| 1. |
- Murari, A., et al.
(author)
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A control oriented strategy of disruption prediction to avoid the configuration collapse of tokamak reactors
- 2024
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In: Nature Communications. - 2041-1723 .- 2041-1723. ; 15:1
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Journal article (peer-reviewed)abstract
- The objective of thermonuclear fusion consists of producing electricity from the coalescence of light nuclei in high temperature plasmas. The most promising route to fusion envisages the confinement of such plasmas with magnetic fields, whose most studied configuration is the tokamak. Disruptions are catastrophic collapses affecting all tokamak devices and one of the main potential showstoppers on the route to a commercial reactor. In this work we report how, deploying innovative analysis methods on thousands of JET experiments covering the isotopic compositions from hydrogen to full tritium and including the major D-T campaign, the nature of the various forms of collapse is investigated in all phases of the discharges. An original approach to proximity detection has been developed, which allows determining both the probability of and the time interval remaining before an incoming disruption, with adaptive, from scratch, real time compatible techniques. The results indicate that physics based prediction and control tools can be developed, to deploy realistic strategies of disruption avoidance and prevention, meeting the requirements of the next generation of devices.
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| 2. |
- Krasilnikov, A., et al.
(author)
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Evidence of 9 Be + p nuclear reactions during 2ω CH and hydrogen minority ICRH in JET-ILW hydrogen and deuterium plasmas
- 2018
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In: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 58:2
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Journal article (peer-reviewed)abstract
- The intensity of 9Be + p nuclear fusion reactions was experimentally studied during second harmonic (2ω CH) ion-cyclotron resonance heating (ICRH) and further analyzed during fundamental hydrogen minority ICRH of JET-ILW hydrogen and deuterium plasmas. In relatively low-density plasmas with a high ICRH power, a population of fast H+ ions was created and measured by neutral particle analyzers. Primary and secondary nuclear reaction products, due to 9Be + p interaction, were observed with fast ion loss detectors, γ-ray spectrometers and neutron flux monitors and spectrometers. The possibility of using 9Be(p, d)2α and 9Be(p, α)6Li nuclear reactions to create a population of fast alpha particles and study their behaviour in non-active stage of ITER operation is discussed in the paper.
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| 3. |
- Joffrin, E., et al.
(author)
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Overview of the JET preparation for deuterium-tritium operation with the ITER like-wall
- 2019
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In: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 59:11
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Research review (peer-reviewed)abstract
- For the past several years, the JET scientific programme (Pamela et al 2007 Fusion Eng. Des. 82 590) has been engaged in a multi-campaign effort, including experiments in D, H and T, leading up to 2020 and the first experiments with 50%/50% D-T mixtures since 1997 and the first ever D-T plasmas with the ITER mix of plasma-facing component materials. For this purpose, a concerted physics and technology programme was launched with a view to prepare the D-T campaign (DTE2). This paper addresses the key elements developed by the JET programme directly contributing to the D-T preparation. This intense preparation includes the review of the physics basis for the D-T operational scenarios, including the fusion power predictions through first principle and integrated modelling, and the impact of isotopes in the operation and physics of D-T plasmas (thermal and particle transport, high confinement mode (H-mode) access, Be and W erosion, fuel recovery, etc). This effort also requires improving several aspects of plasma operation for DTE2, such as real time control schemes, heat load control, disruption avoidance and a mitigation system (including the installation of a new shattered pellet injector), novel ion cyclotron resonance heating schemes (such as the three-ions scheme), new diagnostics (neutron camera and spectrometer, active Alfven eigenmode antennas, neutral gauges, radiation hard imaging systems...) and the calibration of the JET neutron diagnostics at 14 MeV for accurate fusion power measurement. The active preparation of JET for the 2020 D-T campaign provides an incomparable source of information and a basis for the future D-T operation of ITER, and it is also foreseen that a large number of key physics issues will be addressed in support of burning plasmas.
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| 4. |
- Bombarda, F., et al.
(author)
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Runaway electron beam control
- 2019
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In: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 1361-6587 .- 0741-3335. ; 61:1
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Journal article (peer-reviewed)
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- 2018
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In: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 58:1
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Research review (peer-reviewed)
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| 29. |
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- 2018
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In: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 58:9
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Journal article (peer-reviewed)
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| 30. |
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| 31. |
- Hobirk, J., et al.
(author)
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The JET hybrid scenario in Deuterium, Tritium and Deuterium-Tritium
- 2023
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In: Nuclear Fusion. - : Institute of Physics Publishing (IOPP). - 0029-5515 .- 1741-4326. ; 63:11
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Journal article (peer-reviewed)abstract
- The JET hybrid scenario has been developed from low plasma current carbon wall discharges to the record-breaking Deuterium-Tritium plasmas obtained in 2021 with the ITER-like Be/W wall. The development started in pure Deuterium with refinement of the plasma current, and toroidal magnetic field choices and succeeded in solving the heat load challenges arising from 37 MW of injected power in the ITER like wall environment, keeping the radiation in the edge and core controlled, avoiding MHD instabilities and reaching high neutron rates. The Deuterium hybrid plasmas have been re-run in Tritium and methods have been found to keep the radiation controlled but not at high fusion performance probably due to time constraints. For the first time this scenario has been run in Deuterium-Tritium (50:50). These plasmas were re-optimised to have a radiation-stable H-mode entry phase, good impurity control through edge Ti gradient screening and optimised performance with fusion power exceeding 10 MW for longer than three alpha particle slow down times, 8.3 MW averaged over 5 s and fusion energy of 45.8 MJ.
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| 32. |
- Bath, PMW, et al.
(author)
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Baseline characteristics of the 4011 patients recruited into the ‘Efficacy of Nitric Oxide in Stroke’ (ENOS) trial
- 2014
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In: International journal of stroke : official journal of the International Stroke Society. - : SAGE Publications. - 1747-4949. ; 9:6, s. 711-720
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Journal article (peer-reviewed)abstract
- High blood pressure is common in acute stroke and associated with a worse functional outcome. Many patients who present with acute stroke are taking prescribed antihypertensive therapy before their stroke. Aims ENOS tested whether lowering blood pressure and continuing pre-stroke antihypertensive therapy are each safe and effective. Methods This study is an international multi-centre prospective randomized single-blind blinded-endpoint parallel-group partial-factorial controlled trial of transdermal glyceryl trinitrate (a nitric oxide donor, given for seven-days) vs. no glyceryl trinitrate, and of continuing vs. stopping (temporarily for seven-days) pre-stroke antihypertensive drugs if relevant, in patients with acute ischaemic stroke or intracerebral haemorrhage and high systolic blood pressure (140–220 mmHg). Results Recruitment ran from July 2001 to October 2013. Four thousand eleven patients [2097 (52·3%) in the continue/stop arm] were recruited from 173 sites across 23 countries in 5 continents (Asia 14%, Continental Europe 16%, UK 64%). Baseline characteristics include: mean age 70 (standard deviation 12) years; male 57%; mean time from stroke to recruitment 26 ( 13 ) h; mean severity (Scandinavian Stroke Scale) 34 ( 13 ) of 58; mean blood pressure 167 ( 19 )/90 ( 13 ) mmHg; ischaemic stroke 83%; and intracerebral haemorrhage 16%. The main trial results will be presented in May 2014. The results will also be presented in updated Cochrane systematic reviews and included in individual patient data meta-analyses of all relevant randomized controlled trials. Conclusion ENOS is a large completed international trial of blood pressure management in acute stroke and includes patients representative of many stroke services worldwide.
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| 33. |
- Adam, M., et al.
(author)
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Antimalarial drug efficacy and resistance in malaria-endemic countries in HANMAT-PIAM_net countries of the Eastern Mediterranean Region 2016-2020: Clinical and genetic studies
- 2023
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In: Tropical Medicine & International Health. - 1360-2276. ; 28:10, s. 817-829
-
Journal article (peer-reviewed)abstract
- Introduction The World Health Organization recommends regular monitoring of the efficacy of nationally recommended antimalarial drugs. We present the results of studies on the efficacy of recommended antimalarials and molecular markers of artemisinin and partner resistance in Afghanistan, Pakistan, Somalia, Sudan and Yemen.Methods Single-arm prospective studies were conducted to evaluate the efficacy of artesunate-sulfadoxine-pyrimethamine (ASSP) in Afghanistan and Pakistan, artemether-lumefantrine (AL) in all countries, or dihydroartemisinin-piperaquine (DP) in Sudan for the treatment of Plasmodium falciparum. The efficacy of chloroquine (CQ) and AL for the treatment of Plasmodium vivax was evaluated in Afghanistan and Somalia, respectively. Patients were treated and monitored for 28 (CQ, ASSP and AL) or 42 (DP) days. Polymerase chain reaction (PCR)-corrected cure rate and parasite positivity rate at Day 3 were estimated. Mutations in the P. falciparum kelch 13 (Pfk13) gene and amplifications of plasmepsin (Pfpm2) and multidrug resistance-1 (Pfmdr-1) genes were also studied.Results A total of 1680 (249 for ASSP, 1079 for AL and 352 for DP) falciparum cases were successfully assessed. A PCR-adjusted ASSP cure rate of 100% was observed in Afghanistan and Pakistan. For AL, the cure rate was 100% in all but four sites in Sudan, where cure rates ranged from 92.1% to 98.8%. All but one patient were parasite-free at Day 3. For P. vivax, cure rates were 98.2% for CQ and 100% for AL. None of the samples from Afghanistan, Pakistan and Yemen had a Pfk13 mutation known to be associated with artemisinin resistance. In Sudan, the validated Pfk13 R622I mutation accounted for 53.8% (14/26) of the detected non-synonymous Pfk13 mutations, most of which were repeatedly detected in Gadaref. A prevalence of 2.7% and 9.3% of Pfmdr1 amplification was observed in Pakistan and Yemen, respectively.Conclusion High efficacy of ASSP, AL and DP in the treatment of uncomplicated falciparum infection and of CQ and AL in the treatment of P. vivax was observed in the respective countries. The repeated detection of a relatively high rate of Pfk13 R622I mutation in Sudan underscores the need for close monitoring of the efficacy of recommended ACTs, parasite clearance rates and Pfk13 mutations in Sudan and beyond. Registration numbers of the trials: ACTRN12622000944730 and ACTRN12622000873729 for Afghanistan, ACTRN12620000426987 and ACTRN12617001025325 for Pakistan, ACTRN12618001224213 for Somalia, ACTRN12617000276358, ACTRN12622000930785 and ACTRN12618001800213 for Sudan and ACTRN12617000283370 for Yemen.
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| 34. |
- Batistoni, P., et al.
(author)
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14 MeV calibration of JET neutron detectors-phase 2 : in-vessel calibration
- 2018
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In: Nuclear Fusion. - : IOP PUBLISHING LTD. - 0029-5515 .- 1741-4326. ; 58:10
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Journal article (peer-reviewed)abstract
- A new DT campaign (DTE2) is planned at JET in 2020 to minimize the risks of ITER operations. In view of DT operations, a calibration of the JET neutron monitors at 14 MeV neutron energy has been performed using a well calibrated 14 MeV neutron generator (NG) deployed, together with its power supply and control unit, inside the vacuum vessel by the JET remote handling system. The NG was equipped with two calibrated diamond detectors, which continuously monitored its neutron emission rate during the calibration, and activation foils which provided the time integrated yield. Cables embedded in the remote handling boom were used to power the neutron generator, the active detectors and pre-amplifier, and to transport the detectors' signal. The monitoring activation foils were retrieved at the end of each day for decay gamma-ray counting, and replaced by fresh ones. About 76 hours of irradiation, in 9 days, were needed with the neutron generator in 73 different poloidal and toroidal positions in order to calibrate the two neutron yield measuring systems available at JET, the U-235 fission chambers (KN1) and the inner activation system (KN2). The NG neutron emission rates provided by the monitoring detectors were in agreement within 3%. Neutronics calculations have been performed using MCNP code and a detailed model of JET to derive the response of the JET neutron detectors to DT plasma neutrons starting from the response to the NG neutrons, and taking into account the anisotropy of the neutron generator and all the calibration circumstances. These calculations have made use of a very detailed and validated geometrical description of the neutron generator and of the modified. MNCP neutron source subroutine producing neutron energy-angle distribution for the neutrons emitted by the NG. The KN1 calibration factor for a DT plasma has been determined with +/- 4.2%' experimental uncertainty. Corrections due to NG and remote handling effects and the plasma volume effect have been calculated by simulation modelling. The related additional uncertainties are difficult to estimate, however the results of the previous calibration in 2013 have demonstrated that such uncertainties due to modelling are globally <= +/- 3%. It has been found that the difference between KN1 response to DD neutrons and that to DT neutrons is within the uncertainties in the derived responses. KN2 has been calibrated using the Nb-93(n,2n)Nb-92m and Al-27(n,a)Na-24 activation reactions (energy thresholds 10 MeV and 5 MeV respectively). The total uncertainty on the calibration factors is +/- 6% for Nb-93(n,2n)Nb-92m and +/- 8% Al-27(n,a)Na-24 (1 sigma). The calibration factors of the two independent systems KN1 and KN2 will be validated during DT operations. The experience gained and the lessons learnt are presented and discussed in particular with regard to the 14 MeV neutron calibrations in ITER.
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| 35. |
- Ng, S.W.P., et al.
(author)
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Late Triassic granites from Bangka, Indonesia: a continuation of the Main Range granite province of the South-East Asian Tin Belt.
- 2017
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In: Journal of Asian Earth Sciences. - : Elsevier BV. - 1367-9120 .- 1878-5786. ; 138, s. 548-561
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Journal article (peer-reviewed)abstract
- The South-East Asian Tin Belt is one of the most tin-productive regions in the world. It comprises three north-south oriented granite provinces, of which the arc-related Eastern granite province and the collision-related Main Range granite province run across Thailand, Singapore, and Indonesia. These tin-producing granite provinces with different mineral assemblages are separated by Paleo-Tethyan sutures exposed in Thailand and Malaysia. The Eastern Province is usually characterised by granites with biotite ± hornblende. Main Range granites are sometimes characterised by the presence of biotite ± muscovite. However, the physical boundary between the two types of granite is not well-defined on the Indonesian Tin Islands, because the Paleo-Tethyan suture is not exposed on land there. Both hornblende-bearing (previously interpreted as I-type) and hornblende-barren (previously interpreted as S-type) granites are apparently randomly distributed on the Indonesian Tin Islands. Granites exposed on Bangka, the largest and southernmost Tin Island, no matter whether they are hornblende-bearing or hornblende-barren, are geochemically similar to Malaysian Main Range granites. The average ɛNd(t) value obtained from the granites from Bangka (average ɛNd(t) = −8.2) falls within the range of the Main Range Province (−9.6 to −5.4). These granites have SIMS zircon U-Pb ages of ca. 225 Ma and ca. 220 Ma, respectively that are both within the period of Main Range magmatism (∼226–201 Ma) in the Peninsular Malaysia. We suggest that the granites exposed on Bangka represent the continuation of the Main Range Province, and that the Paleo-Tethyan suture lies to the east of the island.
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| 36. |
- Packer, L. W., et al.
(author)
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Activation of ITER materials in JET : nuclear characterisation experiments for the long-term irradiation station
- 2018
-
In: Nuclear Fusion. - : IOP PUBLISHING LTD. - 0029-5515 .- 1741-4326. ; 58:9
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Journal article (peer-reviewed)abstract
- This paper details progress in experimental characterisation work at JET for the long-term irradiation station, conducted as part of a project to perform activation experiments using ITER materials. The aim is to take advantage of the significant 14 MeV neutron yield expected during JET operations to irradiate samples of materials that will be used in the manufacturing of ITER tokamak components, such as Nb3Sn, SS316L steels from a range of manufacturers, SS304B, Alloy 660, W, CuCrZr, OF-Cu, XM-19, Al bronze, NbTi and EUROFER. This paper presents an assessment of the nuclear environment at the relevant irradiation locations at JET, measured using a range of high purity dosimetry foils: Ti, Ni, Y, Fe, Co, Sc, and Ta, irradiated with fusion neutrons at JET over a period of 15 months. Experimental results arc presented and compared to simulation predictions using a JET MCNP model coupled with the FISPACT-II inventory code. Comparisons are made for a total of 11 nuclear reactions using a range of nuclear data libraries in calculations.
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| 37. |
- Lensink, Marc F., et al.
(author)
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Impact of AlphaFold on structure prediction of protein complexes: The CASP15-CAPRI experiment
- 2023
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In: Proteins. - : WILEY. - 0887-3585 .- 1097-0134.
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Journal article (peer-reviewed)abstract
- We present the results for CAPRI Round 54, the 5th joint CASP-CAPRI protein assembly prediction challenge. The Round offered 37 targets, including 14 homodimers, 3 homo-trimers, 13 heterodimers including 3 antibody-antigen complexes, and 7 large assemblies. On average similar to 70 CASP and CAPRI predictor groups, including more than 20 automatics servers, submitted models for each target. A total of 21 941 models submitted by these groups and by 15 CAPRI scorer groups were evaluated using the CAPRI model quality measures and the DockQ score consolidating these measures. The prediction performance was quantified by a weighted score based on the number of models of acceptable quality or higher submitted by each group among their five best models. Results show substantial progress achieved across a significant fraction of the 60+ participating groups. High-quality models were produced for about 40% of the targets compared to 8% two years earlier. This remarkable improvement is due to the wide use of the AlphaFold2 and AlphaFold2-Multimer software and the confidence metrics they provide. Notably, expanded sampling of candidate solutions by manipulating these deep learning inference engines, enriching multiple sequence alignments, or integration of advanced modeling tools, enabled top performing groups to exceed the performance of a standard AlphaFold2-Multimer version used as a yard stick. This notwithstanding, performance remained poor for complexes with antibodies and nanobodies, where evolutionary relationships between the binding partners are lacking, and for complexes featuring conformational flexibility, clearly indicating that the prediction of protein complexes remains a challenging problem.
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| 38. |
- Ng, S.W.-P., et al.
(author)
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Petrogenesis of Malaysian granitoids in the Southeast Asian Tin Belt: Part 1. Geochemical and Sr-Nd isotopic characteristics.
- 2015
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In: Geological Society of America Bulletin. - 0016-7606 .- 1943-2674. ; 127, s. 1209-1237
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Journal article (peer-reviewed)abstract
- The Malaysian granitoids of the Southeast Asian tin belt have been traditionally divided into a Permian to Late Triassic “I-type”–dominated arc-related Eastern province (Indochina terrane) and a Late Triassic “S-type”–dominated collision-related Main Range province (Sibumasu terrane), separated by the Bentong-Raub Paleo-Tethyan suture that closed in the Late Triassic. The present study, however, shows that this model is oversimplified and that the direct application of Chappell and White’s (1974) I- and S-type classification cannot account for many of the characteristics shared by Malaysian granitoids. Despite being commonly hornblende bearing, as is typical for I-type granites, the roof zones of the Eastern province granites are hornblende free. In addition, the Main Range province granitoids contain insignificant primary muscovite, and are dominated by biotite granites, mineralogically similar to many of the plutons of the Eastern province. In general, the Malaysian granitoids from both provinces are more enriched in high field strength elements than typical Cordilleran I- and S-type granitoids. The mineralogy and geochemistry of the Eastern province granitoids, and their relationship with contemporaneous volcanics, confirm their I-type nature. The bulk liquid lines of descent of both granitic provinces largely overlap with one another. Sr-Nd isotopic data further demonstrate that the Malaysian granitoids, especially those of the Main Range, were hybridized melts derived from two “end-member” source regions, one of which is isotopically similar to the Kontum orthoamphibolites and the other akin to the Kontum paragneisses of the Indochina block. However, there are differences in the source rocks for the two provinces, and it is suggested in this paper that these are related to differing proportions of igneous and sedimentary protoliths. The incorporation of sedimentary-sourced melts in the Eastern province is insignificant, which allowed the granites in this belt to maintain their I-type nature. The presence of minor primary tin mineralization in the Eastern province compared to the much more significant tin endowment in the Main Range is considered to reflect the incorporation of a smaller proportion of sedimentary protolith in the melt products of the former.
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| 39. |
- Ng, S.W.--P., et al.
(author)
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Petrogenesis of Malaysian granitoids in the Southeast Asian Tin Belt: Part 2. U-Pb zircon geochronology and tectonic model.
- 2015
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In: Geological Society of America Bulletin. - 0016-7606 .- 1943-2674. ; 127, s. 1238-1258
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Journal article (peer-reviewed)abstract
- In our complementary geochemical study (Part 1), the Malaysian granitoids of the Southeast Asian tin belt were divided into a Middle Permian to Late Triassic I-type–dominated Eastern province (Indochina terrane) and a Triassic to Early Jurassic transitional I/S-type Main Range province (Sibumasu terrane), separated by the Bentong-Raub suture zone which closed in the Late Triassic. Previous geochronology has relied on only a few U-Pb zircon ages together with K-Ar and whole rock Rb-Sr ages that may not accurately record true magmatic ages. We present 39 new high-precision U-Pb zircon ion microprobe ages from granitoids and volcanics across the Malay Peninsula. Our results show that ages from the Eastern province granitoids span 289–220 Ma, with those from the Main Range province granitoids being entirely Late Triassic, spanning 227–201 Ma. A general westerly younging magmatic trend across the Malay Peninsula is considered to reflect steepening and roll-back of the Bentong-Raub subduction zone during progressive closure of Paleo-Tethys. The youngest ages of subduction-related granites in the Eastern province roughly coincide with the youngest ages of marine sedimentary rocks along the Paleo-Tethyan suture zone. Our petrogenetic and U-Pb zircon age data support models that relate the Eastern province granites to pre-collisional Andean-type magmatism and the western Main Range province granites to syn- and post-collisional crustal melting of Sibumasu crust during the Late Triassic. Tin mineralization was mainly associated with the latter phase of magmatism. Two alternative tectonic models are discussed to explain the Triassic evolution of the Malay Peninsula. The first involves a second Late Triassic to Jurassic or Early Cretaceous east-dipping subduction zone west of Sibumasu where subduction-related hornblende and biotite–bearing granites along Sibumasu are paired with Main Range crustal-melt tin-bearing granites, analogous to the Bolivia Cordilleran tin-bearing granite belt. The second model involves westward underthrusting of Indochina beneath the West Malaya Main Range province, resulting in crustal thickening and formation of tin-bearing granites of the Main Ranges. Cretaceous granitoids are also present locally in Singapore (Ubin diorite), on Tioman Island, in the Noring pluton, of the Stong complex (Eastern Province), and along the Sibumasu terrane in southwest Thailand and Burma (Myanmar), reflecting localized crustal melting.
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| 40. |
- Eriksson, Benjamin, et al.
(author)
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Determining the fuel ion ratio for D(T)and T(D) plasmas at JET using neutron time-of-flight spectrometry
- 2022
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In: Plasma Physics and Controlled Fusion. - : Institute of Physics (IOP). - 0741-3335 .- 1361-6587. ; 64
-
Journal article (peer-reviewed)abstract
- The fusion fuel ion ratio, nΤ/nD, is an important plasma parameter that needs to be tuned to maximize the power of a tokamak type fusion reactor. It is recognized as a parameter required for optimizing several ITER operating scenarios, and will likely be continuously monitored in future high-performance fusion devices such as DEMO. Tritium was recently introduced in the Joint European Torus (JET) plasma for the first time since the 1997 DTE1 and 2003 TTE campaigns, enabling the possibility to investigate fuel ion ratios. We present a method for measuring nΤ/nD using neutron time-of-flight (TOF) spectrometry. By fitting the measured neutron spectral features, the relative reaction rate intensities between different ion species can be inferred, from which the fuel ion ratio can be extracted for a corresponding modeled reactivity. Unlike previous measurements of nT/nD using neutron spectrometry, we utilize the neutron energy continuum produced in the three-body TT reaction to determine the fuel ion ratio for plasmas with large concentrations of tritium. Furthermore, the use of neutron TOF spectrometry has never previously been demonstrated for evaluating nT/nD. The method is applied to TOF spectra acquired with TOFOR (JET name KM11) and shown to be consistent with the optical JET diagnostic KT5P which uses optical spectroscopy of a modified Penning gauge plasma to measure tritium and deuterium concentrations in the divertor exhaust gas.
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| 41. |
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| 42. |
- Gu, Feng, et al.
(author)
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Advance reservation for virtual overlay network services
- 2011
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In: 13th International Conference on Transparent Optical Networks (ICTON), 2011. - : IEEE conference proceedings. ; , s. 1-4
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Conference paper (peer-reviewed)abstract
- Network advance reservation is an area of growing interest and focus today. However most proposed solutions in this field have only focused on the scheduling of point-to-point client connections. Now as applications and user communities continue to expand, there is a growing need to extend advance reservation support for multipoint services. To address this concern, a heuristic solution is presented for virtual overlay network scheduling. The scheme uses graph-theoretic schemes and is analyzed in detail using network simulation.
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| 43. |
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| 44. |
- Nocente, M., et al.
(author)
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Fusion product measurements by nuclear diagnostics in the Joint European Torus deuterium-tritium 2 campaign (invited)
- 2022
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In: Review of Scientific Instruments. - : American Institute of Physics (AIP). - 0034-6748 .- 1089-7623. ; 93:9
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Journal article (peer-reviewed)abstract
- A new deuterium-tritium experimental, DTE2, campaign has been conducted at the Joint European Torus (JET) between August 2021 and late December 2021. Motivated by significant enhancements in the past decade at JET, such as the ITER-like wall and enhanced auxiliary heating power, the campaign achieved a new fusion energy world record and performed a broad range of fundamental experiments to inform ITER physics scenarios and operations. New capabilities in the area of fusion product measurements by nuclear diagnostics were available as a result of a decade long enhancement program. These have been tested for the first time in DTE2 and a concise overview is provided here. Confined alpha particle measurements by gamma-ray spectroscopy were successfully demonstrated, albeit with limitations at neutron rates higher than some 10(17) n/s. High resolution neutron spectroscopy measurements with the magnetic proton recoil instrument were complemented by novel data from a set of synthetic diamond detectors, which enabled studies of the supra-thermal contributions to the neutron emission. In the area of escaping fast ion diagnostics, a lost fast ion detector and a set of Faraday cups made it possible to determine information on the velocity space and poloidal distribution of the lost alpha particles for the first time. This extensive set of data provides unique information for fundamental physics studies and validation of the numerical models, which are key to inform the physics and scenarios of ITER. Published under an exclusive license by AIP Publishing.
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| 46. |
- Wu, Alan H B, et al.
(author)
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Analytical and clinical evaluation of the Bayer ADVIA Centaur automated B-type natriuretic peptide assay in patients with heart failure : a multisite study
- 2004
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In: Clinical Chemistry. - : Oxford University Press (OUP). - 0009-9147 .- 1530-8561. ; 50:5, s. 867-873
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Journal article (peer-reviewed)abstract
- BACKGROUND:B-Type natriuretic peptide (BNP) is released from the left ventricle of the heart into the circulation in response to ventricular stretching and volume overload. Increased BNP concentrations are associated with heart failure (HF).METHODS:We evaluated the analytical and clinical performance of the Bayer ADVIA Centaur BNP assay. Studies included precision, analytical correlation (against the Shionogi ShionoRIA and Biosite Triage BNP assays), BNP results for blood collected in plastic tubes containing EDTA vs other collection tubes, high-dose hook effect, detection limits, and interferences. The clinical performance was tested on 2243 blood samples collected from 983 apparently healthy individuals, 538 patients with chronic disease but without HF (renal insufficiency, chronic obstructive pulmonary disease, diabetes, and hypertension), and 722 patients with HF (New York Heart Association classes I-IV).RESULTS:The ADVIA Centaur assay had total imprecision (CV) of 3.4%, 2.9%, and 2.4% at BNP concentrations of 48, 461, and 1768 ng/L, respectively. The Passing-Bablok correlations to the ShionoRIA and Triage were as follows: ADVIA Centaur = 1.11(ShionoRIA) - 1.19 ng/L (r = 0.98); ADVIA Centaur = 0.78(Triage) + 5.89 ng/L (r = 0.92), respectively. Of the different blood collection tubes, only EDTA plastic tubes (with and without the barrier gel) were acceptable. The lower detection limit was 0.5 ng/L, and there were no interferences from common analytes, other neuropeptides, or unusual antibodies. BNP exhibited different reference intervals according to age and gender. BNP concentrations increased progressively as the severity of HF increased.CONCLUSIONS:The ADVIA Centaur is the first commercially available BNP assay for use on an automated immunochemistry platform. This assay has good analytical and clinical performance characteristics for diagnosing HF.
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| 47. |
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