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Search: WFRF:(Elsby R.)

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  • Chu, X., et al. (author)
  • Intracellular Drug Concentrations and Transporters : Measurement, Modeling, and Implications for the Liver
  • 2013
  • In: Clinical Pharmacology and Therapeutics. - : Springer Science and Business Media LLC. - 0009-9236 .- 1532-6535. ; 94:1, s. 126-141
  • Research review (peer-reviewed)abstract
    • Intracellular concentrations of drugs and metabolites are often important determinants of efficacy, toxicity, and drug interactions. Hepatic drug distribution can be affected by many factors, including physicochemical properties, uptake/efflux transporters, protein binding, organelle sequestration, and metabolism.This white paper highlights determinants of hepatocyte drug/metabolite concentrations and provides an update on model systems, methods, and modeling/simulation approaches used to quantitatively assess hepatocellular concentrations of molecules. The critical scientific gaps and future research directions in this field are discussed.
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Type of publication
research review (1)
Type of content
peer-reviewed (1)
Author/Editor
Moss, A. (1)
Matsson, Pär (1)
Lai, Y (1)
Nagar, S (1)
Chu, X. (1)
Korzekwa, K. (1)
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Elsby, R. (1)
Fenner, K. (1)
Galetin, A. (1)
Rosania, G. R. (1)
Bai, J. P. F. (1)
Polli, J. W. (1)
Sugiyama, Y. (1)
Brouwer, K. L. R. (1)
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University
Uppsala University (1)
Language
English (1)
Year
2013 (1)

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