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1.
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2.
  • Glasbey, JC, et al. (author)
  • 2021
  • swepub:Mat__t
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5.
  • Khatri, C, et al. (author)
  • Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
  • 2021
  • In: BMJ open. - : BMJ. - 2044-6055. ; 11:11, s. e050830-
  • Journal article (peer-reviewed)abstract
    • Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.SettingProspective, international, multicentre, observational cohort study.ParticipantsPatients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.ResultsThis study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p<0.001), age >80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).ConclusionsPatients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration numberNCT04323644
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12.
  • Kanai, M, et al. (author)
  • 2023
  • swepub:Mat__t
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13.
  • Abdallah, J, et al. (author)
  • A precise measurement of the B+, B-0 and mean b-hadron lifetime with the DELPHI detector at LEP I
  • 2004
  • In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 33:3, s. 307-324
  • Journal article (peer-reviewed)abstract
    • Final results from the DELPHI Collaboration on the lifetime of B+ and B-0 mesons and the mean b-hadron lifetime, are presented using the data collected at the Z(0) peak in 1994 and 1995. Elaborate, inclusive, secondary vertexing methods have been employed to ensure a b-hadron reconstruction with good efficiency. To separate samples of B+ and B-0 mesons, high performance neural network techniques are used that achieve very high purity signals. The results obtained are: tau(B+) = 1.624+/-0.014 (stat)+/-0.018 (syst) ps tau(B)0 = 1.531+/-0.021 (stat)+/-0.031 (syst) ps tau(B+)/tau(B)0 = 1.060+/-0.021 (stat)+/-0.024 (syst) and for the average b-hadron lifetime: taub/tau(B)0 = 1.570+/-0.005 (stat)+/-0.008 (syst) ps.
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14.
  • Abdallah, J, et al. (author)
  • A precise measurement of the tau lifetime
  • 2004
  • In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 36:3, s. 283-296
  • Journal article (peer-reviewed)abstract
    • The tau lepton lifetime has been measured with the e(+) e(-) --> tau(+) tau(-) events collected by the DELPHI detector at LEP in the years 1991 - 1995. Three different methods have been exploited, using both one-prong and three-prong tau decay channels. Two measurements have been made using events in which both taus decay to a single charged particle. Combining these measurements gave tau(tau) ( 1 prong) = 291.8 +/- 2.3(stat) +/- 1.5(sys) fs. A third measurement using taus which decayed to three charged particles yielded tau(tau) (3 prong) = 288.6 +/- 2.4(stat) +/- 1.3(sys) fs. These were combined with previous DELPHI results to measure the tau lifetime, using the full LEP1 data sample, to be tau(tau) = 290.9 +/- 1.4(stat) +/- 1.0(sys) fs.
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15.
  • Abdallah, J, et al. (author)
  • Determination of heavy quark non-perturbative parametersfrom spectral moments in semileptonic B decays
  • 2006
  • In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 45:1, s. 35-59
  • Journal article (peer-reviewed)abstract
    • Moments of the hadronic invariant mass and of the lepton energy spectra in semileptonic B decays have been determined with the data recorded by the DELPHI detector at LEP. From measurements of the inclusive b-hadron semileptonic decays, and imposing constraints from other measurements on b- and c-quark masses, the first three moments of the lepton energy distribution and of the hadronic mass distribution, have been used to determine parameters which enter into the extraction of vertical bar V-cb vertical bar from the measurement of the inclusive b-hadron semileptonic decay width. The values obtained in the kinetic scheme are: m(b)(1 GeV) = 4.591 +/- 0.062 +/- 0.039 +/- 0.005 GeV/c(2), m(c)(1 GeV) = 1.170 +/- 0.093 +/- 0.055 +/- 0.005 GeV/c(2), m(pi)(2) (1 GeV) = 0.399 +/- 0.048 +/- 0.034 +/- 0.087 GeV2, (p) over tilde (3)(D) = 0.053 +/- 0.017 +/- 0.011 +/- 0.026 GeV3, and include corrections at order 1/m(b)(3). Using these results, and present measurements of the inclusive semileptonic decay partial width of b-hadrons at LEP, an accurate determination of vertical bar V-cb vertical bar is obtained: vertical bar V-cb vertical bar = 0.0421 x (1 +/- 0.014 (meas center dot) +/- 0.014 (fit) +/- 0.015 (th center dot)).
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16.
  • Abdallah, J, et al. (author)
  • Determination of the e(+)e(-)->gamma gamma(gamma) cross-section at LEP 2
  • 2004
  • In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 37:4, s. 405-419
  • Journal article (peer-reviewed)abstract
    • A test of the benchmark QED process e(+) e(-) -->gammagamma(gamma) is reported, using the data collected with the DELPHI detector at LEP 2. The data analysed were recorded at centre-of-mass energies ranging from 161 GeV to 208 GeV and correspond to a total integrated luminosity of 656.4 pb(-1). The Born cross-section for the process e(+) e(-)-->gammagamma(gamma) was determined, confirming the validity of QED at the highest energies ever attained in electron-positron collisions. Lower limits on the parameters of a number of possible deviations from QED, predicted within theoretical frameworks expressing physics beyond the Standard Model, were derived.
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17.
  • Abdallah, J, et al. (author)
  • Measurement of the energy dependence of hadronic jet rates and the strong coupling alpha(s) from the four-jet rate with the DELPHI detector at LEP
  • 2005
  • In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 38:4, s. 413-426
  • Journal article (peer-reviewed)abstract
    • Hadronic events from the data collected with the DELPHI detector at LEP within the energy range from 89 GeV to 209 GeV are selected, their jet rates are determined and compared to predictions of four different event generators. One of them is the recently developed APACIC++ generator which performs a massive matrix element calculation matched to a parton shower followed by string fragmentation. The four-jet rate is used to measure alpha(s) in the next-to-leading-order approximation yielding alpha(s)(M-Z(2)) = 0.1175 +/- 0.0030. The running of alpha(s) determined by using four-jet events has been tested. The logarithmic energy slope is measured to be dalpha(s)(-1)/d log E-cm = 1.14 +/- 0.36. Since the analysis is based on four-jet final states it represents an alternative approach to previous DELPHI alpha(s) measurements using event shape distributions.
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18.
  • Abdallah, J, et al. (author)
  • Measurement of the forward-backward asymmetries of e(+)e(-)-> Z -> b(b)over-bar and e(+)e(-)-> Z -> c(c)over-bar using prompt leptons
  • 2004
  • In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 34:2, s. 109-125
  • Journal article (peer-reviewed)abstract
    • The forward-backward asymmetries of the processes e(+) e(-) --> Z --> b (b) over bar and e(+)e(-) --> Z --> c (c) over bar were measured from a sample of hadronic Z decays collected by the DELPHI experiment between 1993 and 1995. Enriched samples of b (b) over bar and c (c) over bar events were obtained using lifetime information. The tagging of b and c quarks in these samples was based on the semileptonic decay channels b/c --> X + mu and b/c --> X + e combined with charge flow information from the hemisphere opposite to the lepton. Combining the A(FB)(b (b) over bar) and A(FB)(c (c) over bar) measurements presented in this paper with published results based on 1991 and 1992 DELPHI data samples, the following pole asymmetries were obtained: A(FB)(0,b) = 0.1021 +/- 0.0052 (stat) +/- 0.0024 (syst) A(FB)(0,c) = 0.0728 +/- 0.0086 (stat) +/- 0.0063 (syst) The effective value of the weak mixing angle derived from these measurements is sin(2) theta(W,eff)(lept) = 0.23170 +/- 0.00097.
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19.
  • Abdallah, J, et al. (author)
  • Measurement of the W-pair production cross-section and W branching ratios in e(+)e(-) collisions at root s=161-209 GeV
  • 2004
  • In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 34:2, s. 127-144
  • Journal article (peer-reviewed)abstract
    • These final results on e(+) e(-) W+ W- production cross-section measurements at LEP2 use data collected by the DELPHI detector at centre-of-mass energies up to 209 GeV. Measurements of total cross-sections, W angular differential distributions and decay branching fractions, and the value of the CKM element |V-cs| are compared to the expectations of the Standard Model. These results supersede all values previously published by DELPHI.
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20.
  • Abdallah, J, et al. (author)
  • Measurement of vertical bar Vcb vertical bar using the semileptonic decay (B)d(0))over-bar -> D*+l(-)(nu)over-barl
  • 2004
  • In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 33:2, s. 213-232
  • Journal article (peer-reviewed)abstract
    • Data from Z decays in DELPHI have been searched for <(B-d(o))over bar> --> D*+ l(-) (ν) over bar (l) with the D*+ decaying to D(0)pi(+) and D-0 --> K(-)pi(+), K(-)pi(+)pi(+)pi(-) or K- pi(+)(pi(0)). These events are used to measure the CKM matrix element V-cb and the form factor slope, rho(A1)(2): F-D*(1) V-cb = 0.0392 +/- 0.0018 +/- 0.0023; rho(A1)(2) = 1.32 +/- 0.15 +/- 0.33 corresponding to a branching fraction: BR(<(B-d(0))over bar> --> D(*+)l(-)(ν) over bar (l)) = (5.90 +/- 0.22 +/- 0.50)%. Combining these and previous DELPHI measurements gives: FD*(1)V-cb = 0.0377 +/- 0.0011 +/- 0.0019, rho(A1)(2) = 1.39 +/- 0.10 +/- 0.33 and BR(<(B-d(0))over bar> --> D(*+)l(-)(ν) over bar (l)) = (5.39 +/- 0.11 +/- 0.34)% Using F-D*(1) = 0.91 +/- 0.04, yields: V-cb = 0.0414 +/- 0.0012(stat.) +/- 0.0021(syst.) +/- 0.0018 (theory). The b-quark semileptonic branching fraction into a D*+ emitted from higher mass charmed excited states has also been measured to be: BR(b --> D*+ Xl(-)(ν) over bar (l)) = (0.67 +/- 0.08 +/- 0.10)%.
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21.
  • Abdallah, J, et al. (author)
  • Photon events with missing energy in e(+)e(-) collisions at root s=130 to 209 GeV
  • 2005
  • In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 38:4, s. 395-411
  • Journal article (peer-reviewed)abstract
    • The production of single- and multi-photon events has been studied in the reaction e(+) e(-) --> gamma(gamma) + invisible particles. The data collected with the DELPHI detector during the years 1999 and 2000 at centre-of-mass energies between 191 GeV and 209 GeV was combined with earlier data to search for phenomena beyond the Standard Model. The measured number of light neutrino families was consistent with three and the absence of an excess of events beyond that predicted by the Standard Model processes was used to set limits on new physics. Both model-independent searches and searches for new processes predicted by supersymmetric and extra-dimensional models have been made. Limits on new non-standard model interactions between neutrinos and electrons were also determined.
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22.
  • Abdallah, J, et al. (author)
  • Search for B-s(0)-(B-s(0))over-bar oscillations in DELPHI using high-p(t) leptons
  • 2004
  • In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 35:1, s. 35-52
  • Journal article (peer-reviewed)abstract
    • Oscillations in the B-s(0)- <(B-s(0))over bar> system were studied in events selected from about 4.3 million hadronic Z(0) decays registered by DELPHI between 1992 and 2000. This paper presents updates of two published analyses ([11, 12]). The first analysis, which utilizes leptons emitted with large momentum transverse to a jet, was improved by means of a better algorithm for the vertex reconstuction and a new algorithm for flavour-tagging at production time. The second analysis, which utilizes D-s-lepton events, was improved by optimizing the treatment of proper time resolution. No signal of B-s(0) oscillations was observed and limits on the mass difference between the physical B-s(0) states were obtained to be: Deltam(s)>8.0 ps-1 at the 95% C.L. with a sensitivity of Deltam(s)= 9.1 ps(-1) in the high p(t) lepton analysis and Deltam(s)>4.9 ps(-1) at the 95% C.L. with a sensitivity of Deltam(s)=8.6 ps(-1) in the D-s-lepton analysis. Previously published results on these analyses are superseded. The combination of these results with those obtained in other independent analyses previously performed in DELPHI (D-s-hadron, exclusive B-s(0), inclusive vertex) gives: Deltam(s)>8.5 ps(-1) at the 95% C.L. with a sensitivity of Deltam(s)=12.0 ps(-1).
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24.
  • Abdallah, J, et al. (author)
  • Search for fermiophobic Higgs bosons in final states with photons at LEP 2
  • 2004
  • In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 35:3, s. 313-324
  • Journal article (peer-reviewed)abstract
    • Higgs boson production with subsequent decay to photons was searched for in the data collected by the DELPHI detector at centre-of-mass energies between 183 GeV and 209 GeV, corresponding to a total integrated luminosity of nearly 650 pb(-1). No evidence for a signal was found, and limits were set on h(0)Z(0) and h(0)A(0) production with h(0) decay to photons. These results were used to exclude regions in the parameter space of fermiophobic scenarios of Two Higgs Doublet Models.
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25.
  • Abdallah, J, et al. (author)
  • Search for supersymmetric particles assuming R-parity non-conservation in e(+)e(-) collisions at root s=192 to 208 GeV
  • 2004
  • In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 36:1, s. 1-23
  • Journal article (peer-reviewed)abstract
    • Searches for pair-production of supersymmetric particles under the assumption of non-conservation of R-parity with a dominant LL (E) over bar or (U) over bar(D) over bar(D) over bar term have been performed using the data collected by the DELPHI experiment at LEP in e(+)e(-) collisions at centre-of-mass energies from 192 up to 208 GeV. No excess of data above Standard Model expectations was observed. The results were used to constrain the MSSM parameter space and to derive limits on the masses of supersymmetric particles.
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26.
  • Abdallah, J, et al. (author)
  • Search for SUSY in the AMSB scenario with the DELPHI detector
  • 2004
  • In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 34:2, s. 145-156
  • Journal article (peer-reviewed)abstract
    • The DELPHI experiment at the LEP e (+) e(-) collider collected almost 700 pb(-1) at centre-of-mass energies above the Z(0) mass pole and up to 208 GeV. Those data were used to search for SUSY in the Anomaly Mediated SUSY Breaking (AMSB) scenario with a flavour independent common sfermion mass parameter. The searches covered several possible signatures experimentally accessible at LEP, with either the neutralino, the sneutrino or the stau being the Lightest Supersymmetric Particle (LSP). They included: the search for nearly mass-degenerate chargino and neutralino, which is a typical feature of AMSB; the search for Standard-Model-like or invisibly decaying Higgs boson; the search for stable staus; the search for cascade decays of SUSY particles resulting in the LSP and a low multiplicity final state containing neutrinos. No evidence of a signal was found, and thus constraints were set in the space of the parameters of the model.
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27.
  • Abdallah, J, et al. (author)
  • Study of tau-pair production in photon-photon collisions at LEP and limits on the anomalous electromagnetic moments of the tau lepton
  • 2004
  • In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 35:2, s. 159-170
  • Journal article (peer-reviewed)abstract
    • Tau-pair production in the process e(+)e(-) --> e(+)e(-) tau(+)tau(-) was studied using data collected by the DELPHI experiment at LEP2 during the years 1997 - 2000. The corresponding integrated luminosity is 650 pb(-1). The values of the cross-section obtained are found to be in agreement with QED predictions. Limits on the anomalous magnetic and electric dipole moments of the tau lepton are deduced.
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28.
  • Abdallah, J, et al. (author)
  • The measurement of alpha(8) from event shapes with the DELPHI detector at the highest LEP energies
  • 2004
  • In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 37:1, s. 1-23
  • Journal article (peer-reviewed)abstract
    • Hadronic event shape distributions are determined from data in e(+)e(-) collisions between 183 and 207 GeV. From these the strong coupling alpha(s) is extracted in O(alpha(s)(2)), NLLA and matched O(alpha(s)(2))+ NLLA theory. Hadronisation corrections evaluated with fragmentation model generators as well as an analytical power ansatz are applied. Comparing these measurements to those obtained at and around M-Z allows a combined measurement of alpha(s) from all DELPHI data and a test of the energy dependence of the strong coupling.
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33.
  • Thomas, HS, et al. (author)
  • 2019
  • swepub:Mat__t
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34.
  • Niemi, MEK, et al. (author)
  • 2021
  • swepub:Mat__t
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35.
  • Ashmore, T, et al. (author)
  • Suppression of erythropoiesis by dietary nitrate
  • 2015
  • In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. - : Wiley. - 1530-6860. ; 29:3, s. 1102-1112
  • Journal article (peer-reviewed)
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  • Bousquet, J, et al. (author)
  • Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies
  • 2020
  • In: Clinical and translational allergy. - : Wiley. - 2045-7022. ; 10:1, s. 58-
  • Journal article (peer-reviewed)abstract
    • There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.
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  • Grosche, S, et al. (author)
  • Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4
  • 2021
  • In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1, s. 6618-
  • Journal article (peer-reviewed)abstract
    • Previous genome-wide association studies revealed multiple common variants involved in eczema but the role of rare variants remains to be elucidated. Here, we investigate the role of rare variants in eczema susceptibility. We meta-analyze 21 study populations including 20,016 eczema cases and 380,433 controls. Rare variants are imputed with high accuracy using large population-based reference panels. We identify rare exonic variants in DUSP1, NOTCH4, and SLC9A4 to be associated with eczema. In DUSP1 and NOTCH4 missense variants are predicted to impact conserved functional domains. In addition, five novel common variants at SATB1-AS1/KCNH8, TRIB1/LINC00861, ZBTB1, TBX21/OSBPL7, and CSF2RB are discovered. While genes prioritized based on rare variants are significantly up-regulated in the skin, common variants point to immune cell function. Over 20% of the single nucleotide variant-based heritability is attributable to rare and low-frequency variants. The identified rare/low-frequency variants located in functional protein domains point to promising targets for novel therapeutic approaches to eczema.
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  • Kronbichler, A, et al. (author)
  • Rituximab treatment for relapsing minimal change disease and focal segmental glomerulosclerosis: a systematic review
  • 2014
  • In: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 39:4, s. 322-330
  • Journal article (peer-reviewed)abstract
    • <b><i>Background:</i></b> Minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) remain a therapeutic challenge, since steroids and other immunosuppressive agents exhibit an unfavorable adverse event spectrum. The aim of this review was to systematically summarize and analyze data from preexisting studies reporting the outcome of rituximab (RTX) treatment in these patients. <b><i>Methods:</i></b> Study data on adult patients with either steroid-dependent or frequently relapsing MCD/FSGS were identified by a PubMed and Embase search. The number of relapses was calculated and the use of immunosuppressive co-medication prior to and after RTX treatment was quantified. <b><i>Results:</i></b> We identified<b> </b>14 studies<b> </b>including 86 patients with frequently relapsing and steroid-dependent MCD or FSGS. Treatment with RTX reduced the number of relapses per year from 1.3 (0-9) relapses prior to treatment compared to 0 (0-2) after therapy (p < 0.001). Proteinuria decreased from 2.43 (0-15) g/day to 0 (0-4.89) g/day (p < 0.001), while serum albumin increased from 2.9 (1.2-4.6) at baseline to 4.0 (1.8-5.09) g/l after RTX (p = 0.001). The use of immunosuppression used at the time of RTX administration was also reduced after RTX therapy (p < 0.001). Baseline serum albumin was lower (p = 0.018), whereas the number of immunosuppressants prior to RTX was higher (p = 0.018) in patients with relapse after RTX. <b><i>Conclusions:</i></b> The published data suggest that RTX is effective in reducing the number of relapses and sparing immunosuppression in frequently relapsing and steroid-dependent nephrotic syndrome due to MCD and FSGS. These promising findings have to be confirmed in controlled and prospective studies.
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