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1.	Takahashi, Harumi, et al. (author) Correlations between the enantio- and regio-selective metabolisms of warfarin 2017 In: Pharmacogenomics (London). - : Future Medicine Ltd. - 1462-2416 .- 1744-8042. ; 18:2, s. 133-142 Journal article (peer-reviewed)abstract Aim: To clarify whether the activities of multiple CYPs associated with warfarin metabolism would be correlated with each other. Methods: Oral clearances (CLpo) of warfarin enantiomers were estimated in 378 Chinese, Caucasians and African-Americans. The partial metabolic clearances (CLm) for 7-hydroxywarfarin enantiomers were also measured. In addition, CLpo and CLm were determined in a patient on warfarin and rifampicin. Results: Correlations between CLpo for warfarin enantiomers existed across the three populations. In addition, there was a significant correlation between the CLm for 7-hydroxylation of warfarin enantiomers. Under induced conditions by rifampicin, there were significant correlations between the enantio-and regio-selective metabolisms of warfarin. Conclusion: Metabolic activities of CYP2C9, CYP1A2 and CYP3A4 may be regulated by common transcriptional mechanism(s).
2.	Takahashi, Harumi, et al. (author) Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans. 2006 In: Pharmacogenet Genomics. - 1744-6872. ; 16:2, s. 101-10 Journal article (peer-reviewed)

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Nutescu, Edith A. (2); Scordo, Maria Gabrie ... (2); Pengo, Vittorio (2); Padrini, Roberto (2); Takahashi, Harumi (2); Echizen, Hirotoshi (2); show more...; Kijima, Shinichi (1); Lee, Ming Ta Michael (1); Cavallari, Larisa H. (1); Chen, Yuan-Tsong (1); Ritchie, Marylyn D. (1); Ohara, Minami (1); Shibata, Soichi (1); Atsuda, Koichiro (1); Matsubara, Hajime (1); Wilkinson, Grant R (1); Morita, Takashi (1); Barban, Martina (1); Ieiri, Ichiro (1); Otsubo, Kenji (1); Kashima, Toshitaka (1); Kimura, Sosuke (1); show less...

University: Uppsala University (2)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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