| 1. |
- Hibar, D. P., et al.
(författare)
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Cortical abnormalities in bipolar disorder: An MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group
- 2018
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Ingår i: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 23:4, s. 932-942
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Tidskriftsartikel (refereegranskat)abstract
- Despite decades of research, the pathophysiology of bipolar disorder (BD) is still not well understood. Structural brain differences have been associated with BD, but results from neuroimaging studies have been inconsistent. To address this, we performed the largest study to date of cortical gray matter thickness and surface area measures from brain magnetic resonance imaging scans of 6503 individuals including 1837 unrelated adults with BD and 2582 unrelated healthy controls for group differences while also examining the effects of commonly prescribed medications, age of illness onset, history of psychosis, mood state, age and sex differences on cortical regions. In BD, cortical gray matter was thinner in frontal, temporal and parietal regions of both brain hemispheres. BD had the strongest effects on left pars opercularis (Cohen's d='0.293; P=1.71 × 10 '21), left fusiform gyrus (d='0.288; P=8.25 × 10 '21) and left rostral middle frontal cortex (d='0.276; P=2.99 × 10 '19). Longer duration of illness (after accounting for age at the time of scanning) was associated with reduced cortical thickness in frontal, medial parietal and occipital regions. We found that several commonly prescribed medications, including lithium, antiepileptic and antipsychotic treatment showed significant associations with cortical thickness and surface area, even after accounting for patients who received multiple medications. We found evidence of reduced cortical surface area associated with a history of psychosis but no associations with mood state at the time of scanning. Our analysis revealed previously undetected associations and provides an extensive analysis of potential confounding variables in neuroimaging studies of BD. © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
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| 2. |
- Hibar, D. P., et al.
(författare)
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Subcortical volumetric abnormalities in bipolar disorder
- 2016
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Ingår i: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 21:12, s. 1710-1716
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Tidskriftsartikel (refereegranskat)abstract
- Considerable uncertainty exists about the defining brain changes associated with bipolar disorder (BD). Understanding and quantifying the sources of uncertainty can help generate novel clinical hypotheses about etiology and assist in the development of biomarkers for indexing disease progression and prognosis. Here we were interested in quantifying case-control differences in intracranial volume (ICV) and each of eight subcortical brain measures: nucleus accumbens, amygdala, caudate, hippocampus, globus pallidus, putamen, thalamus, lateral ventricles. In a large study of 1710 BD patients and 2594 healthy controls, we found consistent volumetric reductions in BD patients for mean hippocampus (Cohen's d=-0.232; P=3.50 × 10 -7) and thalamus (d=-0.148; P=4.27 × 10 -3) and enlarged lateral ventricles (d=-0.260; P=3.93 × 10 -5) in patients. No significant effect of age at illness onset was detected. Stratifying patients based on clinical subtype (BD type I or type II) revealed that BDI patients had significantly larger lateral ventricles and smaller hippocampus and amygdala than controls. However, when comparing BDI and BDII patients directly, we did not detect any significant differences in brain volume. This likely represents similar etiology between BD subtype classifications. Exploratory analyses revealed significantly larger thalamic volumes in patients taking lithium compared with patients not taking lithium. We detected no significant differences between BDII patients and controls in the largest such comparison to date. Findings in this study should be interpreted with caution and with careful consideration of the limitations inherent to meta-analyzed neuroimaging comparisons. © 2016 Macmillan Publishers Limited, part of Springer Nature.
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| 3. |
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| 4. |
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| 5. |
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| 6. |
- Andreoiu, Corina, et al.
(författare)
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Evolution of Shapes in 59Cu
- 2002
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Ingår i: European Physical Journal A. Hadrons and Nuclei. - : Springer Science and Business Media LLC. - 1434-6001. ; 14:3, s. 317-348
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Tidskriftsartikel (refereegranskat)abstract
- High-spin states in Cu-59 were populated using the fusion-evaporation reaction Si-28 + Ca-40 at a beam energy of 122 MeV. The Gammasphere Ge-detector array in conjunction with the 4pi charged-particle detector array Microball allowed for the detection of gamma-rays in coincidence with evaporated light particles. The resulting extensive high-spin decay scheme of Cu-59 is presented, which comprises more than 320 gamma-ray transitions connecting about 150 excited states. Their spins and parities have been assigned via directional correlations of gamma-rays emitted from oriented states. Average quadrupole moments of rotational bands have been determined from the analysis of residual Doppler shifts. Shell model calculations in the fp shell are invoked to study some of the low-spin states, while the experimental characteristics of the rotational bands are analyzed in the configuration-dependent cranked Nilsson-Strutinsky (CNS) approach.
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| 7. |
- Granger, B. B., et al.
(författare)
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Results of the Chronic Heart Failure Intervention to Improve MEdication Adherence study: A randomized intervention in high-risk patients
- 2015
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Ingår i: American Heart Journal. - : Elsevier BV. - 0002-8703. ; 169:4, s. 539-548
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Tidskriftsartikel (refereegranskat)abstract
- Background Poor adherence to evidence-based medications in heart failure (HF) is a major cause of avoidable hospitalizations, disability, and death. To test the feasibility of improving medication adherence, we performed a randomized proof-of-concept study of a self-management intervention in high-risk patients with HF. Methods Patients with HF who screened positively for poor adherence (<6 Morisky Medication Adherence Scale 8-item) were randomized to either the intervention or attention control group. In the intervention group (n = 44), a nurse conducted self-management training before discharge that focused on identification of medication goals, facilitation of medication-symptom associations, and use of a symptom response plan. The attention control group (n = 42) received usual care; both groups received follow-up calls at 1 week. However, the content of follow-up calls for the attention control group was unrelated to HF medications or symptoms. General linear mixed models were used to evaluate the magnitude of change in adherence and symptom-related events at 3-, 6-, and 12-month follow-up clinic visits. Efficacy was measured as improved medication adherence using nurse-assessed pill counts at each time point. Results Pooled over all time points, patients in the intervention group were more likely to be adherent to medications compared with patients in the attention control group (odds ratio 3.92, t = 3.51, P = .0007). Conclusions A nurse-delivered, self-care intervention improved medication adherence in patients with advanced HF. Further work is needed to examine whether this intervention can be sustained to improve clinical outcomes.
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| 8. |
- Thompson, Paul M., et al.
(författare)
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The ENIGMA Consortium : large-scale collaborative analyses of neuroimaging and genetic data
- 2014
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Ingår i: BRAIN IMAGING BEHAV. - : Springer Science and Business Media LLC. - 1931-7557 .- 1931-7565. ; 8:2, s. 153-182
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Tidskriftsartikel (refereegranskat)abstract
- The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.
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| 9. |
- Ölvander, J., et al.
(författare)
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Preface
- 2018
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Ingår i: Proceedings of NordDesign. - Linköping : Design Research Society. - 9789176851852
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Konferensbidrag (populärvet., debatt m.m.)
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| 10. |
- Ölvander, J., et al.
(författare)
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Preface
- 2018
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Ingår i: Proceedings of NordDesign. - : The Design Society.
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Konferensbidrag (refereegranskat)
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| 11. |
- Andreoiu, Corina, et al.
(författare)
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First Identification of Excited States in 59Zn
- 2002
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Ingår i: European Physical Journal A. Hadrons and Nuclei. - : Springer Science and Business Media LLC. - 1434-6001. ; 15, s. 459-462
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Tidskriftsartikel (refereegranskat)abstract
- Excited states in 59Zn were observed for the first time following the fusion-evaporation reaction 24Mg + 40Ca at a beam energy of 60 MeV. The GASP array in conjunction with the ISIS Silicon ball and the NeutronRing allowed for the detection of n-rays in coincidence with evaporated light particles. The mirror symmetry of 59Zn and 59Cu is discussed.
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| 12. |
- Bergemalm, Daniel, 1977-, et al.
(författare)
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Systemic Inflammation in Preclinical Ulcerative Colitis
- 2021
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Ingår i: Gastroenterology. - : AGA Institute. - 0016-5085 .- 1528-0012. ; 161:5, s. 1526-1539.e9
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Tidskriftsartikel (refereegranskat)abstract
- Background & Aims: Preclinical ulcerative colitis is poorly defined. We aimed to characterize the preclinical systemic inflammation in ulcerative colitis, using a comprehensive set of proteins.Methods: We obtained plasma samples biobanked from individuals who developed ulcerative colitis later in life (n = 72) and matched healthy controls (n = 140) within a population-based screening cohort. We measured 92 proteins related to inflammation using a proximity extension assay. The biologic relevance of these findings was validated in an inception cohort of patients with ulcerative colitis (n = 101) and healthy controls (n = 50). To examine the influence of genetic and environmental factors on these markers, a cohort of healthy twin siblings of patients with ulcerative colitis (n = 41) and matched healthy controls (n = 37) were explored.Results: Six proteins (MMP10, CXCL9, CCL11, SLAMF1, CXCL11 and MCP-1) were up-regulated (P < .05) in preclinical ulcerative colitis compared with controls based on both univariate and multivariable models. Ingenuity Pathway Analyses identified several potential key regulators, including interleukin-1β, tumor necrosis factor, interferon-gamma, oncostatin M, nuclear factor-κB, interleukin-6, and interleukin-4. For validation, we built a multivariable model to predict disease in the inception cohort. The model discriminated treatment-naïve patients with ulcerative colitis from controls with leave-one-out cross-validation (area under the curve = 0.92). Consistently, MMP10, CXCL9, CXCL11, and MCP-1, but not CCL11 and SLAMF1, were significantly up-regulated among the healthy twin siblings, even though their relative abundances seemed higher in incident ulcerative colitis.Conclusions: A set of inflammatory proteins are up-regulated several years before a diagnosis of ulcerative colitis. These proteins were highly predictive of an ulcerative colitis diagnosis, and some seemed to be up-regulated already at exposure to genetic and environmental risk factors.
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| 13. |
- Bergquist, Jonas, et al.
(författare)
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Capillary electrophoresis with laser-induced fluorescence detection : a sensitive method for monitoring extracellular concentrations of amino acids in the periaqueductal grey matter.
- 1996
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Ingår i: Journal of Neuroscience Methods. - : Elsevier BV. - 0165-0270 .- 1872-678X. ; 65:1, s. 33-42
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Tidskriftsartikel (refereegranskat)abstract
- The use of capillary electrophoresis with laser-induced fluorescence detection (CE-LIF) for the analysis of microdialysate samples from the periaqueductal grey matter (PAG) of freely moving rats is described. By employing 3-(4-carboxybenzoyl)-2-quinoline-carboxaldehyde (CBQCA) as a derivatization agent, we simultaneously monitored the concentrations of 8 amino acids (arginine, glutamine, valine, gamma-amino-n-butyric acid (GABA), alanine, glycine, glutamate, and aspartate), with nanomolar and subnanomolar detection limits. Two of the amino acids (GABA and glutamate) were analysed in parallel by conventional high-performance liquid chromatography (HPLC) in order to directly compare the two analytical methods. Other CE methods for analysis of microdialysate have been previously described, and this improved method offers greater sensitivity, ease of use, and the possibility to monitor several amino acids simultaneously. By using this technique together with an optimised form of microdialysis technique, the tiny sample consumption and the improved detection limits permit the detection of fast and transient transmitter changes.
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| 14. |
- Bhattachariya, Anirban, et al.
(författare)
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Spontaneous activity and stretch-induced contractile differentiation are reduced in vascular smooth muscle of miR-143/145 knockout mice.
- 2015
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Ingår i: Acta Physiologica. - : Wiley. - 1748-1716 .- 1748-1708. ; 215:3, s. 133-143
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Tidskriftsartikel (refereegranskat)abstract
- Stretch is essential for maintaining the contractile phenotype of vascular smooth muscle cells, and small non-coding microRNAs are known to be important in this process. Using a Dicer knockout model, we have previously reported that microRNAs are essential for stretch-induced differentiation and regulation of L-type calcium channel expression. The aim of this study was to investigate the importance of the smooth muscle-enriched miR-143/145 microRNA cluster for stretch-induced differentiation of the portal vein.
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| 15. |
- Boy, M., et al.
(författare)
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Interactions between the atmosphere, cryosphere, and ecosystems at northern high latitudes
- 2019
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Ingår i: Atmospheric Chemistry and Physics. - : Copernicus GmbH. - 1680-7316 .- 1680-7324. ; 19:3, s. 2015-2061
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Tidskriftsartikel (refereegranskat)abstract
- The Nordic Centre of Excellence CRAICC (Cryosphere-Atmosphere Interactions in a Changing Arctic Climate), funded by NordForsk in the years 2011-2016, is the largest joint Nordic research and innovation initiative to date, aiming to strengthen research and innovation regarding climate change issues in the Nordic region. CRAICC gathered more than 100 scientists from all Nordic countries in a virtual centre with the objectives of identifying and quantifying the major processes controlling Arctic warming and related feedback mechanisms, outlining strategies to mitigate Arctic warming, and developing Nordic Earth system modelling with a focus on short-lived climate forcers (SLCFs), including natural and anthropogenic aerosols. The outcome of CRAICC is reflected in more than 150 peer-reviewed scientific publications, most of which are in the CRAICC special issue of the journal Atmospheric Chemistry and Physics. This paper presents an overview of the main scientific topics investigated in the centre and provides the reader with a state-of-the-art comprehensive summary of what has been achieved in CRAICC with links to the particular publications for further detail. Faced with a vast amount of scientific discovery, we do not claim to completely summarize the results from CRAICC within this paper, but rather concentrate here on the main results which are related to feedback loops in climate change-cryosphere interactions that affect Arctic amplification.
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| 16. |
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| 17. |
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| 18. |
- Ekman, Jörgen, et al.
(författare)
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Unusual Isospin-Breaking and Isospin-mixing Effects in the A=35 Mirror Nuclei
- 2004
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Ingår i: Physical Review Letters. - 1079-7114. ; 92:13
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Tidskriftsartikel (refereegranskat)abstract
- Excited states have been studied in Ar-35 following the O-16(Mg-24,1alpha1n)Ar-35 fusion-evaporation reaction at 60 MeV using the Ge-detector array GASP. A comparison with the mirror nucleus Cl-35 shows two remarkable features: (i) A surprisingly large energy difference for the 13/2(-) states, in which the hitherto overlooked electromagnetic spin-orbit term is shown to play a major role, and (ii) a very different decay pattern for the 7/2(-) states, which provides direct evidence of isospin mixing.
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| 19. |
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| 20. |
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| 21. |
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| 22. |
- Hamnerius, Yngve, 1950, et al.
(författare)
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Design of Safe Wireless Power Transfer Systems for Electric Vehicles
- 2018
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Ingår i: 2018 2nd URSI Atlantic Radio Science Meeting, AT-RASC 2018. - 9789082598735
-
Konferensbidrag (refereegranskat)abstract
- Wireless charging of electric vehicles is convenient but in order to make it safe the exposure of humans to electromagnetic fields must be below acceptable limits. We have designed a prototype system that transmits 3 kW with an efficiency of 85% where the magnetic fields around and inside the vehicle are below the EU council recommendation of 6.25μT at 85 kHz.
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| 23. |
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| 24. |
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| 25. |
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| 26. |
- Aad, G., et al.
(författare)
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Luminosity determination in pp collisions at √s=13 TeV using the ATLAS detector at the LHC
- 2023
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Ingår i: European Physical Journal C. - : Institute for Ionics. - 1434-6044 .- 1434-6052. ; 83:10
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Tidskriftsartikel (refereegranskat)abstract
- The luminosity determination for the ATLAS detector at the LHC during Run 2 is presented, with pp collisions at a centre-of-mass energy s=13 TeV. The absolute luminosity scale is determined using van der Meer beam separation scans during dedicated running periods in each year, and extrapolated to the physics data-taking regime using complementary measurements from several luminosity-sensitive detectors. The total uncertainties in the integrated luminosity for each individual year of data-taking range from 0.9% to 1.1%, and are partially correlated between years. After standard data-quality selections, the full Run 2 pp data sample corresponds to an integrated luminosity of 140.1 ± 1.2 fb - 1 , i.e. an uncertainty of 0.83%. A dedicated sample of low-pileup data recorded in 2017–2018 for precision Standard Model physics measurements is analysed separately, and has an integrated luminosity of 338.1 ± 3.1 pb - 1 . © 2023, The Author(s).
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| 27. |
- Aad, G., et al.
(författare)
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Measurement of the Centrality Dependence of the Dijet Yield in Formula Presented Collisions at Formula Presented with the ATLAS Detector
- 2024
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Ingår i: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 132:10
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Tidskriftsartikel (refereegranskat)abstract
- ATLAS measured the centrality dependence of the dijet yield using Formula Presented of Formula Presented data collected at Formula Presented in 2016. The event centrality, which reflects the Formula Presented impact parameter, is characterized by the total transverse energy registered in the Pb-going side of the forward calorimeter. The central-to-peripheral ratio of the scaled dijet yields, Formula Presented, is evaluated, and the results are presented as a function of variables that reflect the kinematics of the initial hard parton scattering process. The Formula Presented shows a scaling with the Bjorken Formula Presented of the parton originating from the proton, Formula Presented, while no such trend is observed as a function of Formula Presented. This analysis provides unique input to understanding the role of small proton spatial configurations in Formula Presented collisions by covering parton momentum fractions from the valence region down to Formula Presented and Formula Presented. © 2024 CERN, for the ATLAS Collaboration.
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| 28. |
- Aad, G., et al.
(författare)
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Measurement of the charge asymmetry in top-quark pair production in association with a photon with the ATLAS experiment
- 2023
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Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 843
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Tidskriftsartikel (refereegranskat)abstract
- A measurement of the charge asymmetry in top-quark pair (tt¯) production in association with a photon is presented. The measurement is performed in the single-lepton tt¯ decay channel using proton–proton collision data collected with the ATLAS detector at the Large Hadron Collider at CERN at a centre-of-mass-energy of 13 TeV during the years 2015–2018, corresponding to an integrated luminosity of 139 fb−1. The charge asymmetry is obtained from the distribution of the difference of the absolute rapidities of the top quark and antiquark using a profile likelihood unfolding approach. It is measured to be AC=−0.003±0.029 in agreement with the Standard Model expectation. © 2023 The Author(s)
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| 29. |
- Aad, G., et al.
(författare)
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Measurement of the cross-sections of the electroweak and total production of a Zγ pair in association with two jets in pp collisions at s=13 TeV with the ATLAS detector
- 2023
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Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - 0370-2693. ; 846
-
Tidskriftsartikel (refereegranskat)abstract
- This Letter presents the measurement of the fiducial and differential cross-sections of the electroweak production of a Zγ pair in association with two jets. The analysis uses 140 fb−1 of LHC proton–proton collision data taken at s=13 TeV recorded by the ATLAS detector during the years 2015–2018. Events with a Z boson candidate decaying into either an e+e− or μ+μ− pair, a photon and two jets are selected. The electroweak component is extracted by requiring a large dijet invariant mass and by using the information about the centrality of the system and is measured with an observed and expected significance well above five standard deviations. The fiducial pp→Zγjj cross-section for the electroweak production is measured to be 3.6 ± 0.5 fb. The total fiducial cross-section that also includes contributions where the jets arise from strong interactions is measured to be 16.8−1.8+2.0 fb. The results are consistent with the Standard Model predictions. Differential cross-sections are also measured using the same events and are compared with parton-shower Monte Carlo simulations. Good agreement is observed between data and predictions. © 2023 The Author(s)
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| 30. |
- Aad, G., et al.
(författare)
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Measurement of the Higgs boson mass with H → γγ decays in 140 fb−1 of s=13 TeV pp collisions with the ATLAS detector
- 2023
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Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier B.V.. - 0370-2693 .- 1873-2445. ; 847
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Tidskriftsartikel (refereegranskat)abstract
- The mass of the Higgs boson is measured in the H→γγ decay channel, exploiting the high resolution of the invariant mass of photon pairs reconstructed from the decays of Higgs bosons produced in proton–proton collisions at a centre-of-mass energy s=13 TeV. The dataset was collected between 2015 and 2018 by the ATLAS detector at the Large Hadron Collider, and corresponds to an integrated luminosity of 140 fb−1. The measured value of the Higgs boson mass is 125.17±0.11(stat.)±0.09(syst.) GeV and is based on an improved energy scale calibration for photons, whose impact on the measurement is about four times smaller than in the previous publication. A combination with the corresponding measurement using 7 and 8 TeV pp collision ATLAS data results in a Higgs boson mass measurement of 125.22±0.11(stat.)±0.09(syst.) GeV. With an uncertainty of 1.1 per mille, this is currently the most precise measurement of the mass of the Higgs boson from a single decay channel.
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| 31. |
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| 32. |
- Aad, G., et al.
(författare)
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Measurement of the Sensitivity of Two-Particle Correlations in pp Collisions to the Presence of Hard Scatterings
- 2023
-
Ingår i: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 131:16
-
Tidskriftsartikel (refereegranskat)abstract
- A key open question in the study of multiparticle production in high-energy pp collisions is the relationship between the “ridge”—i.e., the observed azimuthal correlations between particles in the underlying event that extend over all rapidities—and hard or semihard scattering processes. In particular, it is not known whether jets or their soft fragments are correlated with particles in the underlying event. To address this question, two-particle correlations are measured in pp collisions at √s=13 TeV using data collected by the ATLAS experiment at the LHC, with an integrated luminosity of 15.8 pb−1, in two different configurations. In the first case, charged particles associated with jets are excluded from the correlation analysis, while in the second case, correlations are measured between particles within jets and charged particles from the underlying event. Second-order flow coefficients, v2, are presented as a function of event multiplicity and transverse momentum. These measurements show that excluding particles associated with jets does not affect the measured correlations. Moreover, particles associated with jets do not exhibit any significant azimuthal correlations with the underlying event, ruling out hard processes contributing to the ridge.
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| 33. |
- Aad, G., et al.
(författare)
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Measurements of the suppression and correlations of dijets in Xe+Xe collisions at Formula Presented TeV
- 2023
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Ingår i: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 108:2
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Tidskriftsartikel (refereegranskat)abstract
- Measurements of the suppression and correlations of dijets is performed using 3 µ b − 1 of Xe+Xe data at s N N = 5.44 TeV collected with the ATLAS detector at the CERN Large Hadron Collider. Dijets with jets reconstructed using the R = 0.4 anti- k t algorithm are measured differentially in jet p T over the range of 32 to 398 GeV and the centrality of the collisions. Significant dijet momentum imbalance is found in the most central Xe+Xe collisions, which decreases in more peripheral collisions. Results from the measurement of per-pair normalized and absolutely normalized dijet p T balance are compared with previous Pb + Pb measurements at s N N = 5.02 TeV. The differences between the dijet suppression in Xe+Xe and Pb + Pb are further quantified by the ratio of pair nuclear-modification factors. The results are found to be consistent with those measured in Pb + Pb data when compared in classes of the same event activity and when taking into account the difference between the center-of-mass energies of the initial parton scattering process in Xe+Xe and Pb + Pb collisions. These results should provide input for a better understanding of the role of energy density, system size, path length, and fluctuations in the parton energy loss. ©2023 CERN, for the ATLAS Collaboration.
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| 34. |
- Aad, G., et al.
(författare)
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Observation of WZγ Production in pp Collisions at sqrt[s]=13 TeV with the ATLAS Detector
- 2024
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Ingår i: Physical Review Letters. - : NA. - 1079-7114 .- 0031-9007. ; 132:2
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Tidskriftsartikel (refereegranskat)abstract
- This Letter reports the observation of WZγ production and a measurement of its cross section using 140.1±1.2 fb^{-1} of proton-proton collision data recorded at a center-of-mass energy of 13 TeV by the ATLAS detector at the Large Hadron Collider. The WZγ production cross section, with both the W and Z bosons decaying leptonically, pp→WZγ→ℓ^{'}^{±}νℓ^{+}ℓ^{-}γ (ℓ^{(^{'})}=e, μ), is measured in a fiducial phase-space region defined such that the leptons and the photon have high transverse momentum and the photon is isolated. The cross section is found to be 2.01±0.30(stat)±0.16(syst) fb. The corresponding standard model predicted cross section calculated at next-to-leading order in perturbative quantum chromodynamics and at leading order in the electroweak coupling constant is 1.50±0.06 fb. The observed significance of the WZγ signal is 6.3σ, compared with an expected significance of 5.0σ.
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| 35. |
- Aad, G., et al.
(författare)
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Search for lepton-flavour violation in high-mass dilepton final states using 139 fb −1 of pp collisions at √s = 13 TeV with the ATLAS detector
- 2023
-
Ingår i: Journal of High Energy Physics. - : Springer Nature. - 1029-8479 .- 1126-6708. ; 2023:10
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Tidskriftsartikel (refereegranskat)abstract
- A search is performed for a heavy particle decaying into different-flavour, dilepton final states, using 139 fb−1 of proton-proton collision data at s = 13 TeV collected in 2015–2018 by the ATLAS detector at the Large Hadron Collider. Final states with electrons, muons and hadronically decaying tau leptons are considered (eμ, eτ or μτ). No significant excess over the Standard Model predictions is observed. Upper limits on the production cross-section are set as a function of the mass of a Z′ boson, a supersymmetric τ-sneutrino, and a quantum black-hole. The observed 95% CL lower mass limits obtained on a typical benchmark model Z′ boson are 5.0 TeV (eμ), 4.0 TeV (eτ), and 3.9 TeV (μτ), respectively. [Figure not available: see fulltext.]. © 2023, The Author(s).
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| 36. |
- Aad, G., et al.
(författare)
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Search for non-resonant Higgs boson pair production in the 2b+2ℓ+ETmiss final state in pp collisions at s = 13 TeV with the ATLAS detector
- 2024
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Ingår i: Journal of High Energy Physics. - : Springer Science and Business Media Deutschland GmbH. - 1029-8479 .- 1126-6708. ; 2024:2
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Tidskriftsartikel (refereegranskat)abstract
- A search for non-resonant Higgs boson pair (HH) production is presented, in which one of the Higgs bosons decays to a b-quark pair (bb¯) and the other decays to WW*, ZZ*, or τ+τ−, with in each case a final state with ℓ+ℓ−+ neutrinos (ℓ = e, μ). The analysis targets separately the gluon-gluon fusion and vector boson fusion production modes. Data recorded by the ATLAS detector in proton-proton collisions at a centre-of-mass energy of 13 TeV at the Large Hadron Collider, corresponding to an integrated luminosity of 140 fb−1, are used in this analysis. Events are selected to have exactly two b-tagged jets and two leptons with opposite electric charge and missing transverse momentum in the final state. These events are classified using multivariate analysis algorithms to separate the HH events from other Standard Model processes. No evidence of the signal is found. The observed (expected) upper limit on the cross-section for non-resonant Higgs boson pair production is determined to be 9.7 (16.2) times the Standard Model prediction at 95% confidence level. The Higgs boson self-interaction coupling parameter κλ and the quadrilinear coupling parameter κ2V are each separately constrained by this analysis to be within the ranges [−6.2, 13.3] and [−0.17, 2.4], respectively, at 95% confidence level, when all other parameters are fixed. © The Author(s) 2024.
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| 37. |
- Aad, G., et al.
(författare)
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Search for the decay of the Higgs boson to a Z boson and a light pseudoscalar particle decaying to two photons
- 2024
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Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier B.V.. - 0370-2693 .- 1873-2445. ; 850
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Tidskriftsartikel (refereegranskat)abstract
- A search for the decay of the Higgs boson to a Z boson and a light, pseudoscalar particle, a, decaying respectively to two leptons and to two photons is reported. The search uses the full LHC Run 2 proton–proton collision data at s=13 TeV, corresponding to 139 fb−1 collected by the ATLAS detector. This is one of the first searches for this specific decay mode of the Higgs boson, and it probes unexplored parameter space in models with axion-like particles (ALPs) and extended scalar sectors. The mass of the a particle is assumed to be in the range 0.1–33 GeV. The data are analysed in two categories: a merged category where the photons from the a decay are reconstructed in the ATLAS calorimeter as a single cluster, and a resolved category in which two separate photons are detected. The main background processes are from Standard Model Z boson production in association with photons or jets. The data are in agreement with the background predictions, and upper limits on the branching ratio of the Higgs boson decay to Za times the branching ratio a→γγ are derived at the 95% confidence level and they range from 0.08% to 2% depending on the mass of the a particle. The results are also interpreted in the context of ALP models. © 2024 The Author(s)
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| 38. |
- Aad, G., et al.
(författare)
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Search for top-philic heavy resonances in pp collisions at s=13 TeV with the ATLAS detector
- 2024
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Ingår i: European Physical Journal C. - 1434-6044. ; 84:2
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Tidskriftsartikel (refereegranskat)abstract
- A search for the associated production of a heavy resonance with a top-quark or a top-antitop-quark pair, and decaying into a tt¯ pair is presented. The search uses the data recorded by the ATLAS detector in pp collisions at s=13 TeV at the Large Hadron Collider during the years 2015–2018, corresponding to an integrated luminosity of 139 fb-1. Events containing exactly one electron or muon are selected. The two hadronically decaying top quarks from the resonance decay are reconstructed using jets clustered with a large radius parameter of R=1. The invariant mass spectrum of the two top quark candidates is used to search for a resonance signal in the range of 1.0 TeV to 3.2 TeV. The presence of a signal is examined using an approach with minimal model dependence followed by a model-dependent interpretation. No significant excess is observed over the background expectation. Upper limits on the production cross section times branching ratio at 95% confidence level are provided for a heavy Z′ boson based on a simplified model, for Z′ mass between 1.0 TeV and 3.0 TeV. The observed (expected) limits range from 21 (14) fb to 119 (86) fb depending on the choice of model parameters. © The Author(s) 2024.
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| 39. |
- Aad, G., et al.
(författare)
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Software Performance of the ATLAS Track Reconstruction for LHC Run 3
- 2024
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Ingår i: Computing and Software for Big Science. - : Springer Nature. - 2510-2044. ; 8:1
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Tidskriftsartikel (refereegranskat)abstract
- Charged particle reconstruction in the presence of many simultaneous proton–proton (pp) collisions in the LHC is a challenging task for the ATLAS experiment’s reconstruction software due to the combinatorial complexity. This paper describes the major changes made to adapt the software to reconstruct high-activity collisions with an average of 50 or more simultaneous pp interactions per bunch crossing (pile-up) promptly using the available computing resources. The performance of the key components of the track reconstruction chain and its dependence on pile-up are evaluated, and the improvement achieved compared to the previous software version is quantified. For events with an average of 60pp collisions per bunch crossing, the updated track reconstruction is twice as fast as the previous version, without significant reduction in reconstruction efficiency and while reducing the rate of combinatorial fake tracks by more than a factor two. © The Author(s) 2024.
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| 40. |
- Aad, G., et al.
(författare)
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Study of High-Transverse-Momentum Higgs Boson Production in Association with a Vector Boson in the qqbb Final State with the ATLAS Detector
- 2024
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Ingår i: Physical Review Letters. - : American Physical Society (APS). - 0031-9007 .- 1079-7114. ; 132:13
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Tidskriftsartikel (refereegranskat)abstract
- This Letter presents the first study of Higgs boson production in association with a vector boson (V ¼ W or Z) in the fully hadronic qqbb final state using data recorded by the ATLAS detector at the LHC in proton-proton collisions at √s = 13 TeV and corresponding to an integrated luminosity of 137 fb−1. The vector bosons and Higgs bosons are each reconstructed as large-radius jets and tagged using jet substructure techniques. Dedicated tagging algorithms exploiting b-tagging properties are used to identify jets consistent with Higgs bosons decaying into bb̄. Dominant backgrounds from multijet production are determined directly from the data, and a likelihood fit to the jet mass distribution of Higgs boson candidates is used to extract the number of signal events. The VH production cross section is measured inclusively and differentially in several ranges of Higgs boson transverse momentum: 250–450, 450–650, and greater than 650 GeV. The inclusive signal yield relative to the standard model expectation is observed to be μ = 1.4+1.0−0.9 and the corresponding cross section is 3.1 ± 1.3(stat)+1.8−1.4(syst) pb. © 2024 CERN, for the ATLAS Collaboration.
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| 41. |
- Acosta Navarro, Juan Camilo, et al.
(författare)
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Amplification of Arctic warming by past air pollution reductions in Europe
- 2016
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Ingår i: Nature Geoscience. - : Nature Publishing Group. - 1752-0894 .- 1752-0908. ; 9:4, s. 277-
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Tidskriftsartikel (refereegranskat)abstract
- The Arctic region is warming considerably faster than the rest of the globe(1), with important consequences for the ecosystems(2) and human exploration of the region(3). However, the reasons behind this Arctic amplification are not entirely clear(4). As a result of measures to enhance air quality, anthropogenic emissions of particulate matter and its precursors have drastically decreased in parts of the Northern Hemisphere over the past three decades(5). Here we present simulations with an Earth system model with comprehensive aerosol physics and chemistry that show that the sulfate aerosol reductions in Europe since 1980 can potentially explain a significant fraction of Arctic warming over that period. Specifically, the Arctic region receives an additional 0.3Wm(-2) of energy, and warms by 0.5 degrees C on annual average in simulations with declining European sulfur emissions in line with historical observations, compared with a model simulation with fixed European emissions at 1980 levels. Arctic warming is amplified mainly in fall and winter, but the warming is initiated in summer by an increase in incoming solar radiation as well as an enhanced poleward oceanic and atmospheric heat transport. The simulated summertime energy surplus reduces sea-ice cover, which leads to a transfer of heat from the Arctic Ocean to the atmosphere. We conclude that air quality regulations in the Northern Hemisphere, the ocean and atmospheric circulation, and Arctic climate are inherently linked.
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| 42. |
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| 43. |
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| 44. |
- Amerl, M., et al.
(författare)
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Search for nonresonant pair production of Higgs bosons in the Formula Presented final state in pp collisions at Formula Presented with the ATLAS detector
- 2023
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Ingår i: Physical Review D. - : American Physical Society. - 2470-0010 .- 2470-0029. ; 108:5
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Tidskriftsartikel (refereegranskat)abstract
- A search for nonresonant Higgs boson pair production in the Formula Presented final state is presented. The analysis uses Formula Presented of Formula Presented collision data at Formula Presented collected with the ATLAS detector at the Large Hadron Collider, and targets both the gluon-gluon fusion and vector-boson fusion production modes. No evidence of the signal is found and the observed (expected) upper limit on the cross section for nonresonant Higgs boson pair production is determined to be 5.4 (8.1) times the Standard Model predicted cross section at 95% confidence level. Constraints are placed on modifiers to the Formula Presented and Formula Presented couplings. The observed (expected) Formula Presented constraints on the Formula Presented coupling modifier, Formula Presented, are determined to be Formula Presented (Formula Presented), while the corresponding constraints for the Formula Presented coupling modifier, Formula Presented, are Formula Presented (Formula Presented). In addition, constraints on relevant coefficients are derived in the context of the Standard Model effective field theory and Higgs effective field theory, and upper limits on the Formula Presented production cross section are placed in seven Higgs effective field theory benchmark scenarios. © 2023 CERN, for the ATLAS Collaboration.
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| 45. |
- Amini, Rose-Marie, et al.
(författare)
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A population-based study of the outcome for patients with first relapse of Hodgkin's lymphoma
- 2002
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Ingår i: European Journal of Haematology. - : Wiley. - 0902-4441 .- 1600-0609. ; 68:4, s. 225-232
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Tidskriftsartikel (refereegranskat)abstract
- Background: Our aims were to evaluate the response to salvage treatment in relation to initial treatment and to evaluate prognostic factors at the time of relapse in an unselected population of relapsing patients with Hodgkin's lymphoma (HL). Patients and methods: In total, 124 patients younger than 60 yr of age with initial diagnosis of HL in Sweden relapsed between 1985 and 1995. Results: Fifty-eight patients relapsed after initial treatment with radiotherapy (RT) only, 62 after combination chemotherapy (CT), of whom 30 had received additional involved-field RT, and four after a short course of CT followed by extended-field RT. For 37 patients among the 58 relapsers after initial RT treated according to the recommendations of the National guidelines, the 5-yr Hodgkin-specific survival (HLS) was 85%, overall survival (OS) 73% and event-free survival (EFS) 62%, which is not inferior to survival in patients with primarily advanced stages. It was poorer in the 21 patients who initially had received RT only, even though they had been recommended for more extensive treatment. For patients initially treated with a full course (6-8 cycles) of CT the 5-yr HLS was 60%, OS 58% and EFS 22%. Bulky disease and age at diagnosis strongly affected survival in a multivariate analysis. Conclusions: Patients initially treated with RT who relapse have a favourable outcome, provided they have been treated according to the recommendations of the guidelines at the time of diagnosis. Initially bulky disease and, as a consequence, additional RT as part of the initial treatment negatively affect survival at relapse in patients initially treated with a full course of CT.
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| 46. |
- Aulin, C., et al.
(författare)
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Cartilage repair of experimentally 11 induced osteochondral defects in New Zealand White rabbits
- 2013
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Ingår i: Laboratory Animals. - : SAGE Publications. - 0023-6772 .- 1758-1117. ; 47:1, s. 58-65
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Tidskriftsartikel (refereegranskat)abstract
- Articular cartilage has a limited capacity for self-repair in adult humans, and methods used to stimulate regeneration often result in re-growth of fibrous cartilage, which has lower durability. No current treatment option can provide complete repair. The possibility of growth factor delivery into the joint for cartilage regeneration after injury would be an attractive treatment option. A full thickness osteochondral defect of 4 mm in diameter and 2 mm deep was created by mechanical drilling in the medial femoral condyle in 20 female adult New Zealand White rabbits. In an attempt to improve regeneration a hyaluronic hydrogel system, with or without bone morphogenetic protein-2 (BMP-2) was delivered intraarticularly. The contralateral joint defect was treated with saline as control. Throughout the study, rabbits were clinically examined and after 12 (n = 6) or 24 (n = 9) weeks, the rabbits were euthanized and the joints evaluated by histology. The defects healed with fibrocartilage like tissue, and the filling of the defects ranged from less than 25% to complete. The healing of the defects varied both inter- and intra-group wise. Treatment with hyaluronan gel with or without BMP-2 had no effect on cartilage regeneration compared with controls. Instead, severe ectopic bone formation was found in seven joints treated with BMP-2. In conclusion, the present study shows that neither treatment with hyaluronic gel alone, nor in combination with BMP-2, improves the healing of an induced cartilage defect in rabbits. It further shows that BMP-2 can induce ectopic bone formation, which severely affects the functionality of the joint.
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| 47. |
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| 48. |
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| 49. |
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| 50. |
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