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- Blagorodnova, N., et al.
(author)
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COMMON ENVELOPE EJECTION FOR A LUMINOUS RED NOVA IN M101
- 2017
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In: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 834:2
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Journal article (peer-reviewed)abstract
- We present the results of optical, near-infrared, and mid-infrared observations of M101 OT2015-1 (PSN J14021678+ 5426205), a luminous red transient in the Pinwheel galaxy (M101), spanning a total of 16 years. The light curve showed two distinct peaks with absolute magnitudes M-r <= -12.4 and M-r similar or equal to -12, on 2014 November 11 and 2015 February 17, respectively. The spectral energy distributions during the second maximum show a cool outburst temperature of approximate to 3700 K and low expansion velocities (approximate to -300 km s(-1)) for the H I, Ca II, Ba II, and K I lines. From archival data spanning 15-8 years before the outburst, we find a single source consistent with the optically discovered transient, which we attribute to being the progenitor; it has properties consistent with being an F-type yellow supergiant with L similar to 8.7 x 10(4) L-circle dot, T-eff approximate to 7000. K, and an estimated mass of M1= 18 +/- 1 M-circle dot. This star has likely just finished the H-burning phase in the core, started expanding, and is now crossing the Hertzsprung gap. Based on the combination of observed properties, we argue that the progenitor is a binary system, with the more evolved system overfilling the Roche lobe. Comparison with binary evolution models suggests that the outburst was an extremely rare phenomenon, likely associated with the ejection of the common envelope of a massive star. The initial mass of the primary fills the gap between the merger candidates V838 Mon (5-10 M-circle dot) and NGC. 4490-OT. (30M(circle dot)).
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| 6. |
- Ruffini, M., et al.
(author)
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Access and metro network convergence for flexible end-to-end network design [invited]
- 2017
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In: Journal of Optical Communications and Networking. - : Institute of Electrical and Electronics Engineers Inc.. - 1943-0620 .- 1943-0639. ; 9:6, s. 524-535
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Journal article (peer-reviewed)abstract
- This paper reports on the architectural, protocol, physical layer, and integrated testbed demonstrations carried out by the DISCUS FP7 consortium in the area of access-metro network convergence. Our architecture modeling results show the vast potential for cost and power savings that node consolidation can bring. The architecture, however, also recognizes the limits of long-reach transmission for low-latency 5G services and proposes ways to address such shortcomings in future projects. The testbed results, which have been conducted end-toend, across access-metro and core, and have targeted all the layers of the network from the application down to the physical layer, show the practical feasibility of the concepts proposed in the project.
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| 7. |
- Ruffini, M, et al.
(author)
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DISCUS : The Distributed Core For Ubiquitous Broadband Access
- 2013
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In: Future Network and MobileSummit 2013.
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Conference paper (peer-reviewed)abstract
- A new end to end architecture based on Long-Reach Passive OpticalNetwork (LR-PON) with wireless integration, a distributed core built of opticaltransparency islands and an OpenFlow-based control plane, which is beingdeveloped in the EU project DISCUS, is described in this paper. The maintechnological advances and the network modelling and optimization approach arereported.
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| 8. |
- Ruffini, M., et al.
(author)
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DISCUS : An End-to-End Solution for Ubiquitous Broadband Optical Access
- 2014
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In: IEEE Communications Magazine. - 0163-6804 .- 1558-1896. ; 52:2, s. S24-S32
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Journal article (peer-reviewed)abstract
- Fiber to the premises has promised to increase the capacity in telecommunications access networks for well over 30 years. While it is widely recognized that optical-fiber-based access networks will be a necessity in the shortto medium-term future, its large upfront cost and regulatory issues are pushing many operators to further postpone its deployment, while installing intermediate unambitious solutions such as fiber to the cabinet. Such high investment cost of both network access and core capacity upgrade often derives from poor planning strategies that do not consider the necessity to adequately modify the network architecture to fully exploit the cost benefit that a fiber-centric solution can bring. DISCUS is a European Framework 7 Integrated Project that, building on optical-centric solutions such as long-reach passive optical access and flat optical core, aims to deliver a cost-effective architecture for ubiquitous broadband services. DISCUS analyzes, designs, and demonstrates end-to-end architectures and technologies capable of saving cost and energy by reducing the number of electronic terminations in the network and sharing the deployment costs among a larger number of users compared to current fiber access systems. This article describes the network architecture and the supporting technologies behind DISCUS, giving an overview of the concepts and methodologies that will be used to deliver our end-to-end network solution.
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- van Assen, S., et al.
(author)
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EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases
- 2011
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In: Annals of the Rheumatic Diseases. - : BMJ. - 1468-2060 .- 0003-4967. ; 70:3, s. 414-422
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Journal article (peer-reviewed)abstract
- Objectives To develop evidence-based European League Against Rheumatism (EULAR) recommendations for vaccination in patients with autoimmune inflammatory rheumatic diseases (AIIRD). Methods A EULAR task force was composed of experts representing 11 European countries, consisting of eight rheumatologists, four clinical immunologists, one rheumatologist/clinical immunologist, one infectious disease physician, one nephrologist, one paediatrician/rheumatologist and one clinical epidemiologist. Key questions were formulated and the eligible spectrum of AIIRD, immunosuppressive drugs and vaccines were defined in order to perform a systematic literature review. A search was made of Medline from 1966 to October 2009 as well as abstracts from the EULAR meetings of 2008 and 2009 and the American College of Rheumatology (ACR) meetings of 2007 and 2008. Evidence was graded in categories I-IV, the strength of recommendations was graded in categories A-D and Delphi voting was applied to determine the level of agreement between the experts of the task force. Results Eight key questions and 13 recommendations addressing vaccination in patients with AIIRD were formulated. The strength of each recommendation was determined. Delphi voting revealed a very high level of agreement with the recommendations among the experts of the task force. Finally, a research agenda was proposed. Conclusion Recommendations for vaccination in patients with AIIRD based on the currently available evidence and expert opinion were formulated. More research is needed, particularly regarding the incidence of vaccine-preventable infectious diseases and the safety of vaccination in patients with AIIRD.
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| 10. |
- van Assen, S., et al.
(author)
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Vaccination in adult patients with auto-immune inflammatory rheumatic diseases: A systematic literature review for the European League Against Rheumatism evidence-based recommendations for vaccination in adult patients with auto-immune inflammatory rheumatic diseases
- 2011
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In: Autoimmunity Reviews. - : Elsevier BV. - 1873-0183 .- 1568-9972. ; 10:6, s. 341-352
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Research review (peer-reviewed)abstract
- Objectives: To present the systematic literature review (SLR), which formed the basis for the European League Against Rheumatism (EULAR) evidence-based recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD). Methods: AIIRD, vaccines and immunomodulating drugs, as well as eight key questions were defined by the multidisciplinary expert committee commissioned by EULAR for developing the recommendations. A SLR was performed using MedLine through October 2009 and including data from meta-analyses, systematic reviews, randomized trials, and observational studies, excluding case series with participants. Articles in English and regarding patients years of age, were eligible. Results: Several vaccine-preventable infections (VPI) occur more often in AIIRD-patients and most vaccines are efficacious in AIIRD-patients, even when treated with immunomodulating agents, except rituximab. There does not appear to be an increase in vaccination-related harms in vaccinated patients with AIIRD in comparison with unvaccinated patients with AIIRD. However, these studies are underpowered and therefore not conclusive. Conclusion: Based on the current evidence from the literature, recommendations for vaccination in patients with AIIRD were made. However, more research is needed in particular regarding incidence of VPI, harms of vaccination and the influence of (new and established) immunomodulating agents on vaccination efficacy. (C) 2011 Elsevier B.V. All rights reserved.
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| 11. |
- Anders, Berntson, et al.
(author)
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Power dependence and accessible bandwidth for dispersion-managed solitons in asymmetric dispersion maps
- 1998
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In: Electronics Letters. - Goteborg, Sweden : Institution of Engineering and Technology. - 0013-5194 .- 1350-911X. ; 34:21, s. 2054-2056
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Journal article (peer-reviewed)abstract
- The authors investigate how the parameters of dispersion managed solitons depend on the asymmetry of the dispersion map. Using the variational approach and numerical simulations it is shown that asymmetric maps can increase the accessible bandwidth in the normal average dispersion regime and equalise the power in adjacent WDM channels.
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| 12. |
- Anders, Berntson, et al.
(author)
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Power dependence of dispersion-managed solitons for anomalous, zero, and normal path-average dispersion
- 1998
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In: Optics Letters. - Goteborg, Sweden : Chalmers Tekniska Hogskola. - 0146-9592 .- 1539-4794. ; 23:12, s. 900-902
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Reports (other academic/artistic)abstract
- We determine the power dependence of dispersion-managed solitons on map strength and average dispersion, using a combination of numerical simulations and the variational approach. In particular, we investigate the behavior near zero dispersion and identify the region of existence of dispersion-managed solitons in the average normal-dispersion regime.
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| 15. |
- Di Giglio, A., et al.
(author)
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Towards the distributed core for ubiquitous superfast broadband optical access
- 2014
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In: 2014 European Conference on Networks and Communications (EuCNC). ; , s. 1-5
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Conference paper (peer-reviewed)abstract
- In this paper, we describe recent architectural and technological advances of the end to end optical network architecture proposed by the DISCUS project (the DIStributed Core for unlimited bandwidth supply for all Users and Services). The two main targets of DISCUS are the principle of equivalence in the access and the reduction of optical-to-electronic conversions in the metro-core network. Technological advances and techno-economic evaluation of Long-Reach Passive Optical Networks (LR-PON), as well as the optimal metro-core node architecture and the required network control plane framework are reported. Network infrastructure sharing challenges are also discussed.
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| 17. |
- Formenti, Federico, et al.
(author)
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Respiratory oscillations in alveolar oxygen tension measured in arterial blood.
- 2017
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7
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Journal article (peer-reviewed)abstract
- Arterial oxygen partial pressure can increase during inspiration and decrease during expiration in the presence of a variable shunt fraction, such as with cyclical atelectasis, but it is generally presumed to remain constant within a respiratory cycle in the healthy lung. We measured arterial oxygen partial pressure continuously with a fast intra-vascular sensor in the carotid artery of anaesthetized, mechanically ventilated pigs, without lung injury. Here we demonstrate that arterial oxygen partial pressure shows respiratory oscillations in the uninjured pig lung, in the absence of cyclical atelectasis (as determined with dynamic computed tomography), with oscillation amplitudes that exceeded 50 mmHg, depending on the conditions of mechanical ventilation. These arterial oxygen partial pressure respiratory oscillations can be modelled from a single alveolar compartment and a constant oxygen uptake, without the requirement for an increased shunt fraction during expiration. Our results are likely to contribute to the interpretation of arterial oxygen respiratory oscillations observed during mechanical ventilation in the acute respiratory distress syndrome.
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| 18. |
- Lee, Ho-Hsien, et al.
(author)
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Expression, purification and crystallization of CTB-MPR, a candidate mucosal vaccine component against HIV-1
- 2014
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In: IUCrJ. - 2052-2525. ; 1:5, s. 305-317
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Journal article (peer-reviewed)abstract
- CTB-MPR is a fusion protein between the B subunit of cholera toxin (CTB) andthe membrane-proximal region of gp41 (MPR), the transmembrane envelopeprotein ofHuman immunodeficiency virus 1(HIV-1), and has previously beenshown to induce the production of anti-HIV-1 antibodies with antiviralfunctions. To further improve the design of this candidate vaccine, X-raycrystallography experiments were performed to obtain structural informationabout this fusion protein. Several variants of CTB-MPR were designed,constructed and recombinantly expressed inEscherichia coli. The first variantcontained a flexible GPGP linker between CTB and MPR, and yielded crystalsthat diffracted to a resolution of 2.3 A ̊, but only the CTB region was detectedin the electron-density map. A second variant, in which the CTB was directlyattached to MPR, was shown to destabilize pentamer formation. A thirdconstruct containing a polyalanine linker between CTB and MPR proved tostabilize the pentameric form of the protein during purification. The purificationprocedure was shown to produce a homogeneously pure and monodispersesample for crystallization. Initial crystallization experiments led to pseudo-crystals which were ordered in only two dimensions and were disordered inthe third dimension. Nanocrystals obtained using the same precipitant showedpromising X-ray diffraction to 5 A ̊resolution in femtosecond nanocrystallo-graphy experiments at the Linac Coherent Light Source at the SLAC NationalAccelerator Laboratory. The results demonstrate the utility of femtosecondX-ray crystallography to enable structural analysis based on nano/microcrystalsof a protein for which no macroscopic crystals ordered in three dimensions havebeen observed before.
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| 19. |
- Nijhot, J. H. B., et al.
(author)
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Energy enhancement of dispersion-managed solitons and WDM
- 1998
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In: Electronics Letters. - Goteborg, Sweden : Chalmers Tekniska Hogskola. - 0013-5194 .- 1350-911X. ; 34:5, s. 481-482
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Reports (other academic/artistic)abstract
- It is shown that for very strong dispersion management, the energy enhancement depends not only on the dispersion map strength, but also on the ratio between the dispersion difference and the average dispersion. In WDM systems operating near zero average dispersion, this dependence can be exploited to almost equalise the energy per channel.
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| 23. |
- Whitesides, L., et al.
(author)
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iPTF 16asu : A Luminous, Rapidly Evolving, and High-velocity Supernova
- 2017
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In: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 851:2
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Journal article (peer-reviewed)abstract
- Wide-field surveys are discovering a growing number of rare transients whose physical origin is not yet well understood. Here we present optical and UV data and analysis of intermediate Palomar Transient Factory (iPTF) 16asu, a luminous, rapidly evolving, high-velocity, stripped-envelope supernova ( SN). With a rest-frame rise time of just four. days and a peak absolute magnitude of M-g = -20.4 mag, the light curve of iPTF 16asu is faster and more luminous than that of previous rapid transients. The spectra of iPTF 16asu show a featureless blue continuum near peak that develops into an SN Ic-BL spectrum on the decline. We show that while the late-time light curve could plausibly be powered by Ni-56 decay, the early emission requires a different energy source. Nondetections in the X-ray and radio strongly constrain the energy coupled to relativistic ejecta to be at most comparable to the class of low-luminosity gamma-ray bursts (GRBs). We suggest that the early emission may have been powered by either a rapidly spinning-down magnetar or by shock breakout in an extended envelope of a very energetic explosion. In either scenario a central engine is required, making iPTF 16asu an intriguing transition object between superluminous SNe, SNe Ic-BL, and low-luminosity GRBs.
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