty is quantified. Afterwards, a long short-term memory (LSTM) neural network is employed to make a prediction for its behavior. Finally, the RUL of PEMFC is predicted based on historical SOH and the predicted behavior of uncertainty. Validation indicates that the proposed method can make a long-term prediction and provide RUL prediction with high accuracy. Under the dynamic operating condition, in terms of long-term prediction, compared to unscented Kalman filter, adaptive unscented Kalman filter, double-input-echo-state-network and bidirectional LSTM, the proposed method decreases the error by 88.12%, 41.99%, 13.82% and 3.21%, respectively. And under the dynamic operating condition, the proposed method shows good stability. Moreover, the robustness of this method has also been verified.
  •  
50.
  • Yuan, Shuai, et al. (author)
  • Birth weight, childhood obesity, adulthood obesity and body composition, and gastrointestinal diseases : a Mendelian randomization study.
  • 2023
  • In: Obesity. - : John Wiley & Sons. - 1930-7381 .- 1930-739X. ; 31:10, s. 2603-2614
  • Journal article (peer-reviewed)abstract
    • OBJECTIVE: This Mendelian randomization study aimed to investigate the associations of birth weight, childhood BMI, and adulthood BMI, waist-hip ratio, and body composition with the risk of 24 gastrointestinal diseases.METHODS: Independent genetic instruments associated with the exposures at the genome-wide significance level (p < 5 × 10-8 ) were selected from corresponding large-scale genome-wide association studies. Summary-level data for gastrointestinal diseases were obtained from the UK Biobank, the FinnGen study, and large consortia of European ancestry.RESULTS: Genetically predicted higher levels of birth weight were associated with a lower risk of gastroesophageal reflux. Genetically predicted higher childhood BMI was associated with an increased risk of duodenal ulcer, nonalcoholic fatty liver disease, and cholelithiasis. However, the associations did not persist after adjusting for genetically predicted adulthood BMI. Genetically predicted higher adulthood BMI and waist-hip ratio were associated with 19 and 17 gastrointestinal diseases, respectively. Genetically predicted greater visceral adiposity was associated with an increased risk of 17 gastrointestinal diseases. There were no strong associations among genetically predicted whole-body fat and fat-free mass indices with gastrointestinal diseases.CONCLUSIONS: This study suggests that greater adulthood adiposity, measured as either BMI, waist-hip ratio, or visceral adipose tissue, is causally associated with an increased risk of a broad range of gastrointestinal diseases in the European population.
  •  
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