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Search: WFRF:(Dubinina E)

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  • Lundgren, E, et al. (author)
  • Invasin of Yersinia pseudotuberculosis activates human peripheral B cells.
  • 1996
  • In: Infection and Immunity. - 0019-9567 .- 1098-5522. ; 64:3, s. 829-35
  • Journal article (peer-reviewed)abstract
    • The Yersinia pseudotuberculosis cell surface-located protein invasin was found to promote binding between the pathogen and resting peripheral B cells via beta 1 integrin receptors (CD29). B cells responded by expressing several activation markers and by growing, In contrast, T cells did not react, although these cells express CD29. An isogenic invA mutant failed to activate B cells. The mutation could be complemented by providing the invA+ gene in trans. Purified invasin alone did not activate B cells, although it was able to block the binding of bacteria to the cells.
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