| 1. |
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| 2. |
- Ablikim, M., et al.
(author)
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Measurements of (XcJ)-> K+K-K+K- decays
- 2006
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In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 642:3, s. 197-202
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Journal article (peer-reviewed)abstract
- Using 14M psi(2S) events taken with the BESII detector, chi(cJ) -> 2(K+K-) decays are studied. For the four-kaon final state, the branching fractions are B(chi(c0,1,2) ->.2(K+K-)) = (3.48 +/- 0.23 +/- 0.47) x 10(-3), (0.70 +/- 0.13 +/- 0.10) x 10(-3), and (2.17 +/- 0.20 +/- 0.31) x 10(-3). For the phi K+K- final state, the branching fractions, which are measured for the first time, are B(chi(c0,1,2) -> phi K+K-) = (1.03 +/- 0.22 +/- 0.15) x 10(-3), (0.46 +/- 0.16 +/- 0.06) x 10(-3), and (1.67 +/- 0.26 +/- 0.24) x 10(-4). For the phi phi final state, B(chi(c0,2) -> phi phi) = (0.94 +/- 0.21 +/- 0.13) x 10(-3) and (1.70 +/- 0.30 +/- 0.25) x 10(-3).
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| 3. |
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- 2019
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Journal article (peer-reviewed)
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| 4. |
- Ji, Xuemei, et al.
(author)
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Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
- 2018
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In: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 9, s. 1-15
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Journal article (peer-reviewed)abstract
- Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer.
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| 5. |
- McKay, James D., et al.
(author)
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Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
- 2017
-
In: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 49:7, s. 1126-1132
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Journal article (peer-reviewed)abstract
- Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genomewide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer.
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| 6. |
- Zheng, Qiye, et al.
(author)
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High Contrast Thermal Conductivity Change in Ni-Mn-In Heusler Alloys near Room Temperature
- 2019
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In: Advanced Engineering Materials. - Weinheim : Wiley-VCH Verlagsgesellschaft. - 1438-1656 .- 1527-2648. ; 21:5
-
Journal article (peer-reviewed)abstract
- Materials with an abrupt transition between a low and a high thermal conductance state at a critical temperature would be useful for thermal regulation applications. Here, the authors report a high contrast reversible thermal conductivity change through the thermally-induced martensitic transition (MT) in Ni-Mn-In alloys. The authors measure the thermal conductivity of a wide temperature range 130 < T < 530 K using time-domain thermoreflectance (TDTR). The thermal conductivity of these alloys increases from ≈7.0-8.5 W m−1 K−1 to ≈11.5-13.0 W m−1 K−1 through the MT near 300 K as temperature rises, with a rate of change among the highest yet reported in solid-state materials with thermally-induced phase transitions. Based on Hall resistivity measurements, the authors further show that the change of thermal conductivity is dominated by the electronic contribution, which results from a unique carrier mobility change through the MT. Their findings highlight the interplay between the structural disorders and the thermal transport in alloys through solid-state phase transitions and open a new avenue in the search of high-performance materials for thermal regulation. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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| 7. |
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| 8. |
- Campanini, Donato, et al.
(author)
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Raising the superconducting T-c of gallium : In situ characterization of the transformation of alpha-Ga into beta-Ga
- 2018
-
In: Physical Review B. - : American Physical Society. - 2469-9950 .- 2469-9969. ; 97:18
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Journal article (peer-reviewed)abstract
- Gallium (Ga) displays several metastable phases. Superconductivity is strongly enhanced in the metastable beta-Ga with a critical temperature T-c = 6.04(5) K, while stable alpha-Ga has a much lower T-c < 1.2 K. Here we use a membrane-based nanocalorimeter to initiate the transition from alpha-Ga to beta-Ga on demand, as well as study the specific heat of the two phases on one and the same sample. The in situ transformation is initiated by bringing the temperature to about 10 K above the melting temperature of alpha-Ga. After such treatment, the liquid supercools down to 232 K, where beta-Ga solidifies. We find that beta-Ga is a strong-coupling type-I superconductor with Delta(0)/k(B)T(c) = 2.00(5) and a Sommerfeld coefficient gamma(n) = 1.53(4) mJ/molK(2), 2.55 times higher than that in the alpha phase. The results allow a detailed comparison of fundamental thermodynamic properties between the two phases.
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| 9. |
- Campanini, Donato, et al.
(author)
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Superconducting gap evolution in overdoped BaFe2(As1-xPx)(2) single crystals through nanocalorimetry
- 2015
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In: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 91:24
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Journal article (peer-reviewed)abstract
- We report on specific heat measurements on clean overdoped BaFe2(As1-xPx)(2) single crystals performed with a high resolution membrane-based nanocalorimeter. A nonzero residual electronic specific heat coefficient at zero temperature gamma(r) = C/T backslash(T -> 0) is seen for all doping compositions, indicating a considerable fraction of the Fermi surface ungapped or having very deep minima. The remaining superconducting electronic specific heat is analyzed through a two-band s-wave alpha model in order to investigate the gap structure. Close to optimal doping we detect a single zero-temperature gap of Delta(0) similar to 5.3 meV, corresponding to Delta(0)/k(B)T(c) similar to 2.2. Increasing the phosphorus concentration x, the main gap reduces till a value of Delta(0) similar to 1.9 meV for x = 0.55 and a second weaker gap becomes evident. From the magnetic field effect on gamma(r), all samples however show similar behavior [gamma(r)(H) -gamma(r)(H = 0) proportional to H-n, with n between 0.6 and 0.7]. This indicates that, despite a considerable redistribution of the gap weights, the total degree of gap anisotropy does not change drastically with doping.
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| 10. |
- Diao, Xingxing, et al.
(author)
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In vitro and in vivo human metabolism of a new synthetic cannabinoid NM-2201 (CBL-2201)
- 2017
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In: Forensic Toxicology. - : SPRINGER. - 1860-8965 .- 1860-8973. ; 35:1, s. 20-32
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Journal article (peer-reviewed)abstract
- In 2014, NM-2201 (CBL-2201), a novel synthetic cannabinoid (SC), was detected by scientists at Russian and US laboratories. It has been already added to the list of scheduled drugs in Japan, Sweden and Germany. Unfortunately, no human metabolism data are currently available, which makes it challenging to confirm its intake, especially given that all SCs investigated thus far have been found to be extensively metabolized. The present study aims to recommend appropriate marker metabolites by investigating NM-2201 metabolism in human hepatocytes, and to confirm the results in authentic human urine specimens. For the metabolic stability assay, 1 A mu M NM-2201 was incubated in human liver microsomes (HLMs) for up to 1 h; for metabolite profiling, 10 A mu M of NM-2201 was incubated in human hepatocytes for 3 h. Two authentic urine specimens from NM-2201-positive cases were subjected to beta-glucuronidase hydrolysis prior to analysis. The identification of metabolites in hepatocyte samples and urine specimens was achieved with high-resolution mass spectrometry via information-dependent acquisition. NM-2201 was quickly metabolized in HLMs, with an 8.0-min half-life. In human hepatocyte incubation samples, a total of 13 NM-2201 metabolites were identified, generated mainly from ester hydrolysis and further hydroxylation, oxidative defluorination and subsequent glucuronidation. M13 (5-fluoro PB-22 3-carboxyindole) was found to be the major metabolite. In the urine specimens, the parent drug NM-2201 was not detected; M13 was the predominant metabolite after beta-glucuronidase hydrolysis. Therefore, based on the results of our study, we recommend M13 as a suitable urinary marker metabolite for confirming NM-2201 and/or 5F-PB-22 intake.
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| 11. |
- Diao, Xingxing, et al.
(author)
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Strategies to distinguish new synthetic cannabinoid FUBIMINA (BIM-2201) intake from its isomer THJ-2201: metabolism of FUBIMINA in human hepatocytes
- 2016
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In: Forensic Toxicology. - : SPRINGER. - 1860-8965 .- 1860-8973. ; 34:2, s. 256-267
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Journal article (peer-reviewed)abstract
- Since 2013, a new drugs-of-abuse trend attempts to bypass drug legislation by marketing isomers of scheduled synthetic cannabinoids (SCs), e.g., FUBIMINA (BIM-2201) and THJ-2201. It is much more challenging to confirm a specific isomers intake and distinguish it from its structural analog because the isomers and their major metabolites usually have identical molecular weights and display the same product ions. Here, we investigated isomers FUBIMINA and THJ-2201 and propose strategies to distinguish their consumption. THJ-2201 was scheduled in the US, Japan, and Europe; however, FUBIMINA is easily available on the Internet. We previously investigated THJ-2201 metabolism in human hepatocytes, but human FUBIMINA metabolism is unknown. We aim to characterize FUBIMINA metabolism in human hepatocytes, recommend optimal metabolites to confirm its consumption, and propose strategies to distinguish between intakes of FUBIMINA and THJ-2201. FUBIMINA (10 mu M) was incubated in human hepatocytes for 3 h, and metabolites were characterized with high-resolution mass spectrometry (HR-MS). We identified 35 metabolites generated by oxidative defluorination, further carboxylation, hydroxylation, dihydrodiol formation, glucuronidation, and their combinations. We recommend 5-OH-BIM-018 (M34), BIM-018 pentanoic acid (M33), and BIM-018 pentanoic acid dihydrodiol (M7) as FUBIMINA specific metabolites. THJ-2201 produced specific metabolite markers 5-OH-THJ-018 (F26), THJ-018 pentanoic acid (F25), and hydroxylated THJ-2201 (F13). Optimized chromatographic conditions to achieve different retention times and careful selection of specific product ion spectra enabled differentiation of isomeric metabolites, in this case FUBIMINA from THJ-2201. Our HR-MS approach should be applicable for differentiating future isomeric SCs, which is especially important when different isomers have different legal status.
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| 12. |
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| 13. |
- Diao, Zhu, 1981-, et al.
(author)
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Integrated On-Chip Nano-Optomechanical Systems
- 2017
-
In: International Journal of High Speed Electronics and Systems. - Singapore : World Scientific Publishing Co. Pte Ltd. - 0129-1564. ; 26:1-2
-
Journal article (peer-reviewed)abstract
- Recent developments in integrated on-chip nano-optomechanical systems are reviewed. Silicon-based nano-optomechanical devices are fabricated by a two-step process, where the first step is a foundry-enabled photonic circuits patterning and the second step involves in-house mechanical device release. We show theoretically that the enhanced responsivity of near-field optical transduction of mechanical displacement in on-chip nano-optomechanical systems originates from the finesse of the optical cavity to which the mechanical device couples. An enhancement in responsivity of more than two orders of magnitude has been observed when compared side-by-side with free-space interferometry readout. We further demonstrate two approaches to facilitate large-scale device integration, namely, wavelength-division multiplexing and frequency-division multiplexing. They are capable of significantly simplifying the design complexity for addressing individual nano-optomechanical devices embedded in a large array. © 2017 World Scientific Publishing Company.
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| 14. |
- Diao, Zhu, et al.
(author)
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Microscopic parameters from high-resolution specific heat measurements on superoptimally substituted BaFe2(As1-xPx)(2) single crystals
- 2016
-
In: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 93:1
-
Journal article (peer-reviewed)abstract
- We investigate the electronic specific heat of superoptimally substituted BaFe2(As1-x P-x(x))(2) single crystals in the superconducting state using high-resolution nanocalorimetry. From the measurements, we extract the substitution dependence of the condensation energy, superconducting gap Delta, and related microscopic parameters. We find that the anomalous scaling of the specific heat jump Delta C proportional to T-c(3) , found in many iron-based superconductors, in this system originates from a T-c-dependent ratio Delta/k(B)T(c) in combination with a substitution-dependent density of states N(epsilon(F)). A clear enhancement is seen in the effective mass m* as the composition approaches the value that has been associated with a quantum critical point at optimum substitution. However, a simultaneous increase in the superconducting carrier concentration n(s) yields a penetration depth lambda that decreases with increasing T-c without sharp divergence at the quantum critical point. Uemura scaling indicates that T-c is governed by the Fermi temperature T-F for this multiband system.
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| 15. |
- Ji, Xuemei, et al.
(author)
-
Protein-altering germline mutations implicate novel genes related to lung cancer development
- 2020
-
In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
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Journal article (peer-reviewed)abstract
- Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect association with an ATM L2307F (rs56009889) mutation in adenocarcinoma for discovery (adjusted Odds Ratio=8.82, P=1.18x10(-15)) and replication (adjusted OR=2.93, P=2.22x10(-3)) that is more pronounced in females (adjusted OR=6.81 and 3.19 and for discovery and replication). We observe an excess loss of heterozygosity in lung tumors among ATM L2307F allele carriers. L2307F is more frequent (4%) among Ashkenazi Jewish populations. We also observe an association in discovery (adjusted OR=2.61, P=7.98x10(-22)) and replication datasets (adjusted OR=1.55, P=0.06) with a loss-of-function mutation, Q4X (rs150665432) of an uncharacterized gene, KIAA0930. Our findings implicate germline genetic variants in ATM with lung cancer susceptibility and suggest KIAA0930 as a novel candidate gene for lung cancer risk. In lung cancer, relatively few germline mutations are known to impact risk. Here the authors looked at rare variants in 39,146 individuals and find novel germline mutations associated with risk, as well as implicating ATM and a new candidate gene for lung cancer risk.
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| 16. |
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| 17. |
- Smylie, M. P., et al.
(author)
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Anisotropic superconductivity and magnetism in single-crystal RbEuFe4As4
- 2018
-
In: Physical Review B. - College Park : American Physical Society. - 2469-9950 .- 2469-9969. ; 98:10
-
Journal article (peer-reviewed)abstract
- We investigate the anisotropic superconducting and magnetic properties of single-crystal RbEuFe4As4 using magnetotransport and magnetization measurements. We determine a magnetic ordering temperature of the Eu moments of Tm=15K and a superconducting transition temperature of Tc=36.8K. The superconducting phase diagram is characterized by high upper critical field slopes of -70 and -42 kG/K for in-plane and out-of-plane fields, respectively, and a surprisingly low superconducting anisotropy of Γ=1.7. Ginzburg-Landau parameters of κc∌67 and κab∌108 indicate extreme type-II behavior. These superconducting properties are in line with those commonly seen in optimally doped Fe-based superconductors. In contrast, Eu magnetism is quasi-two dimensional (2D), as evidenced by highly anisotropic in-plane and out-of-plane exchange constants of 0.6 K and <0.04 K. A consequence of the quasi-2D nature of the Eu magnetism are strong magnetic fluctuation effects, a large suppression of the magnetic ordering temperature as compared to the Curie-Weiss temperature, and a kinklike anomaly in the specific heat devoid of any singularity. Magnetization curves reveal a clear magnetic easy-plane anisotropy with in-plane and out-of-plane saturation fields of 2 and 4 kG. © 2018 American Physical Society.
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| 18. |
- Willa, K., et al.
(author)
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Nanocalorimeter platform for in situ specific heat measurements and x-ray diffraction at low temperature
- 2017
-
In: Review of Scientific Instruments. - Melville, NY : AIP Publishing. - 0034-6748 .- 1089-7623. ; 88:12
-
Journal article (peer-reviewed)abstract
- Recent advances in electronics and nanofabrication have enabled membrane-based nanocalorimetry for measurements of the specific heat of microgram-sized samples. We have integrated a nanocalorimeter platform into a 4.5 T split-pair vertical-field magnet to allow for the simultaneous measurement of the specific heat and x-ray scattering in magnetic fields and at temperatures as low as 4 K. This multi-modal approach empowers researchers to directly correlate scattering experiments with insights from thermodynamic properties including structural, electronic, orbital, and magnetic phase transitions. The use of a nanocalorimeter sample platform enables numerous technical advantages: precise measurement and control of the sample temperature, quantification of beam heating effects, fast and precise positioning of the sample in the x-ray beam, and fast acquisition of x-ray scans over a wide temperature range without the need for time-consuming re-centering and re-alignment. Furthermore, on an YBa2Cu3O7-delta crystal and a copper foil, we demonstrate a novel approach to x-ray absorption spectroscopy by monitoring the change in sample temperature as a function of incident photon energy. Finally, we illustrate the new insights that can be gained from in situ structural and thermodynamic measurements by investigating the superheated state occurring at the first-order magneto-elastic phase transition of Fe2P, a material that is of interest for magnetocaloric applications.
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| 19. |
- Xie, Xu, et al.
(author)
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Microscale, bendable thermoreflectance sensor for local measurements of the thermal effusivity of biological fluids and tissues
- 2020
-
In: Review of Scientific Instruments. - : AIP Publishing. - 0034-6748 .- 1089-7623. ; 91:4
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Journal article (peer-reviewed)abstract
- Measurements of the thermal transport properties of biological fluids and tissues are important for biomedical applications such as thermal diagnostics and thermal therapeutics. Here, we describe a microscale thermoreflectance sensor to measure the thermal effusivity of fluids and biological samples in a minimally invasive manner. The sensor is based on ultrafast optical pump-probe techniques and employs a metal-coated optical fiber as both a photonic waveguide and a local probe. Calibration of the sensor with five liquids shows that the percentage deviation between experimentally measured effusivity and literature values is on average <3%. We further demonstrate the capability of the sensor by measuring the thermal effusivity of vegetable oil, butter, pork liver, and quail egg white and yolk. We relate the thermal effusivity of the samples to their composition and water content, and establish our technique as a powerful and flexible method for studying the local thermal transport properties of biological materials.
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| 20. |
- Yang, Kexin, et al.
(author)
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Magneto-optic response of the metallic antiferromagnet Fe2As to ultrafast temperature excursions
- 2019
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In: Physical Review Materials. - : AMER PHYSICAL SOC. - 2475-9953. ; 3:12
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Journal article (peer-reviewed)abstract
- The linear magneto-optic Kerr effect (MOKE) is often used to probe magnetism of ferromagnetic materials, but MOKE cannot be applied to collinear antiferromagnets due to the cancellation of sublattice magnetization. Magneto-optic constants that are quadratic in magnetization, however, provide an approach for studying antiferromagnets on picosecond timescales. Here, we combine transient measurements of linear birefringence and optical reflectivity to study the optical response of Fe2As to small ultrafast temperature excursions. We performed temperature-dependent pump-probe measurements on crystallographically isotropic (001) and anisotropic (010) faces of Fe2As bulk crystals. We find that the largest optical signals arise from changes in the index of refraction along the z axis, perpendicular to the Ned vector. Both real and imaginary parts of the transient optical birefringence signal approximately follow the temperature dependence of the magnetic heat capacity, as expected if the changes in dielectric function are dominated by contributions of exchange interactions to the dielectric function.
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| 21. |
- Yang, Kexin, et al.
(author)
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Magnetocrystalline anisotropy of the easy-plane metallic antiferromagnet Fe2As
- 2020
-
In: Physical Review B. - 2469-9950 .- 2469-9969. ; 102:6
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Journal article (peer-reviewed)abstract
- Magnetocrystalline anisotropy is a fundamental property of magnetic materials that determines the dynamics of magnetic precession, the frequency of spin waves, the thermal stability of magnetic domains, and the efficiency of spintronic devices. We combine torque magnetometry and density functional theory calculations to determine the magnetocrystalline anisotropy of the metallic antiferromagnet Fe2As. Fe2As has a tetragonal crystal structure with the Neel vector lying in the (001) plane. We report that the fourfold magnetocrystalline anisotropy in the (001) plane of Fe2As is extremely small, K-22 = -150 J/m(3) at T = 4 K, much smaller than the perpendicular magnetic anisotropy of ferromagnetic structure widely used in spintronic devices. K-22 is strongly temperature dependent and close to zero at T > 150 K. The anisotropy K-1 in the (010) plane is too large to be measured by torque magnetometry and we determine K-1 = -830 kJ/m(3) using first-principles density functional theory. Our simulations show that the contribution to the anisotropy from classical magnetic dipole-dipole interactions is comparable to the contribution from spin-orbit coupling. The calculated fourfold anisotropy in the (001) plane K-22 ranges from -290 to 280 J/m(3), the same order of magnitude as the measured value. We used K-1 from theory to predict the frequency and polarization of the lowest frequency antiferromagnetic resonance mode and find that the mode is linearly polarized in the (001) plane with f = 670 GHz.
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| 22. |
- Zheng, Qiye, et al.
(author)
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Thermal transport through the magnetic martensitic transition in MnxMGe(M = Co, Ni)
- 2018
-
In: Physical Review Materials. - College Park : American Physical Society. - 2475-9953. ; 2:7
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Journal article (peer-reviewed)abstract
- We report on changes in the thermal conductivity of solid-state synthesized MnxMGe (M = Co, Ni, 0.98 < x < 1.02) alloys through their temperature-induced martensitic structural transition. The thermal conductivity is measured by time-domain thermoreflectance. Mn1.014NiGe exhibits an increase in thermal conductivity from 11 to 15.5 W m(-1) K-1 from approximately 575 to 625 K, and Mn1.007CoGe exhibits an increase in thermal conductivity from 7 to 8.5 W m(-1) K-1 from 500 to 550 K. In MnxNiGe, the transition temperature and the magnitude of the change in thermal conductivity are strongly dependent on the alloy composition. Our study advances the fundamental understanding of the thermal transport properties in the MnxMGe(M = Co, Ni) family of alloys and opens a new direction in the search for solid-state phase transition materials with potential applications as thermal regulators.
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