| 1. |
- Aad, G, et al.
(author)
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- 2015
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swepub:Mat__t
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| 2. |
- Girgis, E., et al.
(author)
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Ink-jet-printed (ZnO)(1-x)( TiO2)(x) composite films for solar cell applications
- 2013
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In: Journal of Materials Research. - : Springer Science and Business Media LLC. - 0884-2914 .- 2044-5326. ; 28:3, s. 502-506
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Journal article (peer-reviewed)abstract
- Ink-jet printing technique is used to prepare porous (ZnO)(1-x)(TiO2)(x) composite films on indium tin oxide-coated glass substrates. Dye-sensitized solar cells were fabricated using well-characterized printed films of thickness similar to 20 and 30 mu m, respectively. It is found that the photovoltaic performance of the cells is dependent on the film thickness and the concentrations of ZnO. The obtained results are compared with those of pure ZnO- and TiO2-based cells prepared by the same route to optimize the device efficiency. This study suggests that ink-jet printers promise an inexpensive and simple technology for manufacturing solar cell composite films.
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| 3. |
- Emam, A. N., et al.
(author)
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Hybrid magnetic-plasmonic nanocomposite : Embedding cobalt clusters in gold nanorods
- 2015
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In: RSC Advances. - : Royal Society of Chemistry (RSC). - 2046-2069. ; 5:44, s. 34696-34703
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Journal article (peer-reviewed)abstract
- We developed a method to fabricate hybrid magnetic-plasmonic nanorods (Au-Co NRs) via a modified seed mediated method. The only modification is to use cobalt ions instead of Au3+ in the preparation of the seed solution to obtain gold nanorods doped with Co clusters. By adjusting the amount of cobalt seed solution, Au-Co NRs of controlled aspect ratio can be obtained. The optical properties of the obtained Au-Co NRs were investigated and compared to those of the pure Au NRs. A slight shift and broadening were observed in the alloys compared to the pure ones, which was attributed to the presence of Co clusters leading to suppression of the dielectric properties. High resolution transmission electron microscopy (HRTEM) images indicate the existence of Co clusters in situ in the Au NR host and clearly show the metal-metal interface. The magnetic properties of the obtained Au-Co NRs increase as the concentration of dopant Co cluster seeds increases, as investigated by vibrating sample magnetometry (VSM). Our approach allows us to design nanomaterials of controlled shape, optical and magnetic properties which have many promising applications in tharanostics and photoelectronics.
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| 4. |
- Girgis, E., et al.
(author)
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Cobalt ferrite nanotubes and porous nanorods for dye removal
- 2015
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In: ADVANCES IN NANO RESEARCH. - : TECHNO-PRESS. - 2287-237X. ; 3:2, s. 111-121
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Journal article (peer-reviewed)abstract
- CoFe2O4 nanotubes and porous nanorods were prepared via a simple one-pot template-free hydrothermal method and were used as an adsorbent for the removal of dye contaminants from water. The properties of the synthesized nanotubes and porous nanorods were characterized by electron diffraction, transmission electron microscopy and x-ray powder diffraction. The Adsorption characteristics of the CoFe2O4 were examined using polar red dye and the factors affecting adsorption, such as, initial dye concentration, pH and contact time were evaluated. The overall trend followed an increase of the sorption capacity reaching a maximum of 95% dye removal at low pHs of 2-4. An enhancement in the removal efficiency was also noticed upon increasing the contact time between dye molecules and CoFe2O4 nanoparticles. The final results indicated that the CoFe2O4 nanotubes and porous nanorods can be considered as an efficient low cost and recyclable adsorbent for dye removal with efficiency 94% for Cobalt ferrite nanotubes and for Cobalt ferrite porous nanorods equals 95%
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| 5. |
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| 6. |
- Girgis, E., et al.
(author)
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Nanotoxicity of Gold and Gold-Cobalt Nanoalloy
- 2012
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In: Chemical Research in Toxicology. - : American Chemical Society (ACS). - 0893-228X .- 1520-5010. ; 25:5, s. 1086-1098
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Journal article (peer-reviewed)abstract
- Nanotoxicology test of gold nanoparticles (Au NPs) and gold-cobalt (Au-Co) nanoalloy is an important step in their safety evaluation for biomedical applications. The Au and Au-Co NPs were prepared by reducing the metal ions using sodium borohydride (NaBH4) in the presence of polyvinyl pyrrolidone (PVP) as a capping material. The average size and shape of the nanoparticles (NPs) were characterized using high resolution transmission electron microscopy (HRTEM). Cobalt presence in the nanoalloy was confirmed by energy dispersive X-ray spectroscopy (EDX) analysis, and the magnetic properties of these particles were determined using a vibrating sample magnetometer (VSM). The Gold and gold-cobalt NPs of average size 15 +/- 1.5 nm were administered orally to mice with a dose of 80, 160, and 320 mg/kg per body weight (bw) using gavages. Samples were collected after 7 and 14 days of the treatment. The results indicated that the Au-Co NPs were able to induce significant alteration in the tumor-initiating genes associated with an increase of micronuclei (MNs) formation and generation of DNA adduct (8-hydroxy-2-deoxyguanosine, 8-OHdG) as well as a reduction in the glutathione peroxidase activity. This action of Au-Co NPs was observed using 160 and 320 mg/kg bw at both time intervals. However, Au NPs had much lower effects than Au-Co NPs on alteration in the tumor-initiating genes, frequency of MNs, and generation of 8-0HdG as well as glutathione peroxidase activity except with the highest dose of Au NPs. This study suggests that the potential to cause in vivo genetic and antioxidant enzyme alterations due to the treatment by Au-Co nanoalloy may be attributed to the increase in oxidative stress in mice.
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| 7. |
- Khalil, W. K. B., et al.
(author)
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Genotoxicity Evaluation of Nanomaterials : DNA Damage, Micronuclei, and 8-Hydroxy-2-deoxyguanosine Induced by Magnetic Doped CdSe Quantum Dots in Male Mice
- 2011
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In: Chemical Research in Toxicology. - : American Chemical Society (ACS). - 0893-228X .- 1520-5010. ; 24:5, s. 640-650
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Journal article (peer-reviewed)abstract
- Quantum dots (QDs) are a novel class of inorganic fluorophores which are gaining widespread recognition as a result of their exceptional photophysical properties and their applications as a biomarker and in molecular biomedical imaging. The aim of this study was to evaluate the in vivo genotoxicity in mice exposed to CdSe quantum dots of average size 5.0 +/- 0.2 nm and CdSe doped with 1% cobalt ions of similar size. The quantum dots are surface modified using mercaptoacetic acid (MAA) in order to be biocompatible and water-soluble. The MAA-QDs were given to the mice orally at doses of 500, 1000, and 2000 mg/kg by weight of MAA-QDs. Bone marrow and liver samples were collected after two and seven days of treatment. The results indicated that after two days of treatment, the high dose of doped MAA-QDs was significantly able to induce DNA damage, formation of micronuclei (MNs), and generation of DNA adduct (8-hydroxy-2-deoxyguanosine, 8-OHdG). However, increasing DNA damage and the frequency of MNs formation as well as the generation of DNA adducts were observed with both the undoped MAA-QDs (2000 mg/kg) and doped MAA-QDs (1000 and 2000 mg/kg) after seven days of treatment. The results of our study indicate that exposure to high doses of pure MAA-QDs or MAA-QDs doped with cobalt has the potential to cause indirect in vivo genetic damage, which may be attributed to free radical-induced oxidative stress in mice.
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| 8. |
- Stuparu, Andreea D., et al.
(author)
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Targeted alpha therapy in a systemic mouse model of prostate cancer - a feasibility study
- 2020
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In: Theranostics. - : Ivyspring International Publisher. - 1838-7640. ; 10:6, s. 2612-2620
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Journal article (peer-reviewed)abstract
- 225Ac-PSMA-617 targeted-therapy has demonstrated efficacy in 75-85% of patients; however, responses are not durable. We aimed to establish translatable mouse models of disseminated prostate cancer (PCa) to evaluate effectiveness of 225Ac-PSMA-617 at various disease stages. Methods: C4-2, C4-2B, or 22Rv1 cells were injected into the left ventricle of male NSG mice. Disease progression was monitored using bioluminescence imaging (BLI). For treatment, mice were injected with 40 kBq 225Ac-PSMA-617 at one (early treatment cohort) or three weeks (late treatment cohort) post-inoculation. Treatment efficacy was monitored by BLI of whole-body tumor burden. Mice were sacrificed based on body conditioning score. Results: C4-2 cells yielded metastases in liver, lungs, spleen, stomach, bones, and brain - achieving a clinically relevant model of widespread metastatic disease. The disease burden in the early treatment cohort was stable over 27 weeks in 5/9 mice and progressive in 4/9 mice. These mice were sacrificed due to brain metastases. Median survival of the late treatment cohort was superior to controls (13 vs. 7 weeks; p<0.0001) but inferior to that in the early treatment cohort (13 vs. 27 weeks; p<0.001). Late cohort mice succumbed to extensive liver involvement. The 22Rv1 and C4-2B systemic models were not used for treatment due to high kidney metastatic burden or low take rate, respectively. Conclusion: C4-2 cells reproduced metastatic cancer spread most relevantly. Early treatment with 225Ac-PSMA-617 prevented liver metastases and led to significant survival benefit. Late treatment improved survival without reducing tumor burden in the liver, the main site of metastasis. The current findings suggest that early 225Ac-PSMA-617 intervention is more efficacious in the setting of widespread metastatic PCa.
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