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Search: WFRF:(Flament J)

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  • Kyriakidis, Miltos, et al. (author)
  • A human factors perspective on automated driving
  • 2019
  • In: Theoretical Issues in Ergonomics Science. - : Taylor & Francis. - 1463-922X .- 1464-536X. ; 20:3, s. 223-249
  • Journal article (peer-reviewed)abstract
    • Automated driving can fundamentally change road transportation and improve quality of life. However, at present, the role of humans in automated vehicles (AVs) is not clearly established. Interviews were conducted in April and May 2015 with 12 expert researchers in the field of human factors (HFs) of automated driving to identify commonalities and distinctive perspectives regarding HF challenges in the development of AVs. The experts indicated that an AV up to SAE Level 4 should inform its driver about the AV's capabilities and operational status, and ensure safety while changing between automated and manual modes. HF research should particularly address interactions between AVs, human drivers and vulnerable road users. Additionally, driver-training programmes may have to be modified to ensure that humans are capable of using AVs. Finally, a reflection on the interviews is provided, showing discordance between the interviewees’ statements – which appear to be in line with a long history of HFs research – and the rapid development of automation technology. We expect our perspective to be instrumental for stakeholders involved in AV development and instructive to other parties.
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  • Rusakiewicz, Sylvie, et al. (author)
  • NCR3/NKp30 contributes to pathogenesis in primary Sjogren's syndrome.
  • 2013
  • In: Science translational medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6242 .- 1946-6234. ; 5:195
  • Journal article (peer-reviewed)abstract
    • Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease characterized by a lymphocytic exocrinopathy. However, patients often have evidence of systemic autoimmunity, and they are at markedly increased risk for the development of non- Hodgkin's lymphoma. Similar to other autoimmune disorders, a strong interferon (IFN) signature is present among subsets of pSS patients, although the precise etiology remains uncertain. NCR3/NKp30 is a natural killer (NK)-specific activating receptor regulating the cross talk between NK and dendritic cells and type II IFN secretion. We performed a case-control study of genetic polymorphisms of the NCR3/NKp30 gene and found that rs11575837 (G>A) residing in the promoter was associated with reduced gene transcription and function as well as protection to pSS. We also demonstrated that circulating levels of NCR3/NKp30 were significantly increased among pSS patients compared with controls and correlated with higher NCR3/NKp30 but not CD16-dependent IFN-γ secretion by NK cells. Excess accumulation of NK cells in minor salivary glands correlated with the severity of the exocrinopathy. B7H6, the ligand of NKp30, was expressed by salivary epithelial cells. These findings suggest that NK cells may promote an NKp30-dependent inflammatory state in salivary glands and that blockade of the B7H6/NKp30 axis could be clinically relevant in pSS.
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  • Result 1-7 of 7
Type of publication
journal article (5)
conference paper (2)
Type of content
peer-reviewed (5)
other academic/artistic (2)
Author/Editor
Lin, L. (3)
Ljungman, P (3)
Corash, L (3)
Van Rhenen, D (3)
Pamphilon, D (3)
Davis, K (3)
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Flament, J (3)
Buchholz, D. (1)
Eloranta, Maija-Leen ... (1)
Nordmark, Gunnel (1)
Wahren-Herlenius, Ma ... (1)
Theander, Elke (1)
Rönnblom, Lars (1)
Lessard, Christopher ... (1)
Criswell, Lindsey A. (1)
Grafstrom, R (1)
Nymark, P (1)
Dusinska, M (1)
Ladenstein, R (1)
Andersson, Jan (1)
Eriksson, Per (1)
Forsblad d'Elia, Hel ... (1)
Sandstrom, J. (1)
Bellet, Thierry (1)
Omdal, Roald (1)
Jonsson, Roland (1)
Mariette, Xavier (1)
Wallin, H (1)
Haase, A (1)
Ren, B (1)
Merat, Natasha (1)
de Winter, Joost C. ... (1)
Rasmussen, K (1)
Gottenberg, Jacques- ... (1)
Hagenzieker, Marjan (1)
Nititham, Joanne (1)
Jeliazkova, N (1)
Flament, Maxime (1)
Nocturne, Gaetane (1)
Sene, Damien (1)
Buchholz, B (1)
Kluter, H (1)
Happee, Riender (1)
Kyriakidis, Miltos (1)
Bleeker, EAJ (1)
Reed, Nick (1)
Lioure, B (1)
Taylor, Kimberly E. (1)
Cazenave, J (1)
Gullikksson, H (1)
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University
Karolinska Institutet (6)
University of Gothenburg (1)
Umeå University (1)
Uppsala University (1)
Linköping University (1)
Lund University (1)
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VTI - The Swedish National Road and Transport Research Institute (1)
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Language
English (7)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Social Sciences (1)

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