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Träfflista för sökning "WFRF:(Draoui Hend) "

Search: WFRF:(Draoui Hend)

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  • Haddada, Meriem, et al. (author)
  • Kallikrein-related peptidase 7 overexpression in melanoma cells modulates cell adhesion leading to a malignant phenotype
  • 2018
  • In: Biological chemistry (Print). - : Walter de Gruyter. - 1431-6730 .- 1437-4315. ; 399:9, s. 1099-1105
  • Journal article (peer-reviewed)abstract
    • We recently reported that human melanoma cells, but not benign melanocytes, aberrantly express kallikrein-related peptidase 7 (KLK7). Here, we show a KLK7 overexpression-mediated decrease of cell adhesion to extracellular matrix binding proteins, associated with downregulation of alpha 5/beta 1/alpha v/beta 3 integrin expression. We also report an up-regulation of MCAM/CD146 and an increase in spheroid formation of these cells. Our results demonstrate that aberrant KLK7 expression leads to a switch to a more malignant phenotype suggesting a potential role of KLK7 in melanoma invasion. Thus, KLK7 may represent a biomarker for melanoma progression and may be a potential therapeutic target for melanoma.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Brattsand, Maria (1)
Delaunay, Tiphaine (1)
Deschamps, Lydia (1)
Haddada, Meriem (1)
Walker, Francine (1)
Magdolen, Viktor (1)
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Darmoul, Dalila (1)
Draoui, Hend (1)
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University
Umeå University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2018 (1)

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