| 1. |
- Abele, H., et al.
(author)
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Particle physics at the European Spallation Source
- 2023
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In: Physics reports. - : Elsevier. - 0370-1573 .- 1873-6270. ; 1023, s. 1-84
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Research review (peer-reviewed)abstract
- Presently under construction in Lund, Sweden, the European Spallation Source (ESS) will be the world’s brightest neutron source. As such, it has the potential for a particle physics program with a unique reach and which is complementary to that available at other facilities. This paper describes proposed particle physics activities for the ESS. These encompass the exploitation of both the neutrons and neutrinos produced at the ESS for high precision (sensitivity) measurements (searches).
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| 2. |
- Friman, Styrbjörn, 1948, et al.
(author)
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Long-term, Prolonged-release Tacrolimus-based Immunosuppression in De Novo Liver Transplant Recipients: 5-year Prospective Follow-up of Patients in the DIAMOND Study
- 2021
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In: Transplantation Direct. - : Ovid Technologies (Wolters Kluwer Health). - 2373-8731. ; 7:8
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Journal article (peer-reviewed)abstract
- Background. Immunosuppression with calcineurin inhibitors (CNIs) is reportedly associated with risk of renal impairment in liver transplant recipients. It is believed that this can be mitigated by decreasing initial exposure to CNIs or delaying CNI introduction until 3-4 d posttransplantation. The ADVAGRAF studied in combination with mycophenolate mofetil and basili ximab in liver transplantation (DIAMOND) trial evaluated different administration strategies for prolonged-release tacrolimus (PR-T). Methods. DIAMOND was a 24-wk, open-label, phase 3b trial in de novo liver transplant recipients randomized to: PR-T 0.2 mg/kg/d (Arm 1); PR-T 0.15-0.175 mg/kg/d plus basiliximab (Arm 2); or PR-T 0.2 mg/kg/d delayed until day 5 posttransplant plus basiliximab (Arm 3). In a 5-y follow-up, patients were maintained on an immunosuppressive regimen according to standard clinical practice (NCT02057484). Primary endpoint: graft survival (Kaplan-Meier analysis). Results. Follow-up study included 856 patients. Overall graft survival was 84.6% and 73.5% at 1 and 5 y post transplant, respectively. Five-year rates for Arms 1, 2, and 3 were 74.7%, 71.5%, and 74.5%, respectively. At 5 y, death-censored graft survival in the entire cohort was 74,7%. Overall graft survival in patients remaining on PR-T for z30 d was 79.1%. Graft survival in patients who remained on PR-T at 5 y was 87.3%. Patient survival was 86.6% at 1 y and 76.3% at 5 y, with survival rates similar in the 3 treatment arms at 5 y. Estimated glomerular filtration rate at the end of the 24-wk initial study and 5 y posttransplant was 62.1 and 61.5 mi./min/1.73 m(2), respectively, and was similar between the 3 treatment arms at 5 y. Overall, 18 (2.9%) patients had z1 adverse drug reaction, considered possibly related to PR-T in 6 patients. Conclusions. In the DIAMOND study patient cohort, renal function, graft survival, and patient survival were similar between treatment arms at 5 y posttransplant.
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| 3. |
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| 4. |
- Santoro, V., et al.
(author)
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HighNESS conceptual design report: Volume I
- 2024
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In: Journal of Neutron Research. - 1023-8166 .- 1477-2655. ; 25:3-4, s. 85-314
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Journal article (peer-reviewed)abstract
- The European Spallation Source, currently under construction in Lund, Sweden, is a multidisciplinary international laboratory. Once completed to full specifications, it will operate the world’s most powerful pulsed neutron source. Supported by a 3 million Euro Research and Innovation Action within the EU Horizon 2020 program, a design study (HighNESS) has been completed to develop a second neutron source located below the spallation target. Compared to the first source, designed for high cold and thermal brightness, the new source has been optimized to deliver higher intensity, and a shift to longer wavelengths in the spectral regions of cold (CN, 2–20 Å), very cold (VCN, 10–120 Å), and ultracold (UCN, >500 Å) neutrons. The second source comprises a large liquid deuterium moderator designed to produce CN and support secondary VCN and UCN sources. Various options have been explored in the proposed designs, aiming for world-leading performance in neutronics. These designs will enable the development of several new instrument concepts and facilitate the implementation of a high-sensitivity neutron-antineutron oscillation experiment (NNBAR). This document serves as the Conceptual Design Report for the HighNESS project, representing its final deliverable.
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| 5. |
- Santoro, V., et al.
(author)
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HighNESS conceptual design report: Volume II. the NNBAR experiment.
- 2024
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In: Journal of Neutron Research. - 1023-8166 .- 1477-2655. ; 25:3-4, s. 315-406
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Journal article (peer-reviewed)abstract
- A key aim of the HighNESS project for the European Spallation Source is to enable cutting-edge particle physics experiments. This volume presents a conceptual design report for the NNBAR experiment. NNBAR would exploit a new cold lower moderator to make the first search in over thirty years for free neutrons converting to anti-neutrons. The observation of such a baryon-number-violating signature would be of fundamental significance and tackle open questions in modern physics, including the origin of the matter-antimatter asymmetry. This report shows the design of the beamline, supermirror focusing system, magnetic and radiation shielding, and anti-neutron detector necessary for the experiment. A range of simulation programs are employed to quantify the performance of the experiment and show how background can be suppressed. For a search with full background suppression, a sensitivity improvement of three orders of magnitude is expected, as compared with the previous search. Civil engineering studies for the NNBAR beamline are also shown, as is a costing model for the experiment.
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| 6. |
- Backman, Filip, 1991-, et al.
(author)
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The development of the NNBAR experiment
- 2022
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In: Journal of Instrumentation. - : Institute of Physics (IOP). - 1748-0221. ; 17:10
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Journal article (peer-reviewed)abstract
- The NNBAR experiment for the European Spallation Source will search for free neutrons converting to antineutrons with a sensitivity improvement of three orders of magnitude compared to the last such search. This paper describes progress towards a conceptual design report for NNBAR. The design of a moderator, neutron reflector, beamline, shielding and annihilation detector is reported. The simulations used form part of a model which will be used for optimisation of the experiment design and quantification of its sensitivity.
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| 7. |
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| 8. |
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| 9. |
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| 10. |
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| 11. |
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| 12. |
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| 13. |
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| 14. |
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| 15. |
- Friman, Margareta, et al.
(author)
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Services and issues relating to the work environment
- 1996
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In: B. Edvardsson & S. Modell (Eds.), Service managment. Interdiciplinary percepectives. (pp. 151-180). - Stockholm : Nerenius & Santérus.
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Book chapter (other academic/artistic)
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| 16. |
- Friman, Margareta, 1970-, et al.
(author)
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Transport and children's wellbeing : Future directions
- 2019
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In: Transport and Children's Wellbeing. - : Elsevier. - 9780128146958 - 9780128146941 ; , s. 361-373
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Book chapter (other academic/artistic)abstract
- This book adopts a cross-disciplinary approach on the relationships between transport and children's wellbeing by bringing together a series of works by authors from a variety of disciplinary orientations (e.g., urban planning, geography, psychology, transport engineering, and public health). The book's breadth and diversity convey an inclusive view of the complex nature of transport and children's wellbeing. This closing chapter provides a brief overview of and summarizes some important evidence in this field. We point to gaps in knowledge and diagnose difficulties that will provide a roadmap for future research and practice.
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| 17. |
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| 18. |
- Friman, O., et al.
(author)
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A General Method for Correction of Intensity Inhomogeniety in Two Point Dixon Imaging
- 2008
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In: Proceedings of the International Society for Magnetic Resonance in Medicine annual meeting (ISMRM'08). - : International Society for Magnetic Resonance in Medicine.
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Conference paper (other academic/artistic)abstract
- Two point Dixon imaging can be used for quantitative fat estimation. However, field inhomogeneities pose a problem that needs to be corrected for before quantitative measurements can be obtained. We present a general framework for field inhomogeneitiy correction by fitting a set of smooth 3D spatial basis functions to voxels with high fat content. By choosing the number of basis functions, the smoothness constraint of the field can be controlled. The method is evaluated by measuring the FWHM of the fat peak in histograms for different number of basis functions. It is also compared to a previous method with good results.
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| 19. |
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| 20. |
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| 21. |
- Friman, Vanda, 1952, et al.
(author)
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Secondary immunodeficiency in lymphoproliferative malignancies
- 2016
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In: Hematological Oncology. - : Wiley. - 0278-0232 .- 1099-1069. ; 34:3, s. 121-132
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Journal article (peer-reviewed)abstract
- Secondary immunodeficiencies occur as a consequence of various diseases, including hematological malignancies, and the use of pharmacological therapies, such as immunosuppressive, anti-inflammatory, and biological drugs. Infections are the main cause of morbidity and mortality in multiple myeloma (MM) and chronic lymphocytic leukemia (CLL) patients. Recent advances in treatment have prolonged the duration of remission and the time between relapse phases in MM and CLL patients. However, managing multiple relapses and the use of salvage therapies can lead to cumulative immunosuppression and a higher risk of infections. The pathogenesis of immune deficiency secondary to lymphoproliferative malignancy is multifactorial including disease- and treatment-related factors. Supportive treatment, including early vaccination, anti-infective prophylaxis, and replacement immunoglobulin, plays a key role in preventing infections in MM and CLL. This article provides an overview of the basic immunology necessary to understand the pathogenesis of secondary immunodeficiency and the infectious complications in MM and CLL. We also discuss the evidence supporting the role of prophylactic replacement immunoglobulin treatment in patients with antibody failure secondary to MM and CLL and the indications for its use. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.
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| 22. |
- Grunnet, N., et al.
(author)
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Selected activities in Scandiatransplant
- 2005
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In: Transplantation proceedings. - 0041-1345. ; 37:8, s. 3243-7
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Journal article (peer-reviewed)abstract
- Scandiatransplant is the Nordic organ exchange organization. It has existed for 35 years and it is owned by all organ transplantation hospital departments in the five Nordic countries--Denmark, Finland, Iceland, Norway, and Sweden. The use of living organ donors for kidney transplantation has become a more common procedure not only in Norway but also in Sweden and Denmark. For the first time, in 2003, one transplant center performed relatively more living donor kidney transplantations than with deceased donors. The overall organ transplant activity reveals a remarkably stable situation in the area covered by Scandiatransplant. Scandiatransplant as an organ exchange organization has changed from a solely kidney exchange organization to an organization in which the more immediate vital organs as liver and heart are exchanged more commonly than kidneys.
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| 23. |
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| 24. |
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| 25. |
- Madsen, M., et al.
(author)
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Application of human leukocyte antigen matching in the allocation of kidneys from cadaveric organ donors in the Nordic countries
- 2004
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In: Transplantation. - 0041-1337. ; 77:4, s. 621-3
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Journal article (peer-reviewed)abstract
- The Nordic organ exchange organization Scandiatransplant was founded in 1969. It covers a population of 24.41 million inhabitants in five countries: Denmark (5.45 million), Finland (5.19 million), Iceland (0.29 million), Norway (4.54 million), and Sweden (8.94 million). Initially, the purpose of Scandiatransplant was to establish and maintain a common waiting list for all Nordic patients with end-stage renal failure waiting for a cadaveric kidney transplant. The basis of maintaining a common Nordic waiting list was the recognition of the wide polymorphism of the human leukocyte antigen system, which demands a substantial pool of waiting patients to provide optimal histocompatibility matching between organ donor and recipient. Thus, one of the major tasks of the organization was and still is to specify rules for the exchange of kidneys between the participating transplant centers. Scandiatransplant includes the cooperation of all 10 Nordic kidney transplant centers in addition to eight immunology laboratories. Denmark has four transplant centers located in Copenhagen, Herlev, Odense, and Aarhus. Finland has one center in Helsinki. Norway has one center located in Oslo. Sweden has four kidney transplantation centers located in each of the university hospitals in Goteborg, Malmo, Stockholm, and Uppsala. The fifth Nordic country, Iceland, is participating fully in organ donation but has no individual transplant center. Organ transplantation in Icelandic patients is performed in other Nordic countries.
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| 26. |
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| 27. |
- Nerdal, Kajsa, 1974-
(author)
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Gymnasieelevers presentationer av relationer mellan miljö och människor – en studie om utbildning för hållbar utveckling
- 2014
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Licentiate thesis (other academic/artistic)abstract
- This study investigates how upper secondary school students constitute relations between the environment and humanity. The aim of the study is to analyse relations that emerge between and within the Earth´s major systems (humanity included) and how these relations are composed when students are faced with a fictional decision of consuming a pair of jeans. Using workshop as a data collection method, students creatively visualize their discussions through participatory modelling in groups. The results of the study are based on the analyses of the concluding presentations of the completed models.The results show difficulties in submitting relations between the three dimensions of the concept of sustainable development together with a dualistic worldview, indicating a lack of complexity in the presentations. Therefore, a gap can be identified between the empirical results and the aims of education for sustainable development (ESD) that, according to the Ministry of Education and Research, should be a part of Swedish upper secondary education. In addition, a gap between the steering documents for the Swedish upper secondary schools and the UNESCO guidelines on ESD is revealed, consisting of the latter more distinctly promoting systems thinking and embracing pluralism. Three national programmes are represented in the study; social science, science and economics. Differences between the three are established. Groups with a focus on social science present complexity to higher extent than groups on science orientation. Groups with a focus on economics present least complexity in their presentations.
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| 28. |
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| 29. |
- Pansell, J, et al.
(author)
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Optic nerve sheath diameter is associated with outcome in severe Covid-19
- 2022
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In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 12:1, s. 17255-
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Journal article (peer-reviewed)abstract
- Neurological symptoms are common in Covid-19 and cerebral edema has been shown post-mortem. The mechanism behind this is unclear. Elevated intracranial pressure (ICP) has not been extensively studied in Covid-19. ICP can be estimated noninvasively with measurements of the optic nerve sheath diameter (ONSD). We performed a cohort study with ONSD ultrasound measurements in severe cases of Covid-19 at an intensive care unit (ICU). We measured ONSD with ultrasound in adults with severe Covid-19 in the ICU at Karolinska University Hospital in Sweden. Patients were classified as either having normal or elevated ONSD. We compared ICU length of stay (ICU-LOS) and 90 day mortality between the groups. 54 patients were included. 11 of these (20.4%) had elevated ONSD. Patients with elevated ONSD had 12 days longer ICU-LOS (95% CI 2 to 23 p = 0.03) and a risk ratio of 2.3 for ICU-LOS ≥ 30 days. There were no significant differences in baseline data or 90 day mortality between the groups. Elevated ONSD is common in severe Covid-19 and is associated with adverse outcome. This may be caused by elevated ICP. This is a clinically important finding that needs to be considered when deciding upon various treatment strategies.
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| 30. |
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| 31. |
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| 32. |
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| 33. |
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| 34. |
- Santoro, V., et al.
(author)
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The HighNESS Project at the European Spallation Source : Current Status and Future Perspectives
- 2024
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In: Nuclear science and engineering. - 0029-5639 .- 1943-748X. ; 198:1, s. 31-63
-
Journal article (peer-reviewed)abstract
- The European Spallation Source (ESS), presently under construction in Lund, Sweden, is a multidisciplinary international laboratory that, once completed at full specifications, will operate the world's most powerful pulsed neutron source. Supported by a 3 M Euro Research and Innovation Action within the European Union Horizon 2020 program, a design study (HighNESS) is now underway to develop a second neutron source located below the spallation target. Compared to the first source, which is located above the spallation target and designed for high cold and thermal brightness, the new source is being optimized to deliver higher intensity and a shift to longer wavelengths in the spectral regions of cold neutrons (CNs) (2 to 20 & Aring;), very cold neutrons (VCNs) (10 to 120 & Aring;), and ultracold neutrons (UCNs) (> 500 & Aring;). The second source consists of a large liquid deuterium moderator to deliver CNs and serve secondary VCN and UCN sources, for which different options are under study. These new sources will boost several areas of condensed matter research and will provide unique opportunities in fundamental physics. The HighNESS project is now entering its last year, and we are working toward the Conceptual Design Report of the ESS upgrade. In this paper, results obtained in the first 2 years, ongoing developments, and future perspectives are described.
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| 35. |
- Schaap, M., et al.
(author)
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Standardized evaluation methodology and reference database for evaluating coronary artery centerline extraction algorithms
- 2009
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In: Medical Image Analysis. - : Elsevier. - 1361-8415 .- 1361-8423. ; 13:5, s. 701-714
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Journal article (peer-reviewed)abstract
- Efficiently obtaining a reliable coronary artery centerline from computed tomography angiography data is relevant in clinical practice. Whereas numerous methods have been presented for this purpose, up to now no standardized evaluation methodology has been published to reliably evaluate and compare the performance of the existing or newly developed coronary artery centerline extraction algorithms. This paper describes a standardized evaluation methodology and reference database for the quantitative evaluation of coronary artery centerline extraction algorithms. The contribution of this work is fourfold: (1) a method is described to create a consensus centerline with multiple observers, (2) well-defined measures are presented for the evaluation of coronary artery centerline extraction algorithms, (3) a database containing 32 cardiac CTA datasets with corresponding reference standard is described and made available, and (4) 13 coronary artery centerline extraction algorithms, implemented by different research groups, are quantitatively evaluated and compared. The presented evaluation framework is made available to the medical imaging community for benchmarking existing or newly developed coronary centerline extraction algorithms.
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| 36. |
- Wagner, R., et al.
(author)
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Design of an optimized nested-mirror neutron reflector for a NNBAR experiment
- 2023
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In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 1051
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Journal article (peer-reviewed)abstract
- The NNBAR experiment for the European Spallation Source will search for free neutrons converting to antineutrons with an expected sensitivity improvement of three orders of magnitude compared to the last such search. This paper describes both the simulations of a key component for the experiment, the neutron optical reflector and the expected gains in sensitivity.
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| 37. |
- Waygood, E. O. D., et al.
(author)
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Children's incidental social interaction during travel international case studies from Canada, Japan, and Sweden
- 2017
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In: Journal of Transport Geography. - : Elsevier. - 0966-6923 .- 1873-1236. ; 63, s. 22-29
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Journal article (peer-reviewed)abstract
- Incidental social interactions such as seeing a known person while travelling are theorized to contribute to community connections and social capital. It is argued in such work that walking may be a critical factor, but the frequency of such interactions is generally unknown. For children, these community connections may increase independent travel and contribute to their well-being. Previous research out of Japan found that walking was indeed more likely to result in children seeing people in general and seeing a known person. However, it is not clear whether that is a culturally anecdotal finding, or whether similar findings would occur in different cultural and transportation contexts. Reasons why it may be anecdotal include: in most cases, all elementary school children walk to school in Japan; many trips occur at a local level and are conducted by non-motorized modes in Japan; greeting others (aisatsu) is a cultural value in Japan. This study examines whether one's transport mode relates to having incidental social interaction during their trips for children aged 10–11 in Canada (177), Japan (178), and Sweden (144). Further to previous work, the research carried out here asked the children what type of interaction occurred (spoke, waved, no interaction, or other) which would relate to building or maintaining community connections. The findings demonstrate that the results are internationally applicable and that most incidental social interactions result in a verbal communication in all three countries.
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| 38. |
- Waygood, E. O. D., et al.
(author)
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Children's life satisfaction and travel satisfaction : Evidence from Canada, Japan, and Sweden
- 2019
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In: Travel Behaviour & Society. - : Elsevier. - 2214-367X .- 2214-3688. ; 16, s. 214-223
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Journal article (peer-reviewed)abstract
- Travel satisfaction has been linked to life satisfaction for adults, but no evidence exists currently for children's travel. Children's travel differs from adult's in numerous ways including limitations related to independent travel and available transport options. Children's travel is often more local and their desire to explore and learn about their environment may be higher than for adults. The importance of social interaction during travel or at locations may also be a greater consideration for children. Further, many of their destinations are pre-determined such as going to school (not all adults work, but nearly all children of school age attend school). This paper analyzes the relationship between travel satisfaction and life satisfaction for children aged 9–12 in Canada, Japan, and Sweden (n = 425) using partial least squares structural equation modeling. In line with previous findings among adults, the analyses show a significant path from travel satisfaction to life satisfaction among children, suggesting a moderate relationship. Unexpectedly, negative relationships for increased frequency of nearly all mode uses (walking, bus, and car) on travel satisfaction (directly) and life satisfaction (indirectly) were found, which may suggest that children do not enjoy frequent travel. These results suggest a relationship that is likely important, but not necessarily in the ways anticipated.
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| 39. |
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| 40. |
- Waygood, E. O. D, et al.
(author)
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Transport and child well-being : An integrative review
- 2017
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In: Travel Behaviour & Society. - : Elsevier. - 2214-367X .- 2214-3688. ; 9, s. 32-49
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Journal article (peer-reviewed)abstract
- Understanding children’s travel is an important part of drawing a complete picture of over-all well-being in society. Children’s active travel to school, independent travel, transport and physical activity, and crashes have been reviewed, yet it may not be a complete picture. If research on children’s travel has the ultimate goal of improving children’s well-being, there is currently no general synthesis on the research linking transport and child well-being. This integrative review asks, “what evidence is there that transport affects child well-being?” It organizes the findings by two key measures: the domain of well-being and the transport means-of-influence. The five main domains of child well-being are: physical, psychological, cognitive, social, and economic. The three means of transport influence are: as access, intrinsic, or external. Findings are identified as being consistent, inconsistent, or one-off (e.g. only one study). The results show that transport plays a role in all domains of children’s well-being. Most benefits identified are associated with active travel and independent travel. Most negative impacts are associated with traffic. While numerous one-off results exist which suggest that there may be many other impacts, research that repeats prior work is needed to support or refute these such results. Finally, potential relationships between transport and well-being are suggested.
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| 41. |
- Wesslén, Lars, et al.
(author)
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An increase in sudden unexpected cardiac deaths among young Swedish orienteers during 1979-1992
- 1996
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In: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 17:6, s. 902-910
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Journal article (peer-reviewed)abstract
- BACKGROUND: Sixteen cases of sudden unexpected cardiac death, 15 males and one female, are known to have occurred among young Swedish orienteers from 1979 to 1992, of which seven cases occurred between 1989 and 1992. This is considered to be indicative of an increased death rate. RESULTS: Histopathological evaluation showed myocarditis in a higher than expected proportion of cases. In one such case, which we studied before the sudden unexpected death occurred, the victim had suffered a Chlamydia pneumoniae infection verified by serology, and a nucleotide sequence was found in the heart and lung by means of the polymerase chain reaction (PCR) that hybridized with a probe specific for that organism. Male Swedish orienteers do not, however, seem to have an increased rate of exposure to this agent. No further sudden unexpected deaths among young orienteers have occurred over the past 3.5 years. At the beginning of that period, attempts were made to modify training habits and attitudes.
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| 42. |
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