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1.	Lecoutre, S, et al. (author) Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health 2024 In: Nature metabolism. - 2522-5812. ; 6:7, s. 1329-1346 Journal article (peer-reviewed)
2.	Maqdasy, S, et al. (author) Impaired phosphocreatine metabolism in white adipocytes promotes inflammation 2022 In: Nature metabolism. - 2522-5812. ; 4:2, s. 190-202 Journal article (peer-reviewed)
3.	Maqdasy, S, et al. (author) Impaired phosphocreatine metabolism in white adipocytes promotes inflammation 2022 In: Nature metabolism. - : Springer Science and Business Media LLC. - 2522-5812. ; 4:2, s. 190- Journal article (peer-reviewed)abstract The mechanisms promoting disturbed white adipocyte function in obesity remain largely unclear. Herein, we integrate white adipose tissue (WAT) metabolomic and transcriptomic data from clinical cohorts and find that the WAT phosphocreatine/creatine ratio is increased and creatine kinase-B expression and activity is decreased in the obese state. In human in vitro and murine in vivo models, we demonstrate that decreased phosphocreatine metabolism in white adipocytes alters adenosine monophosphate-activated protein kinase activity via effects on adenosine triphosphate/adenosine diphosphate levels, independently of WAT beigeing. This disturbance promotes a pro-inflammatory profile characterized, in part, by increased chemokine (C-C motif) ligand 2 (CCL2) production. These data suggest that the phosphocreatine/creatine system links cellular energy shuttling with pro-inflammatory responses in human and murine white adipocytes. Our findings provide unexpected perspectives on the mechanisms driving WAT inflammation in obesity and may present avenues to target adipocyte dysfunction.
4.	Klingelhuber, F, et al. (author) A spatiotemporal proteomic map of human adipogenesis 2024 In: Nature metabolism. - 2522-5812. Journal article (peer-reviewed)
5.	Lopez-Yus, M, et al. (author) CRISPR/Cas9-mediated deletion of adipocyte genes associated with NAFLD alters adipocyte lipid handling and reduces steatosis in hepatocytes in vitro 2023 In: American journal of physiology. Cell physiology. - 1522-1563. ; 325:5, s. C1178-C1189 Journal article (peer-reviewed)
6.	Mejhert, N, et al. (author) The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology 2022 In: Developmental cell. - 1878-1551. ; 57:3, s. 387-397.e4 Journal article (peer-reviewed)
7.	Mejhert, N, et al. (author) The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology 2022 In: Developmental cell. - : Elsevier BV. - 1878-1551 .- 1534-5807. ; 57:3, s. 387- Journal article (peer-reviewed)
8.	Dollet, L, et al. (author) Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M 2024 In: Cell reports. Medicine. - 2666-3791. ; 5:1, s. 101348- Journal article (peer-reviewed)
9.	Frendo-Cumbo, S, et al. (author) Deficiency of the autophagy gene ATG16L1 induces insulin resistance through KLHL9/KLHL13/CUL3-mediated IRS1 degradation 2019 In: The Journal of biological chemistry. - 1083-351X. ; 294:44, s. 16172-16185 Journal article (peer-reviewed)
10.	Pillon, NJ, et al. (author) Sphingolipid changes do not underlie fatty acid-evoked GLUT4 insulin resistance nor inflammation signals in muscle cells 2018 In: Journal of lipid research. - 1539-7262. ; 59:7, s. 1148-1163 Journal article (peer-reviewed)

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Type of publication: journal article (10)

Type of content: peer-reviewed (10)

Author/Editor: Ryden, M (10); Frendo-Cumbo, S (10); Mejhert, N (6); Zierath, JR (5); Krook, A (4); Renzi, G. (3); show more...; Pillon, NJ (3); Bergo, MO (3); Couchet, M (3); Krahmer, N (3); Rizo-Roca, D (3); Song, J. (2); Moritz, Thomas (2); Aouadi, M (2); Gao, H. (2); de Castro Barbosa, T ... (2); Kerr, A (2); Burtt, NP (2); Costanzo, MC (2); Flannick, J (2); Jang, DK (2); Massier, L (2); Choudhury, RP (2); Jalkanen, J (2); Omar-Hmeadi, M (2); Zhong, J. (1); Liu, Z. (1); Dmytriyeva, O (1); Dollet, L (1); Caidahl, K (1); Barres, R (1); Wallberg-Henriksson, ... (1); Chibalin, AV (1); Clement, K (1); Xavier, RJ (1); Moritz, T. (1); Petrus, P (1); Lorente-Cebrian, S (1); Rouault, C. (1); Wabitsch, M (1); Brozinick, JT (1); Lundell, LS (1); Deshmukh, AS (1); Taylor, AJ (1); Raught, B (1); Klingelhuber, F (1); Pendergrast, LA (1); Lansbury, EL (1); Elmastas, M (1); Cervone, DT (1); show less...

University: Karolinska Institutet (10); Swedish University of Agricultural Sciences (2)

Language: English (10)

Research subject (UKÄ/SCB): Medical and Health Sciences (2); Natural sciences (1); Engineering and Technology (1)

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