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1.	Parniczky, A, et al. (author) Antibiotic therapy in acute pancreatitis: From global overuse to evidence based recommendations 2019 In: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. - : Elsevier BV. - 1424-3911. ; 19:4, s. 488-499 Journal article (peer-reviewed)
2.	Bein, K, et al. (author) Genetic determinants of ammonia-induced acute lung injury in mice 2021 In: American journal of physiology. Lung cellular and molecular physiology. - : American Physiological Society. - 1522-1504 .- 1040-0605. ; 320:1, s. L41-L62 Journal article (peer-reviewed)abstract In this study, a genetically diverse panel of 43 mouse strains was exposed to ammonia, and genome-wide association mapping was performed employing a single-nucleotide polymorphism (SNP) assembly. Transcriptomic analysis was used to help resolve the genetic determinants of ammonia-induced acute lung injury. The encoded proteins were prioritized based on molecular function, nonsynonymous SNP within a functional domain or SNP within the promoter region that altered expression. This integrative functional approach revealed 14 candidate genes that included Aatf, Avil, Cep162, Hrh4, Lama3, Plcb4, and Ube2cbp, which had significant SNP associations, and Aff1, Bcar3, Cntn4, Kcnq5, Prdm10, Ptcd3, and Snx19, which had suggestive SNP associations. Of these genes, Bcar3, Cep162, Hrh4, Kcnq5, and Lama3 are particularly noteworthy and had pathophysiological roles that could be associated with acute lung injury in several ways.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Das, K. (1); Szabo, A. (1); Chang, MC (1); Sud, A (1); Sandblom, G. (1); Xia, Q. (1); show more...; Novak, J. (1); Upadhyay, S (1); Ganguly, K (1); Moore, D (1); Malecka-Panas, E (1); Huang, W (1); Poropat, G (1); Capurso, G (1); Sumegi, J (1); Sutton, R (1); Kaminski, N (1); Varga, M (1); Gasiorowska, A (1); Bein, K (1); Martin, TM (1); Concel, VJ (1); Brant, KA (1); Di, YPP (1); Fabisiak, JP (1); Vuga, LJ (1); Kostem, E (1); Eskin, E (1); Prows, DR (1); Jang, AS (1); Leikauf, GD (1); Bertilsson, Sara (1); Mayerle, J (1); Szabo, I (1); Hegyi, P (1); Chang, YT (1); Han, JM (1); Szentesi, Á (1); Dominguez-Munoz, JE (1); Papp, M (1); Czako, L (1); Takacs, M (1); Chen, WW (1); Marino, MV (1); Gomes, AP (1); Molero, X (1); Jumaa, H. (1); Xue, P (1); Szucs, A. (1); Parniczky, A (1); show less...

University: Karolinska Institutet (2); Lund University (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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