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1.	Tabiri, S, et al. (author) 2021 swepub:Mat__t
2.	Bravo, L, et al. (author) 2021 swepub:Mat__t
3.	Azatyan, A, et al. (author) RITA downregulates Hedgehog-GLI in medulloblastoma and rhabdomyosarcoma via JNK-dependent but p53-independent mechanism 2019 In: Cancer letters. - : Elsevier BV. - 1872-7980 .- 0304-3835. ; 442, s. 341-350 Journal article (peer-reviewed)
4.	Gallo-Oller, G, et al. (author) A new background subtraction method for Western blot densitometry band quantification through image analysis software 2018 In: Journal of immunological methods. - : Elsevier BV. - 1872-7905 .- 0022-1759. ; 457, s. 1-5 Journal article (peer-reviewed)
5.	Gallo-Oller, G, et al. (author) Cytotoxicity of poly-guanidine in medulloblastoma cell lines 2023 In: Investigational new drugs. - 1573-0646. ; 41:5, s. 688-698 Journal article (peer-reviewed)
6.	Gallo-Oller, G, et al. (author) Establishment of an induction protocol for medulloblastoma during prenatal stages of a floxed-cre inducible model 2018 In: CANCER RESEARCH. - 0008-5472. ; 78:13 Conference paper (other academic/artistic)
7.	Hald, OH, et al. (author) Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma 2019 In: Oncogene. - : Springer Science and Business Media LLC. - 1476-5594 .- 0950-9232. ; 38:15, s. 2800-2813 Journal article (peer-reviewed)
8.	Marquez, M, et al. (author) Effects of Polyguanidine on the Cytoskeleton of Medulloblastoma Cells 2021 In: PEDIATRIC BLOOD & CANCER. - 1545-5009. ; 68, s. S302-S303 Conference paper (other academic/artistic)
9.	Sandén, Emma, et al. (author) Establishment and characterization of an orthotopic patient-derived Group 3 medulloblastoma model for preclinical drug evaluation 2017 In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7, s. 46366- Journal article (peer-reviewed)abstract Medulloblastomas comprise a heterogeneous group of tumours and can be subdivided into four molecular subgroups (WNT, SHH, Group 3 and Group 4) with distinct prognosis, biological behaviour and implications for targeted therapies. Few experimental models exist of the aggressive and poorly characterized Group 3 tumours. In order to establish a reproducible transplantable Group 3 medulloblastoma model for preclinical therapeutic studies, we acquired a patient-derived tumour sphere culture and inoculated low-passage spheres into the cerebellums of NOD-scid mice. Mice developed symptoms of brain tumours with a latency of 17–18 weeks. Neurosphere cultures were re-established and serially transplanted for 3 generations, with a negative correlation between tumour latency and numbers of injected cells. Xenografts replicated the phenotype of the primary tumour, including high degree of clustering in DNA methylation analysis, high proliferation, expression of tumour markers, MYC amplification and elevated MYC expression, and sensitivity to the MYC inhibitor JQ1. Xenografts maintained maintained expression of tumour-derived VEGFA and stromal-derived COX-2. VEGFA, COX-2 and c-Myc are highly expressed in Group 3 compared to other medulloblastoma subgroups, suggesting that these molecules are relevant therapeutic targets in Group 3 medulloblastoma.

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Result 1-9 of 9

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Type of publication: journal article (5); conference paper (2)

Type of content: peer-reviewed (5); other academic/artistic (2)

Author/Editor: Davies, M. (2); Evans, H. (2); Jones, G. (2); King, M. (2); Lopes, L. (2); Losada, M. (2); show more...; Martin, B. (2); Negri, G. (2); Nordberg, M. (2); Qureshi, A. (2); Robson, A. (2); Romano, M. (2); Shaw, K. (2); Ventura, D. (2); Wall, R. (2); Williams, S. (2); Yang, H. (2); Morton, A. (2); Davies, E. (2); Liu, H. (2); Valente, P. (2); Liu, T. (2); Bertoli, G (2); Stewart, G. (2); Martin, J. (2); Alves, R. (2); Aytac, E (2); Campain, N (2); Davies, RJ (2); Hompes, R (2); Lakkis, Z (2); McGrath, JS (2); Maciel, J (2); Rausa, E (2); Rottoli, M (2); Shaikh, (2); Tsarkov, P (2); Brown, A. (2); James, A. (2); Zhang, Y. (2); Cardoso, J. (2); Sharma, S. (2); Silva, M. (2); Martin, S. (2); Diaz, S (2); Jones, M. (2); Manca, G. (2); Moore, R. (2); Russ, J. (2); Shaw, S. (2); show less...

University: Karolinska Institutet (8); Uppsala University (1); Lund University (1)

Language: English (9)

Research subject (UKÄ/SCB): Medical and Health Sciences (2); Engineering and Technology (1)

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