| 1. |
- Krasilnikov, A., et al.
(author)
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Evidence of 9 Be + p nuclear reactions during 2ω CH and hydrogen minority ICRH in JET-ILW hydrogen and deuterium plasmas
- 2018
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In: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 58:2
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Journal article (peer-reviewed)abstract
- The intensity of 9Be + p nuclear fusion reactions was experimentally studied during second harmonic (2ω CH) ion-cyclotron resonance heating (ICRH) and further analyzed during fundamental hydrogen minority ICRH of JET-ILW hydrogen and deuterium plasmas. In relatively low-density plasmas with a high ICRH power, a population of fast H+ ions was created and measured by neutral particle analyzers. Primary and secondary nuclear reaction products, due to 9Be + p interaction, were observed with fast ion loss detectors, γ-ray spectrometers and neutron flux monitors and spectrometers. The possibility of using 9Be(p, d)2α and 9Be(p, α)6Li nuclear reactions to create a population of fast alpha particles and study their behaviour in non-active stage of ITER operation is discussed in the paper.
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| 2. |
- Joffrin, E., et al.
(author)
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Overview of the JET preparation for deuterium-tritium operation with the ITER like-wall
- 2019
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In: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 59:11
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Research review (peer-reviewed)abstract
- For the past several years, the JET scientific programme (Pamela et al 2007 Fusion Eng. Des. 82 590) has been engaged in a multi-campaign effort, including experiments in D, H and T, leading up to 2020 and the first experiments with 50%/50% D-T mixtures since 1997 and the first ever D-T plasmas with the ITER mix of plasma-facing component materials. For this purpose, a concerted physics and technology programme was launched with a view to prepare the D-T campaign (DTE2). This paper addresses the key elements developed by the JET programme directly contributing to the D-T preparation. This intense preparation includes the review of the physics basis for the D-T operational scenarios, including the fusion power predictions through first principle and integrated modelling, and the impact of isotopes in the operation and physics of D-T plasmas (thermal and particle transport, high confinement mode (H-mode) access, Be and W erosion, fuel recovery, etc). This effort also requires improving several aspects of plasma operation for DTE2, such as real time control schemes, heat load control, disruption avoidance and a mitigation system (including the installation of a new shattered pellet injector), novel ion cyclotron resonance heating schemes (such as the three-ions scheme), new diagnostics (neutron camera and spectrometer, active Alfven eigenmode antennas, neutral gauges, radiation hard imaging systems...) and the calibration of the JET neutron diagnostics at 14 MeV for accurate fusion power measurement. The active preparation of JET for the 2020 D-T campaign provides an incomparable source of information and a basis for the future D-T operation of ITER, and it is also foreseen that a large number of key physics issues will be addressed in support of burning plasmas.
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- 2018
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In: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 58:1
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Research review (peer-reviewed)
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| 28. |
- Zeng, Chenjie, et al.
(author)
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Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus
- 2016
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In: Breast Cancer Research. - : Springer Science and Business Media LLC. - 1465-5411 .- 1465-542X. ; 18
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Journal article (peer-reviewed)abstract
- Background: Multiple recent genome-wide association studies (GWAS) have identified a single nucleotide polymorphism (SNP), rs10771399, at 12p11 that is associated with breast cancer risk. Method: We performed a fine-scale mapping study of a 700 kb region including 441 genotyped and more than 1300 imputed genetic variants in 48,155 cases and 43,612 controls of European descent, 6269 cases and 6624 controls of East Asian descent and 1116 cases and 932 controls of African descent in the Breast Cancer Association Consortium (BCAC; http://bcac.ccge.medschl.cam.ac.uk/), and in 15,252 BRCA1 mutation carriers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Stepwise regression analyses were performed to identify independent association signals. Data from the Encyclopedia of DNA Elements project (ENCODE) and the Cancer Genome Atlas (TCGA) were used for functional annotation. Results: Analysis of data from European descendants found evidence for four independent association signals at 12p11, represented by rs7297051 (odds ratio (OR) = 1.09, 95 % confidence interval (CI) = 1.06-1.12; P = 3 x 10(-9)), rs805510 (OR = 1.08, 95 % CI = 1.04-1.12, P = 2 x 10(-5)), and rs1871152 (OR = 1.04, 95 % CI = 1.02-1.06; P = 2 x 10(-4)) identified in the general populations, and rs113824616 (P = 7 x 10(-5)) identified in the meta-analysis of BCAC ER-negative cases and BRCA1 mutation carriers. SNPs rs7297051, rs805510 and rs113824616 were also associated with breast cancer risk at P < 0.05 in East Asians, but none of the associations were statistically significant in African descendants. Multiple candidate functional variants are located in putative enhancer sequences. Chromatin interaction data suggested that PTHLH was the likely target gene of these enhancers. Of the six variants with the strongest evidence of potential functionality, rs11049453 was statistically significantly associated with the expression of PTHLH and its nearby gene CCDC91 at P < 0.05. Conclusion: This study identified four independent association signals at 12p11 and revealed potentially functional variants, providing additional insights into the underlying biological mechanism(s) for the association observed between variants at 12p11 and breast cancer risk.
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| 30. |
- Di Siena, A., et al.
(author)
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Impact of realistic fast ion distribution function in gyrokinetic GENE simulations
- 2017
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In: 44th EPS Conference on Plasma Physics, EPS 2017. - : European Physical Society (EPS). - 9781510849303
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Conference paper (peer-reviewed)abstract
- Understanding the stabilising mechanism of fast particles on plasma turbulence is an essential task for a fusion reactor, where the energetic particles can constitute a significant fraction of the main ions. While the consideration of equivalent Maxwellian distributed fast ions in the simulations has greatly improved the agreement with experiments, fast ion electromagnetic stabilization seems to be somewhat over-estimated. Power balance is usually reached only with increased plasma gradients. However, it is well known that to rigorously model highly non thermalised particles, a non-Maxwellian background distribution function is needed. To this aim, a previous study on a particular JET plasma has been revised and analysed with the gyrokinetic code GENE. Fast particles have been modelled with a number of different analytic and numerical distributions. The latter have been imported from the modelling tools NEMO/SPOT and SELFO.
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| 31. |
- Di Siena, A., et al.
(author)
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Non-Maxwellian background effects in gyrokinetic simulations with GENE
- 2016
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In: Journal of Physics, Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 775:1
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Journal article (peer-reviewed)abstract
- The interaction between fast particles and core turbulence has been established as a central issue for a tokamak reactor. Recent results predict significant enhancement of electromagnetic stabilisation of ITG turbulence in the presence of fast ions. However, most of these simulations were performed with the assumption of equivalent Maxwellian distributed particles, whereas to rigorously model fast ions, a non-Maxwellian background distribution function is needed. To this aim, the underlying equations in the gyrokinetic code GENE have been re-derived and implemented for a completely general background distribution function. After verification studies, a previous investigation on a particular JET plasma has been revised with linear simulations. The plasma is composed by Deuterium, electron, Carbon impurities, NBI fast Deuterium and ICRH 3He. Fast particle distributions have been modelled with a number of different analytic choices in order to study the impact of non-Maxwellian distributions on the plasma turbulence: slowing down and anisotropic Maxwellian. Linear growth rates are studied as a function of the wave number and compared with those obtained using an equivalent Maxwellian. Generally, the choice of the 3He distribution seems to have a stronger impact on the microinstabilities than that of the fast Deuterium.
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| 32. |
- Di Siena, A., et al.
(author)
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Non-Maxwellian fast particle effects in gyrokinetic GENE simulations
- 2018
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In: Physics of Plasmas. - : American Institute of Physics Inc.. - 1070-664X .- 1089-7674. ; 25:4
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Journal article (peer-reviewed)abstract
- Fast ions have recently been found to significantly impact and partially suppress plasma turbulence both in experimental and numerical studies in a number of scenarios. Understanding the underlying physics and identifying the range of their beneficial effect is an essential task for future fusion reactors, where highly energetic ions are generated through fusion reactions and external heating schemes. However, in many of the gyrokinetic codes fast ions are, for simplicity, treated as equivalent-Maxwellian-distributed particle species, although it is well known that to rigorously model highly non-thermalised particles, a non-Maxwellian background distribution function is needed. To study the impact of this assumption, the gyrokinetic code GENE has recently been extended to support arbitrary background distribution functions which might be either analytical, e.g., slowing down and bi-Maxwellian, or obtained from numerical fast ion models. A particular JET plasma with strong fast-ion related turbulence suppression is revised with these new code capabilities both with linear and nonlinear gyrokinetic simulations. It appears that the fast ion stabilization tends to be less strong but still substantial with more realistic distributions, and this improves the quantitative power balance agreement with experiments.
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| 33. |
- Doerk, H., et al.
(author)
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Gyrokinetic study of turbulence suppression in a JET-ILW power scan
- 2016
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In: Plasma Physics and Controlled Fusion. - : IOP PUBLISHING LTD. - 0741-3335 .- 1361-6587. ; 58:11
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Journal article (peer-reviewed)abstract
- For exploring tokamak operation regimes that deliver both high beta and good energy confinement, power scans at JET with ITER-like wall have been performed. Relatively weak degradation of the confinement time coincides with increased core temperature of the ions at high power. The changes in core turbulence characteristics during a power scan with an optimized (broad) q profile are analyzed by means of nonlinear gyrokinetic simulations. The increase in beta is crucial for stabilizing ion temperature gradient driven turbulence, accompanied by increased ion to electron temperature ratio, the presence of a dynamic fast ion species, as well as the geometric stabilization by increased thermal and suprathermal pressure. A sensitivity study with respect to the q profile reveals that electromagnetic effects are more pronounced at larger values of q. Further, it is confirmed that turbulence suppression due to rotation becomes less effective in such strongly electromagnetic systems. Electrostatic simplified models may thus perform well in present-day devices, in which high beta is often correlated with high rotation, but provide poor extrapolation towards low rotation devices. Implications for ITER and reactor plasmas are discussed.
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| 34. |
- Yang, Yaohua, et al.
(author)
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Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk
- 2019
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In: Cancer Research. - : AMER ASSOC CANCER RESEARCH. - 0008-5472 .- 1538-7445. ; 79:3, s. 505-517
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Journal article (peer-reviewed)abstract
- DNA methylation is instrumental for gene regulation. Global changes in the epigenetic landscape have been recognized as a hallmark of cancer. However, the role of DNA methylation in epithelial ovarian cancer (EOC) remains unclear. In this study, high-density genetic and DNA methylation data in white blood cells from the Framingham Heart Study (N = 1,595) were used to build genetic models to predict DNA methylation levels. These prediction models were then applied to the summary statistics of a genome-wide association study (GWAS) of ovarian cancer including 22,406 EOC cases and 40,941 controls to investigate genetically predicted DNA methylation levels in association with EOC risk. Among 62,938 CpG sites investigated, genetically predicted methylation levels at 89 CpG were significantly associated with EOC risk at a Bonferroni-corrected threshold of P < 7.94 x 10(-7). Of them, 87 were located at GWAS-identified EOC susceptibility regions and two resided in a genomic region not previously reported to be associated with EOC risk. Integrative analyses of genetic, methylation, and gene expression data identified consistent directions of associations across 12 CpG, five genes, and EOC risk, suggesting that methylation at these 12 CpG may influence EOC risk by regulating expression of these five genes, namely MAPT, HOXB3, ABHD8, ARHGAP27, and SKAP1. We identified novel DNA methylation markers associated with EOC risk and propose that methylation at multiple CpG may affect EOC risk via regulation of gene expression. Significance: Identification of novel DNA methylation markers associated with EOC risk suggests that methylation at multiple CpG may affect EOC risk through regulation of gene expression.
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